Faculty

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Eric Lin Chang, MD
Chair and Professor of Radiation Oncology
Radiation Oncology
NOR G358 1441 EASTLAKE AVE Health Sciences Campus Los Angeles
+1 323 865 3072

Overview

Prior to joining USC Keck School of Medicine as Professor and Chair of Radiation Oncology, Dr. Eric L. Chang was on the faculty as an attending radiation oncologist at The University of Texas M. D. Anderson Cancer Center for over 12 years, rising to an academic rank of Professor. Having established the first Gamma Knife radiosurgery program at M. D. Anderson which treats over 450 patients a year, he served as the Director of the CNS Stereotactic Radiation Program comprising the Gamma Knife program, and the Steretoactic Body Radiation Therapy (SBRT) program for spine which treats over 100 spine patients a year. He is board certified by the American Board of Radiology in radiation oncology and specializes in the radiotherapeutic evaluation and management of patients with tumors of the central nervous system. He attended Harvard Medical School where he received his Doctorate in Medicine.

Dr. Chang's post-graduate training was conducted at the Harvard Joint Center for Radiation Therapy, in Boston, Massachusetts. He has held research leadership roles including having served as member, and Chair of the M. D. Anderson Cancer Center Clinical Research Committee (CRC) Chair. He is the 2011 CNS track leader for the American Society for Clinical Oncology (ASCO) Scientific Program Committee, and member of the ASCO Cancer Education Committee. Dr. Chang is currently the co-leader for the American Society of Radiation Oncology (ASTRO) brain metastasis guidelines development task force and member of the Annual Program Committee of the Educational Council of ASTRO. He is current member of the American College of Radiology Appropriateness Criteria Expert Panel on bone metastases. He has been listed in the Best Doctors Directory. Dr. Chang led a phase III randomized controlled trial on brain metastasis published in the Lancet Oncology 2009 which is starting to change the practice patterns for metastatic brain disease. Dr. Chang has been selected as a plenary speaker for past meetings of ASTRO and the American Association for Neurological Surgeons (AANS). He has authored or co-authored over 100 peer-reviewed papers and abstracts.

Awards

James D. Cox Mentorship Award

Sigma Xi Research Society,

Howard Hughes Medical Institute Research Fellowship

Vail, Colorado: American Society for Clinical Oncology (ASCO) Award, Methods in Clinical Cancer Research Workshop, 1997

The American College of Radiation Oncology (ACRO), Howard H. Wong Fellowship in Radiation Oncology

The American Society for Therapeutic Radiology and Oncology (ASTRO), Travel Grant to attend ESTRO an

Named in Strathmore's Who's Who

Listed in Best Doctors in America

Listed in Best Doctors in America

Publications

Redmond KJ, Lo SS, Soltys SG, Yamada Y, Barani IJ, Brown PD, Chang EL, Gerszten PC, Chao ST, Amdur RJ, De Salles AA, Guckenberger M, Teh BS, Sheehan J, Kersh CR, Fehlings MG, Sohn MJ, Chang UK, Ryu S, Gibbs IC, Sahgal A. Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey. J Neurosurg Spine. 2016 Nov 11; 1-8. View in: PubMed

Redmond KJ, Robertson S, Lo SS, Soltys SG, Ryu S, McNutt T, Chao ST, Yamada Y, Ghia A, Chang EL, Sheehan J, Sahgal A. Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine. Int J Radiat Oncol Biol Phys. 2016 Sep 17. View in: PubMed

Bernstein MB, Chang EL, Amini B, Pan H, Cabanillas M, Wang XA, Allen PK, Rhines LD, Tatsui C, Li J, Brown PD, Ghia AJ. Spine Stereotactic Radiosurgery for Patients with Metastatic Thyroid Cancer: Secondary Analysis of Phase I/II Trials. Thyroid. 2016 Sep; 26(9):1269-75. View in: PubMed

Tao R, Bishop AJ, Brownlee Z, Allen PK, Settle SH, Chang EL, Wang X, Amini B, Tannir NM, Tatsui C, Rhines LD, Brown PD, Ghia AJ. Stereotactic Body Radiation Therapy for Spinal Metastases in the Postoperative Setting: A Secondary Analysis of Mature Phase 1-2 Trials. Int J Radiat Oncol Biol Phys. 2016 Aug 1; 95(5):1405-13. View in: PubMed

Lo SS, Soliman H, Chang EL, Sahgal A. In Regard to Johnson et al. Int J Radiat Oncol Biol Phys. 2016 Jul 1; 95(3):1083-5. View in: PubMed

Ghia AJ, Chang EL, Bishop AJ, Pan HY, Boehling NS, Amini B, Allen PK, Li J, Rhines LD, Tannir NM, Tatsui CE, Brown PD, Yang JN. Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of Phase I/II trials. J Neurosurg Spine. 2016 May; 24(5):829-36. View in: PubMed

Wong K, Opimo AB, Olch AJ, All S, Waxer JF, Clark D, Cheng J, Chlebik A, Erdreich-Epstein A, Krieger MD, Tamrazi B, Dhall G, Finlay JL, Chang EL. Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature. Cureus. 2016; 8(4):e585. View in: PubMed

Soffietti R, Rudà R, Trakul N, Chang EL. Point/Counterpoint: Is stereotactic radiosurgery needed following resection of brain metastasis? Neuro Oncol. 2016 Jan; 18(1):12-5. View in: PubMed

Lo SS, Redmond KJ, Chang EL, Foote M, Knisely JP, Sahgal A. Stereotactic radiosurgery alone for limited brain metastases: are we ready for prime time? CNS Oncol. 2016 Jan; 5(1):1-4. View in: PubMed

Thibault I, Chang EL, Sheehan J, Ahluwalia MS, Guckenberger M, Sohn MJ, Ryu S, Foote M, Lo SS, Muacevic A, Soltys SG, Chao S, Gerszten P, Lis E, Yu E, Bilsky M, Fisher C, Schiff D, Fehlings MG, Ma L, Chang S, Chow E, Parelukar WR, Vogelbaum MA, Sahgal A. Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group. Lancet Oncol. 2015 Dec; 16(16):e595-603. View in: PubMed

Redmond KJ, Sahgal A, Foote M, Knisely J, Gerszten PC, Chao ST, Suh JH, Sloan AE, Chang EL, Machtay M, Lo SS. Single versus multiple session stereotactic body radiotherapy for spinal metastasis: the risk-benefit ratio. Future Oncol. 2015 Sep; 11(17):2405-15. View in: PubMed

Bishop AJ, Tao R, Rebueno NC, Christensen EN, Allen PK, Wang XA, Amini B, Tannir NM, Tatsui CE, Rhines LD, Li J, Chang EL, Brown PD, Ghia AJ. Outcomes for Spine Stereotactic Body Radiation Therapy and an Analysis of Predictors of Local Recurrence. Int J Radiat Oncol Biol Phys. 2015 Aug 1; 92(5):1016-26. View in: PubMed

Sahgal A, Kocher M, Tago M, Chang EL. In Reply to Gemici and Yaprak and Lowrey and Marcus. Int J Radiat Oncol Biol Phys. 2015 Jul 15; 92(4):948-9. View in: PubMed

Awan M, Liu S, Sahgal A, Das S, Chao ST, Chang EL, Knisely JP, Redmond K, Sohn JW, Machtay M, Sloan AE, Mansur DB, Rogers LR, Lo SS. Extra-CNS metastasis from glioblastoma: a rare clinical entity. Expert Rev Anticancer Ther. 2015 May; 15(5):545-52. View in: PubMed

Sahgal A, Aoyama H, Kocher M, Neupane B, Collette S, Tago M, Shaw P, Beyene J, Chang EL. Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: individual patient data meta-analysis. Int J Radiat Oncol Biol Phys. 2015 Mar 15; 91(4):710-7. View in: PubMed

Penas-Prado M, Hess KR, Fisch MJ, Lagrone LW, Groves MD, Levin VA, De Groot JF, Puduvalli VK, Colman H, Volas-Redd G, Giglio P, Conrad CA, Salacz ME, Floyd JD, Loghin ME, Hsu SH, Gonzalez J, Chang EL, Woo SY, Mahajan A, Aldape KD, Yung WK, Gilbert MR. Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma. Neuro Oncol. 2015 Feb; 17(2):266-73. View in: PubMed

Lo SS, Kubicky CD, Chang EL, Sahgal A. Is there any role for stereotactic body radiotherapy in the management of metastatic epidural spinal cord compression? CNS Oncol. 2015 Jan; 4(1):1-4. View in: PubMed

Sellin JN, Reichardt W, Bishop AJ, Suki D, Rhines LD, Settle SH, Brown PD, Li J, Rao G, Chang EL, Tatsui CE. Factors affecting survival in 37 consecutive patients undergoing de novo stereotactic radiosurgery for contiguous sites of vertebral body metastasis from renal cell carcinoma. J Neurosurg Spine. 2015 Jan; 22(1):52-9. View in: PubMed

Tuchman A, Yu C, Chang EL, Kim PE, Rusch MC, Apuzzo ML. Radiosurgery for metastatic disease at the craniocervical junction. World Neurosurg. 2014 Dec; 82(6):1331-6. View in: PubMed

Pan HY, Allen PK, Wang XS, Chang EL, Rhines LD, Tatsui CE, Amini B, Wang XA, Tannir NM, Brown PD, Ghia AJ. Incidence and predictive factors of pain flare after spine stereotactic body radiation therapy: secondary analysis of phase 1/2 trials. Int J Radiat Oncol Biol Phys. 2014 Nov 15; 90(4):870-6. View in: PubMed

Grosshans DR, Zhu XR, Melancon A, Allen PK, Poenisch F, Palmer M, McAleer MF, McGovern SL, Gillin M, DeMonte F, Chang EL, Brown PD, Mahajan A. Spot scanning proton therapy for malignancies of the base of skull: treatment planning, acute toxicities, and preliminary clinical outcomes. Int J Radiat Oncol Biol Phys. 2014 Nov 1; 90(3):540-6. View in: PubMed

Lam TC, Sahgal A, Chang EL, Lo SS. Stereotactic radiosurgery for multiple brain metastases. Expert Rev Anticancer Ther. 2014 Oct; 14(10):1153-72. View in: PubMed

Tsai CJ, Wang Y, Allen PK, Mahajan A, McCutcheon IE, Rao G, Rhines LD, Tatsui CE, Armstrong TS, Maor MH, Chang EL, Brown PD, Li J. Outcomes after surgery and radiotherapy for spinal myxopapillary ependymoma: update of the MD anderson cancer center experience. Neurosurgery. 2014 Sep; 75(3):205-14. View in: PubMed

Kubicky CD, Sahgal A, Chang EL, Lo SS. Rare primary central nervous system tumors. Rare Tumors. 2014 Jul 30; 6(3):5449. View in: PubMed

Lo SS, Loblaw A, Chang EL, Mayr NA, Teh BS, Huang Z, Yao M, Ellis RJ, Biswas T, Sohn JW, Machtay M, Sahgal A. Emerging applications of stereotactic body radiotherapy. Future Oncol. 2014 May; 10(7):1299-310. View in: PubMed

Zhu XR, Poenisch F, Li H, Zhang X, Sahoo N, Wu RY, Li X, Lee AK, Chang EL, Choi S, Pugh T, Frank SJ, Gillin MT, Mahajan A, Grosshans DR. A single-field integrated boost treatment planning technique for spot scanning proton therapy. Radiat Oncol. 2014; 9:202. View in: PubMed

Verma J, Jonasch E, Allen PK, Weinberg JS, Tannir N, Chang EL, Mahajan A. The impact of tyrosine kinase inhibitors on the multimodality treatment of brain metastases from renal cell carcinoma. Am J Clin Oncol. 2013 Dec; 36(6):620-4. View in: PubMed

Ghia AJ, Chang EL, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy. Neurosurgery. 2013 Oct; 73(4):624-30; discussion 630-1. View in: PubMed

Lo SS, Sahgal A, Slotman BJ, Mansur DB, Khouri A, Sloan AE, Machtay M, Chang EL. What is the most appropriate clinical target volume for glioblastoma? CNS Oncol. 2013 Sep; 2(5):419-25. View in: PubMed

Lo SS, Chang EL, Ryu S, Chung H, Slotman BJ, Teh BS, Sahgal A. Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapy. Part I: spinal tumors. Future Oncol. 2013 Sep; 9(9):1299-302. View in: PubMed

Lo SS, Chang EL, Ryu S, Chung H, Slotman BJ, Teh BS, Sahgal A. Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapy. Part II: nonspinal tumors. Future Oncol. 2013 Sep; 9(9):1303-6. View in: PubMed

Husain ZA, Thibault I, Letourneau D, Ma L, Keller H, Suh J, Chiang V, Chang EL, Rampersaud RK, Perry J, Larson DA, Sahgal A. Stereotactic body radiotherapy: a new paradigm in the management of spinal metastases. CNS Oncol. 2013 May; 2(3):259-70. View in: PubMed

Likhacheva A, Pinnix CC, Parikh NR, Allen PK, McAleer MF, Chiu MS, Sulman EP, Mahajan A, Guha-Thakurta N, Prabhu SS, Cahill DP, Luo D, Shiu AS, Brown PD, Chang EL. Predictors of survival in contemporary practice after initial radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys. 2013 Mar 1; 85(3):656-61. View in: PubMed

ACR Appropriateness Criteria ® spinal bone metastases. J Palliat Med. 2013 Jan; 16(1):9-19. View in: PubMed

Likhacheva A, Pinnix CC, Parikh N, Allen PK, Guha-Thakurta N, McAleer M, Sulman EP, Mahajan A, Shiu A, Luo D, Chiu M, Brown PD, Prabhu SS, Chang EL. Validation of Recursive Partitioning Analysis and Diagnosis-Specific Graded Prognostic Assessment in patients treated initially with radiosurgery alone. J Neurosurg. 2012 Dec; 117 Suppl:38-44. View in: PubMed

Weksberg DC, Palmer MB, Vu KN, Rebueno NC, Sharp HJ, Luo D, Yang JN, Shiu AS, Rhines LD, McAleer MF, Brown PD, Chang EL. Generalizable class solutions for treatment planning of spinal stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 2012 Nov 1; 84(3):847-53. View in: PubMed

Garg AK, Shiu AS, Yang J, Wang XS, Allen P, Brown BW, Grossman P, Frija EK, McAleer MF, Azeem S, Brown PD, Rhines LD, Chang EL. Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer. 2012 Oct 15; 118(20):5069-77. View in: PubMed

Tsao MN, Rades D, Wirth A, Lo SS, Danielson BL, Gaspar LE, Sperduto PW, Vogelbaum MA, Radawski JD, Wang JZ, Gillin MT, Mohideen N, Hahn CA, Chang EL. Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol. 2012 Jul-Sep; 2(3):210-25. View in: PubMed

Pinnix CC, Fontanilla HP, Hayes-Jordan A, Subbiah V, Bilton SD, Chang EL, Grosshans DR, McAleer MF, Sulman EP, Woo SY, Anderson P, Green HL, Mahajan A. Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery. Int J Radiat Oncol Biol Phys. 2012 May 1; 83(1):317-26. View in: PubMed

ACR Appropriateness Criteria® non-spine bone metastases. J Palliat Med. 2012 May; 15(5):521-6. View in: PubMed

Gallant NM, Leydiker K, Tang H, Feuchtbaum L, Lorey F, Puckett R, Deignan JL, Neidich J, Dorrani N, Chang E, Barshop BA, Cederbaum SD, Abdenur JE, Wang RY. Biochemical, molecular, and clinical characteristics of children with short chain acyl-CoA dehydrogenase deficiency detected by newborn screening in California. Mol Genet Metab. 2012 May; 106(1):55-61. View in: PubMed

Boehling NS, Grosshans DR, Allen PK, McAleer MF, Burton AW, Azeem S, Rhines LD, Chang EL. Vertebral compression fracture risk after stereotactic body radiotherapy for spinal metastases. J Neurosurg Spine. 2012 Apr; 16(4):379-86. View in: PubMed

Wang XS, Rhines LD, Shiu AS, Yang JN, Selek U, Gning I, Liu P, Allen PK, Azeem SS, Brown PD, Sharp HJ, Weksberg DC, Cleeland CS, Chang EL. Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol. 2012 Apr; 13(4):395-402. View in: PubMed

Lal LS, Byfield SD, Chang EL, Franzini L, Miller LA, Arbuckle R, Reasonda L, Feng C, Adamus A, Swint JM. Cost-effectiveness analysis of a randomized study comparing radiosurgery with radiosurgery and whole brain radiation therapy in patients with 1 to 3 brain metastases. Am J Clin Oncol. 2012 Feb; 35(1):45-50. View in: PubMed

Sahgal A, Ma L, Weinberg V, Gibbs IC, Chao S, Chang UK, Werner-Wasik M, Angelov L, Chang EL, Sohn MJ, Soltys SG, Létourneau D, Ryu S, Gerszten PC, Fowler J, Wong CS, Larson DA. Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2012 Jan 1; 82(1):107-16. View in: PubMed

Weksberg DC, Bilton SD, Chang EL. Use of a deformable atlas to identify cryptic critical structures in the treatment of glioblastoma multiforme. PLoS One. 2012; 7(3):e32098. View in: PubMed

Lo SS, Sahgal A, Ma L, Chang EL. Advances in radiation therapy of brain metastasis. Prog Neurol Surg. 2012; 25:96-109. View in: PubMed

Klish DS, Grossman P, Allen PK, Rhines LD, Chang EL. Irradiation of spinal metastases: should we continue to include one uninvolved vertebral body above and below in the radiation field? Int J Radiat Oncol Biol Phys. 2011 Dec 1; 81(5):1495-9. View in: PubMed

Walker GV, Ahmed S, Allen P, Gidley PW, Woo SY, DeMonte F, Chang EL, Mahajan A. Radiation-induced middle ear and mastoid opacification in skull base tumors treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2011 Dec 1; 81(5):e819-23. View in: PubMed

Hatiboglu MA, Chang EL, Suki D, Sawaya R, Wildrick DM, Weinberg JS. Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery. Neurosurgery. 2011 Oct; 69(4):796-806; discussion 806. View in: PubMed

Garg AK, Wang XS, Shiu AS, Allen P, Yang J, McAleer MF, Azeem S, Rhines LD, Chang EL. Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center experience. Cancer. 2011 Aug 1; 117(15):3509-16. View in: PubMed

Wolff JE, Rytting M, Vats T, Ater J, Mahajan A, Woo S, Ketonen L, Kuttesch J, Liu D, Thall P, Chang EL. Induction treatment for diffuse intrinsic pontine glioma, experience of M. D. Anderson Cancer Center. Anticancer Res. 2011 Jun; 31(6):2265-9. View in: PubMed

Sahgal A, Bilsky M, Chang EL, Ma L, Yamada Y, Rhines LD, Létourneau D, Foote M, Yu E, Larson DA, Fehlings MG. Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient. J Neurosurg Spine. 2011 Feb; 14(2):151-66. View in: PubMed

Lo SS, Sahgal A, Wang JZ, Mayr NA, Sloan A, Mendel E, Chang EL. Stereotactic body radiation therapy for spinal metastases. Discov Med. 2010 Apr; 9(47):289-96. View in: PubMed

Nguyen QN, Shiu AS, Rhines LD, Wang H, Allen PK, Wang XS, Chang EL. Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 15; 76(4):1185-92. View in: PubMed

Lo SS, Fakiris AJ, Chang EL, Mayr NA, Wang JZ, Papiez L, Teh BS, McGarry RC, Cardenes HR, Timmerman RD. Stereotactic body radiation therapy: a novel treatment modality. Nat Rev Clin Oncol. 2010 Jan; 7(1):44-54. View in: PubMed

Du W, Yang JN, Chang EL, Luo D, McAleer MF, Shiu A, Martel MK. A quality assurance procedure to evaluate cone-beam CT image center congruence with the radiation isocenter of a linear accelerator. J Appl Clin Med Phys. 2010; 11(4):3297. View in: PubMed

Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009 Nov; 10(11):1037-44. View in: PubMed

Torres MA, Chang EL, Mahajan A, Lege DG, Riley BA, Zhang X, Lii M, Kornguth DG, Pelloski CE, Woo SY. Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both? Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1033-9. View in: PubMed

Hadziahmetovic M, Clarke JW, Cavaliere R, Mayr NA, Montebello JF, Grecula JC, Newton HB, Chang EL, Lo SS. CNS germinomas: what is the best treatment strategy? Expert Rev Neurother. 2008 Oct; 8(10):1527-36. View in: PubMed

Wang H, Shiu A, Wang C, O'Daniel J, Mahajan A, Woo S, Liengsawangwong P, Mohan R, Chang EL. Dosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2008 Jul 15; 71(4):1261-71. View in: PubMed

Sahgal A, Larson DA, Chang EL. Stereotactic body radiosurgery for spinal metastases: a critical review. Int J Radiat Oncol Biol Phys. 2008 Jul 1; 71(3):652-65. View in: PubMed

Nguyen QN, Chang EL. Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base. Curr Oncol Rep. 2008 Jul; 10(4):338-43. View in: PubMed

Mahajan A, Woo SY, Kornguth DG, Hughes D, Huh W, Chang EL, Herzog CE, Pelloski CE, Anderson P. Multimodality treatment of osteosarcoma: radiation in a high-risk cohort. Pediatr Blood Cancer. 2008 May; 50(5):976-82. View in: PubMed

Clarke JW, Chang EL, Levin VA, Mayr NA, Hong E, Cavaliere R, Lo SS. Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients. Expert Rev Anticancer Ther. 2008 May; 8(5):733-41. View in: PubMed

Lo SS, Fakiris AJ, Abdulrahman R, Henderson MA, Chang EL, Suh JH, Timmerman RD. Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in pediatric brain tumors. Expert Rev Neurother. 2008 Jan; 8(1):121-32. View in: PubMed

Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007 Aug; 7(2):151-60. View in: PubMed

Wang C, Shiu A, Lii M, Woo S, Chang EL. Automatic target localization and verification for on-line image-guided stereotactic body radiotherapy of the spine. Technol Cancer Res Treat. 2007 Jun; 6(3):187-96. View in: PubMed

Akyurek S, Chang EL, Mahajan A, Hassenbusch SJ, Allen PK, Mathews LA, Shiu AS, Maor MH, Woo SY. Stereotactic radiosurgical treatment of cerebral metastases arising from breast cancer. Am J Clin Oncol. 2007 Jun; 30(3):310-4. View in: PubMed

Chang EL, Akyurek S, Avalos T, Rebueno N, Spicer C, Garcia J, Famiglietti R, Allen PK, Chao KS, Mahajan A, Woo SY, Maor MH. Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma. Int J Radiat Oncol Biol Phys. 2007 May 1; 68(1):144-50. View in: PubMed

Hermanto U, Frija EK, Lii MJ, Chang EL, Mahajan A, Woo SY. Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: does IMRT increase the integral dose to normal brain? Int J Radiat Oncol Biol Phys. 2007 Mar 15; 67(4):1135-44. View in: PubMed

Olch AJ, Geurts M, Thomadsen B, Famiglietti R, Chang EL. Portal imaging practice patterns of children's oncology group institutions: Dosimetric assessment and recommendations for minimizing unnecessary exposure. Int J Radiat Oncol Biol Phys. 2007 Feb 1; 67(2):594-600. View in: PubMed

Chang EL, Wefel JS, Maor MH, Hassenbusch SJ, Mahajan A, Lang FF, Woo SY, Mathews LA, Allen PK, Shiu AS, Meyers CA. A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone. Neurosurgery. 2007 Feb; 60(2):277-83; discussion 283-4. View in: PubMed

Lo SS, Chang EL, Yamada Y, Sloan AE, Suh JH, Mendel E. Stereotactic radiosurgery and radiation therapy for spinal tumors. Expert Rev Neurother. 2007 Jan; 7(1):85-93. View in: PubMed

Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutcheon I, Mahajan A, Maor MH, Woo SY. Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M. D. Anderson Cancer Center. J Neurooncol. 2006 Nov; 80(2):177-83. View in: PubMed

Nguyen QN, Chang EL, Allen PK, Maor MH, Ater JL, Mahajan A, Wolff JE, Weinberg JS, Woo SY. Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure. Cancer. 2006 Nov 1; 107(9):2228-36. View in: PubMed

Hu C, Chang EL, Hassenbusch SJ, Allen PK, Woo SY, Mahajan A, Komaki R, Liao Z. Nonsmall cell lung cancer presenting with synchronous solitary brain metastasis. Cancer. 2006 May 1; 106(9):1998-2004. View in: PubMed

Lo SS, Chang EL, Sloan AE. Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in the management of intracranial ependymoma. Expert Rev Neurother. 2006 Apr; 6(4):501-7. View in: PubMed

Suh JH, Stea B, Nabid A, Kresl JJ, Fortin A, Mercier JP, Senzer N, Chang EL, Boyd AP, Cagnoni PJ, Shaw E. Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases. J Clin Oncol. 2006 Jan 1; 24(1):106-14. View in: PubMed

Lee CT, Bilton SD, Famiglietti RM, Riley BA, Mahajan A, Chang EL, Maor MH, Woo SY, Cox JD, Smith AR. Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys. 2005 Oct 1; 63(2):362-72. View in: PubMed

Mahajan A, McCutcheon IE, Suki D, Chang EL, Hassenbusch SJ, Weinberg JS, Shiu A, Maor MH, Woo SY. Case-control study of stereotactic radiosurgery for recurrent glioblastoma multiforme. J Neurosurg. 2005 Aug; 103(2):210-7. View in: PubMed

Lo SS, Chang EL, Suh JH. Stereotactic radiosurgery with and without whole-brain radiotherapy for newly diagnosed brain metastases. Expert Rev Neurother. 2005 Jul; 5(4):487-95. View in: PubMed

Hutchinson LM, Chang EL, Becker CM, Ushiyama N, Behonick D, Shih MC, DeWolf WC, Gaston SM, Zetter BR. Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer. Clin Biochem. 2005 Jun; 38(6):558-71. View in: PubMed

Pelloski CE, Mahajan A, Maor M, Chang EL, Woo S, Gilbert M, Colman H, Yang H, Ledoux A, Blair H, Passe S, Jenkins RB, Aldape KD. YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma. Clin Cancer Res. 2005 May 1; 11(9):3326-34. View in: PubMed

Chang EL, Selek U, Hassenbusch SJ, Maor MH, Allen PK, Mahajan A, Sawaya R, Woo SY. Outcome variation among "radioresistant" brain metastases treated with stereotactic radiosurgery. Neurosurgery. 2005 May; 56(5):936-45; discussion 936-45. View in: PubMed

Chang EL, Shiu AS, Lii MF, Rhines LD, Mendel E, Mahajan A, Weinberg JS, Mathews LA, Brown BW, Maor MH, Cox JD. Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2004 Aug 1; 59(5):1288-94. View in: PubMed

Selek U, Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen P, Weinberg J, Sawaya R, Maor MH. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1097-106. View in: PubMed

Kudchadker RJ, Chang EL, Bryan F, Maor MH, Famiglietti R. An evaluation of radiation exposure from portal films taken during definitive course of pediatric radiotherapy. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1229-35. View in: PubMed

Soyuer S, Chang EL, Selek U, Shi W, Maor MH, DeMonte F. Radiotherapy after surgery for benign cerebral meningioma. Radiother Oncol. 2004 Apr; 71(1):85-90. View in: PubMed

Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH. Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. Cancer. 2004 Apr 1; 100(7):1491-7. View in: PubMed

Shiu AS, Chang EL, Ye JS, Lii M, Rhines LD, Mendel E, Weinberg J, Singh S, Maor MH, Mohan R, Cox JD. Near simultaneous computed tomography image-guided stereotactic spinal radiotherapy: an emerging paradigm for achieving true stereotaxy. Int J Radiat Oncol Biol Phys. 2003 Nov 1; 57(3):605-13. View in: PubMed

Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen PK, Sawaya R, Maor MH. The role of tumor size in the radiosurgical management of patients with ambiguous brain metastases. Neurosurgery. 2003 Aug; 53(2):272-80; discussion 280-1. View in: PubMed

Lee HK, Chang EL, Fuller GN, Aldape KD, Atkinson GJ, Levy LB, McCutcheon IE, Maor MH. The prognostic value of neurologic function in astrocytic spinal cord glioma. Neuro Oncol. 2003 Jul; 5(3):208-13. View in: PubMed

Chang EL, Yi W, Allen PK, Levin VA, Sawaya RE, Maor MH. Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys. 2003 Jun 1; 56(2):519-28. View in: PubMed

Chang EL, Maor MH. Standard and novel radiotherapeutic approaches to neoplastic meningitis. Curr Oncol Rep. 2003 Jan; 5(1):24-8. View in: PubMed

Chang EL, Wong PF, Forster KM, Petru MD, Kowalski AV, Maor MH. Verification techniques and dose distribution for computed tomographic planned supine craniospinal radiation therapy. Med Dosim. 2003; 28(2):127-31. View in: PubMed

Chang EL, Lo S. Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 2003; 8(5):398-410. View in: PubMed

Chang EL, Allen P, Wu C, Ater J, Kuttesch J, Maor MH. Acute toxicity and treatment interruption related to electron and photon craniospinal irradiation in pediatric patients treated at the University of Texas M. D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys. 2002 Mar 15; 52(4):1008-16. View in: PubMed

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