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Eva Astrid Operskalski, PhD
Associate Professor of Research Pediatrics
HRA 300 1640 Marengo Off Campus Los Angeles
+1 323 865 1554


Dr. Operskalski is Director of Clinical Research at the MCA Center and has over 25 years experience co-directing or managing complex multi-center investigations of factors that influence HIV and hepatitis B and C disease occurrence and outcome. Since joining MCA she has coordinated the numerous clinical research studies carried out by the program, including studies of the Pediatric AIDS Clinical Trials Group (PACTG), which is now the International Maternal Pediatric Adolescent Center Trials (IMPAACT) Group, other NIH-funded studies, and MCA's own investigator-initiated studies. The studies include therapeutic trials for HIV and other infectious diseases, vaccine studies, and observational studies of long-term outcomes of disease and therapy. She has participated in the development of collaborative activities related to maternal child and adolescent infectious disease prevention and treatment, including successful grant proposals to the national Health Resources and Services Administration to expand MCA’s coordinated clinical services and access to research for women, infants, children, and youth. Dr. Operskalski's research focus has been the epidemiology of HIV, HCV, and other transfusion-transmitted infections; specifically, factors that influence progression from infection to disease (including the effect of interactions of HIV, HTLV, HBV, HCV, EBV, CMV on progression and transmission of each) and factors that influence transmission by blood transfusion, and heterosexual and household contact. She was Principal Investigator for a clinic-based HIV vaccine preparedness (VPS) pilot study, sponsored by the PACTG, to investigate whether network analysis can be used to establish clinic-based cohorts of adolescents for HIV vaccine preparedness activities and vaccine trials. The VPS brought together a multi-disciplinary team of investigators from the KSOM Departments of Pediatrics and Preventive Medicine, as well as from Johns Hopkins University School of Public Health, and the Desmond Tutu HIV Centre in Cape Town and the Perinatal HIV Research Unit in Johannesburg, South Africa. These investigators have extensive experience and expertise in public health, epidemiology, prevention, social network mapping, and clinical research.


Spencer LY, Christiansen S, Wang CH, Mack WJ, Young M, Strickler HD, Anastos K, Minkoff H, Cohen M, Geenblatt RM, Karim R, Operskalski E, Frederick T, Homans JD, Landay A, Kovacs A. Systemic Immune Activation and HIV Shedding in the Female Genital Tract. J Acquir Immune Defic Syndr. 2016 Feb 1; 71(2):155-62. View in: PubMed

Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 1; 71(2):172-80. View in: PubMed

Jackman RP, Deng X, Bolgiano D, Utter GH, Schechterly C, Lebedeva M, Operskalski E, Luban NL, Alter H, Busch MP, Slichter SJ, Norris PJ. Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response. Transfusion. 2014 Mar; 54(3):672-80. View in: PubMed

Karim R, Mack WJ, Stiller T, Operskalski E, Frederick T, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Kovacs A. Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach. AIDS. 2013 Jun 1; 27(9):1473-81. View in: PubMed

Wohl AR, Galvan FH, Carlos JA, Myers HF, Garland W, Witt MD, Cadden J, Operskalski E, Jordan W, George S. A comparison of MSM stigma, HIV stigma and depression in HIV-positive Latino and African American men who have sex with men (MSM). AIDS Behav. 2013 May; 17(4):1454-64. View in: PubMed

Operskalski EA. HHV-8, Transfusion, and Mortality. J Infect Dis. 2012 Nov; 206(10):1485-7. View in: PubMed

Frederick T, Homans J, Spencer L, Kramer F, Stek A, Operskalski E, Kovacs A. The Effect of Prenatal Highly Active Antiretroviral Therapy on the Transmission of Congenital and Perinatal/Early Postnatal Cytomegalovirus Among HIV-Infected and HIV-Exposed Infants. Clin Infect Dis. 2012 Sep; 55(6):877-84. View in: PubMed

Selvarajah S, Keating S, Heitman J, Lu K, Simmons G, Norris PJ, Operskalski E, Mosley JW, Busch MP. Detection of host immune responses in acute phase sera of spontaneous resolution versus persistent hepatitis C virus infection. J Gen Virol. 2012 Aug; 93(Pt 8):1673-9. View in: PubMed

Homans J, Christensen S, Stiller T, Wang CH, Mack W, Anastos K, Minkoff H, Young M, Greenblatt R, Cohen M, Strickler H, Karim R, Spencer LY, Operskalski E, Frederick T, Kovacs A. Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding. J Acquir Immune Defic Syndr. 2012 May 1; 60(1):99-110. View in: PubMed

Wohl AR, Galvan FH, Myers HF, Garland W, George S, Witt M, Cadden J, Operskalski E, Jordan W, Carpio F, Lee ML. Do social support, stress, disclosure and stigma influence retention in HIV care for Latino and African American men who have sex with men and women? AIDS Behav. 2011 Aug; 15(6):1098-110. View in: PubMed

Operskalski EA, Kovacs A. HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies. Curr HIV/AIDS Rep. 2011 Mar; 8(1):12-22. View in: PubMed

Bernardin F, Operskalski E, Busch M, Delwart E. Transfusion transmission of highly prevalent commensal human viruses. Transfusion. 2010 Nov; 50(11):2474-83. View in: PubMed

Wohl AR, Galvan FH, Myers HF, Garland W, George S, Witt M, Cadden J, Operskalski E, Jordan W, Carpio F. Social support, stress and social network characteristics among HIV-positive Latino and African American women and men who have sex with men. AIDS Behav. 2010 Oct; 14(5):1149-58. View in: PubMed

Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, Young MA, Tien PC, Augenbraun M, Strickler HD, Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis. 2010 Mar 15; 201(6):823-34. View in: PubMed

Valente TW, Zogg JB, Christensen S, Richardson J, Kovacs A, Operskalski E. Using social networks to recruit an HIV vaccine preparedness cohort. J Acquir Immune Defic Syndr. 2009 Dec 1; 52(4):514-23. View in: PubMed

French AL, Lin MY, Evans CT, Benning L, Glesby MJ, Young MA, Operskalski EA, Augenbraun M, Peters M. Long-term serologic follow-up of isolated hepatitis B core antibody in HIV-infected and HIV-uninfected women. Clin Infect Dis. 2009 Jul 1; 49(1):148-54. View in: PubMed

Cannon MJ, Operskalski EA, Mosley JW, Radford K, Dollard SC. Lack of evidence for human herpesvirus-8 transmission via blood transfusion in a historical US cohort. J Infect Dis. 2009 Jun 1; 199(11):1592-8. View in: PubMed

Kapetanovic S, Christensen S, Karim R, Lin F, Mack WJ, Operskalski E, Frederick T, Spencer L, Stek A, Kramer F, Kovacs A. Correlates of perinatal depression in HIV-infected women. AIDS Patient Care STDS. 2009 Feb; 23(2):101-8. View in: PubMed

Operskalski EA, Mack WJ, Strickler HD, French AL, Augenbraun M, Tien PC, Villacres MC, Spencer LY, Degiacomo M, Kovacs A. Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women. J Clin Virol. 2008 Apr; 41(4):255-63. View in: PubMed

French AL, Operskalski E, Peters M, Strickler HD, Tien PC, Sharp GB, Glesby MJ, Young M, Augenbraun M, Seaberg E, Kovacs A. Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. J Infect Dis. 2007 May 15; 195(10):1437-42. View in: PubMed

Laskus T, Operskalski EA, Radkowski M, Wilkinson J, Mack WJ, deGiacomo M, Al-Harthi L, Chen Z, Xu J, Kovacs A. Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women. J Infect Dis. 2007 Jan 1; 195(1):124-33. View in: PubMed

Diaz RS, Pardini R, Catroxo M, Operskalski EA, Mosley JW, Busch MP. HIV-1 superinfection is not a common event. J Clin Virol. 2005 Aug; 33(4):328-30. View in: PubMed

Mosley JW, Operskalski EA, Tobler LH, Andrews WW, Phelps B, Dockter J, Giachetti C, Busch MP. Viral and host factors in early hepatitis C virus infection. Hepatology. 2005 Jul; 42(1):86-92. View in: PubMed

Laskus T, Wilkinson J, Gallegos-Orozco JF, Radkowski M, Adair DM, Nowicki M, Operskalski E, Buskell Z, Seeff LB, Vargas H, Rakela J. Analysis of hepatitis C virus quasispecies transmission and evolution in patients infected through blood transfusion. Gastroenterology. 2004 Sep; 127(3):764-76. View in: PubMed

Operskalski EA, Mosley JW, Tobler LH, Fiebig EW, Nowicki MJ, Mimms LT, Gallarda J, Phelps BH, Busch MP. HCV viral load in anti-HCV-reactive donors and infectivity for their recipients. Transfusion. 2003 Oct; 43(10):1433-41. View in: PubMed

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