Faculty

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Fred R Sattler, MD
Professor of Medicine
Chief, Division of Infectious Diseases
Medicine
IRD 436 Off Campus Los Angeles
+1 323 226 4635

Overview

Dr. Fred Sattler is Chief of the Division of Infectious Diseases, which is steadily growing in numbers and stature both within the University and in the scientific community. The Division provides enormous 1) consultative service to the local teaching hospital affiliated with the University of Southern California, 2) primary care to nearly 3000 HIV infected ambulatory patients, and 3) oversight of the epidemiology programs at the teaching hospitals.

Dr. Sattler is principal investigator of the AIDS Clinical Trials Unit at USC of the NIAID funded AIDS Clinical Trials Group. The grant is currently in its 19th year of funding at USC. Dr. Sattler has provided scientific leadership for nearly two decades, most recently in studies that evaluate the pathophysiology and management of HIV associated weight loss, changes in body fat and metabolic complications. He continues to serve as a chair, co-chair, vice-chair, or protocol team member for a number of studies including ACTG 313, 329, 392, 892, 5079, 5112s, 5116s, 5124s and 5125s and along with other studies in planning. As an outgrowth of studies of AIDS muscle wasting, Dr. Sattler conducted investigator-initiated pilot studies in the USC GCRC to evaluate the effects of anabolic androgens in elderly subjects with loss of skeletal muscle mass (sarcopenia) and muscle strength and who are thus at risk for frailty and who have gains in central fat and are at risk for the metabolic syndrome. These studies have demonstrated dose dependent improvements in muscle mass, maximal voluntary strength, and leg power, which are necessary constituents for physical function, independence, and quality of life during aging. Study subjects also experienced a dose-related decrease in total and central fat as an additional response to study intervention.

Based on the results of these studies which have been presented in at the Endocrine Society meetings, Dr. Sattler obtained commitments from Genentech, Tap, Solvay pharmaceutical companies to supply rhGH (recombinant human growth hormone), leuprolide acetate, and a new, more physiologic topical formulation of testosterone to study the interactions of the growth hormone/IGF-1 and hypothalamic-pituitary-gonadal axes in regulating muscle and adipose tissue in elderly persons. These activities culminated in his being funded by the National Institutes of Aging as PI to conduct a multicenter four-year study to evaluate the effects of restoring these hormonal axes to youthful levels on net anabolic protein balance. The translational effects of these interventions as measured by net anabolic balance of skeletal muscle protein synthesis and breakdown, body composition (DEXA, MRI and total body water analysis by stable isotope biology), anthropometry, skeletal muscle strength, power, and physical function, maximal ventilatory capacity, and aerobic endurance are being measured in the USC GCRC

Despite Dr. Sattler's extensive research activities and multiple important administrative posts, he is highly committed to teaching at all levels. Whether guiding a clinical fellow through logical decision-making in a complex case, or mentoring students, postdoctoral fellows, or junior faculty, he remains thoroughly accessible, insightful, and compassionate, while ceaselessly energetic.

Awards

Pennsylvania State University : Outstanding Instructor Award, 1981

Phi Beta Kappa: Elected Member, 1969

National Institutes of Allergy and Infectious Diseases: National Research Fellowship Award, 1977-1979

Publications

Luetkemeyer AF, Firnhaber C, Kendall MA, Wu X, Mazurek GH, Benator DA, Arduino R, Fernandez M, Guy E, Johnson P, Metchock B, Sattler F, Telzak E, Wang YF, Weiner M, Swindells S, Sanne IM, Havlir DV, Grinsztejn B, Alland D. Evaluation of Xpert MTB/RIF Versus AFB Smear and Culture to Identify Pulmonary Tuberculosis in Patients With Suspected Tuberculosis From Low and Higher Prevalence Settings. Clin Infect Dis. 2016 May 1; 62(9):1081-8. View in: PubMed

Dieli-Conwright CM, Kiwata JL, Tuzon CT, Spektor TM, Sattler FR, Rice JC, Schroeder ET. Acute Response of PGC-1a and IGF-1 Isoforms to Maximal Eccentric Exercise in Skeletal Muscle of Postmenopausal Women. J Strength Cond Res. 2016 Apr; 30(4):1161-70. View in: PubMed

Sattler FR, He J, Letendre S, Wilson C, Sanders C, Heaton R, Ellis R, Franklin D, Aldrovandi G, Marra CM, Clifford D, Morgello S, Grant I, McCutchan JA. Abdominal Obesity Contributes to Neurocognitive Impairment in HIV-Infected Patients With Increased Inflammation and Immune Activation. J Acquir Immune Defic Syndr. 2015 Mar 1; 68(3):281-8. View in: PubMed

Alderete TL, Sattler FR, Richey JM, Allayee H, Mittelman SD, Sheng X, Tucci J, Gyllenhammer LE, Grant EG, Goran MI. Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics. Obesity (Silver Spring). 2015 Feb 3. View in: PubMed

Grant PM, Komarow L, Sanchez A, Sattler FR, Asmuth DM, Pollard RB, Zolopa AR. Clinical and Immunologic Predictors of Death After an Acute Opportunistic Infection: Results from ACTG A5164. HIV Clin Trials. 2014 Jul-Aug; 15(4):133-9. View in: PubMed

Sattler FR. Growth hormone in the aging male. Best Pract Res Clin Endocrinol Metab. 2013 Aug; 27(4):541-55. View in: PubMed

Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. J Strength Cond Res. 2012 May; 26(5):1374-82. View in: PubMed

Schroeder ET, He J, Yarasheski KE, Binder EF, Castaneda-Sceppa C, Bhasin S, Dieli-Conwright CM, Kawakubo M, Roubenoff R, Azen SP, Sattler FR. Value of measuring muscle performance to assess changes in lean mass with testosterone and growth hormone supplementation. Eur J Appl Physiol. 2012 Mar; 112(3):1123-31. View in: PubMed

Yarasheski KE, Castaneda-Sceppa C, He J, Kawakubo M, Bhasin S, Binder EF, Schroeder ET, Roubenoff R, Azen SP, Sattler FR. Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study. Am J Clin Nutr. 2011 Jul; 94(1):172-81. View in: PubMed

Sattler FR, Bhasin S, He J, Yarasheski KE, Binder EF, Schroeder ET, Castaneda-Sceppa C, Kawakubo M, Roubenoff R, Dunn M, Hahn C, Stewart Y, Martinez C, Azen SP. Durability of the effects of testosterone and growth hormone supplementation in older community-dwelling men: the HORMA Trial. Clin Endocrinol (Oxf). 2011 Jul; 75(1):103-11. View in: PubMed

Sanchez A, Azen C, Jones B, Louie S, Sattler F. Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis. Tuberc Res Treat. 2011; 2011:346295. View in: PubMed

Krishnan S, Schouten JT, Jacobson DL, Benson CA, Collier AC, Koletar SL, Santana J, Sattler FR, Mitsuyasu R. Incidence of non-AIDS-defining cancer in antiretroviral treatment-naïve subjects after antiretroviral treatment initiation: an ACTG longitudinal linked randomized trials analysis. Oncology. 2011; 80(1-2):42-9. View in: PubMed

Sattler F, Bhasin S, He J, Chou CP, Castaneda-Sceppa C, Yarasheski K, Binder E, Schroeder ET, Kawakubo M, Zhang A, Roubenoff R, Azen S. Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial. J Gerontol A Biol Sci Med Sci. 2011 Jan; 66(1):122-9. View in: PubMed

Beringer PM, Owens H, Nguyen A, Mordwinkin N, Louie S, Mak M, Sattler F. Estimation of glomerular filtration rate by using serum cystatin C and serum creatinine concentrations in patients with human immunodeficiency virus. Pharmacotherapy. 2010 Oct; 30(10):1004-10. View in: PubMed

Dubé MP, Sattler FR. Inflammation and complications of HIV disease. J Infect Dis. 2010 Jun 15; 201(12):1783-5. View in: PubMed

Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. Hormone replacement therapy and messenger RNA expression of estrogen receptor coregulators after exercise in postmenopausal women. Med Sci Sports Exerc. 2010 Mar; 42(3):422-9. View in: PubMed

Jensky NE, Sims JK, Dieli-Conwright CM, Sattler FR, Rice JC, Schroeder ET. Exercise does not influence myostatin and follistatin messenger RNA expression in young women. J Strength Cond Res. 2010 Feb; 24(2):522-30. View in: PubMed

Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal women. J Appl Physiol. 2009 Nov; 107(5):1381-8. View in: PubMed

Bhasin S, He EJ, Kawakubo M, Schroeder ET, Yarasheski K, Opiteck GJ, Reicin A, Chen F, Lam R, Tsou JA, Castaneda-Sceppa C, Binder EF, Azen SP, Sattler FR. N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone. J Clin Endocrinol Metab. 2009 Nov; 94(11):4224-33. View in: PubMed

Sattler FR, Castaneda-Sceppa C, Binder EF, Schroeder ET, Wang Y, Bhasin S, Kawakubo M, Stewart Y, Yarasheski KE, Ulloor J, Colletti P, Roubenoff R, Azen SP. Testosterone and growth hormone improve body composition and muscle performance in older men. J Clin Endocrinol Metab. 2009 Jun; 94(6):1991-2001. View in: PubMed

Sattler FR, Rajicic N, Mulligan K, Yarasheski KE, Koletar SL, Zolopa A, Alston Smith B, Zackin R, Bistrian B. Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trial. Am J Clin Nutr. 2008 Nov; 88(5):1313-21. View in: PubMed

Sattler FR. Pathogenesis and treatment of lipodystrophy: what clinicians need to know. Top HIV Med. 2008 Oct-Nov; 16(4):127-33. View in: PubMed

Fujita S, Rasmussen BB, Cadenas JG, Drummond MJ, Glynn EL, Sattler FR, Volpi E. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes. 2007 Jun; 56(6):1615-22. View in: PubMed

Tebas P, Zhang J, Yarasheski K, Evans S, Fischl MA, Shevitz A, Feinberg J, Collier AC, Shikuma C, Brizz B, Sattler F. Switching to a protease inhibitor-containing, nucleoside-sparing regimen (lopinavir/ritonavir plus efavirenz) increases limb fat but raises serum lipid levels: results of a prospective randomized trial (AIDS clinical trial group 5125s). J Acquir Immune Defic Syndr. 2007 Jun 1; 45(2):193-200. View in: PubMed

Schroeder ET, Wang Y, Castaneda-Sceppa C, Cloutier G, Vallejo AF, Kawakubo M, Jensky NE, Coomber S, Azen SP, Sattler FR. Reliability of maximal voluntary muscle strength and power testing in older men. J Gerontol A Biol Sci Med Sci. 2007 May; 62(5):543-9. View in: PubMed

Bhasin S, Parker RA, Sattler F, Haubrich R, Alston B, Umbleja T, Shikuma CM. Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity. J Clin Endocrinol Metab. 2007 Mar; 92(3):1049-57. View in: PubMed

Mulligan K, Zackin R, Von Roenn JH, Chesney MA, Egorin MJ, Sattler FR, Benson CA, Liu T, Umbleja T, Shriver S, Auchus RJ, Schambelan M. Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. J Clin Endocrinol Metab. 2007 Feb; 92(2):563-70. View in: PubMed

Schroeder ET, Castaneda-Sceppa C, Wang Y, Binder EF, Kawakubo M, Stewart Y, Storer T, Roubenoff R, Bhasin S, Yarasheski KE, Sattler FR, Azen SP. Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial. Clin Trials. 2007; 4(5):560-71. View in: PubMed

Vallejo AF, Schroeder ET, Zheng L, Jensky NE, Sattler FR. Cardiopulmonary responses to eccentric and concentric resistance exercise in older adults. Age Ageing. 2006 May; 35(3):291-7. View in: PubMed

Dreyer HC, Blanco CE, Sattler FR, Schroeder ET, Wiswell RA. Satellite cell numbers in young and older men 24 hours after eccentric exercise. Muscle Nerve. 2006 Feb; 33(2):242-53. View in: PubMed

Schroeder ET, Vallejo AF, Zheng L, Stewart Y, Flores C, Nakao S, Martinez C, Sattler FR. Six-week improvements in muscle mass and strength during androgen therapy in older men. J Gerontol A Biol Sci Med Sci. 2005 Dec; 60(12):1586-92. View in: PubMed

Storer TW, Woodhouse LJ, Sattler F, Singh AB, Schroeder ET, Beck K, Padero M, Mac P, Yarasheski KE, Geurts P, Willemsen A, Harms MK, Bhasin S. A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment. J Clin Endocrinol Metab. 2005 Aug; 90(8):4474-82. View in: PubMed

Mulligan K, Zackin R, Clark RA, Alston-Smith B, Liu T, Sattler FR, Delvers TB, Currier JS. Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. Arch Intern Med. 2005 Mar 14; 165(5):578-85. View in: PubMed

Borucki MJ, Spritzler J, Asmuth DM, Gnann J, Hirsch MS, Nokta M, Aweeka F, Nadler PI, Sattler F, Alston B, Nevin TT, Owens S, Waterman K, Hubbard L, Caliendo A, Pollard RB. A phase II, double-masked, randomized, placebo-controlled evaluation of a human monoclonal anti-Cytomegalovirus antibody (MSL-109) in combination with standard therapy versus standard therapy alone in the treatment of AIDS patients with Cytomegalovirus retinitis. Antiviral Res. 2004 Nov; 64(2):103-11. View in: PubMed

Schroeder ET, Zheng L, Ong MD, Martinez C, Flores C, Stewart Y, Azen C, Sattler FR. Effects of androgen therapy on adipose tissue and metabolism in older men. J Clin Endocrinol Metab. 2004 Oct; 89(10):4863-72. View in: PubMed

Schroeder ET, Zheng L, Yarasheski KE, Qian D, Stewart Y, Flores C, Martinez C, Terk M, Sattler FR. Treatment with oxandrolone and the durability of effects in older men. J Appl Physiol. 2004 Mar; 96(3):1055-62. View in: PubMed

Young EM, Considine RV, Sattler FR, Deeg MA, Buchanan TA, Degawa-Yamauchi M, Shankar S, Edmondson-Melançon H, Hernandez J, Dubé MP. Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy. Cardiovasc Toxicol. 2004; 4(2):179-86. View in: PubMed

Schroeder ET, Terk M, Sattler FR. Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E16-24. View in: PubMed

Sattler F. Body habitus changes related to lipodystrophy. Clin Infect Dis. 2003 Apr 1; 36(Suppl 2):S84-90. View in: PubMed

Schroeder ET, Singh A, Bhasin S, Storer TW, Azen C, Davidson T, Martinez C, Sinha-Hikim I, Jaque SV, Terk M, Sattler FR. Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E120-8. View in: PubMed

Sattler FR, Schroeder ET, Dube MP, Jaque SV, Martinez C, Blanche PJ, Azen S, Krauss RM. Metabolic effects of nandrolone decanoate and resistance training in men with HIV. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-22. View in: PubMed

Dubé MP, Qian D, Edmondson-Melançon H, Sattler FR, Goodwin D, Martinez C, Williams V, Johnson D, Buchanan TA. Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy. Clin Infect Dis. 2002 Aug 15; 35(4):475-81. View in: PubMed

Stohl W, Cheema GS, Briggs WS, Xu D, Sosnovtseva S, Roschke V, Ferrara DE, Labat K, Sattler FR, Pierangeli SS, Hilbert DM. B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patients. Clin Immunol. 2002 Aug; 104(2):115-22. View in: PubMed

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