Faculty

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Gangning Liang, MD, PhD
Professor of Research Urology
Director of Epigenetic Translational Research of The USC Institute of Urology.
Urology
NOR 7338 Health Sciences Campus Los Angeles
+1 323 865 0470

Publications

DNA methylation aberrancies as a guide for surveillance and treatment of human cancers. Epigenetics. 2017 Mar 30; 0. View in: PubMed

epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data. Genome Biol. 2017 Feb 21; 18(1):38. View in: PubMed

Nucleosome Positioning and NDR Structure at RNA Polymerase III Promoters. Sci Rep. 2017 Feb 08; 7:41947. View in: PubMed

Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers. Oncotarget. 2017 Jan 17; 8(3):5439-5448. View in: PubMed

Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients. Sci Rep. 2017 Jan 13; 7:40636. View in: PubMed

Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biol. 2017 Jan 12; 18(1):3. View in: PubMed

Genetic and Epigenetic Alterations in Bladder Cancer. Int Neurourol J. 2016 Nov; 20(Suppl 2):S84-94. View in: PubMed

Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine. Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37):10238-44. View in: PubMed

Identification of DNA Methylation-Independent Epigenetic Events Underlying Clear Cell Renal Cell Carcinoma. Cancer Res. 2016 Apr 1; 76(7):1954-64. View in: PubMed

DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells. Nat Commun. 2016; 7:11453. View in: PubMed

The Role of DNA Methylation in Cancer. Adv Exp Med Biol. 2016; 945:151-172. View in: PubMed

Isoform switching and exon skipping induced by the DNA methylation inhibitor 5-Aza-2'-deoxycytidine. Sci Rep. 2016; 6:24545. View in: PubMed

Hypermethylation of the VTRNA1-3 Promoter is Associated with Poor Outcome in Lower Risk Myelodysplastic Syndrome Patients. Genes (Basel). 2015 Oct 14; 6(4):977-90. View in: PubMed

Unique Role for a DNA Methyltransferase Isoform in Lung Cancer. EBioMedicine. 2015 Oct; 2(10):1272-3. View in: PubMed

CT prediction of the Fuhrman grade of clear cell renal cell carcinoma (RCC): towards the development of computer-assisted diagnostic method. Abdom Imaging. 2015 Oct; 40(8):3168-74. View in: PubMed

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell. 2015 Aug 27; 162(5):961-73. View in: PubMed

Outlining the limits of partial nephrectomy. Transl Androl Urol. 2015 Jun; 4(3):294-300. View in: PubMed

Linker histone H1. 2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015; 5:16714. View in: PubMed

Gene body methylation can alter gene expression and is a therapeutic target in cancer. Cancer Cell. 2014 Oct 13; 26(4):577-90. View in: PubMed

Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review. Clin Rev Allergy Immunol. 2014 Oct; 47(2):128-35. View in: PubMed

A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence. Clin Cancer Res. 2014 Apr 1; 20(7):1978-89. View in: PubMed

Reprogramming of the human intestinal epigenome by surgical tissue transposition. Genome Res. 2014 Apr; 24(4):545-53. View in: PubMed

Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. Urology. 2013 Jul; 82(1):253. e9-15. View in: PubMed

SNF5 is an essential executor of epigenetic regulation during differentiation. PLoS Genet. 2013 Apr; 9(4):e1003459. View in: PubMed

Functional DNA demethylation is accompanied by chromatin accessibility. Nucleic Acids Res. 2013 Apr; 41(7):3973-85. View in: PubMed

Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells. PLoS One. 2013; 8(9):e75136. View in: PubMed

Diagnostic markers of urothelial cancer based on DNA methylation analysis. BMC Cancer. 2013; 13:275. View in: PubMed

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res. 2012 Dec; 22(12):2497-506. View in: PubMed

DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell. 2012 May 25; 21(5):655-67. View in: PubMed

Gene Reactivation by 5-Aza-2'-Deoxycytidine-Induced Demethylation Requires SRCAP-Mediated H2A. Z Insertion to Establish Nucleosome Depleted Regions. PLoS Genet. 2012 Mar; 8(3):e1002604. View in: PubMed

Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31. 1 predict outcome in AML. Blood. 2012 Jan 5; 119(1):206-16. View in: PubMed

Epigenetic alterations in bladder cancer and their potential clinical implications. Adv Urol. 2012; 2012:546917. View in: PubMed

Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells. Epigenetics Chromatin. 2012; 5(1):3. View in: PubMed

Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming. Cell. 2011 Dec 9; 147(6):1283-94. View in: PubMed

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet. 2011 Nov 15; 20(22):4299-310. View in: PubMed

OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14497-502. View in: PubMed

Conditional inactivation of the CXCR4 receptor in osteoprecursors reduces postnatal bone formation due to impaired osteoblast development. J Biol Chem. 2011 Jul 29; 286(30):26794-805. View in: PubMed

Creating a flexible multiple microRNA expression vector by linking precursor microRNAs. Biochem Biophys Res Commun. 2011 Jul 29; 411(2):276-80. View in: PubMed

Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics. 2011 Apr; 6(4):450-64. View in: PubMed

Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet. 2011; 7(2):e1001286. View in: PubMed

Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res. 2010 Oct 15; 70(20):8169-78. View in: PubMed

H2A. Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes. Mol Cell. 2010 Sep 24; 39(6):901-11. View in: PubMed

Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet. 2010 Apr; 6(4):e1000917. View in: PubMed

Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome. PLoS One. 2010; 5(9). View in: PubMed

Tissue inhibitor of metalloproteinase 1 expression associated with gene demethylation confers anoikis resistance in early phases of melanocyte malignant transformation. Transl Oncol. 2009 Dec; 2(4):329-40. View in: PubMed

Rethinking how DNA methylation patterns are maintained. Nat Rev Genet. 2009 Nov; 10(11):805-11. View in: PubMed

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. Mol Cell Biol. 2009 Oct; 29(19):5366-76. View in: PubMed

The tumor suppressor microRNA-101 becomes an epigenetic player by targeting the polycomb group protein EZH2 in cancer. Cell Cycle. 2009 Aug; 8(15):2313-4. View in: PubMed

Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer. Int J Cancer. 2009 Aug 1; 125(3):723-9. View in: PubMed

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther. 2009 Jun; 8(6):1579-88. View in: PubMed

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res. 2009 Mar 15; 69(6):2623-9. View in: PubMed

Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun. 2009 Feb 13; 379(3):726-31. View in: PubMed

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):12979-84. View in: PubMed

RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. Cancer Res. 2008 Aug 1; 68(15):6208-14. View in: PubMed

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res. 2008 Aug; 36(14):4689-98. View in: PubMed

Examination of IGF2 and H19 loss of imprinting in bladder cancer. Cancer Res. 2007 Nov 15; 67(22):10753-8. View in: PubMed

Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell. 2007 Nov; 12(5):432-44. View in: PubMed

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1; 67(13):6400-8. View in: PubMed

Methylation-sensitive single-nucleotide primer extension (Ms-SNuPE) for quantitative measurement of DNA methylation. Nat Protoc. 2007; 2(8):1931-6. View in: PubMed

Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells. Mol Cell Biol. 2006 Oct; 26(19):7331-41. View in: PubMed

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14080-5. View in: PubMed

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006 Jun; 9(6):435-43. View in: PubMed

Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Eur J Cancer. 2005 Nov; 41(17):2769-78. View in: PubMed

Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer. Nat Clin Pract Urol. 2005 Oct; 2(10):502-10. View in: PubMed

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine. Mol Cancer Ther. 2005 Oct; 4(10):1515-20. View in: PubMed

Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clin Cancer Res. 2004 Nov 15; 10(22):7457-65. View in: PubMed

Preferential response of cancer cells to zebularine. Cancer Cell. 2004 Aug; 6(2):151-8. View in: PubMed

Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004 May 27; 429(6990):457-63. View in: PubMed

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7357-62. View in: PubMed

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol. 2004 Feb; 24(3):1270-8. View in: PubMed

Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res. 2004 Jan; 2(1):62-72. View in: PubMed

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Res. 2002 Nov 15; 62(22):6456-61. View in: PubMed

Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene. 2002 Sep 26; 21(43):6694-702. View in: PubMed

Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Gene. 2002 Sep 18; 298(1):91-9. View in: PubMed

Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction. Methods. 2002 Jun; 27(2):150-5. View in: PubMed

Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine. Cancer Res. 2002 Feb 15; 62(4):961-6. View in: PubMed

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol. 2002 Jan; 22(2):480-91. View in: PubMed

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