Faculty

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Gary Craig Kanel, MD
Clinical Professor of Pathology (Part Time)
Pathology
GNH 1100 North State Street Off Campus Los Angeles
+1 323 226 7127

Publications

Elmasry S, Wadhwa S, Bang BR, Cook L, Chopra S, Kanel G, Kim B, Harper T, Feng Z, Jerome KR, Kahn J, Saito T. Detection of Occult Hepatitis C Virus Infection in Patients Who Achieved a Sustained Virologic Response to Direct-acting Antiviral Agents for Recurrent Infection After Liver Transplantation. Gastroenterology. 2016 Nov 9. View in: PubMed

Chen WT, Zhu G, Pfaffenbach K, Kanel G, Stiles B, Lee AS. GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. Oncogene. 2014 Oct 16; 33(42):4997-5005. View in: PubMed

Chen WT, Ha D, Kanel G, Lee AS. Targeted Deletion of ER Chaperone GRP94 in the Liver Results in Injury, Repopulation of GRP94-Positive Hepatocytes, and Spontaneous Hepatocellular Carcinoma Development in Aged Mice. Neoplasia. 2014 Aug; 16(8):617-26. View in: PubMed

Chen WT, Tseng CC, Pfaffenbach K, Kanel G, Luo B, Stiles BL, Lee AS. Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology. 2014 Mar; 59(3):947-57. View in: PubMed

Nookala A, Saberi B, Ter-Oganesyan R, Kanel G, Duong P, Saito T. Isolated arterioportal fistula presenting with variceal hemorrhage. World J Gastroenterol. 2013 May 7; 19(17):2714-7. View in: PubMed

Xie G, Wang X, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA, Deleve LD. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 2012 Apr; 142(4):918-927. e6. View in: PubMed

Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82. View in: PubMed

He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles BL. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol. 2010 May; 176(5):2302-8. View in: PubMed

Byun HM, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, Yang AS. Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet. 2009 Dec 15; 18(24):4808-17. View in: PubMed

Guo J, Young SK, Lorenzo CR, Lee CM, Kanel GC, Brynes RK, Chandrasoma P, Naritoku WY. Phlegmonous gastritis in a patient with myeloid sarcoma: a case report. Appl Immunohistochem Mol Morphol. 2009 Oct; 17(5):458-62. View in: PubMed

Harb R, Xie G, Lutzko C, Guo Y, Wang X, Hill CK, Kanel GC, DeLeve LD. Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology. 2009 Aug; 137(2):704-12. View in: PubMed

Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology. 2009 Aug; 50(2):462-71. View in: PubMed

Palta R, Thobani S, Donovan JA, Kanel GC, Gutierrez G, Fong TL. Prolonged cholestasis associated with benazepril therapy. Am J Gastroenterol. 2009 Jan; 104(1):245-6. View in: PubMed

DeLeve LD, Wang X, Kanel GC, Atkinson RD, McCuskey RS. Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 2008 Oct; 173(4):993-1001. View in: PubMed

Chu MW, Siegmund KD, Eckstam CL, Kim JY, Yang AS, Kanel GC, Tavaré S, Shibata D. Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet. 2007; 8:50. View in: PubMed

Verma S, Bhakta H, Nowain A, Kanel G, Squires K. Occult hepatic opportunistic infection (OI) and highly active antiretroviral therapy (HAART) induced immune reconstitution: an important cause of jaundice in a patient with AIDS. AIDS Res Hum Retroviruses. 2006 Oct; 22(10):1052-3. View in: PubMed

Verma S, Bonacini M, Govindarajan S, Kanel G, Lindsay KL, Redeker A. More advanced hepatic fibrosis in hispanics with chronic hepatitis C infection: role of patient demographics, hepatic necroinflammation, and steatosis. Am J Gastroenterol. 2006 Aug; 101(8):1817-23. View in: PubMed

Netto GJ, Watkins DL, Williams JW, Colby TV, dePetris G, Sharkey FE, Corless CL, Lewin D, Petrovic L, Sharma S, Kanel G, Theise N, West AB, Koehler A, Jhala NC, Lefkowitch J, Lezzoni J, Jennings LW, Tillery GW, Klintmalm GB. Interobserver agreement in hepatitis C grading and staging and in the Banff grading schema for acute cellular rejection: the "hepatitis C 3" multi-institutional trial experience. Arch Pathol Lab Med. 2006 Aug; 130(8):1157-62. View in: PubMed

Verma S, Wang CH, Govindarajan S, Kanel G, Squires K, Bonacini M. Do type and duration of antiretroviral therapy attenuate liver fibrosis in HIV-hepatitis C virus-coinfected patients? Clin Infect Dis. 2006 Jan 15; 42(2):262-70. View in: PubMed

Nowain A, Bhakta H, Pais S, Kanel G, Verma S. Isolated hepatic metastasis from a gastrointestinal stromal tumor (GIST) 17 years after initial resection: need for long-term surveillance. J Clin Gastroenterol. 2005 Nov-Dec; 39(10):925. View in: PubMed

Verma S, Bhakta H, Nowain A, Pais S, Kanel G, Squires K. Severe cholestatic liver injury days after initiating antiretroviral therapy in a patient with AIDS: drug toxicity or immune reconstitution inflammatory syndrome? Dig Dis Sci. 2005 Oct; 50(10):1813-7. View in: PubMed

Nowain A, Bhakta H, Pais S, Kanel G, Verma S. Gastrointestinal stromal tumors: clinical profile, pathogenesis, treatment strategies and prognosis. J Gastroenterol Hepatol. 2005 Jun; 20(6):818-24. View in: PubMed

Morgan TR, Weiss DG, Nemchausky B, Schiff ER, Anand B, Simon F, Kidao J, Cecil B, Mendenhall CL, Nelson D, Lieber C, Pedrosa M, Jeffers L, Bloor J, Lumeng L, Marsano L, McClain C, Mishra G, Myers B, Leo M, Ponomarenko Y, Taylor D, Chedid A, French S, Kanel G, Murray N, Pinto P, Fong TL, Sather MR. Colchicine treatment of alcoholic cirrhosis: a randomized, placebo-controlled clinical trial of patient survival. Gastroenterology. 2005 Apr; 128(4):882-90. View in: PubMed

Mendler MH, Kanel G, Govindarajan S. Proposal for a histological scoring and grading system for non-alcoholic fatty liver disease. Liver Int. 2005 Apr; 25(2):294-304. View in: PubMed

Baydur A, Kanel G, Koss M. Tracheobronchomalacia and noninvasive ventilation revisited. Chest. 2004 Oct; 126(4):1390-2. View in: PubMed

Lee TD, Sadda MR, Mendler MH, Bottiglieri T, Kanel G, Mato JM, Lu SC. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res. 2004 Jan; 28(1):173-81. View in: PubMed

DeLeve LD, Wang X, Kanel GC, Ito Y, Bethea NW, McCuskey MK, Tokes ZA, Tsai J, McCuskey RS. Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology. 2003 Oct; 38(4):900-8. View in: PubMed

Deleve LD, Wang X, Tsai J, Kanel G, Strasberg S, Tokes ZA. Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology. 2003 Sep; 125(3):882-90. View in: PubMed

Baydur A, Kanel G. Tracheobronchomalacia and tracheal hemorrhage in patients with Duchenne muscular dystrophy receiving long-term ventilation with uncuffed tracheostomies. Chest. 2003 Apr; 123(4):1307-11. View in: PubMed

Martínez-Chantar ML, Corrales FJ, Martínez-Cruz LA, García-Trevijano ER, Huang ZZ, Chen L, Kanel G, Avila MA, Mato JM, Lu SC. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J. 2002 Aug; 16(10):1292-4. View in: PubMed

Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, Avila MA, Kanel G, Mato JM. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A. 2001 May 8; 98(10):5560-5. View in: PubMed

Hu KQ, Tiyyagura L, Kanel G, Redeker AG. Acute hepatitis induced by bupropion. Dig Dis Sci. 2000 Sep; 45(9):1872-3. View in: PubMed

Wang X, Kanel GC, DeLeve LD. Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology. 2000 Feb; 31(2):428-34. View in: PubMed

Lawrence MA, Ginsberg D, Stein JP, Kanel G, Skinner DG. Coccidioidomycosis prostatitis associated with prostate cancer. BJU Int. 1999 Aug; 84(3):372-3. View in: PubMed

DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, Kanel GC. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology. 1999 Jun; 29(6):1779-91. View in: PubMed

Huang ZZ, Mato JM, Kanel G, Lu SC. Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. Hepatology. 1999 May; 29(5):1471-8. View in: PubMed

Huang ZZ, Mato JM, Kanel G, Lu SC. Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. Hepatology. 1999 May; 29(5):1471-8. View in: PubMed

Hoefs JC, Wang F, Kanel G. Functional measurement of nonfibrotic hepatic mass in cirrhotic patients. Am J Gastroenterol. 1997 Nov; 92(11):2054-8. View in: PubMed

Han SH, Kanel G, Korula J. Peritoneal mucinous carcinomatosis. A possible explanation for an unusual laparoscopic appearance. Dig Dis Sci. 1997 Jun; 42(6):1270-3. View in: PubMed

Zuckerman E, Kanel G, Ha C, Kahn J, Gottesman BS, Korula J. Low albumin gradient ascites complicating severe pseudomembranous colitis. Gastroenterology. 1997 Mar; 112(3):991-4. View in: PubMed

Bonacini M, Kanel G, Alamy M. Duodenal and hepatic toxoplasmosis in a patient with HIV infection: review of the literature. Am J Gastroenterol. 1996 Sep; 91(9):1838-40. View in: PubMed

Shakil AO, Korula J, Kanel GC, Murray NG, Reynolds TB. Diagnostic features of tuberculous peritonitis in the absence and presence of chronic liver disease: a case control study. Am J Med. 1996 Feb; 100(2):179-85. View in: PubMed

Hoefs JC, Wang F, Kanel G, Braunstein P. The liver-spleen scan as a quantitative liver function test: correlation with liver severity at peritoneoscopy. Hepatology. 1995 Oct; 22(4 Pt 1):1113-21. View in: PubMed

Hoefs J, Chang K, Wang F, Kanel G, Morgan T, Braunstein P. Perfused Kupffer cell mass. Correlation with histology and severity of chronic liver disease. Dig Dis Sci. 1995 Mar; 40(3):552-60. View in: PubMed

Baydur A, Cabula OS, Krishnareddy N, Kanel GC. Fatal intrathoracic hemorrhage in a patient with von Recklinghausen's disease. Respiration. 1995; 62(2):104-6. View in: PubMed

Fong TL, Kanel GC, Conrad A, Valinluck B, Charboneau F, Adkins RH. Clinical significance of concomitant hepatitis C infection in patients with alcoholic liver disease. Hepatology. 1994 Mar; 19(3):554-7. View in: PubMed

Kanel GC. Hepatic lesions resembling alcoholic liver disease. Pathology (Phila). 1994; 3(1):77-104. View in: PubMed

Sumino Y, Kravetz D, Kanel GC, McHutchison JG, Reynolds TB. Ultrasonographic diagnosis of acute alcoholic hepatitis 'pseudoparallel channel sign' of intrahepatic artery dilatation. Gastroenterology. 1993 Nov; 105(5):1477-82. View in: PubMed

Baydur A, Pandya K, Sharma OP, Kanel GC, Carlson M. Control of ventilation, respiratory muscle strength, and granulomatous involvement of skeletal muscle in patients with sarcoidosis. Chest. 1993 Feb; 103(2):396-402. View in: PubMed

Korula J, Yellin A, Kanel G, Campofiori G, Nichols P. Hepatocellular carcinoma coexisting with hepatic adenoma. Incidental discovery after long-term oral contraceptive use. West J Med. 1991 Oct; 155(4):416-8. View in: PubMed

Korula J, Yellin A, Kanel GC, Nichols P. Portal vein thrombosis complicating endoscopic variceal sclerotherapy. Convincing further evidence. Dig Dis Sci. 1991 Aug; 36(8):1164-7. View in: PubMed

Moulding TS, Redeker AG, Kanel GC. Acetaminophen, isoniazid, and hepatic toxicity. Ann Intern Med. 1991 Mar 1; 114(5):431. View in: PubMed

Runyon BA, Sugano S, Kanel G, Mellencamp MA. A rodent model of cirrhosis, ascites, and bacterial peritonitis. Gastroenterology. 1991 Feb; 100(2):489-93. View in: PubMed

Akriviadis EA, Steindel H, Pinto PC, Fong TL, Kanel G, Reynolds TB, Gupta S. Failure of colchicine to improve short-term survival in patients with alcoholic hepatitis. Gastroenterology. 1990 Sep; 99(3):811-8. View in: PubMed

Kanel GC, Cassidy W, Shuster L, Reynolds TB. Cocaine-induced liver cell injury: comparison of morphological features in man and in experimental models. Hepatology. 1990 Apr; 11(4):646-51. View in: PubMed

Moulding TS, Redeker AG, Kanel GC. Twenty isoniazid-associated deaths in one state. Am Rev Respir Dis. 1989 Sep; 140(3):700-5. View in: PubMed

Yang SS, Kanel G. Fibrinous pericarditis in alcoholic liver disease. J Clin Gastroenterol. 1989 Feb; 11(1):53-5. View in: PubMed

Kage M, Korula J, Harada A, Mucientes F, Kanel G, Peters RL. Effects of sodium tetradecyl sulfate endoscopic variceal sclerotherapy on the esophagus. A prospective clinical and histopathologic study. J Clin Gastroenterol. 1987 Dec; 9(6):635-43. View in: PubMed

Dudley FJ, Kanel GC, Wood LJ, Reynolds TB. Hepatorenal syndrome without avid sodium retention. Hepatology. 1986 Mar-Apr; 6(2):248-51. View in: PubMed

Govindarajan S, Kanel GC, De Cock KM, Redeker AG, Falzarano JS. Delta agent superinfection. Rapidly progressive liver disease in a hepatitis B virus carrier. Arch Pathol Lab Med. 1985 May; 109(5):395-7. View in: PubMed

Rector WG, Uchida T, Kanel GC, Redeker AG, Reynolds TB. Fulminant hepatic and renal failure complicating Wilson's disease. Liver. 1984 Dec; 4(6):341-7. View in: PubMed

Kanel GC, Govindarajan S, Peters RL. Chronic delta infection and liver biopsy changes in chronic active hepatitis B. Ann Intern Med. 1984 Jul; 101(1):51-4. View in: PubMed

Govindarajan S, Kanel GC, Peters RL. Prevalence of delta-antibody among chronic hepatitis B virus infected patients in the Los Angeles area: its correlation with liver biopsy diagnosis. Gastroenterology. 1983 Jul; 85(1):160-2. View in: PubMed

Kanel GC, Radvan G, Peters RL. High-density lipoprotein cholesterol and liver disease. Hepatology. 1983 May-Jun; 3(3):343-8. View in: PubMed

Sepersky R, Callow A, Kanel G, Kaplan M. Portasystemic shunts in primary biliary cirrhosis: survival is the same as in patients with Laennec's cirrhosis and postnecrotic cirrhosis. Dig Dis Sci. 1982 Jun; 27(6):507-12. View in: PubMed

Hallé P, Paré P, Kaptein E, Kanel G, Redeker AG, Reynolds TB. Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis. Gastroenterology. 1982 May; 82(5 Pt 1):925-31. View in: PubMed

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