My interest is directed at understanding of host recognition and viral evasion upon viral infection, specifically during delivery of the viral genome to the host cell. Using RNAi and yeast genetics, I will explore novel protein interactions involved in viral DNA sensing and viral evasion immediately following infection and during viral genome replication.
Seo GJ, Choi Y, Jung JU. No TRIFling Matter on STING. Cell Host Microbe. 2016 Sep 14; 20(3):277-8. View in: PubMed
Seo GJ, Yang A, Tan B, Kim S, Liang Q, Choi Y, Yuan W, Feng P, Park HS, Jung JU. Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep. 2015 Oct 13; 13(2):440-9. View in: PubMed
Liang Q, Seo GJ, Choi YJ, Ge J, Rodgers MA, Shi M, Jung JU. Autophagy side of MB21D1/cGAS DNA sensor. Autophagy. 2014 Jun; 10(6):1146-7. View in: PubMed
Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU. Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses. Cell Host Microbe. 2014 Feb 12; 15(2):228-38. View in: PubMed
Seo GJ, Kincaid RP, Phanaksri T, Burke JM, Pare JM, Cox JE, Hsiang TY, Krug RM, Sullivan CS. Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells. Cell Host Microbe. 2013 Oct 16; 14(4):435-45. View in: PubMed