My interest is directed at understanding of host recognition and viral evasion upon viral infection, specifically during delivery of the viral genome to the host cell. Using RNAi and yeast genetics, I will explore novel protein interactions involved in viral DNA sensing and viral evasion immediately following infection and during viral genome replication.
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep. 2015 Oct 13; 13(2):440-9. View in: PubMed
Autophagy side of MB21D1/cGAS DNA sensor. Autophagy. 2014 Jun; 10(6):1146-7. View in: PubMed
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses. Cell Host Microbe. 2014 Feb 12; 15(2):228-38. View in: PubMed
Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells. Cell Host Microbe. 2013 Oct 16; 14(4):435-45. View in: PubMed