Faculty

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Helena Chang Chui, MD
Chair and Professor of Neurology
Raymond and Betty Mc Carron Chair in Neurology
Neurology
CHP 215 Health Sciences Campus Los Angeles
+1 323 442 7686

Overview

Dr. Chui is internationally recognized for her research in Alzheimer disease and vascular cognitive impairment. She is the principal investigator for the NIA-funded Alzheimer Disease Research Center, as well as a multi-institutional program project on vascular dementia.

Dr. Chui is the author of over 120 publications and has served on the editorial board for Stroke, Alzheimer Disease and Associated Disorders, and Archives of Neurology. She holds the Raymond and Betty McCarron endowed Chair at the Keck School of Medicine and serves as the Chair of the Department of Neurology.

Awards

Pasadena Magazine: Top Doctor, 2011

Publications

Yassine HN, Feng Q, Azizkhanian I, Rawat V, Castor K, Fonteh AN, Harrington MG, Zheng L, Reed BR, DeCarli C, Jagust WJ, Chui HC. Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis. JAMA Neurol. 2016 Oct 1; 73(10):1208-1216. View in: PubMed

La Morgia C, Ross-Cisneros FN, Koronyo Y, Hannibal J, Gallassi R, Cantalupo G, Sambati L, Pan BX, Tozer KR, Barboni P, Provini F, Avanzini P, Carbonelli M, Pelosi A, Chui H, Liguori R, Baruzzi A, Koronyo-Hamaoui M, Sadun AA, Carelli V. Melanopsin retinal ganglion cell loss in Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):90-109. View in: PubMed

Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui HC, Schneider LS. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimers Res Ther. 2016; 8:25. View in: PubMed

Zheng L, Vinters HV, Mack WJ, Weiner MW, Chui HC. Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition. J Cereb Blood Flow Metab. 2016 Jan; 36(1):204-15. View in: PubMed

Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W, Chui HC, Driscoll I, Resnick SM, Espeland MA, Chen JC, Wassertheil-Smoller S, Goodwin M, DeNise R, Lipton M, Hannigan J, Carpini A, Noble D, Guzman W, Kotchen JM, Goveas J, Kerwin D, Ulmer J, Censky S, Flinton T, Matusewic T, Prost R, Stefanick ML, Swope S, Sawyer-Glover AM, Hartley S, Jackson R, Hallarn R, Kennedy B, Bolognone J, Casimir L, Kochis A, Robbins J, Zaragoza S, Carter C, Ryan J, Macias D, Sonico J, Nathan L, Voigt B, Villablanca P, Nyborg G, Godinez S, Perrymann A, Limacher M, Anderson S, Toombs ME, Bennett J, Jones K, Brum S, Chatfield S, Vantrees K, Robinson J, Wilson C, Koch K, Hart S, Carroll J, Cherrico M, Ockene J, Churchill L, Fellows D, Serio A, Jackson S, Spavich D, Margolis K, Bjerk C, Truwitt C, Peitso M, Camcrena A, Grim R, Levin J, Perron M, Brunner R, Golding R, Pansky L, Arguello S, Hammons J, Peterson N, Murphy C, Morgan M, Castillo M, Beckman T, Huang B, Kuller L, McHugh P, Meltzer C, Davis D, Davis J, Kost P, Lucas K, Potter T, Tarr L, Shumaker S, Espeland M, Coker L, Williamson J, Felton D, Gleiser L, Rapp S, Legault C, Dailey M, Casanova R, Robertson J, Hogan P, Gaussoin S, Nance P, Summerville C, Peral R, Tan J, Bryan N, Davatzikos C, Desiderio L, Buckholtz N, Molchan S, Resnick S, Rossouw J, Pottern L. A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women. Front Hum Neurosci. 2016; 10:495. View in: PubMed

Yassine HN, Feng Q, Chiang J, Petrosspour LM, Fonteh AN, Chui HC, Harrington MG. ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease. J Am Heart Assoc. 2016; 5(2). View in: PubMed

Chui H, Gerstorf D, Hoppmann CA, Luszcz MA. Trajectories of depressive symptoms in old age: Integrating age-, pathology-, and mortality-related changes. Psychol Aging. 2015 Dec; 30(4):940-51. View in: PubMed

Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R, McArdle JJ, Manson JE, Chui HC, Espeland MA. Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study. Ann Neurol. 2015 Sep; 78(3):466-76. View in: PubMed

Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, Sears RL, Chatzopoulou D, Huang AY, Wojta KJ, Klein E, Lee J, Beekly DL, Boxer A, Faber KM, Haase CM, Miller J, Poon WW, Rosen A, Rosen H, Sapozhnikova A, Shapira J, Varpetian A, Foroud TM, Levenson RW, Levey AI, Kukull WA, Mendez MF, Ringman J, Chui H, Cotman C, DeCarli C, Miller BL, Geschwind DH, Coppola G. A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy. JAMA Neurol. 2015 Apr 1; 72(4):414-22. View in: PubMed

Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD. Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States. JAMA Neurol. 2015 Feb 1; 72(2):209-16. View in: PubMed

Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. View in: PubMed

Chui HC, Ramirez-Gomez L. Clinical and imaging features of mixed Alzheimer and vascular pathologies. Alzheimers Res Ther. 2015; 7(1):21. View in: PubMed

Brothers A, Chui H, Diehl M. Measuring future time perspective across adulthood: development and evaluation of a brief multidimensional questionnaire. Gerontologist. 2014 Dec; 54(6):1075-88. View in: PubMed

Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA. Effects of multiple genetic Loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov 1; 71(11):1394-404. View in: PubMed

Villeneuve S, Reed BR, Madison CM, Wirth M, Marchant NL, Kriger S, Mack WJ, Sanossian N, DeCarli C, Chui HC, Weiner MW, Jagust WJ. Vascular risk and Aß interact to reduce cortical thickness in AD vulnerable brain regions. Neurology. 2014 Jul 1; 83(1):40-7. View in: PubMed

Sachdev P, Kalaria R, O'Brien J, Skoog I, Alladi S, Black SE, Blacker D, Blazer DG, Chen C, Chui H, Ganguli M, Jellinger K, Jeste DV, Pasquier F, Paulsen J, Prins N, Rockwood K, Roman G, Scheltens P. Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):206-18. View in: PubMed

Tsao S, Gajawelli N, Hwang DH, Kriger S, Law M, Chui H, Weiner M, Lepore N. Mapping of ApoE4 Related White Matter Damage using Diffusion MRI. Proc SPIE Int Soc Opt Eng. 2014 Apr 9; 9039:90390H. View in: PubMed

Tsao S, Ma SJ, Michels PA, Gajawelli N, Law M, Chui H, Lepore N. The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR. Proc SPIE Int Soc Opt Eng. 2014 Apr 9; 9039:90390I. View in: PubMed

Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N, Mack W, Mungas D, Chui HC, Decarli C, Weiner MW, Jagust WJ. Cortical thickness mediates the effect of ß-amyloid on episodic memory. Neurology. 2014 Mar 4; 82(9):761-7. View in: PubMed

Rannikmäe K, Kalaria RN, Greenberg SM, Chui HC, Schmitt FA, Samarasekera N, Al-Shahi Salman R, Sudlow CL. APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis. J Neurol Neurosurg Psychiatry. 2014 Mar; 85(3):300-5. View in: PubMed

Reed B, Villeneuve S, Mack W, Decarli C, Chui HC, Jagust W. Associations between serum cholesterol levels and cerebral amyloidosis. JAMA Neurol. 2014 Feb 1; 71(2):195-200. View in: PubMed

Diehl M, Chui H, Hay EL, Lumley MA, Grühn D, Labouvie-Vief G. Change in coping and defense mechanisms across adulthood: longitudinal findings in a European American sample. Dev Psychol. 2014 Feb; 50(2):634-48. View in: PubMed

Hajjar I, Marmerelis V, Shin DC, Chui H. Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension. Cerebrovasc Dis. 2014; 38(1):10-6. View in: PubMed

Lee JY, Park S, Mackin S, Ewers M, Chui H, Jagust W, Insel PS, Weiner MW. Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression. PLoS One. 2014; 9(1):e87747. View in: PubMed

Lyness SA, Lee AY, Zarow C, Teng EL, Chui HC. 10-minute delayed recall from the modified mini-mental state test predicts Alzheimer's disease pathology. J Alzheimers Dis. 2014 Jan 1; 39(3):575-82. View in: PubMed

Frazier DT, Seider T, Bettcher BM, Mack WJ, Jastrzab L, Chao L, Weiner MW, DeCarli C, Reed BR, Mungas D, Chui HC, Kramer JH. The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort. Cerebrovasc Dis. 2014; 38(6):441-7. View in: PubMed

Zheng L, Vinters HV, Mack WJ, Zarow C, Ellis WG, Chui HC. Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes. Stroke. 2013 Oct; 44(10):2835-41. View in: PubMed

Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ. The aging brain and cognition: contribution of vascular injury and aß to mild cognitive dysfunction. JAMA Neurol. 2013 Apr; 70(4):488-95. View in: PubMed

Hajjar I, Brown L, Mack WJ, Chui H. Alzheimer pathology and angiotension receptor blockers. JAMA Neurol. 2013 Mar 1; 70(3):414. View in: PubMed

Chao LL, Decarli C, Kriger S, Truran D, Zhang Y, Laxamana J, Villeneuve S, Jagust WJ, Sanossian N, Mack WJ, Chui HC, Weiner MW. Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One. 2013; 8(6):e65175. View in: PubMed

Hajjar I, Brown L, Mack WJ, Chui H. Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series. Arch Neurol. 2012 Dec; 69(12):1632-8. View in: PubMed

Cardenas VA, Reed B, Chao LL, Chui H, Sanossian N, Decarli CC, Mack W, Kramer J, Hodis HN, Yan M, Buonocore MH, Carmichael O, Jagust WJ, Weiner MW. Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults. Stroke. 2012 Nov; 43(11):2865-70. View in: PubMed

Reed BR, Marchant NL, Jagust WJ, Decarli CC, Mack W, Chui HC. Coronary risk correlates with cerebral amyloid deposition. Neurobiol Aging. 2012 Sep; 33(9):1979-87. View in: PubMed

Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA. Evidence for a role of the rare p. A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 1; 21(15):3500-12. View in: PubMed

Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. View in: PubMed

Jung S, Zarow C, Mack WJ, Zheng L, Vinters HV, Ellis WG, Lyness SA, Chui HC. Preservation of neurons of the nucleus basalis in subcortical ischemic vascular disease. Arch Neurol. 2012 Jul; 69(7):879-86. View in: PubMed

Zarow C, Weiner MW, Ellis WG, Chui HC. Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample. Brain Behav. 2012 Jul; 2(4):435-42. View in: PubMed

Marchant NL, Reed BR, Decarli CS, Madison CM, Weiner MW, Chui HC, Jagust WJ. Cerebrovascular disease, beta-amyloid, and cognition in aging. Neurobiol Aging. 2012 May; 33(5):1006. e25-36. View in: PubMed

Hajjar I, Hart M, Chen YL, Mack W, Milberg W, Chui H, Lipsitz L. Effect of Antihypertensive Therapy on Cognitive Function in Early Executive Cognitive Impairment: A Double-blind Randomized Clinical Trial. Arch Intern Med. 2012 Mar 12; 172(5):442-4. View in: PubMed

Zheng L, Mack WJ, Chui HC, Heflin L, Mungas D, Reed B, Decarli C, Weiner MW, Kramer JH. Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults. J Am Geriatr Soc. 2012 Mar; 60(3):499-504. View in: PubMed

Chui HC, Zheng L, Reed BR, Vinters HV, Mack WJ. Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review. Alzheimers Res Ther. 2012; 4(1):1. View in: PubMed

Lee JY, Insel P, Mackin RS, Schuff N, Chui H, Decarli C, Park KH, Mueller SG, Weiner MW. Different associations of white matter lesions with depression and cognition. BMC Neurol. 2012; 12:83. View in: PubMed

Zheng L, Teng EL, Varma R, Mack WJ, Mungas D, Lu PH, Chui HC. Chinese-language montreal cognitive assessment for cantonese or mandarin speakers: age, education, and gender effects. Int J Alzheimers Dis. 2012; 2012:204623. View in: PubMed

Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011 Sep; 42(9):2672-713. View in: PubMed

Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. View in: PubMed

Seshadri S, Beiser A, Au R, Wolf PA, Evans DA, Wilson RS, Petersen RC, Knopman DS, Rocca WA, Kawas CH, Corrada MM, Plassman BL, Langa KM, Chui HC. Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement. 2011 Jan; 7(1):35-52. View in: PubMed

Lavretsky H, Zheng L, Weiner MW, Mungas D, Reed B, Kramer JH, Jagust W, Chui H, Mack WJ. Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study. Am J Psychiatry. 2010 May; 167(5):589-97. View in: PubMed

Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. View in: PubMed

Mueller SG, Mack WJ, Mungas D, Kramer JH, Cardenas-Nicolson V, Lavretsky H, Greene M, Schuff N, Chui HC, Weiner MW. Influences of lobar gray matter and white matter lesion load on cognition and mood. Psychiatry Res. 2010 Feb 28; 181(2):90-6. View in: PubMed

Kuczynski B, Targan E, Madison C, Weiner M, Zhang Y, Reed B, Chui HC, Jagust W. White matter integrity and cortical metabolic associations in aging and dementia. Alzheimers Dement. 2010 Jan; 6(1):54-62. View in: PubMed

Schuff N, Matsumoto S, Kmiecik J, Studholme C, Du A, Ezekiel F, Miller BL, Kramer JH, Jagust WJ, Chui HC, Weiner MW. Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimers Dement. 2009 Nov; 5(6):454-62. View in: PubMed

Tomaszewski Farias S, Cahn-Weiner DA, Harvey DJ, Reed BR, Mungas D, Kramer JH, Chui H. Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults. Clin Neuropsychol. 2009 Apr; 23(3):446-61. View in: PubMed

Weintraub S, Salmon D, Mercaldo N, Ferris S, Graff-Radford NR, Chui H, Cummings J, DeCarli C, Foster NL, Galasko D, Peskind E, Dietrich W, Beekly DL, Kukull WA, Morris JC. The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery. Alzheimer Dis Assoc Disord. 2009 Apr-Jun; 23(2):91-101. View in: PubMed

T Cuenco K, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA. Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol. 2008 Dec; 65(12):1640-8. View in: PubMed

Lavretsky H, Zheng L, Weiner MW, Mungas D, Reed B, Kramer JH, Jagust W, Chui H, Mack WJ. The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. Int J Geriatr Psychiatry. 2008 Oct; 23(10):1040-50. View in: PubMed

Zarow C, Sitzer TE, Chui HC. Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues. Curr Neurol Neurosci Rep. 2008 Sep; 8(5):363-70. View in: PubMed

Kuczynski B, Reed B, Mungas D, Weiner M, Chui HC, Jagust W. Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease. Arch Neurol. 2008 May; 65(5):650-5. View in: PubMed

Petitti DB, Crooks VC, Chiu V, Buckwalter JG, Chui HC. Incidence of dementia in long-term hormone users. Am J Epidemiol. 2008 Mar 15; 167(6):692-700. View in: PubMed

Carey CL, Kramer JH, Josephson SA, Mungas D, Reed BR, Schuff N, Weiner MW, Chui HC. Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly. Stroke. 2008 Feb; 39(2):397-402. View in: PubMed

Jagust WJ, Zheng L, Harvey DJ, Mack WJ, Vinters HV, Weiner MW, Ellis WG, Zarow C, Mungas D, Reed BR, Kramer JH, Schuff N, DeCarli C, Chui HC. Neuropathological basis of magnetic resonance images in aging and dementia. Ann Neurol. 2008 Jan; 63(1):72-80. View in: PubMed

Cahn-Weiner DA, Farias ST, Julian L, Harvey DJ, Kramer JH, Reed BR, Mungas D, Wetzel M, Chui H. Cognitive and neuroimaging predictors of instrumental activities of daily living. J Int Neuropsychol Soc. 2007 Sep; 13(5):747-57. View in: PubMed

Lee S, Tsang A, Chui H, Kwok K, Cheung E. A community epidemiological survey of generalized anxiety disorder in Hong Kong. Community Ment Health J. 2007 Aug; 43(4):305-19. View in: PubMed

Chui HC. Subcortical ischemic vascular dementia. Neurol Clin. 2007 Aug; 25(3):717-40, vi. View in: PubMed

Kramer JH, Mungas D, Reed BR, Wetzel ME, Burnett MM, Miller BL, Weiner MW, Chui HC. Longitudinal MRI and cognitive change in healthy elderly. Neuropsychology. 2007 Jul; 21(4):412-8. View in: PubMed

Reed BR, Mungas DM, Kramer JH, Ellis W, Vinters HV, Zarow C, Jagust WJ, Chui HC. Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease. Brain. 2007 Mar; 130(Pt 3):731-9. View in: PubMed

Yonelinas AP, Widaman K, Mungas D, Reed B, Weiner MW, Chui HC. Memory in the aging brain: doubly dissociating the contribution of the hippocampus and entorhinal cortex. Hippocampus. 2007; 17(11):1134-40. View in: PubMed

Lyness SA, Hernandez I, Chui HC, Teng EL. Performance of Spanish speakers on the Mattis dementia rating scale (MDRS). Arch Clin Neuropsychol. 2006 Dec; 21(8):827-36. View in: PubMed

Chui HC, Zarow C, Mack WJ, Ellis WG, Zheng L, Jagust WJ, Mungas D, Reed BR, Kramer JH, Decarli CC, Weiner MW, Vinters HV. Cognitive impact of subcortical vascular and Alzheimer's disease pathology. Ann Neurol. 2006 Dec; 60(6):677-87. View in: PubMed

Murrell J, Ghetti B, Cochran E, Macias-Islas MA, Medina L, Varpetian A, Cummings JL, Mendez MF, Kawas C, Chui H, Ringman JM. The A431E mutation in PSEN1 causing familial Alzheimer's disease originating in Jalisco State, Mexico: an additional fifteen families. Neurogenetics. 2006 Nov; 7(4):277-9. View in: PubMed

Morris JC, Weintraub S, Chui HC, Cummings J, Decarli C, Ferris S, Foster NL, Galasko D, Graff-Radford N, Peskind ER, Beekly D, Ramos EM, Kukull WA. The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):210-6. View in: PubMed

Chui HC. Vascular cognitive impairment: today and tomorrow. Alzheimers Dement. 2006 Jul; 2(3):185-94. View in: PubMed

Du AT, Schuff N, Chao LL, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 May; 27(5):733-40. View in: PubMed

Lee AY, Jeong SH, Choi BH, Sohn EH, Chui H. Pulse pressure correlates with leukoaraiosis in Alzheimer disease. Arch Gerontol Geriatr. 2006 Mar-Apr; 42(2):157-66. View in: PubMed

Chui H, Skoog I. Advances in vascular cognitive impairment 2005. Stroke. 2006 Feb; 37(2):323-5. View in: PubMed

Chui HC, Gatz M. Cultural diversity in Alzheimer disease: the interface between biology, belief, and behavior. Alzheimer Dis Assoc Disord. 2005 Oct-Dec; 19(4):250-5. View in: PubMed

Mack WJ, Teng E, Zheng L, Paz S, Chui H, Varma R. Category fluency in a latino sample: associations with age, education, gender, and language. J Clin Exp Neuropsychol. 2005 Jul; 27(5):591-8. View in: PubMed

Zarow C, Vinters HV, Ellis WG, Weiner MW, Mungas D, White L, Chui HC. Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia. Ann Neurol. 2005 Jun; 57(6):896-903. View in: PubMed

Du AT, Schuff N, Chao LL, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005 Apr; 26(4):553-9. View in: PubMed

Johnson NA, Jahng GH, Weiner MW, Miller BL, Chui HC, Jagust WJ, Gorno-Tempini ML, Schuff N. Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology. 2005 Mar; 234(3):851-9. View in: PubMed

Chui H. Neuropathology lessons in vascular dementia. Alzheimer Dis Assoc Disord. 2005 Jan-Mar; 19(1):45-52. View in: PubMed

Crooks VC, Clark L, Petitti DB, Chui H, Chiu V. Validation of multi-stage telephone-based identification of cognitive impairment and dementia. BMC Neurol. 2005; 5(1):8. View in: PubMed

Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. View in: PubMed

Kramer JH, Schuff N, Reed BR, Mungas D, Du AT, Rosen HJ, Jagust WJ, Miller BL, Weiner MW, Chui HC. Hippocampal volume and retention in Alzheimer's disease. J Int Neuropsychol Soc. 2004 Jul; 10(4):639-43. View in: PubMed

Winstein CJ, Rose DK, Tan SM, Lewthwaite R, Chui HC, Azen SP. A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: A pilot study of immediate and long-term outcomes. Arch Phys Med Rehabil. 2004 Apr; 85(4):620-8. View in: PubMed

Reed BR, Mungas DM, Kramer JH, Betz BP, Ellis W, Vinters HV, Zarow C, Jagust WJ, Chui HC. Clinical and neuropsychological features in autopsy-defined vascular dementia. Clin Neuropsychol. 2004 Feb; 18(1):63-74. View in: PubMed

Kramer JH, Mungas D, Reed BR, Schuff N, Weiner MW, Miller BL, Chui HC. Forgetting in dementia with and without subcortical lacunes. Clin Neuropsychol. 2004 Feb; 18(1):32-40. View in: PubMed

Green RC, Cupples LA, Kurz A, Auerbach S, Go R, Sadovnick D, Duara R, Kukull WA, Chui H, Edeki T, Griffith PA, Friedland RP, Bachman D, Farrer L. Depression as a risk factor for Alzheimer disease: the MIRAGE Study. Arch Neurol. 2003 May; 60(5):753-9. View in: PubMed

Zarow C, Lyness SA, Mortimer JA, Chui HC. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch Neurol. 2003 Mar; 60(3):337-41. View in: PubMed

Lyness SA, Zarow C, Chui HC. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiol Aging. 2003 Jan-Feb; 24(1):1-23. View in: PubMed

Román GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC. Subcortical ischaemic vascular dementia. Lancet Neurol. 2002 Nov; 1(7):426-36. View in: PubMed

Hsu YY, Schuff N, Amend DL, Du AT, Norman D, Chui HC, Jagust WJ, Weiner MW. Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes. Alzheimer Dis Assoc Disord. 2002 Apr-Jun; 16(2):58-64. View in: PubMed

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