Faculty

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Jang-Hyun Youn, PhD
Associate Professor of Physiology & Biophysics
Physiology and Biophysics
2250 Alcazar Steet, CSC 214 Health Sciences Campus Los Angeles
+1 323 442 3260

Publications

Youn JH. Fat sensing and metabolic syndrome. Rev Endocr Metab Disord. 2014 Dec; 15(4):263-75. View in: PubMed

Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May; 306(9):F1059-68. View in: PubMed

Choi AY, Choi JH, Hwang KY, Jeong YJ, Choe W, Yoon KS, Ha J, Kim SS, Youn JH, Yeo EJ, Kang I. Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase C?1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2014 Apr; 19(4):682-97. View in: PubMed

Oh YT, Kim J, Kang I, Youn JH. Regulation of hypothalamic-pituitary-adrenal axis by circulating free Fatty acids in male wistar rats: role of individual free Fatty acids. Endocrinology. 2014 Mar; 155(3):923-31. View in: PubMed

Oh YT, Kim J, Youn JH. Role of pituitary in K+ homeostasis: impaired renal responses to altered K+ intake in hypophysectomized rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15; 304(12):R1166-74. View in: PubMed

Youn JH. Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol. 2013 May; 33(3):248-56. View in: PubMed

McDonough AA, Youn JH. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. View in: PubMed

Oh YT, Oh KS, Kang I, Youn JH. A Fall in Plasma Free Fatty Acid (FFA) Level Activates the Hypothalamic-Pituitary-Adrenal Axis Independent of Plasma Glucose: Evidence for Brain Sensing of Circulating FFA. Endocrinology. 2012 Aug; 153(8):3587-92. View in: PubMed

Stefanovski D, Youn JH, Rees M, Watanabe RM, Ader M, Ionut V, Jackson AU, Boehnke M, Collins FS, Bergman RN. Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care. 2012 May; 35(5):1015-20. View in: PubMed

Kang I, Kim SW, Youn JH. Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab. 2011 Oct; 96(10):3048-55. View in: PubMed

Oh KS, Oh YT, Kim SW, Kita T, Kang I, Youn JH. Gut sensing of dietary K? intake increases renal K?excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R421-9. View in: PubMed

Oh YT, Oh KS, Choi YM, Jokiaho A, Donovan C, Choi S, Kang I, Youn JH. Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E1012-21. View in: PubMed

Choi S, Yoon H, Oh KS, Oh YT, Kim YI, Kang I, Youn JH. Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism. 2011 Jan; 60(1):134-44. View in: PubMed

Rashid MA, Lee S, Tak E, Lee J, Choi TG, Lee JW, Kim JB, Youn JH, Kang I, Ha J, Kim SS. Carbonyl reductase 1 protects pancreatic ß-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med. 2010 Nov 30; 49(10):1522-33. View in: PubMed

Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU. eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E846-53. View in: PubMed

Won JC, Park JY, Kim YM, Koh EH, Seol S, Jeon BH, Han J, Kim JR, Park TS, Choi CS, Lee WJ, Kim MS, Lee IK, Youn JH, Lee KU. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):290-7. View in: PubMed

Greenlee M, Wingo CS, McDonough AA, Youn JH, Kone BC. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 5; 150(9):619-25. View in: PubMed

Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. View in: PubMed

Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough AA. AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. View in: PubMed

Koh EH, Park JY, Park HS, Jeon MJ, Ryu JW, Kim M, Kim SY, Kim MS, Kim SW, Park IS, Youn JH, Lee KU. Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes. 2007 Dec; 56(12):2973-81. View in: PubMed

Lee FN, Oh G, McDonough AA, Youn JH. Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. View in: PubMed

Kim YI, Lee FN, Choi WS, Lee S, Youn JH. Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes. 2006 Aug; 55(8):2311-7. View in: PubMed

Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough AA. Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. View in: PubMed

Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo I, Oh GT, Park IS, Youn JH, Park SW, Lee KU, Park JY. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2488-94. View in: PubMed

McDonough AA, Youn JH. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. View in: PubMed

Song KH, Lee WJ, Koh JM, Kim HS, Youn JY, Park HS, Koh EH, Kim MS, Youn JH, Lee KU, Park JY. alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun. 2005 Jan 7; 326(1):197-202. View in: PubMed

Rhee MS, Perianayagam A, Chen P, Youn JH, McDonough AA. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. View in: PubMed

Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004 Jul; 10(7):727-33. View in: PubMed

Lee FN, Zhang L, Zheng D, Choi WS, Youn JH. Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E69-74. View in: PubMed

Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn JH, Lee KU. Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003 Sep; 52(9):2331-7. View in: PubMed

Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40. View in: PubMed

McDonough AA, Thompson CB, Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. View in: PubMed

Choi CS, Lee FN, McDonough AA, Youn JH. Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. View in: PubMed

Kim CH, Youn JH, Park JY, Hong SK, Park KS, Park SW, Suh KI, Lee KU. Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E977-84. View in: PubMed

Gulve EA, Henriksen EJ, Rodnick KJ, Youn JH, Holloszy JO. Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol. 1993 Mar; 264(3 Pt 1):E319-27. View in: PubMed

Ren JM, Youn JH, Gulve EA, Henriksen EJ, Holloszy JO. Effects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle. Biochim Biophys Acta. 1993 Feb 9; 1145(2):199-204. View in: PubMed

Slentz CA, Gulve EA, Rodnick KJ, Henriksen EJ, Youn JH, Holloszy JO. Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol. 1992 Aug; 73(2):486-92. View in: PubMed

Youn JH, Gulve EA, Holloszy JO. Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol. 1991 Mar; 260(3 Pt 1):C555-61. View in: PubMed

Gulve EA, Cartee GD, Youn JH, Holloszy JO. Prolonged incubation of skeletal muscle increases system A amino acid transport. Am J Physiol. 1991 Jan; 260(1 Pt 1):C88-95. View in: PubMed

Youn JH, Kaslow HR, Bergman RN. Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7. View in: PubMed

Youn JH, Youn MS, Bergman RN. Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J Biol Chem. 1986 Dec 5; 261(34):15960-9. View in: PubMed

Youn JH, Kim HC, Lee HK, Min BG. Computed insulin profiles for normalization of glycemia in diabetic patients. Bull Math Biol. 1983; 45(5):739-48. View in: PubMed

Oh YT, Tran D, Buchanan TA, Selsted ME, Youn JH. The theta-defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2015 May 19; ajpendo. 00131. 2015. View in: PubMed

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