Faculty

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Jang-Hyun Youn, PhD
Associate Professor of Physiology & Biophysics
Physiology and Biophysics
CSC 214, 2250 Alcazar Steet Health Sciences Campus Los Angeles
+1 323 442 3260

Publications

Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem. 2017 Jul 21; 49:8-14. View in: PubMed

Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 Mar; 32(2):100-111. View in: PubMed

Circulating free fatty acids inhibit food intake in an oleate-specific manner in rats. Physiol Behav. 2016 Dec 01; 167:194-201. View in: PubMed

Fat sensing and metabolic syndrome. Rev Endocr Metab Disord. 2014 Dec; 15(4):263-75. View in: PubMed

Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68. View in: PubMed

Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase C?1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2014 Apr; 19(4):682-97. View in: PubMed

Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. Endocrinology. 2014 Mar; 155(3):923-31. View in: PubMed

Role of pituitary in K+ homeostasis: impaired renal responses to altered K+ intake in hypophysectomized rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15; 304(12):R1166-74. View in: PubMed

Need to quickly excrete K(+)? Turn off NCC. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. View in: PubMed

Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol. 2013 May; 33(3):248-56. View in: PubMed

A Fall in plasma free fatty acid (FFA) level activates the hypothalamic-pituitary-adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA. Endocrinology. 2012 Aug; 153(8):3587-92. View in: PubMed

Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care. 2012 May; 35(5):1015-20. View in: PubMed

Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab. 2011 Oct; 96(10):3048-55. View in: PubMed

Gut sensing of dietary K? intake increases renal K?excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R421-9. View in: PubMed

Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E1012-21. View in: PubMed

Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism. 2011 Jan; 60(1):134-44. View in: PubMed

Carbonyl reductase 1 protects pancreatic ß-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med. 2010 Nov 30; 49(10):1522-33. View in: PubMed

eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E846-53. View in: PubMed

Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):290-7. View in: PubMed

Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 05; 150(9):619-25. View in: PubMed

Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. View in: PubMed

AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. View in: PubMed

Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes. 2007 Dec; 56(12):2973-81. View in: PubMed

Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. View in: PubMed

Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes. 2006 Aug; 55(8):2311-7. View in: PubMed

Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. View in: PubMed

Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2488-94. View in: PubMed

Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. View in: PubMed

alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun. 2005 Jan 07; 326(1):197-202. View in: PubMed

Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. View in: PubMed

Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E69-74. View in: PubMed

Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004 Jul; 10(7):727-33. View in: PubMed

Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003 Sep; 52(9):2331-7. View in: PubMed

Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40. View in: PubMed

Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. View in: PubMed

Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. View in: PubMed

Free fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats. Diabetes. 2001 Feb; 50(2):418-24. View in: PubMed

Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F95-F102. View in: PubMed

Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E977-84. View in: PubMed

Acute effect of growth hormone to induce peripheral insulin resistance is independent of FFA and insulin levels in rats. Am J Physiol. 1999 Oct; 277(4 Pt 1):E742-9. View in: PubMed

Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 1999 Jun; 276(6 Pt 1):C1411-9. View in: PubMed

Reduced glucose clearance as the major determinant of postabsorptive hyperglycemia in diabetic rats. Am J Physiol. 1998 Feb; 274(2 Pt 1):E257-64. View in: PubMed

Prolonged suppression of glucose metabolism causes insulin resistance in rat skeletal muscle. Am J Physiol. 1997 Feb; 272(2 Pt 1):E288-96. View in: PubMed

The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin receptor tyrosine kinase activity or membrane glycoprotein PC-1. Biochem Mol Med. 1996 Dec; 59(2):174-81. View in: PubMed

Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics. Am J Physiol. 1996 Nov; 271(5 Pt 1):E855-64. View in: PubMed

Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats. Am J Physiol. 1996 May; 270(5 Pt 1):E752-8. View in: PubMed

Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats. Diabetes. 1996 May; 45(5):651-8. View in: PubMed

Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes. 1996 Apr; 45(4):446-53. View in: PubMed

Assessment of extracellular glucose distribution and glucose transport activity in conscious rats. Am J Physiol. 1995 Apr; 268(4 Pt 1):E712-21. View in: PubMed

Interactions between effects of W-7, insulin, and hypoxia on glucose transport in skeletal muscle. Am J Physiol. 1994 Oct; 267(4 Pt 2):R888-94. View in: PubMed

Time courses of changes in hepatic and skeletal muscle insulin action and GLUT4 protein in skeletal muscle after STZ injection. Diabetes. 1994 Apr; 43(4):564-71. View in: PubMed

Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats. Diabetes. 1993 May; 42(5):757-63. View in: PubMed

Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol. 1993 Mar; 264(3 Pt 1):E319-27. View in: PubMed

Effects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle. Biochim Biophys Acta. 1993 Feb 09; 1145(2):199-204. View in: PubMed

Enhanced glucose tolerance in spontaneously hypertensive rats. Pancreatic beta-cell hyperfunction with normal insulin sensitivity. Diabetes. 1992 Jul; 41(7):872-8. View in: PubMed

Conversion of oral glucose to lactate in dogs. Primary site and relative contribution to blood lactate. Diabetes. 1991 Jun; 40(6):738-47. View in: PubMed

Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol. 1991 Mar; 260(3 Pt 1):C555-61. View in: PubMed

Prolonged incubation of skeletal muscle increases system A amino acid transport. Am J Physiol. 1991 Jan; 260(1 Pt 1):C88-95. View in: PubMed

Enhancement of hepatic glycogen by gluconeogenic precursors: substrate flux or metabolic control? Am J Physiol. Enhancement of hepatic glycogen by gluconeogenic precursors: substrate flux or metabolic control? Am J Physiol. 1990 Jun; 258(6 Pt 1):E899-906. View in: PubMed

Assessment of insulin sensitivity in vivo: a critical review. Diabetes Metab Rev. 1989 Aug; 5(5):411-29. View in: PubMed

Glucose phosphorylation is not rate limiting for accumulation of glycogen from glucose in perfused livers from fasted rats. J Biol Chem. 1989 Jan 05; 264(1):168-72. View in: PubMed

Response to deep hypoglycemia does not involve glucoreceptors in carotid perfused tissue. Am J Physiol. 1988 Nov; 255(5 Pt 1):E680-7. View in: PubMed

Regulation of glycogen synthase in muscle and adipose tissue during fasting and refeeding. Am J Physiol. 1988 Jun; 254(6 Pt 1):E720-5. View in: PubMed

Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol. 1987 Dec; 253(6 Pt 1):E595-602. View in: PubMed

Patterns of glycogen turnover in liver characterized by computer modeling. Am J Physiol. 1987 Oct; 253(4 Pt 1):E360-9. View in: PubMed

Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7. View in: PubMed

Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J Biol Chem. 1986 Dec 05; 261(34):15960-9. View in: PubMed

Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol (1985). 1992 Aug; 73(2):486-92. View in: PubMed

Computed insulin profiles for normalization of glycemia in diabetic patients. Bull Math Biol. 1983; 45(5):739-48. View in: PubMed

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