Faculty

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Jeffrey S. Upperman, MD
Associate Professor of Surgery
Associate Dean For Faculty Diversity
Pediatrics
CHL MailStop72 Off Campus Los Angeles
+1 323 361 7078

Overview

I chose to work in pediatric surgery because...

I developed a love of surgery during my medical training and pediatric surgery became a perfect match between my love of children and my enjoyment of performing surgery. If I were to point to a specific point in my life where I made the decision to become a pediatric surgeon it was during assisting a more senior surgeon on one of my first procedures to correct a congenital anomaly in an infant. I accompanied the senior surgeon out to see the family after the procedure. Watching him be able to go up to this family and say the words, "Your baby is going to be OK" and see the joy spread over that family really typified for me what we refer to around here as providing the "80-year cure."

I joined Childrens Hospital Los Angeles because...

I decided to come to Los Angeles to be a part of a state-of-the-science, tertiary care, healthcare center that was a leader in pediatric disease and treatment. I had experience working for the Childrens Hospital of Pittsburgh and had recently been deployed from my military obligation as a Major in the United States Army Medical Corps serving in Operation Iraqi Freedom 2 and was looking for other challenges. I decided to explore potential opportunities in Southern California and was recruited to work at Childrens Hospital Los Angeles.

I come to work every day because...

I view what I do as the ultimate community service. Coming to work every day, of course, pays the bills, but I am the kind of person who wants to be of service to the largest group of people possible.

Publications

Strumwasser A, Speer AL, Inaba K, Branco BC, Upperman JS, Ford HR, Lam L, Talving P, Shulman I, Demetriades D. The impact of acute coagulopathy on mortality in pediatric trauma patients. J Trauma Acute Care Surg. 2016 Aug; 81(2):312-8. View in: PubMed

Golden J, Isani M, Bowling J, Zagory J, Goodhue CJ, Burke RV, Upperman JS, Gayer CP. Limiting chest computed tomography in the evaluation of pediatric thoracic trauma. J Trauma Acute Care Surg. 2016 Aug; 81(2):271-7. View in: PubMed

Berg BM, Salzman GA, Burke RV, Santore MT, Dingeldein MW, Upperman JS. The pediatric surgeon's readiness to respond: commitment to advance preparation and effective coordinated response. J Pediatr Surg. 2016 Jun; 51(6):1054-8. View in: PubMed

Goodhue CJ, Demeter NE, Burke RV, Toor KT, Upperman JS, Merritt RJ. Mixed-Methods Pilot Study: Disaster Preparedness of Families With Children Followed in an Intestinal Rehabilitation Clinic. Nutr Clin Pract. 2016 Apr; 31(2):257-65. View in: PubMed

LeeVan E, Zmora O, Cazzulino F, Burke RV, Zagory J, Upperman JS. Management of pediatric blunt renal trauma: A systematic review. J Trauma Acute Care Surg. 2016 Mar; 80(3):519-28. View in: PubMed

Bachman SL, Salzman GA, Burke RV, Arbogast H, Ruiz P, Upperman JS. Observed child restraint misuse in a large, urban community: Results from three years of inspection events. J Safety Res. 2016 Feb; 56:17-22. View in: PubMed

Tavakoli N, Demeter NE, Burke RV, Chen MK, Upperman JS. Defining the Role of a Pediatric Surgery Fellowship Program Director: Results of a National Cross-sectional Survey. Am Surg. 2016 Jan; 82(1):E9-12. View in: PubMed

Bachman SL, Arbogast H, Ruiz P, Farag M, Demeter NE, Upperman JS, Burke RV. A School-Hospital Partnership Increases Knowledge of Pedestrian and Motor Vehicle Safety. J Community Health. 2015 Dec; 40(6):1057-64. View in: PubMed

Riley CL, Sarani B, Sullivan JA, Upperman JS, Kane-Gill SL, Bailey H. Critical Violent Injury in the United States: A Review and Call to Action. Crit Care Med. 2015 Nov; 43(11):2460-7. View in: PubMed

Golden J, Dossa A, Goodhue CJ, Upperman JS, Gayer CP. Admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients. J Trauma Acute Care Surg. 2015 Oct; 79(4):555-62. View in: PubMed

Burke RV, Goodhue CJ, Berg BM, Spears R, Barnes J, Upperman JS. Academic-Community Partnership to Develop a Novel Disaster Training Tool for School Nurses: Emergency Triage Drill Kit. NASN Sch Nurse. 2015 Sep; 30(5):265-8. View in: PubMed

Salzman GA, Burke RV, Muller VM, Spurrier RG, Zaslow TL, Upperman JS. Assessing medical care availability for student athletes of a large urban high school district. J Pediatr Surg. 2015 Jul; 50(7):1192-5. View in: PubMed

Lin AC, Salzman GA, Bachman SL, Burke RV, Zaslow T, Piasek CZ, Edison BR, Hamilton A, Upperman JS. Assessment of parental knowledge and attitudes toward pediatric sports-related concussions. Sports Health. 2015 Mar; 7(2):124-9. View in: PubMed

Musigdilok VV, Demeter NE, Burke RV, Shook E, Ajayakumar J, Berg BM, Hawkins MD, Ferree J, MacAloney BW, Chung S, Pellegrino JL, Tolli D, Hansen G, Upperman JS. Assessing American Red Cross First Aid mobile app user trends: Implications for resilience. Am J Disaster Med. 2015; 10(4):273-83. View in: PubMed

Lyle KC, Milton J, Fagbuyi D, LeFort R, Sirbaugh P, Gonzalez J, Upperman JS, Carmack T, Anderson M. Pediatric disaster preparedness and response and the nation's children's hospitals. Am J Disaster Med. 2015; 10(2):83-91. View in: PubMed

Dries D, Reed MJ, Kissoon N, Christian MD, Dichter JR, Devereaux AV, Upperman JS. Special Populations: Care of the Critically Ill and Injured During Pandemics and Disasters: CHEST Consensus Statement. Chest. 2014 Oct 1; 146(4 Suppl):e75S-86S. View in: PubMed

Devereaux AV, Tosh PK, Hick JL, Hanfling D, Geiling J, Reed MJ, Uyeki TM, Shah UA, Fagbuyi DB, Skippen P, Dichter JR, Kissoon N, Christian MD, Upperman JS. Engagement and Education: Care of the Critically Ill and Injured During Pandemics and Disasters: CHEST Consensus Statement. Chest. 2014 Oct 1; 146(4 Suppl):e118S-33S. View in: PubMed

Duron V, Burke RV, Bliss D, Ford HR, Upperman JS. Survival of pediatric blunt trauma patients presenting with no signs of life in the field. J Trauma Acute Care Surg. 2014 Sep; 77(3):422-6. View in: PubMed

Short SS, Lin AC, Merianos DJ, Burke RV, Upperman JS. Smartphones, trainees, and mobile education: implications for graduate medical education. J Grad Med Educ. 2014 Jun; 6(2):199-202. View in: PubMed

Arbogast H, Burke RV, Muller V, Ruiz P, Knudson MM, Upperman JS. Randomized controlled trial to evaluate the effectiveness of a video game as a child pedestrian educational tool. J Trauma Acute Care Surg. 2014 May; 76(5):1317-21. View in: PubMed

Muller VM, Burke RV, Berg BM, Lin AC, Upperman JS. A Mixed-methods Pilot Study of Disaster Preparedness and Resiliency Among Faith-based Organizations. Prehosp Disaster Med. 2014 Apr; 29(2):127-33. View in: PubMed

Muller VM, Burke RV, Arbogast H, Ruiz PC, Nunez NM, Mateo KR, Cazzulino F, Upperman JS. Evaluation of a child passenger safety class in increasing parental knowledge. Accid Anal Prev. 2014 Feb; 63:37-40. View in: PubMed

Cazzulino F, Burke RV, Muller V, Arbogast H, Upperman JS. Cell phones and young drivers: a systematic review regarding the association between psychological factors and prevention. Traffic Inj Prev. 2014; 15(3):234-42. View in: PubMed

Lin AC, Burke RV, Berg BM, Muller VM, Upperman JS. Disaster preparedness education in South Los Angeles faith-based organizations: A pilot study in promoting personal and community preparedness and resiliency. Am J Disaster Med. 2014; 9(4):287-96. View in: PubMed

Berg BM, Muller VM, Wilson M, Amara R, Fruhwirth K, Stevenson K, Burke RV, Upperman JS. Meeting children's needs: A mixed-methods approach to a regionalized pediatric surge plan-The Los Angeles County experience. Am J Disaster Med. 2014; 9(3):161-9. View in: PubMed

Behar S, Burke R, Upperman J, Nager AL. Competency-based pediatric disaster training. Am J Disaster Med. 2014; 9(1):5-16. View in: PubMed

Goodhue CJ, Lin AC, Burke RV, Berg BM, Upperman JS. Consider the children: pediatric disaster planning. Nurs Manage. 2013 Nov; 44(11):44-51. View in: PubMed

Nosanov L, Inaba K, Okoye O, Resnick S, Upperman J, Shulman I, Rhee P, Demetriades D. The impact of blood product ratios in massively transfused pediatric trauma patients. Am J Surg. 2013 Nov; 206(5):655-60. View in: PubMed

Barthel ER, Pierce JR, Speer AL, Levin DE, Goodhue CJ, Ford HR, Grikscheit TC, Upperman JS. Delayed family reunification of pediatric disaster survivors increases mortality and inpatient hospital costs: a simulation study. J Surg Res. 2013 Sep; 184(1):430-7. View in: PubMed

Barber J, Tronzo M, Harold Horvat C, Clermont G, Upperman J, Vodovotz Y, Yotov I. A three-dimensional mathematical and computational model of necrotizing enterocolitis. J Theor Biol. 2013 Apr 7; 322:17-32. View in: PubMed

Westphaln K, Lowe C, Burke RV, Kawaguchi A, Pierce JR, Upperman JS. Emergency management of pancreatic injury in a 5-year-old. Adv Emerg Nurs J. 2013 Apr-Jun; 35(2):122-8. View in: PubMed

Lin AC, Burke RV, Reynaldo S, Berg BM, Upperman JS. Pediatric Surge Pocket Guide: review of an easily accessible tool for managing an influx of pediatric patients. Am J Disaster Med. 2013; 8(1):75-82. View in: PubMed

Papillon S, Goodhue CJ, Zmora O, Sharma SS, Wells WJ, Ford HR, Upperman JS, Wang KS, Bushman GA, Kim R, Pierce JR. Congenital heart disease and heterotaxy: upper gastrointestinal fluoroscopy can be misleading and surgery in an asymptomatic patient is not beneficial. J Pediatr Surg. 2013 Jan; 48(1):164-9. View in: PubMed

Shah SR, McKenna C, Miller M, Shultz B, Upperman JS, Gaines BA. Safety factors related to all-terrain vehicle injuries in children. J Trauma Acute Care Surg. 2012 Oct; 73(9 Suppl 3):S273-6. View in: PubMed

Barthel ER, Pierce JR, Goodhue CJ, Burke RV, Ford HR, Upperman JS. Can a pediatric trauma center improve the response to a mass casualty incident? J Trauma Acute Care Surg. 2012 Oct; 73(4):885-9. View in: PubMed

Goodhue CJ, Burke RV, Ferrer RR, Chokshi NK, Dorey F, Upperman JS. Willingness to respond in a disaster: a pediatric nurse practitioner national survey. J Pediatr Health Care. 2012 Jul; 26(4):e7-e20. View in: PubMed

Iqbal CW, Levy SM, Tsao K, Petrosyan M, Kane TD, Pontarelli EM, Upperman JS, Malek M, Burns RC, Hill S, Wulkan ML, St Peter SD. Laparoscopic versus open distal pancreatectomy in the management of traumatic pancreatic disruption. J Laparoendosc Adv Surg Tech A. 2012 Jul; 22(6):595-8. View in: PubMed

Balasuriya D, Iverson E, Burke RV, Upperman JS. Community Engagement and Pediatric Disaster Readiness in a Large Urban Disaster Resource Hospital Network: The Case of "The Great California ShakeOut". Disaster Med Public Health Prep. 2012 Jun; 6(2):182-6. View in: PubMed

Curtis JW, Curtis A, Upperman JS. Using a Geographic Information System (GIS) to Assess Pediatric Surge Potential After an Earthquake. Disaster Med Public Health Prep. 2012 Jun; 6(2):163-9. View in: PubMed

Castle SL, Burke RV, Arbogast H, Upperman JS. Bicycle helmet legislation and injury patterns in trauma patients under age 18. J Surg Res. 2012 Apr; 173(2):327-31. View in: PubMed

McElroy SJ, Hobbs S, Kallen M, Tejera N, Rosen MJ, Grishin A, Matta P, Schneider C, Upperman J, Ford H, Polk DB, Weitkamp JH. Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes. PLoS One. 2012; 7(5):e38373. View in: PubMed

Burke RV, Berg BM, Vee P, Morton I, Nager A, Neches R, Wetzel R, Upperman JS. Using robotic telecommunications to triage pediatric disaster victims. J Pediatr Surg. 2012 Jan; 47(1):221-4. View in: PubMed

Guner YS, Franklin AL, Chokshi NK, Castle SL, Pontarelli E, Wang J, Wang L, Prasadarao NV, Upperman JS, Grishin AV, Ford HR. P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Lab Invest. 2011 Nov; 91(11):1668-79. View in: PubMed

Tegtmeyer K, Conway EE, Upperman JS, Kissoon N. Education in a pediatric emergency mass critical care setting. Pediatr Crit Care Med. 2011 Nov; 12(6 Suppl):S135-40. View in: PubMed

Burke RV, Goodhue CJ, Chokshi NK, Upperman JS. Factors associated with willingness to respond to a disaster: a study of healthcare workers in a tertiary setting. Prehosp Disaster Med. 2011 Jul-Aug; 26(4):244-50. View in: PubMed

Barthel ER, Pierce JR, Goodhue CJ, Ford HR, Grikscheit TC, Upperman JS. Availability of a pediatric trauma center in a disaster surge decreases triage time of the pediatric surge population: a population kinetics model. Theor Biol Med Model. 2011; 8:38. View in: PubMed

Upperman JS, Burd R, Cox C, Ehrlich P, Mooney D, Groner JI. Pediatric applied trauma research network: a call to action. J Trauma. 2010 Nov; 69(5):1304-7. View in: PubMed

Burke RV, Iverson E, Goodhue CJ, Neches R, Upperman JS. Disaster and mass casualty events in the pediatric population. Semin Pediatr Surg. 2010 Nov; 19(4):265-70. View in: PubMed

Upperman JS, Burd R, Cox C, Ehrlich P, Mooney D, Groner JI. Pediatric applied trauma research network: a call to action. J Pediatr Surg. 2010 Nov; 45(11):2278-82. View in: PubMed

Sauser K, Burke RV, Ferrer RR, Goodhue CJ, Chokshi NC, Upperman JS. Disaster preparedness among medical students: a survey assessment. Am J Disaster Med. 2010 Sep-Oct; 5(5):275-84. View in: PubMed

Mackoff RL, Iverson EF, Kiekel P, Dorey F, Upperman JS, Metzenberg AB. Attitudes of genetic counselors towards genetic susceptibility testing in children. J Genet Couns. 2010 Aug; 19(4):402-16. View in: PubMed

Rodriguez KA, Goodhue CJ, Upperman JS. Pediatric nurse practitioner implementation of a pediatric trauma continuity clinic utilizing the "medical home" model. J Trauma Nurs. 2010 Apr-Jun; 17(2):64-6; quiz 67-8. View in: PubMed

Ferrer RR, Balasuriya D, Iverson E, Upperman JS. Pediatric disaster preparedness of a hospital network in a large metropolitan region. Am J Disaster Med. 2010 Jan-Feb; 5(1):27-34. View in: PubMed

Goodhue CJ, Burke RV, Chambers S, Ferrer RR, Upperman JS. Disaster Olympix: a unique nursing emergency preparedness exercise. J Trauma Nurs. 2010 Jan-Mar; 17(1):5-10. View in: PubMed

Arciero JC, Ermentrout GB, Upperman JS, Vodovotz Y, Rubin JE. Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis. PLoS One. 2010; 5(4):e10066. View in: PubMed

Guner YS, Friedlich P, Wee CP, Dorey F, Camerini V, Upperman JS. State-based analysis of necrotizing enterocolitis outcomes. J Surg Res. 2009 Nov; 157(1):21-9. View in: PubMed

Neches R, Ryutov T, Kichkaylo T, Burke RV, Claudius IA, Upperman JS. Design and evaluation of a disaster preparedness logistics tool. Am J Disaster Med. 2009 Nov-Dec; 4(6):309-20. View in: PubMed

Chokshi NK, Simeone DM, Chari RS, Dorey F, Guner YS, Upperman JS. A survey of academic surgeons: work, stress, and research. Surgery. 2009 Sep; 146(3):462-8. View in: PubMed

Pieretti-Vanmarcke R, Velmahos GC, Nance ML, Islam S, Falcone RA, Wales PW, Brown RL, Gaines BA, McKenna C, Moore FO, Goslar PW, Inaba K, Barmparas G, Scaife ER, Metzger RR, Brockmeyer DL, Upperman JS, Estrada J, Lanning DA, Rasmussen SK, Danielson PD, Hirsh MP, Consani HF, Stylianos S, Pineda C, Norwood SH, Bruch SW, Drongowski R, Barraco RD, Pasquale MD, Hussain F, Hirsch EF, McNeely PD, Fallat ME, Foley DS, Iocono JA, Bennett HM, Waxman K, Kam K, Bakhos L, Petrovick L, Chang Y, Masiakos PT. Clinical clearance of the cervical spine in blunt trauma patients younger than 3 years: a multi-center study of the american association for the surgery of trauma. J Trauma. 2009 Sep; 67(3):543-9; discussion 549-50. View in: PubMed

Upperman JS, Berg B. Introduction pediatric disaster and emergency services national summit. J Trauma. 2009 Aug; 67(2 Suppl):S71-2. View in: PubMed

Cobb JP, Cairns CB, Bulger E, Wong HR, Parsons PE, Angus DC, Gentile NT, Hoyt DB, Schwinn DA, Wiener-Kronish JP, Upperman JS. The United States critical illness and injury trials group: an introduction. J Trauma. 2009 Aug; 67(2 Suppl):S159-60. View in: PubMed

Guner YS, Ochoa CJ, Wang J, Zhang X, Steinhauser S, Stephenson L, Grishin A, Upperman JS. Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochem Biophys Res Commun. 2009 Jun 26; 384(2):221-5. View in: PubMed

Gold JI, Montano Z, Shields S, Mahrer NE, Vibhakar V, Ybarra T, Yee N, Upperman J, Blake N, Stevenson K, Nager AL. Pediatric disaster preparedness in the medical setting: integrating mental health. Am J Disaster Med. 2009 May-Jun; 4(3):137-46. View in: PubMed

Nwomeh BC, Hayes J, Caniano DA, Upperman JS, Kelleher KJ. A parental educational intervention to facilitate informed consent for emergency operations in children. J Surg Res. 2009 Apr; 152(2):258-63. View in: PubMed

Hunter CJ, Williams M, Petrosyan M, Guner Y, Mittal R, Mock D, Upperman JS, Ford HR, Prasadarao NV. Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis. Infect Immun. 2009 Mar; 77(3):1031-43. View in: PubMed

Ferrer RR, Ramirez M, Sauser K, Iverson E, Upperman JS. Emergency drills and exercises in healthcare organizations: assessment of pediatric population involvement using after-action reports. Am J Disaster Med. 2009 Jan-Feb; 4(1):23-32. View in: PubMed

Claudius I, Behar S, Ballow S, Wood R, Stevenson K, Blake N, Upperman JS. Disaster drill exercise documentation and management: are we drilling to standard? J Emerg Nurs. 2008 Dec; 34(6):504-8. View in: PubMed

Guner YS, Chokshi N, Petrosyan M, Upperman JS, Ford HR, Grikscheit TC. Necrotizing enterocolitis--bench to bedside: novel and emerging strategies. Semin Pediatr Surg. 2008 Nov; 17(4):255-65. View in: PubMed

Hunter CJ, Singamsetty VK, Chokshi NK, Boyle P, Camerini V, Grishin AV, Upperman JS, Ford HR, Prasadarao NV. Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis. J Infect Dis. 2008 Aug 15; 198(4):586-93. View in: PubMed

Behar S, Upperman JS, Ramirez M, Dorey F, Nager A. Training medical staff for pediatric disaster victims: a comparison of different teaching methods. Am J Disaster Med. 2008 Jul-Aug; 3(4):189-99. View in: PubMed

Biffl WL, Spain DA, Reitsma AM, Minter RM, Upperman J, Wilson M, Adams R, Goldman EB, Angelos P, Krummel T, Greenfield LJ. Responsible development and application of surgical innovations: a position statement of the Society of University Surgeons. J Am Coll Surg. 2008 Jun; 206(3):1204-9. View in: PubMed

Ballow S, Behar S, Claudius I, Stevenson K, Neches R, Upperman JS. Hospital-based disaster preparedness for pediatric patients: how to design a realistic set of drill victims. Am J Disaster Med. 2008 May-Jun; 3(3):171-80. View in: PubMed

Chokshi NK, Guner YS, Hunter CJ, Upperman JS, Grishin A, Ford HR. The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):92-9. View in: PubMed

Hunter CJ, Upperman JS, Ford HR, Camerini V. Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC). Pediatr Res. 2008 Feb; 63(2):117-23. View in: PubMed

Chokshi NK, Behar S, Nager AL, Dorey F, Upperman JS. Disaster management among pediatric surgeons: preparedness, training and involvement. Am J Disaster Med. 2008 Jan-Feb; 3(1):5-14. View in: PubMed

Ochoa C, Chokshi N, Upperman JS, Jurkovich GJ, Ford HR. Prior studies comparing outcomes from trauma care at children's hospitals versus adult hospitals. J Trauma. 2007 Dec; 63(6 Suppl):S87-91; discussion S92-5. View in: PubMed

Sun J, Liu YH, Chen H, Nguyen MP, Mishina Y, Upperman JS, Ford HR, Shi W. Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect. Biochem Biophys Res Commun. 2007 Aug 17; 360(1):238-43. View in: PubMed

Cetin S, Leaphart CL, Li J, Ischenko I, Hayman M, Upperman J, Zamora R, Watkins S, Ford HR, Wang J, Hackam DJ. Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1347-58. View in: PubMed

Upperman JS, Camerini V, Lugo B, Yotov I, Sullivan J, Rubin J, Rubin J, Clermont G, Zamora R, Ermentrout GB, Ford HR, Vodovotz Y. Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem. J Pediatr Surg. 2007 Mar; 42(3):445-53. View in: PubMed

Upperman JS, Balise D, Morad Y, Ford H, Mahour GH. Trauma video review: a valuable resource. Pediatrics. 2006 Aug; 118(2):839; author reply 839-40. View in: PubMed

Potoka D, McClain R, Upperman JS. Pediatric cystadenoma of the mesocolon. J Pediatr Surg. 2006 Jan; 41(1):e63-4. View in: PubMed

Grishin AV, Wang J, Potoka DA, Hackam DJ, Upperman JS, Boyle P, Zamora R, Ford HR. Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. J Immunol. 2006 Jan 1; 176(1):580-8. View in: PubMed

Upperman JS, Staley P, Friend K, Benes J, Dailey J, Neches W, Wiener ES. The introduction of computerized physician order entry and change management in a tertiary pediatric hospital. Pediatrics. 2005 Nov; 116(5):e634-42. View in: PubMed

Upperman JS. Glutathione (GSH) levels in necrotizing enterocolitis (NEC). J Pediatr Surg. 2005 Nov; 40(11):1813; author reply 1813-4. View in: PubMed

Zamora R, Grishin A, Wong C, Boyle P, Wang J, Hackam D, Upperman JS, Tracey KJ, Ford HR. High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G643-52. View in: PubMed

Zuckerbraun BS, Otterbein LE, Boyle P, Jaffe R, Upperman J, Zamora R, Ford HR. Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G607-13. View in: PubMed

Upperman JS, Potoka D, Grishin A, Hackam D, Zamora R, Ford HR. Mechanisms of nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis. Semin Pediatr Surg. 2005 Aug; 14(3):159-66. View in: PubMed

Cutter CS, Upperman JS. Not your father's specialty: preparing residents and associates for collaborative leadership. Bull Am Coll Surg. 2005 Jul; 90(7):15-9. View in: PubMed

Upperman JS, Sheridan RL. Pediatric trauma susceptibility to sepsis. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S108-11. View in: PubMed

Upperman JS, Sheridan RL, Marshall J. Pediatric surgical site and soft tissue infections. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S36-41. View in: PubMed

Upperman JS, Pillage G, Siddiqi MQ, Zeevi A, Kelly N, Ford HR, Kammerer C, Spolarics Z. Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients. Shock. 2005 Mar; 23(3):197-201. View in: PubMed

Hackam DJ, Upperman JS, Grishin A, Ford HR. Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg. 2005 Feb; 14(1):49-57. View in: PubMed

Upperman JS, Staley P, Friend K, Neches W, Kazimer D, Benes J, Wiener ES. The impact of hospitalwide computerized physician order entry on medical errors in a pediatric hospital. J Pediatr Surg. 2005 Jan; 40(1):57-9. View in: PubMed

Kelly N, Friend K, Boyle P, Zhang XR, Wong C, Hackam DJ, Zamora R, Ford HR, Upperman JS. The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis. Surgery. 2004 Sep; 136(3):557-66. View in: PubMed

Cetin S, Dunklebarger J, Li J, Boyle P, Ergun O, Qureshi F, Ford H, Upperman J, Watkins S, Hackam DJ. Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes. Surgery. 2004 Aug; 136(2):375-83. View in: PubMed

Grishin A, Wang J, Hackam D, Qureshi F, Upperman J, Zamora R, Ford HR. p38 MAP kinase mediates endotoxin-induced expression of cyclooxygenase-2 in enterocytes. Surgery. 2004 Aug; 136(2):329-35. View in: PubMed

Upperman JS. RAS-ACS is shaping future College leaders: an interview with Jeffrey S. Upperman, MD [interview by Diane S. Schneidman]. Bull Am Coll Surg. 2004 Jul; 89(7):9-13. View in: PubMed

Upperman JS, Barksdale EM. Images in clinical medicine. Congenital lymphedema. N Engl J Med. 2004 Feb 5; 350(6):e5. View in: PubMed

Upperman JS. Surgical genomics is here. Surgery. 2003 Nov; 134(5):846. View in: PubMed

Potoka DA, Upperman JS, Zhang XR, Kaplan JR, Corey SJ, Grishin A, Zamora R, Ford HR. Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G861-9. View in: PubMed

Upperman JS, Shultz B, Gaines BA, Hackam D, Cassidy LD, Ford HR, Helmkemp J. All-terrain vehicle rules and regulations: impact on pediatric mortality. J Pediatr Surg. 2003 Sep; 38(9):1284-6. View in: PubMed

Upperman JS, Potoka DA, Zhang XR, Wong K, Zamora R, Ford HR. Mechanism of intestinal-derived fungal sepsis by gliotoxin, a fungal metabolite. J Pediatr Surg. 2003 Jun; 38(6):966-70. View in: PubMed

Upperman JS, Gaines B, Hackam D. H-type congenital tracheoesophageal fistula. Am J Surg. 2003 Jun; 185(6):599-600. View in: PubMed

Potoka DA, Upperman JS, Nadler EP, Wong CT, Zhou X, Zhang XR, Ford HR. NF-kappaB inhibition enhances peroxynitrite-induced enterocyte apoptosis. J Surg Res. 2002 Jul; 106(1):7-14. View in: PubMed

Stanford A, Upperman JS, Boyle P, Schall L, Ojimba JI, Ford HR. Long-term follow-up of patients with necrotizing enterocolitis. J Pediatr Surg. 2002 Jul; 37(7):1048-1050; discussion 1048-1050. View in: PubMed

Stanford A, Upperman JS, Nguyen N, Barksdale E, Wiener ES. Surgical management of open versus laparoscopic adrenalectomy: outcome analysis. J Pediatr Surg. 2002 Jul; 37(7):1027-9. View in: PubMed

Potoka DA, Nadler EP, Upperman JS, Ford HR. Role of nitric oxide and peroxynitrite in gut barrier failure. World J Surg. 2002 Jul; 26(7):806-11. View in: PubMed

Hackam DJ, Potoka D, Meza M, Pollock A, Gardner M, Abrams P, Upperman J, Schall L, Ford H. Utility of radiographic hepatic injury grade in predicting outcome for children after blunt abdominal trauma. J Pediatr Surg. 2002 Mar; 37(3):386-9. View in: PubMed

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