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Jeffrey S. Upperman, MD
Associate Professor of Surgery
Associate Dean For Faculty Diversity
CHL MailStop72 Off Campus Los Angeles
+1 323 361 7078


I chose to work in pediatric surgery because...

I developed a love of surgery during my medical training and pediatric surgery became a perfect match between my love of children and my enjoyment of performing surgery. If I were to point to a specific point in my life where I made the decision to become a pediatric surgeon it was during assisting a more senior surgeon on one of my first procedures to correct a congenital anomaly in an infant. I accompanied the senior surgeon out to see the family after the procedure. Watching him be able to go up to this family and say the words, "Your baby is going to be OK" and see the joy spread over that family really typified for me what we refer to around here as providing the "80-year cure."

I joined Childrens Hospital Los Angeles because...

I decided to come to Los Angeles to be a part of a state-of-the-science, tertiary care, healthcare center that was a leader in pediatric disease and treatment. I had experience working for the Childrens Hospital of Pittsburgh and had recently been deployed from my military obligation as a Major in the United States Army Medical Corps serving in Operation Iraqi Freedom 2 and was looking for other challenges. I decided to explore potential opportunities in Southern California and was recruited to work at Childrens Hospital Los Angeles.

I come to work every day because...

I view what I do as the ultimate community service. Coming to work every day, of course, pays the bills, but I am the kind of person who wants to be of service to the largest group of people possible.


Specific Etiologies Associated With the Multiple Organ Dysfunction Syndrome in Children: Part 2. Pediatr Crit Care Med. 2017 Mar; 18(3_suppl Suppl 1):S58-S66. View in: PubMed

Specific Etiologies Associated With the Multiple Organ Dysfunction Syndrome in Children: Part 1. Pediatr Crit Care Med. 2017 Mar; 18(3_suppl Suppl 1):S50-S57. View in: PubMed

Pediatric Trauma Assessment and Management Database: Leveraging Existing Data Systems to Predict Mortality and Functional Status after Pediatric Injury. J Am Coll Surg. 2017 Feb 21. View in: PubMed

The Role of Adult Perceptions and Supervision Behavior in Preventing Child Injury. J Community Health. 2017 Jan 02. View in: PubMed

Routine post-operative esophagram is not necessary after repair of esophageal atresia. Am J Surg. 2016 Dec 30. View in: PubMed

Surgical Infection Society Curriculum Development Symposium: An Overview. Surg Infect (Larchmt). 2016 Dec; 17(6):665-674. View in: PubMed

Re-evaluation of liver transaminase cutoff for CT after pediatric blunt abdominal trauma. Pediatr Surg Int. 2016 Nov 23. View in: PubMed

Qualitative assessment of simulation-based training for pediatric trauma resuscitation. Surgery. 2016 Nov 11. View in: PubMed

The impact of acute coagulopathy on mortality in pediatric trauma patients. J Trauma Acute Care Surg. 2016 Aug; 81(2):312-8. View in: PubMed

Limiting chest computed tomography in the evaluation of pediatric thoracic trauma. J Trauma Acute Care Surg. 2016 Aug; 81(2):271-7. View in: PubMed

The pediatric surgeon's readiness to respond: commitment to advance preparation and effective coordinated response. J Pediatr Surg. 2016 Jun; 51(6):1054-8. View in: PubMed

Mixed-Methods Pilot Study: Disaster Preparedness of Families With Children Followed in an Intestinal Rehabilitation Clinic. Nutr Clin Pract. 2016 Apr; 31(2):257-65. View in: PubMed

Management of pediatric blunt renal trauma: A systematic review. J Trauma Acute Care Surg. 2016 Mar; 80(3):519-28. View in: PubMed

Observed child restraint misuse in a large, urban community: Results from three years of inspection events. J Safety Res. 2016 Feb; 56:17-22. View in: PubMed

Implementation and analysis of initial trauma registry in Iquitos, Peru. Health Promot Perspect. 2016; 6(4):174-179. View in: PubMed

Defining the Role of a Pediatric Surgery Fellowship Program Director: Results of a National Cross-sectional Survey. Am Surg. 2016 Jan; 82(1):E9-12. View in: PubMed

Mullerian-Type Ciliated Cyst of the Thigh with PAX-8 and WT1 Positivity: A Case Report and Review of the Literature. Case Rep Med. 2016; 2016:2487820. View in: PubMed

A School-Hospital Partnership Increases Knowledge of Pedestrian and Motor Vehicle Safety. J Community Health. 2015 Dec; 40(6):1057-64. View in: PubMed

Critical Violent Injury in the United States: A Review and Call to Action. Crit Care Med. 2015 Nov; 43(11):2460-7. View in: PubMed

Admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients. J Trauma Acute Care Surg. 2015 Oct; 79(4):555-62. View in: PubMed

Academic-Community Partnership to Develop a Novel Disaster Training Tool for School Nurses: Emergency Triage Drill Kit. NASN Sch Nurse. 2015 Sep; 30(5):265-8. View in: PubMed

Assessing medical care availability for student athletes of a large urban high school district. J Pediatr Surg. 2015 Jul; 50(7):1192-5. View in: PubMed

Assessment of parental knowledge and attitudes toward pediatric sports-related concussions. Sports Health. 2015 Mar; 7(2):124-9. View in: PubMed

Pediatric disaster preparedness and response and the nation's children's hospitals. Am J Disaster Med. 2015; 10(2):83-91. View in: PubMed

Assessing American Red Cross First Aid mobile app user trends: Implications for resilience. Am J Disaster Med. 2015; 10(4):273-83. View in: PubMed

Special Populations: Care of the Critically Ill and Injured During Pandemics and Disasters: CHEST Consensus Statement. Chest. 2014 Oct 1; 146(4 Suppl):e75S-86S. View in: PubMed

Engagement and Education: Care of the Critically Ill and Injured During Pandemics and Disasters: CHEST Consensus Statement. Chest. 2014 Oct 1; 146(4 Suppl):e118S-33S. View in: PubMed

Survival of pediatric blunt trauma patients presenting with no signs of life in the field. J Trauma Acute Care Surg. 2014 Sep; 77(3):422-6. View in: PubMed

Smartphones, trainees, and mobile education: implications for graduate medical education. J Grad Med Educ. 2014 Jun; 6(2):199-202. View in: PubMed

Randomized controlled trial to evaluate the effectiveness of a video game as a child pedestrian educational tool. J Trauma Acute Care Surg. 2014 May; 76(5):1317-21. View in: PubMed

A Mixed-methods Pilot Study of Disaster Preparedness and Resiliency Among Faith-based Organizations. Prehosp Disaster Med. 2014 Apr; 29(2):127-33. View in: PubMed

Evaluation of a child passenger safety class in increasing parental knowledge. Accid Anal Prev. 2014 Feb; 63:37-40. View in: PubMed

Disaster preparedness education in South Los Angeles faith-based organizations: A pilot study in promoting personal and community preparedness and resiliency. Am J Disaster Med. 2014; 9(4):287-96. View in: PubMed

Competency-based pediatric disaster training. Am J Disaster Med. 2014; 9(1):5-16. View in: PubMed

Cell phones and young drivers: a systematic review regarding the association between psychological factors and prevention. Traffic Inj Prev. 2014; 15(3):234-42. View in: PubMed

Meeting children's needs: A mixed-methods approach to a regionalized pediatric surge plan-The Los Angeles County experience. Am J Disaster Med. 2014; 9(3):161-9. View in: PubMed

Consider the children: pediatric disaster planning. Nurs Manage. 2013 Nov; 44(11):44-51. View in: PubMed

The impact of blood product ratios in massively transfused pediatric trauma patients. Am J Surg. 2013 Nov; 206(5):655-60. View in: PubMed

Delayed family reunification of pediatric disaster survivors increases mortality and inpatient hospital costs: a simulation study. J Surg Res. 2013 Sep; 184(1):430-7. View in: PubMed

A three-dimensional mathematical and computational model of necrotizing enterocolitis. J Theor Biol. 2013 Apr 7; 322:17-32. View in: PubMed

Emergency management of pancreatic injury in a 5-year-old. Adv Emerg Nurs J. 2013 Apr-Jun; 35(2):122-8. View in: PubMed

Pediatric Surge Pocket Guide: review of an easily accessible tool for managing an influx of pediatric patients. Am J Disaster Med. 2013; 8(1):75-82. View in: PubMed

Congenital heart disease and heterotaxy: upper gastrointestinal fluoroscopy can be misleading and surgery in an asymptomatic patient is not beneficial. J Pediatr Surg. 2013 Jan; 48(1):164-9. View in: PubMed

Can a pediatric trauma center improve the response to a mass casualty incident? J Trauma Acute Care Surg. Can a pediatric trauma center improve the response to a mass casualty incident? J Trauma Acute Care Surg. 2012 Oct; 73(4):885-9. View in: PubMed

Safety factors related to all-terrain vehicle injuries in children. J Trauma Acute Care Surg. 2012 Oct; 73(9 Suppl 3):S273-6. View in: PubMed

Laparoscopic versus open distal pancreatectomy in the management of traumatic pancreatic disruption. J Laparoendosc Adv Surg Tech A. 2012 Jul; 22(6):595-8. View in: PubMed

Willingness to respond in a disaster: a pediatric nurse practitioner national survey. J Pediatr Health Care. 2012 Jul; 26(4):e7-e20. View in: PubMed

Community Engagement and Pediatric Disaster Readiness in a Large Urban Disaster Resource Hospital Network: The Case of "The Great California ShakeOut". Disaster Med Public Health Prep. 2012 Jun; 6(2):182-6. View in: PubMed

Using a Geographic Information System (GIS) to Assess Pediatric Surge Potential After an Earthquake. Disaster Med Public Health Prep. 2012 Jun; 6(2):163-9. View in: PubMed

Bicycle helmet legislation and injury patterns in trauma patients under age 18. J Surg Res. 2012 Apr; 173(2):327-31. View in: PubMed

Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes. PLoS One. 2012; 7(5):e38373. View in: PubMed

Using robotic telecommunications to triage pediatric disaster victims. J Pediatr Surg. 2012 Jan; 47(1):221-4. View in: PubMed

P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Lab Invest. 2011 Nov; 91(11):1668-79. View in: PubMed

Education in a pediatric emergency mass critical care setting. Pediatr Crit Care Med. 2011 Nov; 12(6 Suppl):S135-40. View in: PubMed

Factors associated with willingness to respond to a disaster: a study of healthcare workers in a tertiary setting. Prehosp Disaster Med. 2011 Jul-Aug; 26(4):244-50. View in: PubMed

Availability of a pediatric trauma center in a disaster surge decreases triage time of the pediatric surge population: a population kinetics model. Theor Biol Med Model. 2011; 8:38. View in: PubMed

Pediatric applied trauma research network: a call to action. J Trauma. 2010 Nov; 69(5):1304-7. View in: PubMed

Disaster and mass casualty events in the pediatric population. Semin Pediatr Surg. 2010 Nov; 19(4):265-70. View in: PubMed

Pediatric applied trauma research network: a call to action. J Pediatr Surg. 2010 Nov; 45(11):2278-82. View in: PubMed

Disaster preparedness among medical students: a survey assessment. Am J Disaster Med. 2010 Sep-Oct; 5(5):275-84. View in: PubMed

Attitudes of genetic counselors towards genetic susceptibility testing in children. J Genet Couns. 2010 Aug; 19(4):402-16. View in: PubMed

Pediatric nurse practitioner implementation of a pediatric trauma continuity clinic utilizing the "medical home" model. J Trauma Nurs. 2010 Apr-Jun; 17(2):64-6; quiz 67-8. View in: PubMed

Pediatric disaster preparedness of a hospital network in a large metropolitan region. Am J Disaster Med. 2010 Jan-Feb; 5(1):27-34. View in: PubMed

Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis. PLoS One. 2010; 5(4):e10066. View in: PubMed

Disaster Olympix: a unique nursing emergency preparedness exercise. J Trauma Nurs. 2010 Jan-Mar; 17(1):5-10. View in: PubMed

Health informatics for pediatric disaster preparedness planning. Appl Clin Inform. 2010; 1(3):256-64. View in: PubMed

Design and evaluation of a disaster preparedness logistics tool. Am J Disaster Med. 2009 Nov-Dec; 4(6):309-20. View in: PubMed

State-based analysis of necrotizing enterocolitis outcomes. J Surg Res. 2009 Nov; 157(1):21-9. View in: PubMed

A survey of academic surgeons: work, stress, and research. Surgery. 2009 Sep; 146(3):462-8. View in: PubMed

Clinical clearance of the cervical spine in blunt trauma patients younger than 3 years: a multi-center study of the american association for the surgery of trauma. J Trauma. 2009 Sep; 67(3):543-9; discussion 549-50. View in: PubMed

Introduction pediatric disaster and emergency services national summit. J Trauma. 2009 Aug; 67(2 Suppl):S71-2. View in: PubMed

The United States critical illness and injury trials group: an introduction. J Trauma. 2009 Aug; 67(2 Suppl):S159-60. View in: PubMed

Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochem Biophys Res Commun. 2009 Jun 26; 384(2):221-5. View in: PubMed

Pediatric disaster preparedness in the medical setting: integrating mental health. Am J Disaster Med. 2009 May-Jun; 4(3):137-46. View in: PubMed

A parental educational intervention to facilitate informed consent for emergency operations in children. J Surg Res. 2009 Apr; 152(2):258-63. View in: PubMed

Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis. Infect Immun. 2009 Mar; 77(3):1031-43. View in: PubMed

Emergency drills and exercises in healthcare organizations: assessment of pediatric population involvement using after-action reports. Am J Disaster Med. 2009 Jan-Feb; 4(1):23-32. View in: PubMed

Disaster drill exercise documentation and management: are we drilling to standard? J Emerg Nurs. Disaster drill exercise documentation and management: are we drilling to standard? J Emerg Nurs. 2008 Dec; 34(6):504-8. View in: PubMed

Necrotizing enterocolitis--bench to bedside: novel and emerging strategies. Semin Pediatr Surg. 2008 Nov; 17(4):255-65. View in: PubMed

Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis. J Infect Dis. 2008 Aug 15; 198(4):586-93. View in: PubMed

Training medical staff for pediatric disaster victims: a comparison of different teaching methods. Am J Disaster Med. 2008 Jul-Aug; 3(4):189-99. View in: PubMed

Responsible development and application of surgical innovations: a position statement of the Society of University Surgeons. J Am Coll Surg. 2008 Jun; 206(3):1204-9. View in: PubMed

Hospital-based disaster preparedness for pediatric patients: how to design a realistic set of drill victims. Am J Disaster Med. 2008 May-Jun; 3(3):171-80. View in: PubMed

The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):92-9. View in: PubMed

Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC). Pediatr Res. 2008 Feb; 63(2):117-23. View in: PubMed

Disaster management among pediatric surgeons: preparedness, training and involvement. Am J Disaster Med. 2008 Jan-Feb; 3(1):5-14. View in: PubMed

Prior studies comparing outcomes from trauma care at children's hospitals versus adult hospitals. J Trauma. 2007 Dec; 63(6 Suppl):S87-91; discussion S92-5. View in: PubMed

Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect. Biochem Biophys Res Commun. 2007 Aug 17; 360(1):238-43. View in: PubMed

Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1347-58. View in: PubMed

Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem. J Pediatr Surg. 2007 Mar; 42(3):445-53. View in: PubMed

Trauma video review: a valuable resource. Pediatrics. 2006 Aug; 118(2):839; author reply 839-40. View in: PubMed

Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. J Immunol. 2006 Jan 1; 176(1):580-8. View in: PubMed

Pediatric cystadenoma of the mesocolon. J Pediatr Surg. 2006 Jan; 41(1):e63-4. View in: PubMed

Glutathione (GSH) levels in necrotizing enterocolitis (NEC). J Pediatr Surg. 2005 Nov; 40(11):1813; author reply 1813-4. View in: PubMed

The introduction of computerized physician order entry and change management in a tertiary pediatric hospital. Pediatrics. 2005 Nov; 116(5):e634-42. View in: PubMed

High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod. Am J Physiol Gastrointest Liver Physiol. 2005 Oct; 289(4):G643-52. View in: PubMed

Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G607-13. View in: PubMed

Mechanisms of nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis. Semin Pediatr Surg. 2005 Aug; 14(3):159-66. View in: PubMed

Not your father's specialty: preparing residents and associates for collaborative leadership. Bull Am Coll Surg. 2005 Jul; 90(7):15-9. View in: PubMed

Pediatric surgical site and soft tissue infections. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S36-41. View in: PubMed

Pediatric trauma susceptibility to sepsis. Pediatr Crit Care Med. 2005 May; 6(3 Suppl):S108-11. View in: PubMed

Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients. Shock. 2005 Mar; 23(3):197-201. View in: PubMed

Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg. 2005 Feb; 14(1):49-57. View in: PubMed

The impact of hospitalwide computerized physician order entry on medical errors in a pediatric hospital. J Pediatr Surg. 2005 Jan; 40(1):57-9. View in: PubMed

The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis. Surgery. 2004 Sep; 136(3):557-66. View in: PubMed

p38 MAP kinase mediates endotoxin-induced expression of cyclooxygenase-2 in enterocytes. Surgery. 2004 Aug; 136(2):329-35. View in: PubMed

Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes. Surgery. 2004 Aug; 136(2):375-83. View in: PubMed

RAS-ACS is shaping future College leaders: an interview with Jeffrey S. Upperman, MD [interview by Diane S. Schneidman]. Bull Am Coll Surg. 2004 Jul; 89(7):9-13. View in: PubMed

Images in clinical medicine. Congenital lymphedema. N Engl J Med. 2004 Feb 5; 350(6):e5. View in: PubMed

Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G861-9. View in: PubMed

Surgical genomics is here. Surgery. 2003 Nov; 134(5):846. View in: PubMed

All-terrain vehicle rules and regulations: impact on pediatric mortality. J Pediatr Surg. 2003 Sep; 38(9):1284-6. View in: PubMed

Mechanism of intestinal-derived fungal sepsis by gliotoxin, a fungal metabolite. J Pediatr Surg. 2003 Jun; 38(6):966-70. View in: PubMed

H-type congenital tracheoesophageal fistula. Am J Surg. 2003 Jun; 185(6):599-600. View in: PubMed

NF-kappaB inhibition enhances peroxynitrite-induced enterocyte apoptosis. J Surg Res. 2002 Jul; 106(1):7-14. View in: PubMed

Long-term follow-up of patients with necrotizing enterocolitis. J Pediatr Surg. 2002 Jul; 37(7):1048-1050; discussion 1048-1050. View in: PubMed

Surgical management of open versus laparoscopic adrenalectomy: outcome analysis. J Pediatr Surg. 2002 Jul; 37(7):1027-9. View in: PubMed

Role of nitric oxide and peroxynitrite in gut barrier failure. World J Surg. 2002 Jul; 26(7):806-11. View in: PubMed

Utility of radiographic hepatic injury grade in predicting outcome for children after blunt abdominal trauma. J Pediatr Surg. 2002 Mar; 37(3):386-9. View in: PubMed

Special feature: picture of the month. Arch Pediatr Adolesc Med. 2001 Nov; 155(11):1271-2. View in: PubMed

Controversies in the management of necrotizing enterocolitis. Surg Infect (Larchmt). 2001; 2(2):113-9; discussion 119-20. View in: PubMed

Inhibition of NF-kappaB by IkappaB prevents cytokine-induced NO production and promotes enterocyte apoptosis in vitro. Shock. 2000 Sep; 14(3):366-73. View in: PubMed

Early functional outcome in children with pelvic fractures. J Pediatr Surg. 2000 Jun; 35(6):1002-5. View in: PubMed

Effects of hypoxia on granulocytic-monocytic progenitors in rats. Role of bone marrow stroma. Am J Hematol. 2000 May; 64(1):20-5. View in: PubMed

Nitric oxide and intestinal barrier failure. Semin Pediatr Surg. 1999 Aug; 8(3):148-54. View in: PubMed

Post-hemorrhagic shock mesenteric lymph is cytotoxic to endothelial cells and activates neutrophils. Shock. 1998 Dec; 10(6):407-14. View in: PubMed

Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg. 1998 Oct; 228(4):518-27. View in: PubMed

Differential effects of acute hypoxia and endotoxin on the secretion and expression of bone marrow interleukin-1 and interleukin-6. Shock. 1997 May; 7(5):324-31. View in: PubMed

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