I am interested in neuroscience and immunology, especially in the interplay between immune cells and the nervous system in neurosurgical disorders such as glioma. My research career began after college when I studied the mechanisms of action of novel therapeutics for chronic lymphocytic leukemia (CLL) under the direction of John C. Byrd, MD, at Ohio State University. I then earned my medical degree from the University of California, San Diego (UCSD), where I also completed cognitive neuroscience research in the laboratory of Martin P. Paulus, MD, now director of the Laureate Institute for Brain Research. My clinical experiences at UCSD exposed me to neurosurgical practice, which attracted my interest on scientific, practical, and human levels. I greatly enjoy being in the operating room and helping people with neurosurgical problems. For many neurosurgical diseases, there is no cure, and for this reason I feel a strong pull to lend my knowledge and efforts towards research in this area. Currently, I work in the lab of Omid Akbari, PhD, on regulatory T cells and innate lymphoid cells, furthering our understanding of these important immune players and enhancing my own research tool set as preparation for future projects in the immunology of neurosurgical diseases, and independent work in this field.
Rigas D, Lewis G, Aron JL, Wang B, Banie H, Sankaranarayanan I, Galle-Treger L, Maazi H, Lo R, Freeman GJ, Sharpe AH, Soroosh P, Akbari O. ILC2 Suppression by Regulatory T Cells Attenuates Airway Hyperreactivity and Requires ICOS:ICOS-Ligand Interaction. J Allergy Clin Immunol. 2016 Oct 4. View in: PubMed
Aron JL, Gosselin R, Moll S, Arkin CF, Mantha S. Effects of recombinant factor VIIa on thrombin generation and thromboelastography in a patient with dabigatran-associated intracranial hemorrhage. J Thromb Thrombolysis. 2014; 37(2):76-9. View in: PubMed
Wittmann M, Simmons AN, Aron JL, Paulus MP. Accumulation of neural activity in the posterior insula encodes the passage of time. Neuropsychologia. 2010 Aug; 48(10):3110-20. View in: PubMed
Lovero KL, Simmons AN, Aron JL, Paulus MP. Anterior insular cortex anticipates impending stimulus significance. Neuroimage. 2009 Apr 15; 45(3):976-83. View in: PubMed
Aron JL, Paulus MP. Location, location: using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use. Addiction. 2007 Apr; 102 Suppl 1:33-43. View in: PubMed
Aron JL, Parthun MR, Marcucci G, Kitada S, Mone AP, Davis ME, Shen T, Murphy T, Wickham J, Kanakry C, Lucas DM, Reed JC, Grever MR, Byrd JC. Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Blood. 2003 Jul 15; 102(2):652-8. View in: PubMed
Byrd JC, Kitada S, Flinn IW, Aron JL, Pearson M, Lucas D, Reed JC. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. Blood. 2002 Feb 1; 99(3):1038-43. View in: PubMed