Faculty

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Jing-Hsiung James Ou, PhD
Professor of Molecular Microbiology & Immunology
Molecular Microbiology and Immunology
HMR 402A 2011 Zonal Avenue Health Sciences Campus Los Angeles
+1 323 442 1720

Overview

The research of our laboratory is centered on hepatitis B virus (HBV), hepatitis C virus (HCV), and liver cancer. We are particularly interested in understanding how these two viruses interact with their host cells, how they invaded host immunity to establish persistent infection, and how they cause liver diseases including hepatocellular carcinoma.

Publications

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Partial Hepatectomy and Castration of HBV Transgenic Mice. Methods Mol Biol. 2017; 1540:259-266. View in: PubMed

Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6. J Virol. 2016 Dec 01; 90(23):10928-10935. View in: PubMed

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 May 17; 44(5):1204-14. View in: PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2; 12(1):1-222. View in: PubMed

Hepatitis C virus and autophagy. Biol Chem. 2015 Nov; 396(11):1215-22. View in: PubMed

Autophagy, a double-edged sword in hepatocarcinogenesis. Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1004968. View in: PubMed

Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell Death Differ. 2015 Jun; 22(6):1025-34. View in: PubMed

TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism. PLoS Pathog. 2015 May; 11(5):e1004937. View in: PubMed

Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma. Virol Sin. 2015 Apr; 30(2):85-91. View in: PubMed

Oncogenic viruses and cancer. Virol Sin. 2015 Apr; 30(2):83-4. View in: PubMed

Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24. View in: PubMed

HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS Pathog. 2015 Mar; 11(3):e1004764. View in: PubMed

Virus control goes epigenetic. PLoS Pathog. 2014 Sep; 10(9):e1004370. View in: PubMed

Functions of autophagy in normal and diseased liver. Autophagy. 2013 Aug; 9(8):1131-58. View in: PubMed

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry. J Biol Chem. 2012 Dec 7; 287(50):41922-30. View in: PubMed

Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice. J Virol. 2012 Sep; 86(18):9599-605. View in: PubMed

Replication of hepatitis C virus RNA on autophagosomal membranes. J Biol Chem. 2012 May 25; 287(22):18036-43. View in: PubMed

Effects of Lipofectamine 2000/siRNA Complexes on Autophagy in Hepatoma Cells. Mol Biotechnol. 2012 May; 51(1):1-8. View in: PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. View in: PubMed

Enhancement of hepatitis B virus replication by androgen and its receptor in mice. J Virol. 2012 Feb; 86(4):1904-10. View in: PubMed

Hepatitis C virus translation preferentially depends on active RNA replication. PLoS One. 2012; 7(8):e43600. View in: PubMed

Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to fas signaling. PLoS One. 2012; 7(5):e36818. View in: PubMed

Autophagy required for hepatitis B virus replication in transgenic mice. J Virol. 2011 Dec; 85(24):13453-6. View in: PubMed

IFN-α/β and autophagy: tug-of-war between HCV and the host. Autophagy. 2011 Nov; 7(11):1394-6. View in: PubMed

Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J Virol. 2011 Oct; 85(20):10899-904. View in: PubMed

Effects of interferon-a/ß on HBV replication determined by viral load. PLoS Pathog. 2011 Jul; 7(7):e1002159. View in: PubMed

Krüppel-like factor 15 activates hepatitis B virus gene expression and replication. Hepatology. 2011 Jul; 54(1):109-21. View in: PubMed

Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury. PLoS One. 2011; 6(10):e26240. View in: PubMed

The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PLoS One. 2011; 6(7):e22979. View in: PubMed

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 1; 185(11):6985-98. View in: PubMed

Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo. J Virol. 2010 Sep; 84(18):9326-31. View in: PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. View in: PubMed

Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med. 2010 May 19; 2(32):32ra35. View in: PubMed

Autophagy by hepatitis B virus and for hepatitis B virus. Autophagy. 2010 May; 6(4):548-9. View in: PubMed

The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4383-8. View in: PubMed

Autophagy in viral replication and pathogenesis. Mol Cells. 2010 Jan; 29(1):1-7. View in: PubMed

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 3; 106(5):1548-53. View in: PubMed

PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis. Autophagy. 2009 Feb; 5(2):244-6. View in: PubMed

Ubiquitin-independent degradation of hepatitis C virus F protein. J Virol. 2009 Jan; 83(2):612-21. View in: PubMed

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology. 2008 Oct; 48(4):1054-61. View in: PubMed

Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. View in: PubMed

Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. View in: PubMed

Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc. J Biomed Sci. 2008 Jul; 15(4):417-25. View in: PubMed

Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein. Virology. 2007 Jul 5; 363(2):454-61. View in: PubMed

Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology. 2007 Jan; 45(1):16-21. View in: PubMed

Redox modulation of the hepatitis C virus replication complex is calcium dependent. Free Radic Biol Med. 2006 Nov 1; 41(9):1488-98. View in: PubMed

[Genetics of heteroplasmy in the mtDNA control region among the Chinese Han population]. Fa Yi Xue Za Zhi. 2006 Jun; 22(3):198-203. View in: PubMed

Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G847-51. View in: PubMed

Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. Virology. 2005 Nov 10; 342(1):150-8. View in: PubMed

Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. J Virol. 2004 Jul; 78(13):6908-14. View in: PubMed

The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo. J Virol. 2004 Apr; 78(7):3797-802. View in: PubMed

Phosphorylation analysis of hepatitis B virus core protein in mammalian cells. Methods Mol Med. 2004; 95:227-33. View in: PubMed

Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells. Hepatology. 2004 Jan; 39(1):81-9. View in: PubMed

Endogenous polymerase assay for the analysis of hepatitis B virus in transgenic mice. Methods Mol Med. 2004; 95:295-302. View in: PubMed

A heat inducible tyrosinase with distinct properties from Bacillus thuringiensis. Lett Appl Microbiol. 2004; 39(5):407-12. View in: PubMed

[Horizontal gene transfer]. Yi Chuan. 2003 Sep; 25(5):623-7. View in: PubMed

The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice. J Hepatol. 2003 Aug; 39(2):262-8. View in: PubMed

Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway. J Virol. 2003 Jul; 77(14):7707-12. View in: PubMed

Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4. J Biol Chem. 2003 Mar 14; 278(11):9353-60. View in: PubMed

Triple decoding of hepatitis C virus RNA by programmed translational frameshifting. Mol Cell Biol. 2003 Mar; 23(5):1489-97. View in: PubMed

Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum. J Virol. 2003 Jan; 77(2):1578-83. View in: PubMed

Membrane topology of the hepatitis C virus NS2 protein. J Biol Chem. 2002 Sep 6; 277(36):33228-34. View in: PubMed

Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C. Virology. 2002 Aug 15; 300(1):20-30. View in: PubMed

Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J Virol. 2002 Jun; 76(12):5875-81. View in: PubMed

Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol. 2002 Mar; 76(5):2579-84. View in: PubMed

Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase. J Biol Chem. 2001 Dec 21; 276(51):47993-9. View in: PubMed

Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor. J Virol. 2001 Sep; 75(18):8400-6. View in: PubMed

Transitional cell carcinoma in dialysis patients. Eur Urol. 2000 Jan; 37(1):90-4. View in: PubMed

Activation of p53 tumor suppressor by hepatitis C virus core protein. Virology. 1999 Nov 10; 264(1):134-41. View in: PubMed

Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation. J Virol. 1999 Feb; 73(2):1239-44. View in: PubMed

Expression and Dimerization of Hepatitis C Virus Core Protein in E. coli. Methods Mol Med. 1999; 19:325-30. View in: PubMed

Molecular biology of hepatitis B virus e antigen. J Gastroenterol Hepatol. 1997 Oct; 12(9-10):S178-87. View in: PubMed

Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication. J Gen Virol. 1997 Aug; 78 ( Pt 8):2055-65. View in: PubMed

Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol. 1997 Feb; 71(2):1301-9. View in: PubMed

Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1997 Jan 20; 227(2):515-8. View in: PubMed

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol. 1996 Sep; 70(9):5845-51. View in: PubMed

Interaction between hepatitis C virus core protein and E1 envelope protein. J Virol. 1996 Aug; 70(8):5177-82. View in: PubMed

Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22. Arch Virol. 1996; 141(3-4):425-38. View in: PubMed

Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter. Virology. 1995 Dec 1; 214(1):198-206. View in: PubMed

Differential subcellular localization of hepatitis C virus core gene products. Virology. 1995 Nov 10; 213(2):455-61. View in: PubMed

Detection of Cellular Proteins and Viral Core Protein Interacting with the 5' Untranslated Region of Hepatitis C Virus RNA. J Biomed Sci. 1995 Aug; 2(3):227-236. View in: PubMed

Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs. J Virol. 1995 Feb; 69(2):1025-9. View in: PubMed

Key role of a CCAAT element in regulating hepatitis B virus surface protein expression. Virology. 1995 Feb 01; 206(2):1155-8. View in: PubMed

Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3. Virology. 1994 Nov 15; 205(1):127-32. View in: PubMed

Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins. Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1348-54. View in: PubMed

Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment. J Clin Microbiol. 1994 Sep; 32(9):2235-41. View in: PubMed

Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution. Virology. 1994 Feb 15; 199(1):124-31. View in: PubMed

Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6459-63. View in: PubMed

Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol Cell Biol. 1993 Jan; 13(1):443-8. View in: PubMed

Brefeldin A as a regulator of grp78 gene expression in mammalian cells. J Biol Chem. 1992 Apr 5; 267(10):7128-33. View in: PubMed

Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex. J Virol. 1992 Feb; 66(2):914-21. View in: PubMed

Characterization of the hepatitis B virus EnhI enhancer and X promoter complex. J Virol. 1991 Dec; 65(12):6686-92. View in: PubMed

Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment. J Virol. 1991 Sep; 65(9):5080-3. View in: PubMed

Phosphorylation of hepatitis B virus precore and core proteins. J Virol. 1991 May; 65(5):2327-31. View in: PubMed

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