Faculty

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Jing-Hsiung James Ou, PhD
Professor of Molecular Microbiology & Immunology
Molecular Microbiology and Immunology
HMR 402A 2011 Zonal Avenue Health Sciences Campus Los Angeles
+1 323 442 1720

Overview

The research of our laboratory is centered on hepatitis B virus (HBV), hepatitis C virus (HCV), and liver cancer. We are particularly interested in understanding how these two viruses interact with their host cells, how they invaded host immunity to establish persistent infection, and how they cause liver diseases including hepatocellular carcinoma.

Awards

Academia Sinica: has faculty rank, 2016

American Academy of Microbiology: has faculty rank, 2011

Hepatitis B Foundation: has faculty rank, 2017

Chinese Society for Cellular and Molecular Biology: has faculty rank, 2017

Society for Chinese Bioscientist in America: has faculty rank, 1992

American Association for the Advancement of Science: has faculty rank, 2010

American Association for the Advancement of Science: Elected Fellow, 2010

American Academy of Microbiology: ORNG Application Instance for Person, 2011

American Academy of Microbiology: Elected Fellow, 2011

Hepatitis B Foundation: ORNG Application Instance for Person, 2017

Society for Chinese Bioscientist in America: ORNG Application Instance for Person, 1992

Chinese Society for Cellular and Molecular Biology: ORNG Application Instance for Person, 2017

Academia Sinica: ORNG Application Instance for Person, 2016

American Association for the Advancement of Science: ORNG Application Instance for Person, 2010

Society for Chinese Bioscientist in America: Cathay Hepatitis Research Award, 1992

Chinese Society for Cellular and Molecular Biology: person in primary position, 2017

Hepatitis B Foundation: person in primary position, 2017

American Association for the Advancement of Science: person in primary position, 2010

Academia Sinica: person in primary position, 2016

American Academy of Microbiology: person in primary position, 2011

Hepatitis B Foundation: start date, 2017

Society for Chinese Bioscientist in America: start date, 1992

Academia Sinica: start date, 2016

American Association for the Advancement of Science: start date, 2010

American Academy of Microbiology: start date, 2011

Society for Chinese Bioscientist in America: full name, 1992

Chinese Society for Cellular and Molecular Biology: full name, 2017

American Academy of Microbiology: full name, 2011

Hepatitis B Foundation: full name, 2017

American Association for the Advancement of Science: full name, 2010

Academia Sinica: full name, 2016

American Academy of Microbiology: Fellow, 2011

American Association for the Advancement of Science: Faculty Rank, 2010

Hepatitis B Foundation: Faculty Rank, 2017

Academia Sinica: Faculty Rank, 2016

American Association for the Advancement of Science: preferred title, 2010

American Academy of Microbiology: preferred title, 2011

Society for Chinese Bioscientist in America: preferred title, 1992

Hepatitis B Foundation: preferred title, 2017

Academia Sinica: preferred title, 2016

American Association for the Advancement of Science: Fellow, 2010

Academia Sinica: Position, 2016

American Academy of Microbiology: Position, 2011

Society for Chinese Bioscientist in America: Position, 1992

Hepatitis B Foundation: Bruce Witte Distinguished Lectureship, 2017

Hepatitis B Foundation: is primary position, 2017

Academia Sinica: is primary position, 2016

American Association for the Advancement of Science: is primary position, 2010

Society for Chinese Bioscientist in America: is primary position, 1992

American Academy of Microbiology: is primary position, 2011

American Academy of Microbiology: Keck School of Medicine of USC, 2011

American Association for the Advancement of Science: Keck School of Medicine of USC, 2010

Academia Sinica: Keck School of Medicine of USC, 2016

Hepatitis B Foundation: Keck School of Medicine of USC, 2017

Society for Chinese Bioscientist in America: Keck School of Medicine of USC, 1992

American Association for the Advancement of Science: Award or Honor Receipt, 2010

American Academy of Microbiology: Award or Honor Receipt, 2011

Hepatitis B Foundation: Award or Honor Receipt, 2017

Society for Chinese Bioscientist in America: Award or Honor Receipt, 1992

Academia Sinica: Award or Honor Receipt, 2016

Academia Sinica: Professor of Molecular Microbiology & Immunology, 2016

American Association for the Advancement of Science: Professor of Molecular Microbiology & Immunology, 2010

Society for Chinese Bioscientist in America: Professor of Molecular Microbiology & Immunology, 1992

Hepatitis B Foundation: Professor of Molecular Microbiology & Immunology, 2017

American Academy of Microbiology: Professor of Molecular Microbiology & Immunology, 2011

American Association for the Advancement of Science: Position, 2010

Hepatitis B Foundation: Position, 2017

American Association for the Advancement of Science: position in organization, 2010

Hepatitis B Foundation: position in organization, 2017

Society for Chinese Bioscientist in America: position in organization, 1992

American Academy of Microbiology: position in organization, 2011

Academia Sinica: position in organization, 2016

Publications

Partial Hepatectomy and Castration of HBV Transgenic Mice. Methods Mol Biol. 2017; 1540:259-266. View in: PubMed

Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6. J Virol. 2016 Dec 01; 90(23):10928-10935. View in: PubMed

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016 May 17; 44(5):1204-14. View in: PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2; 12(1):1-222. View in: PubMed

Hepatitis C virus and autophagy. Biol Chem. 2015 Nov; 396(11):1215-22. View in: PubMed

Autophagy, a double-edged sword in hepatocarcinogenesis. Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1004968. View in: PubMed

TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism. PLoS Pathog. 2015 May; 11(5):e1004937. View in: PubMed

Oncogenic viruses and cancer. Virol Sin. 2015 Apr; 30(2):83-4. View in: PubMed

Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma. Virol Sin. 2015 Apr; 30(2):85-91. View in: PubMed

Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24. View in: PubMed

HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication. PLoS Pathog. 2015 Mar; 11(3):e1004764. View in: PubMed

Virus control goes epigenetic. PLoS Pathog. 2014 Sep; 10(9):e1004370. View in: PubMed

Functions of autophagy in normal and diseased liver. Autophagy. 2013 Aug; 9(8):1131-58. View in: PubMed

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry. J Biol Chem. 2012 Dec 7; 287(50):41922-30. View in: PubMed

Replication of hepatitis C virus RNA on autophagosomal membranes. J Biol Chem. 2012 May 25; 287(22):18036-43. View in: PubMed

Effects of Lipofectamine 2000/siRNA Complexes on Autophagy in Hepatoma Cells. Mol Biotechnol. 2012 May; 51(1):1-8. View in: PubMed

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. View in: PubMed

Hepatitis C virus translation preferentially depends on active RNA replication. PLoS One. 2012; 7(8):e43600. View in: PubMed

IFN-α/β and autophagy: tug-of-war between HCV and the host. Autophagy. 2011 Nov; 7(11):1394-6. View in: PubMed

Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J Virol. 2011 Oct; 85(20):10899-904. View in: PubMed

Krüppel-like factor 15 activates hepatitis B virus gene expression and replication. Hepatology. 2011 Jul; 54(1):109-21. View in: PubMed

Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury. PLoS One. 2011; 6(10):e26240. View in: PubMed

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 1; 185(11):6985-98. View in: PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. View in: PubMed

Autophagy by hepatitis B virus and for hepatitis B virus. Autophagy. 2010 May; 6(4):548-9. View in: PubMed

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 3; 106(5):1548-53. View in: PubMed

PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis. Autophagy. 2009 Feb; 5(2):244-6. View in: PubMed

Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. View in: PubMed

Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. View in: PubMed

Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology. 2007 Jan; 45(1):16-21. View in: PubMed

Redox modulation of the hepatitis C virus replication complex is calcium dependent. Free Radic Biol Med. 2006 Nov 1; 41(9):1488-98. View in: PubMed

[Genetics of heteroplasmy in the mtDNA control region among the Chinese Han population]. Fa Yi Xue Za Zhi. 2006 Jun; 22(3):198-203. View in: PubMed

Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G847-51. View in: PubMed

A heat inducible tyrosinase with distinct properties from Bacillus thuringiensis. Lett Appl Microbiol. 2004; 39(5):407-12. View in: PubMed

[Horizontal gene transfer]. Yi Chuan. 2003 Sep; 25(5):623-7. View in: PubMed

The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice. J Hepatol. 2003 Aug; 39(2):262-8. View in: PubMed

Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase. J Biol Chem. 2001 Dec 21; 276(51):47993-9. View in: PubMed

Transitional cell carcinoma in dialysis patients. Eur Urol. 2000 Jan; 37(1):90-4. View in: PubMed

Expression and Dimerization of Hepatitis C Virus Core Protein in E. coli. Methods Mol Med. 1999; 19:325-30. View in: PubMed

Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22. Arch Virol. 1996; 141(3-4):425-38. View in: PubMed

Detection of Cellular Proteins and Viral Core Protein Interacting with the 5' Untranslated Region of Hepatitis C Virus RNA. J Biomed Sci. 1995 Aug; 2(3):227-236. View in: PubMed

Key role of a CCAAT element in regulating hepatitis B virus surface protein expression. Virology. 1995 Feb 01; 206(2):1155-8. View in: PubMed

Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins. Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1348-54. View in: PubMed

Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment. J Clin Microbiol. 1994 Sep; 32(9):2235-41. View in: PubMed

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