Faculty

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Jobin Varkey, PhD
Assistant Professor of Research Biochemistry and Molecular Biology
Zilkha Neurogenetic Institute
ZNI 115 Health Sciences Campus Los Angeles
+1 323 442 0106

Awards

Department of Biotechnology, Government of India: DBT Ramalingaswami Fellowship, 2013-2016

Council of Scientific and Industrial Research, Government of India: Senior Research Fellowship, 2004-2007

Department of Biotechnology, Government of India: MS Scholarship, 1999-2001

Council of Scientific and Industrial Research, Government of India: Junior Research Fellowship, 2002-2004

Publications

Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. a-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8. View in: PubMed

Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. a-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8. View in: PubMed

Basak S, Prasad GV, Varkey J, Chattopadhyay K. Early sodium dodecyl sulfate induced collapse of a-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. View in: PubMed

Basak S, Prasad GV, Varkey J, Chattopadhyay K. Early sodium dodecyl sulfate induced collapse of a-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. View in: PubMed

Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. Nonaggregated a-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding. Biochemistry. 2014 Jun 24; 53(24):3889-96. View in: PubMed

Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. Nonaggregated a-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding. Biochemistry. 2014 Jun 24; 53(24):3889-96. View in: PubMed

Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. View in: PubMed

Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. View in: PubMed

Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. a-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30. View in: PubMed

Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. a-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30. View in: PubMed

Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49):19965-70. View in: PubMed

Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49):19965-70. View in: PubMed

Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. Remodeling of Lipid Vesicles into Cylindrical Micelles by a-Synuclein in an Extended a-Helical Conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11. View in: PubMed

Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. Remodeling of Lipid Vesicles into Cylindrical Micelles by a-Synuclein in an Extended a-Helical Conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11. View in: PubMed

Meier F, Abeywardana T, Dhall A, Marotta NP, Varkey J, Langen R, Chatterjee C, Pratt MR. Semisynthetic, Site-Specific Ubiquitin Modification of a-Synuclein Reveals Differential Effects on Aggregation. J Am Chem Soc. 2012 Mar 28; 134(12):5468-71. View in: PubMed

Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss JC, Stamou DG, Steven AC, Langen R. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010 Oct 15; 285(42):32486-93. View in: PubMed

Varkey J, Singh S, Nagaraj R. Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23. View in: PubMed

Varkey J, Nagaraj R. Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6. View in: PubMed

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