Faculty

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Jobin Varkey, PhD
Assistant Professor of Research Physiology and Neuroscience
Zilkha Neurogenetic Institute
ZNI 115 Health Sciences Campus Los Angeles
+1 323 442 0106

Awards

Department of Biotechnology, Government of India: DBT Ramalingaswami Fellowship, 2013-2016

Council of Scientific and Industrial Research, Government of India: Senior Research Fellowship, 2004-2007

Council of Scientific and Industrial Research, Government of India: Junior Research Fellowship, 2002-2004

Department of Biotechnology, Government of India: MS Scholarship, 1999-2001

Publications

. View in: PubMed

Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. J Magn Reson. 2017 Jul; 280:127-139. View in: PubMed

a-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8. View in: PubMed

Early sodium dodecyl sulfate induced collapse of a-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. View in: PubMed

Nonaggregated a-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014 Jun 24; 53(24):3889-96. View in: PubMed

Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. View in: PubMed

a-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30. View in: PubMed

Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49):19965-70. View in: PubMed

Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19965-70. View in: PubMed

Remodeling of lipid vesicles into cylindrical micelles by a-synuclein in an extended a-helical conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11. View in: PubMed

Semisynthetic, site-specific ubiquitin modification of a-synuclein reveals differential effects on aggregation. J Am Chem Soc. 2012 Mar 28; 134(12):5468-71. View in: PubMed

Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010 Oct 15; 285(42):32486-93. View in: PubMed

Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23. View in: PubMed

Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6. View in: PubMed

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