Faculty

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John C. Lipham, MD
Associate Professor of Clinical Surgery
Division Chief of Upper Gi and General Surgery
Director, Foregut Cancer Program
Chief of USC Affiliated Academic Programs At Hoag Memorial Hospital
Surgery
HCC 514 Health Sciences Campus Los Angeles
+1 714 288 8098

Overview

John C. Lipham, M.D. is Chief of the Division of Upper GI and General Surgery and Associate Professor of Surgery at the Keck School of Medicine of USC. Dr. Lipham also served as the Foregut Cancer Program Director and Chief of USC Affiliated Academic Programs at Hoag. He was instrumental in establishing the Hoag-USC Surgical Center for Digestive Diseases. He focuses on benign and malignant diseases of the esophagus and stomach. His clinical interests include the diagnosis and treatment of GERD, hiatal hernias, Barrett's esophagus, esophageal motility disorders, achalasia, malignant diseases of the esophagus and stomach, and gastroparesis. His current research interests include developing minimally invasive methods of diagnosing and treating gastroesophageal reflux disease, Barrett's, esophageal cancer and gastric cancer.

Publications

Warren HF, Reynolds JL, Lipham JC, Zehetner J, Bildzukewicz NA, Taiganides PA, Mickley J, Aye RW, Farivar AS, Louie BE. Multi-institutional outcomes using magnetic sphincter augmentation versus Nissen fundoplication for chronic gastroesophageal reflux disease. Surg Endosc. 2016 Aug; 30(8):3289-96. View in: PubMed

Reynolds JL, Zehetner J, Nieh A, Bildzukewicz N, Sandhu K, Katkhouda N, Lipham JC. Charges, outcomes, and complications: a comparison of magnetic sphincter augmentation versus laparoscopic Nissen fundoplication for the treatment of GERD. Surg Endosc. 2016 Aug; 30(8):3225-30. View in: PubMed

Ganz RA, Edmundowicz SA, Taiganides PA, Lipham JC, Smith CD, DeVault KR, Horgan S, Jacobsen G, Luketich JD, Smith CC, Schlack-Haerer SC, Kothari SN, Dunst CM, Watson TJ, Peters J, Oelschlager BK, Perry KA, Melvin S, Bemelman WA, Smout AJ, Dunn D. Long-term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux. Clin Gastroenterol Hepatol. 2016 May; 14(5):671-7. View in: PubMed

Saino G, Bonavina L, Lipham JC, Dunn D, Ganz RA. Magnetic Sphincter Augmentation for Gastroesophageal Reflux at 5 Years: Final Results of a Pilot Study Show Long-Term Acid Reduction and Symptom Improvement. J Laparoendosc Adv Surg Tech A. 2015 Oct; 25(10):787-92. View in: PubMed

Cologne KG, Zehetner J, Liwanag L, Cash C, Senagore AJ, Lipham JC. Three-dimensional Laparoscopy: Does Improved Visualization Decrease the Learning Curve Among Trainees in Advanced Procedures? Surg Laparosc Endosc Percutan Tech. 2015 Aug; 25(4):321-3. View in: PubMed

Reynolds JL, Zehetner J, Wu P, Shah S, Bildzukewicz N, Lipham JC. Laparoscopic Magnetic Sphincter Augmentation vs Laparoscopic Nissen Fundoplication: A Matched-Pair Analysis of 100 Patients. J Am Coll Surg. 2015 Jul; 221(1):123-8. View in: PubMed

Zehetner J, DeMeester SR, Alicuben ET, Oh DS, Lipham JC, Hagen JA, DeMeester TR. Intraoperative Assessment of Perfusion of the Gastric Graft and Correlation With Anastomotic Leaks After Esophagectomy. Ann Surg. 2015 Jul; 262(1):74-8. View in: PubMed

Johnson CS, Louie BE, Wille A, Dunst CM, Worrell SG, DeMeester SR, Reynolds J, Dixon J, Lipham JC, Lada M, Peters JH, Watson TJ, Farivar AS, Aye RW. The Durability of Endoscopic Therapy for Treatment of Barrett's Metaplasia, Dysplasia, and Mucosal Cancer After Nissen Fundoplication. J Gastrointest Surg. 2015 May; 19(5):799-805. View in: PubMed

Lipham JC, Taiganides PA, Louie BE, Ganz RA, DeMeester TR. Safety analysis of first 1000 patients treated with magnetic sphincter augmentation for gastroesophageal reflux disease. Dis Esophagus. 2015 May; 28(4):305-11. View in: PubMed

Zehetner J, Degnera E, Olasky J, Mason RA, Drangsholt S, Moazzez A, Darehzereshki A, Lipham JC, Katkhouda N. Percutaneous cholecystostomy versus laparoscopic cholecystectomy in patients with acute cholecystitis and failed conservative management: a matched-pair analysis. Surg Laparosc Endosc Percutan Tech. 2014 Dec; 24(6):523-7. View in: PubMed

Reynolds JL, Zehetner J, Bildzukewicz N, Katkhouda N, Dandekar G, Lipham JC. Magnetic Sphincter Augmentation with the LINX Device for Gastroesophageal Reflux Disease after U. S. Food and Drug Administration Approval. Am Surg. 2014 Oct; 80(10):1034-8. View in: PubMed

Hunt BM, Louie BE, Dunst CM, Lipham JC, Farivar AS, Sharata A, Aye RW. Esophagectomy for failed endoscopic therapy in patients with high-grade dysplasia or intramucosal carcinoma. Dis Esophagus. 2014 May; 27(4):362-7. View in: PubMed

Cash JC, Zehetner J, Hedayati B, Bildzukewicz NA, Katkhouda N, Mason RJ, Lipham JC. Outcomes following laparoscopic transhiatal esophagectomy for esophageal cancer. Surg Endosc. 2014 Feb; 28(2):492-9. View in: PubMed

Darehzereshki A, Goldfarb M, Zehetner J, Moazzez A, Lipham JC, Mason RJ, Katkhouda N. Biologic Versus Nonbiologic Mesh in Ventral Hernia Repair: A Systematic Review and Meta-analysis. World J Surg. 2014 Jan; 38(1):40-50. View in: PubMed

Bonavina L, Saino G, Lipham JC, Demeester TR. LINX(®) Reflux Management System in chronic gastroesophageal reflux: a novel effective technology for restoring the natural barrier to reflux. Therap Adv Gastroenterol. 2013 Jul; 6(4):261-8. View in: PubMed

Oezcelik A, Ayazi S, DeMeester SR, Zehetner J, Abate E, Dunn J, Grant KS, Lipham JC, Hagen JA, DeMeester TR. Adenocarcinoma of the esophagus in the young. J Gastrointest Surg. 2013 Jun; 17(6):1032-5. View in: PubMed

Zehetner J, Pelipad D, Darehzereshki A, Mason RJ, Lipham JC, Katkhouda N. Single-access laparoscopic cholecystectomy versus classic laparoscopic cholecystectomy: a systematic review and meta-analysis of randomized controlled trials. Surg Laparosc Endosc Percutan Tech. 2013 Jun; 23(3):235-43. View in: PubMed

Ganz RA, Peters JH, Horgan S, Bemelman WA, Dunst CM, Edmundowicz SA, Lipham JC, Luketich JD, Melvin WS, Oelschlager BK, Schlack-Haerer SC, Smith CD, Smith CC, Dunn D, Taiganides PA. Esophageal sphincter device for gastroesophageal reflux disease. N Engl J Med. 2013 Feb 21; 368(8):719-27. View in: PubMed

Zehetner J, Ravari F, Ayazi S, Skibba A, Darehzereshki A, Pelipad D, Mason RJ, Katkhouda N, Lipham JC. Minimally invasive surgical approach for the treatment of gastroparesis. Surg Endosc. 2013 Jan; 27(1):61-6. View in: PubMed

Lipham JC, DeMeester TR, Ganz RA, Bonavina L, Saino G, Dunn DH, Fockens P, Bemelman W. The LINX® reflux management system: confirmed safety and efficacy now at 4 years. Surg Endosc. 2012 Oct; 26(10):2944-9. View in: PubMed

Theodorou D, Ayazi S, Demeester SR, Zehetner J, Peyre CG, Grant KS, Augustin F, Oh DS, Lipham JC, Chandrasoma PT, Hagen JA, Demeester TR. Intraluminal pH and Goblet Cell Density in Barrett's Esophagus. J Gastrointest Surg. 2012 Mar; 16(3):469-74. View in: PubMed

Oezcelik A, DeMeester SR, Hindoyan K, Leers JM, Ayazi S, Abate E, Zehetner J, Hagen JA, Lipham JC, DeMeester TR. Circular stapled pyloroplasty: a fast and effective technique for pyloric disruption during esophagectomy with gastric pull-up. Dis Esophagus. 2011 Aug; 24(6):423-9. View in: PubMed

Ayazi S, Hagen JA, Zehetner J, Banki F, Augustin F, Ayazi A, DeMeester SR, Oh DS, Sohn HJ, Lipham JC, DeMeester TR. Day-to-day discrepancy in Bravo pH monitoring is related to the degree of deterioration of the lower esophageal sphincter and severity of reflux disease. Surg Endosc. 2011 Jul; 25(7):2219-23. View in: PubMed

Ayazi S, DeMeester SR, Hsieh CC, Zehetner J, Sharma G, Grant KS, Oh DS, Lipham JC, Hagen JA, DeMeester TR. Thoraco-abdominal pressure gradients during the phases of respiration contribute to gastroesophageal reflux disease. Dig Dis Sci. 2011 Jun; 56(6):1718-22. View in: PubMed

Zehetner J, Demeester SR, Ayazi S, Kilday P, Augustin F, Hagen JA, Lipham JC, Sohn HJ, Demeester TR. Laparoscopic versus open repair of paraesophageal hernia: the second decade. J Am Coll Surg. 2011 May; 212(5):813-20. View in: PubMed

Leers JM, DeMeester SR, Oezcelik A, Klipfel N, Ayazi S, Abate E, Zehetner J, Lipham JC, Chan L, Hagen JA, DeMeester TR. The prevalence of lymph node metastases in patients with T1 esophageal adenocarcinoma a retrospective review of esophagectomy specimens. Ann Surg. 2011 Feb; 253(2):271-8. View in: PubMed

Zehetner J, DeMeester SR, Hagen JA, Ayazi S, Augustin F, Lipham JC, DeMeester TR. Endoscopic resection and ablation versus esophagectomy for high-grade dysplasia and intramucosal adenocarcinoma. J Thorac Cardiovasc Surg. 2011 Jan; 141(1):39-47. View in: PubMed

Zehetner J, Lipham JC, Ayazi S, Banki F, Oezcelik A, DeMeester SR, Hagen JA, DeMeester TR. Esophagectomy for cancer in octogenarians. Dis Esophagus. 2010 Nov; 23(8):666-9. View in: PubMed

Bonavina L, DeMeester T, Fockens P, Dunn D, Saino G, Bona D, Lipham J, Bemelman W, Ganz RA. Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: one- and 2-year results of a feasibility trial. Ann Surg. 2010 Nov; 252(5):857-62. View in: PubMed

Ayazi S, Hagen JA, Zehetner J, Lilley M, Wali P, Augustin F, Oezcelik A, Sohn HJ, Lipham JC, Demeester SR, DeMeester TR. Loss of alkalization in proximal esophagus: a new diagnostic paradigm for patients with laryngopharyngeal reflux. J Gastrointest Surg. 2010 Nov; 14(11):1653-9. View in: PubMed

Zehetner J, DeMeester SR, Ayazi S, Costales JL, Augustin F, Oezcelik A, Lipham JC, Sohn HJ, Hagen JA, DeMeester TR. Long-term follow-up after anti-reflux surgery in patients with Barrett's esophagus. J Gastrointest Surg. 2010 Oct; 14(10):1483-91. View in: PubMed

Oezcelik A, Banki F, Ayazi S, Abate E, Zehetner J, Sohn HJ, Hagen JA, DeMeester SR, Lipham JC, Palmer SL, DeMeester TR. Detection of gastric conduit ischemia or anastomotic breakdown after cervical esophagogastrostomy: the use of computed tomography scan versus early endoscopy. Surg Endosc. 2010 Aug; 24(8):1948-51. View in: PubMed

Ayazi S, Tamhankar A, DeMeester SR, Zehetner J, Wu C, Lipham JC, Hagen JA, DeMeester TR. The impact of gastric distension on the lower esophageal sphincter and its exposure to acid gastric juice. Ann Surg. 2010 Jul; 252(1):57-62. View in: PubMed

Abate E, DeMeester SR, Zehetner J, Oezcelik A, Ayazi S, Costales J, Banki F, Lipham JC, Hagen JA, DeMeester TR. Recurrence after esophagectomy for adenocarcinoma: defining optimal follow-up intervals and testing. J Am Coll Surg. 2010 Apr; 210(4):428-35. View in: PubMed

Ayazi S, Hagen JA, Chandrasoma P, Gholami P, Zehetner J, Oezcelik A, Lipham JC, Demeester SR, Demeester TR, Kline MM. Esophageal intraepithelial eosinophils in dysphagic patients with gastroesophageal reflux disease. Dig Dis Sci. 2010 Apr; 55(4):967-72. View in: PubMed

Banki F, Flanagan P, Zehetner J, Armstrong A, Hagen JA, Joshi A, Sinha R, Oh D, Oezcelik A, DeMeester SR, Abate E, Lipham JC, Chandrasoma P, Crookes PF, DeMeester TR. Progressive mucosal injury in patients with gastroesophageal reflux disease and increasing peripheral blood eosinophil counts. Arch Surg. 2010 Apr; 145(4):363-6. View in: PubMed

Zehetner J, Lipham JC, Ayazi S, Oezcelik A, Abate E, Chen W, Demeester SR, Sohn HJ, Banki F, Hagen JA, Dickey M, Demeester TR. A simplified technique for intrathoracic stomach repair: laparoscopic fundoplication with Vicryl mesh and BioGlue crural reinforcement. Surg Endosc. 2010 Mar; 24(3):675-9. View in: PubMed

Ayazi S, Hagen JA, Zehetner J, Oezcelik A, Abate E, Kohn GP, Sohn HJ, Lipham JC, Demeester SR, Demeester TR. Proximal esophageal pH monitoring: improved definition of normal values and determination of a composite pH score. J Am Coll Surg. 2010 Mar; 210(3):345-50. View in: PubMed

Ayazi S, Hagen JA, Zehetner J, Ross O, Wu C, Oezcelik A, Abate E, Sohn HJ, Banki F, Lipham JC, DeMeester SR, Demeester TR. The value of high-resolution manometry in the assessment of the resting characteristics of the lower esophageal sphincter. J Gastrointest Surg. 2009 Dec; 13(12):2113-20. View in: PubMed

Ayazi S, Leers JM, Oezcelik A, Abate E, Peyre CG, Hagen JA, DeMeester SR, Banki F, Lipham JC, DeMeester TR, Crookes PF. Measurement of gastric pH in ambulatory esophageal pH monitoring. Surg Endosc. 2009 Sep; 23(9):1968-73. View in: PubMed

Leers JM, DeMeester SR, Chan N, Ayazi S, Oezcelik A, Abate E, Banki F, Lipham JC, Hagen JA, DeMeester TR. Clinical characteristics, biologic behavior, and survival after esophagectomy are similar for adenocarcinoma of the gastroesophageal junction and the distal esophagus. J Thorac Cardiovasc Surg. 2009 Sep; 138(3):594-602; discussion 601-2. View in: PubMed

Ayazi S, Hagen JA, Chan LS, DeMeester SR, Lin MW, Ayazi A, Leers JM, Oezcelik A, Banki F, Lipham JC, DeMeester TR, Crookes PF. Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms. J Gastrointest Surg. 2009 Aug; 13(8):1440-7. View in: PubMed

Ayazi S, Lipham JC, Hagen JA, Tang AL, Zehetner J, Leers JM, Oezcelik A, Abate E, Banki F, DeMeester SR, DeMeester TR. A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold. J Gastrointest Surg. 2009 Aug; 13(8):1422-9. View in: PubMed

Peyre SE, Peyre CG, Hagen JA, Sullivan ME, Lipham JC, Demeester SR, Peters JH, Demeester TR. Laparoscopic Nissen fundoplication assessment: task analysis as a model for the development of a procedural checklist. Surg Endosc. 2009 Jun; 23(6):1227-32. View in: PubMed

Oezcelik A, Banki F, DeMeester SR, Leers JM, Ayazi S, Abate E, Hagen JA, Lipham JC, DeMeester TR. Delayed esophagogastrostomy: a safe strategy for management of patients with ischemic gastric conduit at time of esophagectomy. J Am Coll Surg. 2009 Jun; 208(6):1030-4. View in: PubMed

Leers JM, Ayazi S, Hagen JA, Terterov S, Klipfel N, Oezcelik A, Abate E, Lipham JC, DeMeester SR, Banki F, DeMeester TR. Survival in lymph node negative adenocarcinoma of the esophagus after R0 resection with and without neoadjuvant therapy: evidence for downstaging of N status. J Am Coll Surg. 2009 Apr; 208(4):553-6. View in: PubMed

Oezcelik A, Hagen JA, Halls JM, Leers JM, Abate E, Ayazi S, Zehetner J, DeMeester SR, Banki F, Lipham JC, DeMeester TR. An improved method of assessing esophageal emptying using the timed barium study following surgical myotomy for achalasia. J Gastrointest Surg. 2009 Jan; 13(1):14-8. View in: PubMed

Chiu PW, Ayazi S, Hagen JA, Lipham JC, Zehetner J, Abate E, Oezcelik A, Hsieh CC, DeMeester SR, Banki F, Chandrasoma P, DeMeester TR. Esophageal pH exposure and epithelial cell differentiation. Dis Esophagus. 2009; 22(7):596-9. View in: PubMed

Leers JM, DeMeester SR, Ayazi S, Tang AL, Peyre CG, Lipham JC, Hagen JA, DeMeester TR. Recurrence of intramucosal esophageal adenocarcinoma arising in a former esophagostomy site: a unique case report. Dis Esophagus. 2009; 22(6):E17-20. View in: PubMed

Ayazi S, Lipham JC, Portale G, Peyre CG, Streets CG, Leers JM, Demeester SR, Banki F, Chan LS, Hagen JA, Demeester TR. Bravo catheter-free pH monitoring: normal values, concordance, optimal diagnostic thresholds, and accuracy. Clin Gastroenterol Hepatol. 2009 Jan; 7(1):60-7. View in: PubMed

Bonavina L, Saino GI, Bona D, Lipham J, Ganz RA, Dunn D, DeMeester T. Magnetic augmentation of the lower esophageal sphincter: results of a feasibility clinical trial. J Gastrointest Surg. 2008 Dec; 12(12):2133-40. View in: PubMed

Banki F, Yacoub WN, Hagen JA, Mason RJ, Ayazi S, DeMeester SR, Lipham JC, Danenberg K, Danenberg P, DeMeester TR. Plasma DNA is more reliable than carcinoembryonic antigen for diagnosis of recurrent esophageal cancer. J Am Coll Surg. 2008 Jul; 207(1):30-5. View in: PubMed

Rizzetto C, DeMeester SR, Hagen JA, Peyre CG, Lipham JC, DeMeester TR. En bloc esophagectomy reduces local recurrence and improves survival compared with transhiatal resection after neoadjuvant therapy for esophageal adenocarcinoma. J Thorac Cardiovasc Surg. 2008 Jun; 135(6):1228-36. View in: PubMed

Rodrigo S, Abboud G, Oh D, DeMeester SR, Hagen J, Lipham J, DeMeester TR, Chandrasoma P. High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults. Am J Gastroenterol. 2008 Feb; 103(2):435-42. View in: PubMed

Banki F, Mason RJ, Hagen JA, Demeester SR, Lipham JC, Danenberg K, Danenberg P, Demeester TR. Plasma DNA: a molecular marker of surgical insult and postoperative recovery in esophageal cancer. Eur Surg Res. 2008; 40(3):273-8. View in: PubMed

Peyre CG, DeMeester SR, Rizzetto C, Bansal N, Tang AL, Ayazi S, Leers JM, Lipham JC, Hagen JA, DeMeester TR. Vagal-sparing esophagectomy: the ideal operation for intramucosal adenocarcinoma and barrett with high-grade dysplasia. Ann Surg. 2007 Oct; 246(4):665-71; discussion 671-4. View in: PubMed

Oh DS, DeMeester SR, Vallbohmer D, Mori R, Kuramochi H, Hagen JA, Lipham J, Danenberg KD, Danenberg PV, Chandrasoma P, DeMeester TR. Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery. Arch Surg. 2007 Jun; 142(6):554-9; discussion 559-60. View in: PubMed

Banki F, Mason RJ, Oh D, Hagen JA, DeMeester SR, Lipham JC, Tanaka K, Danenberg KD, Yacoub WN, Danenberg PV, DeMeester TR. Plasma DNA as a molecular marker for completeness of resection and recurrent disease in patients with esophageal cancer. Arch Surg. 2007 Jun; 142(6):533-8; discussion 538-9. View in: PubMed

Oh DS, Hagen JA, Chandrasoma PT, Dunst CM, Demeester SR, Alavi M, Bremner CG, Lipham J, Rizzetto C, Cote R, Demeester TR. Clinical biology and surgical therapy of intramucosal adenocarcinoma of the esophagus. J Am Coll Surg. 2006 Aug; 203(2):152-61. View in: PubMed

Oh DS, Hagen JA, Fein M, Bremner CG, Dunst CM, Demeester SR, Lipham J, Demeester TR. The impact of reflux composition on mucosal injury and esophageal function. J Gastrointest Surg. 2006 Jun; 10(6):787-96; discussion 796-7. View in: PubMed

Tharavej C, Hagen JA, Portale G, Hsieh CC, Gandamihardja TA, Lipham JC, Peters JH, DeMeester SR, Crookes PF, Bremner CG, DeMeester TR. Bravo capsule induction of esophageal hypercontractility and chest pain. Surg Endosc. 2006 May; 20(5):783-6. View in: PubMed

Tharavej C, Hagen JA, Peters JH, Portale G, Lipham J, DeMeester SR, Bremner CG, DeMeester TR. Predictive factors of coexisting cancer in Barrett's high-grade dysplasia. Surg Endosc. 2006 Mar; 20(3):439-43. View in: PubMed

Lipham JC, DeMeester TR. Preoperative diagnosis of lymph node metastasis: a dream? Gastric Cancer. 2006; 9(2):70-1. View in: PubMed

Mason RJ, Lipham J, Eckerling G, Schwartz A, Demeester TR. Gastric electrical stimulation: an alternative surgical therapy for patients with gastroparesis. Arch Surg. 2005 Sep; 140(9):841-6; discussion 847-8. View in: PubMed

Maish MS, DeMeester SR, Choustoulakis E, Briel JW, Hagen JA, Peters JH, Lipham JC, Bremner CG, DeMeester TR. The safety and usefulness of endoscopy for evaluation of the graft and anastomosis early after esophagectomy and reconstruction. Surg Endosc. 2005 Aug; 19(8):1093-102. View in: PubMed

Rowe VL, Hood DB, Lipham J, Terramani T, Torres G, Katz S, Kohl R, Weaver FA. Initial experience with dorsal venous arch arterialization for limb salvage. Ann Vasc Surg. 2002 Mar; 16(2):187-92. View in: PubMed

Rowe VL, Salim A, Lipham J, Asensio JA. Shank vessel injuries. Surg Clin North Am. 2002 Feb; 82(1):91-104, xx. View in: PubMed

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