Faculty

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John Traian Nicoloff, MD
Bernard J. Hanley Chair in Medicine
Professor of Medicine
Medicine
IRD 620 Off Campus Los Angeles
+1 626 993 2810

Overview

Dr. Nicoloff's current research includes hormonal factors regulating human pituitary TSH release, mechanism of nonsuppressible thyroxine secretion, alternate routes of T4 and T3 metabolism, and significance of circulating serum thyroglobulin in the management of neoplastic and other thyroid disease states.

Dr. Nicoloff earned his medical degree from University of California, Los Angeles. Following his residency, he went on to complete a Metabolism Fellowship at University of Washington- Kings County Hospital.

Awards

Nathan and Zora Zolen: Medical Scholarship, 1958

American Thyroid Association: Distinguished Service Award, 2004

Harper Foundation: Scholarship, 1955-1957

American Thyroid Association: Thyroid Pathophysiology Medal, 2006

American Thyroid Association: Paul Starr Award, 1984

Lederle Laboratories: Graduate Scholar, 1956

Publications

Angell TE, Lechner MG, Nguyen CT, Salvato VL, Nicoloff JT, LoPresti JS. Clinical features and hospital outcomes in thyroid storm: a retrospective cohort study. J Clin Endocrinol Metab. 2015 Feb; 100(2):451-9. View in: PubMed

Angell TE, Spencer CA, Rubino BD, Nicoloff JT, LoPresti JS. In search of an unstimulated thyroglobulin baseline value in low-risk papillary thyroid carcinoma patients not receiving radioactive iodine ablation. Thyroid. 2014 Jul; 24(7):1127-33. View in: PubMed

Spencer C, Fatemi S, Singer P, Nicoloff J, Lopresti J. Serum Basal thyroglobulin measured by a second-generation assay correlates with the recombinant human thyrotropin-stimulated thyroglobulin response in patients treated for differentiated thyroid cancer. Thyroid. 2010 Jun; 20(6):587-95. View in: PubMed

Fatemi S, Bedri J, Nicoloff JT. Encephalopathy associated with Hashimoto's thyroiditis: use of serum immunoglobulin G as a marker of disease activity. Thyroid. 2003 Feb; 13(2):227-8. View in: PubMed

Ringold DA, Nicoloff JT, Kesler M, Davis H, Hamilton A, Mack T. Further evidence for a strong genetic influence on the development of autoimmune thyroid disease: the California twin study. Thyroid. 2002 Aug; 12(8):647-53. View in: PubMed

Spencer CA, LoPresti JS, Fatemi S, Nicoloff JT. Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement. Thyroid. 1999 May; 9(5):435-41. View in: PubMed

Spencer CA, Takeuchi M, Kazarosyan M, Wang CC, Guttler RB, Singer PA, Fatemi S, LoPresti JS, Nicoloff JT. Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 1998 Apr; 83(4):1121-7. View in: PubMed

Ortega AE, Peters JH, Incarbone R, Estrada L, Ehsan A, Kwan Y, Spencer CJ, Moore-Jeffries E, Kuchta K, Nicoloff JT. A prospective randomized comparison of the metabolic and stress hormonal responses of laparoscopic and open cholecystectomy. J Am Coll Surg. 1996 Sep; 183(3):249-56. View in: PubMed

Spencer CA, LoPresti JS, Nicoloff JT, Dlott R, Schwarzbein D. Multiphasic thyrotropin responses to thyroid hormone administration in man. J Clin Endocrinol Metab. 1995 Mar; 80(3):854-9. View in: PubMed

LoPresti JS, Nicoloff JT. 3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man. J Clin Endocrinol Metab. 1994 Mar; 78(3):688-92. View in: PubMed

Nicoloff JT, LoPresti JS. Myxedema coma. A form of decompensated hypothyroidism. Endocrinol Metab Clin North Am. 1993 Jun; 22(2):279-90. View in: PubMed

Spencer CA, Schwarzbein D, Guttler RB, LoPresti JS, Nicoloff JT. Thyrotropin (TSH)-releasing hormone stimulation test responses employing third and fourth generation TSH assays. J Clin Endocrinol Metab. 1993 Feb; 76(2):494-8. View in: PubMed

Nicoloff JT, Spencer CA. Non-thyrotropin-dependent thyroid secretion. J Clin Endocrinol Metab. 1992 Aug; 75(2):343. View in: PubMed

Nicoloff JT, Spencer CA. Integration of thyroid hormones with hypothalamic factors on pituitary TSH secretion. Acta Med Austriaca. 1992; 19 Suppl 1:68-71. View in: PubMed

LoPresti JS, Mizuno L, Nimalysuria A, Anderson KP, Spencer CA, Nicoloff JT. Characteristics of 3,5,3'-triiodothyronine sulfate metabolism in euthyroid man. J Clin Endocrinol Metab. 1991 Oct; 73(4):703-9. View in: PubMed

LoPresti JS, Gray D, Nicoloff JT. Influence of fasting and refeeding on 3,3',5'-triiodothyronine metabolism in man. J Clin Endocrinol Metab. 1991 Jan; 72(1):130-6. View in: PubMed

Nicoloff JT, Spencer CA. Clinical review 12: The use and misuse of the sensitive thyrotropin assays. J Clin Endocrinol Metab. 1990 Sep; 71(3):553-8. View in: PubMed

LoPresti JS, Anderson KP, Nicoloff JT. Does a hidden pool of reverse triiodothyronine (rT3) production contribute to total thyroxine (T4) disposal in high T4 states in man. J Clin Endocrinol Metab. 1990 May; 70(5):1479-84. View in: PubMed

Fried JC, LoPresti JS, Micon M, Bauer M, Tuchschmidt JA, Nicoloff JT. Serum triiodothyronine values. Prognostic indicators of acute mortality due to Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome. Arch Intern Med. 1990 Feb; 150(2):406-9. View in: PubMed

Spencer CA, LoPresti JS, Patel A, Guttler RB, Eigen A, Shen D, Gray D, Nicoloff JT. Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab. 1990 Feb; 70(2):453-60. View in: PubMed

LoPresti JS, Eigen A, Kaptein E, Anderson KP, Spencer CA, Nicoloff JT. Alterations in 3,3'5'-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man. J Clin Invest. 1989 Nov; 84(5):1650-6. View in: PubMed

LoPresti JS, Fried JC, Spencer CA, Nicoloff JT. Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1989 Jun 15; 110(12):970-5. View in: PubMed

Gray DS, Takahashi M, Fisler JS, LoPresti J, Nicoloff JT, Bray GA. Effect of carbohydrate refeeding on free fatty acids after a fast in obese diabetic and obese non-diabetic females. Metabolism. 1989 Mar; 38(3):208-14. View in: PubMed

Silberman H, Eisenberg D, Ryan J, Shofler R, Niland J, Kaptein E, Nicoloff J, Spencer C. The relation of thyroid indices in the critically ill patient to prognosis and nutritional factors. Surg Gynecol Obstet. 1988 Mar; 166(3):223-8. View in: PubMed

Kaptein EM, Kaptein JS, Chang EI, Egodage PM, Nicoloff JT, Massry SG. Thyroxine transfer and distribution in critical nonthyroidal illnesses, chronic renal failure, and chronic ethanol abuse. J Clin Endocrinol Metab. 1987 Oct; 65(4):606-16. View in: PubMed

Cashin-Hemphill L, Spencer CA, Nicoloff JT, Blankenhorn DH, Nessim SA, Chin HP, Lee NA. Alterations in serum thyroid hormonal indices with colestipol-niacin therapy. Ann Intern Med. 1987 Sep; 107(3):324-9. View in: PubMed

Spencer C, Eigen A, Shen D, Duda M, Qualls S, Weiss S, Nicoloff J. Specificity of sensitive assays of thyrotropin (TSH) used to screen for thyroid disease in hospitalized patients. Clin Chem. 1987 Aug; 33(8):1391-6. View in: PubMed

Spencer CA, Lai-Rosenfeld AO, Guttler RB, LoPresti J, Marcus AO, Nimalasuriya A, Eigen A, Doss RC, Green BJ, Nicoloff JT. Thyrotropin secretion in thyrotoxic and thyroxine-treated patients: assessment by a sensitive immunoenzymometric assay. J Clin Endocrinol Metab. 1986 Aug; 63(2):349-55. View in: PubMed

Penny R, Sims ME, Campbell WG, Spencer CA, Nicoloff JT. Thyroid indices in arterial and venous cord blood: significantly greater levels of reverse triidothyronine in venous blood than in arterial blood. Metabolism. 1986 Jul; 35(7):645-8. View in: PubMed

Nimalasuriya A, Spencer CA, Lin SC, Tse JK, Nicoloff JT. Studies on the diurnal pattern of serum 3,5,3'-triiodothyronine. J Clin Endocrinol Metab. 1986 Jan; 62(1):153-8. View in: PubMed

Spencer CA, Platler BW, Nicoloff JT. The effect of [125I]thyroglobulin tracer heterogeneity on serum Tg RIA measurement. Clin Chim Acta. 1985 Dec 13; 153(2):105-15. View in: PubMed

Spencer CA, Platler BW, Guttler RB, Nicoloff JT. Heterogeneity of 125I-labeled human thyroglobulin preparations. Clin Chim Acta. 1985 Sep 30; 151(2):121-32. View in: PubMed

Penny R, Spencer CA, Frasier SD, Nicoloff JT. Cord serum thyroid-stimulating hormone and thyroglobulin levels decline with increasing birth weight in newborns. J Clin Endocrinol Metab. 1984 Nov; 59(5):979-85. View in: PubMed

Lum SM, Nicoloff JT, Spencer CA, Kaptein EM. Peripheral tissue mechanism for maintenance of serum triiodothyronine values in a thyroxine-deficient state in man. J Clin Invest. 1984 Feb; 73(2):570-5. View in: PubMed

Nicoloff JT, Lum SM, Spencer CA, Morris R. Peripheral autoregulation of thyroxine to triiodothyronine conversion in man. Horm Metab Res Suppl. 1984; 14:74-9. View in: PubMed

Spencer CA, Lum SM, Wilber JF, Kaptein EM, Nicoloff JT. Dynamics of serum thyrotropin and thyroid hormone changes in fasting. J Clin Endocrinol Metab. 1983 May; 56(5):883-8. View in: PubMed

Penny R, Spencer CA, Frasier SD, Nicoloff JT. Thyroid-stimulating hormone and thyroglobulin levels decrease with chronological age in children and adolescents. J Clin Endocrinol Metab. 1983 Jan; 56(1):177-80. View in: PubMed

LoPresti JS, Warren DW, Kaptein EM, Croxson MS, Nicoloff JT. Urinary immunoprecipitation method for estimation of thyroxine to triiodothyronine conversion in altered thyroid states. J Clin Endocrinol Metab. 1982 Oct; 55(4):666-70. View in: PubMed

Alexander CM, Kaptein EM, Lum SM, Spencer CA, Kumar D, Nicoloff JT. Pattern of recovery of thyroid hormone indices associated with treatment of diabetes mellitus. J Clin Endocrinol Metab. 1982 Feb; 54(2):362-6. View in: PubMed

Warren DW, LoPresti JS, Nicoloff JT. A new method for measurement of the conversion ratio of thyroxine to triiodothyronine in euthyroid man. J Clin Endocrinol Metab. 1981 Dec; 53(6):1218-22. View in: PubMed

Kaptein EM, Grieb DA, Spencer CA, Wheeler WS, Nicoloff JT. Thyroxine metabolism in the low thyroxine state of critical nonthyroidal illnesses. J Clin Endocrinol Metab. 1981 Oct; 53(4):764-71. View in: PubMed

Kaptein EM, MacIntyre SS, Weiner JM, Spencer CA, Nicoloff JT. Free thyroxine estimates in nonthyroidal illness: comparison of eight methods. J Clin Endocrinol Metab. 1981 Jun; 52(6):1073-7. View in: PubMed

Nicoloff JT, Warren DW, Mizuno L, Spencer CA, Kaptein EM. Hepatic thyroxine (T4) uptake as a mechanism for regulation of triiodothyronine (T3) generation in rat liver slices. Life Sci. 1981 Apr 13-20; 28(15-16):1713-8. View in: PubMed

Spencer CA, Nicoloff JT. Improved radioimmunoassay for human TSH. Clin Chim Acta. 1980 Dec 22; 108(3):415-24. View in: PubMed

Spencer CA, Greenstadt MA, Wheeler WS, Kletzky OA, Nicoloff JT. The influence of long-term low dose thyrotropin-releasing hormone infusions on serum thyrotropin and prolactin concentrations in man. J Clin Endocrinol Metab. 1980 Oct; 51(4):771-5. View in: PubMed

Kaptein EM, Kletzky OA, Spencer CA, Nicoloff JT. Effects of prolonged dopamine infusion on anterior pituitary function in normal males. J Clin Endocrinol Metab. 1980 Sep; 51(3):488-91. View in: PubMed

Kaptein EM, Spencer CA, Kamiel MB, Nicoloff JT. Prolonged dopamine administration and thyroid hormone economy in normal and critically ill subjects. J Clin Endocrinol Metab. 1980 Aug; 51(2):387-93. View in: PubMed

Singer PA, Nicoloff JT, Stein RB, Jaramillo J. Transient TRH deficiency after prolonged thyroid hormone therapy. J Clin Endocrinol Metab. 1978 Sep; 47(3):512-8. View in: PubMed

Singer PA, Mestman JH, Manning PR, Nicoloff JT. Hypothalamic-hypothyroidism secondary to Sheehan's syndrome. West J Med. 1974 May; 120(5):416-8. View in: PubMed

Singer PA, Nicoloff JT. Assessment of thyrotropin-releasing hormone and thyrotropin reserve in man. J Clin Invest. 1973 May; 52(5):1099-107. View in: PubMed

Singer PA, Nicoloff JT. Estimation of the triodothyronine secretion rate in euthyroid man. J Clin Endocrinol Metab. 1972 Jul; 35(1):82-9. View in: PubMed

Singer PA, Nicoloff JT. Metabolic clearance rates of diiodotyrosine in man. J Clin Endocrinol Metab. 1972 Apr; 34(4):666-70. View in: PubMed

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