Faculty

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John Traian Nicoloff, MD
Professor of Medicine
Bernard J. Hanley Chair in Medicine
Medicine
IRD 620 Off Campus Los Angeles
+1 626 993 2810

Overview

Dr. Nicoloff's current research includes hormonal factors regulating human pituitary TSH release, mechanism of nonsuppressible thyroxine secretion, alternate routes of T4 and T3 metabolism, and significance of circulating serum thyroglobulin in the management of neoplastic and other thyroid disease states.

Dr. Nicoloff earned his medical degree from University of California, Los Angeles. Following his residency, he went on to complete a Metabolism Fellowship at University of Washington- Kings County Hospital.

Awards

American Thyroid Association: Thyroid Pathophysiology Medal, 2006

American Thyroid Association: Distinguished Service Award, 2004

American Thyroid Association: Paul Starr Award, 1984

Nathan and Zora Zolen: Medical Scholarship, 1958

Lederle Laboratories: Graduate Scholar, 1956

Harper Foundation: Scholarship, 1955-1957

Publications

Clinical features and hospital outcomes in thyroid storm: a retrospective cohort study. J Clin Endocrinol Metab. 2015 Feb; 100(2):451-9. View in: PubMed

In search of an unstimulated thyroglobulin baseline value in low-risk papillary thyroid carcinoma patients not receiving radioactive iodine ablation. Thyroid. 2014 Jul; 24(7):1127-33. View in: PubMed

Serum Basal thyroglobulin measured by a second-generation assay correlates with the recombinant human thyrotropin-stimulated thyroglobulin response in patients treated for differentiated thyroid cancer. Thyroid. 2010 Jun; 20(6):587-95. View in: PubMed

Encephalopathy associated with Hashimoto's thyroiditis: use of serum immunoglobulin G as a marker of disease activity. Thyroid. 2003 Feb; 13(2):227-8. View in: PubMed

Further evidence for a strong genetic influence on the development of autoimmune thyroid disease: the California twin study. Thyroid. 2002 Aug; 12(8):647-53. View in: PubMed

Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement. Thyroid. 1999 May; 9(5):435-41. View in: PubMed

Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 1998 Apr; 83(4):1121-7. View in: PubMed

A prospective randomized comparison of the metabolic and stress hormonal responses of laparoscopic and open cholecystectomy. J Am Coll Surg. 1996 Sep; 183(3):249-56. View in: PubMed

Multiphasic thyrotropin responses to thyroid hormone administration in man. J Clin Endocrinol Metab. 1995 Mar; 80(3):854-9. View in: PubMed

3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man. J Clin Endocrinol Metab. 1994 Mar; 78(3):688-92. View in: PubMed

Myxedema coma. A form of decompensated hypothyroidism. Endocrinol Metab Clin North Am. 1993 Jun; 22(2):279-90. View in: PubMed

Thyrotropin (TSH)-releasing hormone stimulation test responses employing third and fourth generation TSH assays. J Clin Endocrinol Metab. 1993 Feb; 76(2):494-8. View in: PubMed

Non-thyrotropin-dependent thyroid secretion. J Clin Endocrinol Metab. 1992 Aug; 75(2):343. View in: PubMed

Integration of thyroid hormones with hypothalamic factors on pituitary TSH secretion. Acta Med Austriaca. 1992; 19 Suppl 1:68-71. View in: PubMed

Characteristics of 3,5,3'-triiodothyronine sulfate metabolism in euthyroid man. J Clin Endocrinol Metab. 1991 Oct; 73(4):703-9. View in: PubMed

Influence of fasting and refeeding on 3,3',5'-triiodothyronine metabolism in man. J Clin Endocrinol Metab. 1991 Jan; 72(1):130-6. View in: PubMed

Clinical review 12: The use and misuse of the sensitive thyrotropin assays. J Clin Endocrinol Metab. 1990 Sep; 71(3):553-8. View in: PubMed

Does a hidden pool of reverse triiodothyronine (rT3) production contribute to total thyroxine (T4) disposal in high T4 states in man. J Clin Endocrinol Metab. 1990 May; 70(5):1479-84. View in: PubMed

Serum triiodothyronine values. Prognostic indicators of acute mortality due to Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome. Arch Intern Med. 1990 Feb; 150(2):406-9. View in: PubMed

Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab. 1990 Feb; 70(2):453-60. View in: PubMed

Alterations in 3,3'5'-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man. J Clin Invest. 1989 Nov; 84(5):1650-6. View in: PubMed

Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1989 Jun 15; 110(12):970-5. View in: PubMed

Effect of carbohydrate refeeding on free fatty acids after a fast in obese diabetic and obese non-diabetic females. Metabolism. 1989 Mar; 38(3):208-14. View in: PubMed

The relation of thyroid indices in the critically ill patient to prognosis and nutritional factors. Surg Gynecol Obstet. 1988 Mar; 166(3):223-8. View in: PubMed

Thyroxine transfer and distribution in critical nonthyroidal illnesses, chronic renal failure, and chronic ethanol abuse. J Clin Endocrinol Metab. 1987 Oct; 65(4):606-16. View in: PubMed

Alterations in serum thyroid hormonal indices with colestipol-niacin therapy. Ann Intern Med. 1987 Sep; 107(3):324-9. View in: PubMed

Specificity of sensitive assays of thyrotropin (TSH) used to screen for thyroid disease in hospitalized patients. Clin Chem. 1987 Aug; 33(8):1391-6. View in: PubMed

Thyrotropin secretion in thyrotoxic and thyroxine-treated patients: assessment by a sensitive immunoenzymometric assay. J Clin Endocrinol Metab. 1986 Aug; 63(2):349-55. View in: PubMed

Thyroid indices in arterial and venous cord blood: significantly greater levels of reverse triidothyronine in venous blood than in arterial blood. Metabolism. 1986 Jul; 35(7):645-8. View in: PubMed

Studies on the diurnal pattern of serum 3,5,3'-triiodothyronine. J Clin Endocrinol Metab. 1986 Jan; 62(1):153-8. View in: PubMed

The effect of [125I]thyroglobulin tracer heterogeneity on serum Tg RIA measurement. Clin Chim Acta. 1985 Dec 13; 153(2):105-15. View in: PubMed

Heterogeneity of 125I-labeled human thyroglobulin preparations. Clin Chim Acta. 1985 Sep 30; 151(2):121-32. View in: PubMed

Cord serum thyroid-stimulating hormone and thyroglobulin levels decline with increasing birth weight in newborns. J Clin Endocrinol Metab. 1984 Nov; 59(5):979-85. View in: PubMed

Peripheral tissue mechanism for maintenance of serum triiodothyronine values in a thyroxine-deficient state in man. J Clin Invest. 1984 Feb; 73(2):570-5. View in: PubMed

Peripheral autoregulation of thyroxine to triiodothyronine conversion in man. Horm Metab Res Suppl. 1984; 14:74-9. View in: PubMed

Dynamics of serum thyrotropin and thyroid hormone changes in fasting. J Clin Endocrinol Metab. 1983 May; 56(5):883-8. View in: PubMed

Thyroid-stimulating hormone and thyroglobulin levels decrease with chronological age in children and adolescents. J Clin Endocrinol Metab. 1983 Jan; 56(1):177-80. View in: PubMed

Urinary immunoprecipitation method for estimation of thyroxine to triiodothyronine conversion in altered thyroid states. J Clin Endocrinol Metab. 1982 Oct; 55(4):666-70. View in: PubMed

Pattern of recovery of thyroid hormone indices associated with treatment of diabetes mellitus. J Clin Endocrinol Metab. 1982 Feb; 54(2):362-6. View in: PubMed

A new method for measurement of the conversion ratio of thyroxine to triiodothyronine in euthyroid man. J Clin Endocrinol Metab. 1981 Dec; 53(6):1218-22. View in: PubMed

Thyroxine metabolism in the low thyroxine state of critical nonthyroidal illnesses. J Clin Endocrinol Metab. 1981 Oct; 53(4):764-71. View in: PubMed

Free thyroxine estimates in nonthyroidal illness: comparison of eight methods. J Clin Endocrinol Metab. 1981 Jun; 52(6):1073-7. View in: PubMed

Hepatic thyroxine (T4) uptake as a mechanism for regulation of triiodothyronine (T3) generation in rat liver slices. Life Sci. 1981 Apr 13-20; 28(15-16):1713-8. View in: PubMed

Improved radioimmunoassay for human TSH. Clin Chim Acta. 1980 Dec 22; 108(3):415-24. View in: PubMed

The influence of long-term low dose thyrotropin-releasing hormone infusions on serum thyrotropin and prolactin concentrations in man. J Clin Endocrinol Metab. 1980 Oct; 51(4):771-5. View in: PubMed

Effects of prolonged dopamine infusion on anterior pituitary function in normal males. J Clin Endocrinol Metab. 1980 Sep; 51(3):488-91. View in: PubMed

Prolonged dopamine administration and thyroid hormone economy in normal and critically ill subjects. J Clin Endocrinol Metab. 1980 Aug; 51(2):387-93. View in: PubMed

Transient TRH deficiency after prolonged thyroid hormone therapy. J Clin Endocrinol Metab. 1978 Sep; 47(3):512-8. View in: PubMed

Hypothalamic-hypothyroidism secondary to Sheehan's syndrome. West J Med. 1974 May; 120(5):416-8. View in: PubMed

Assessment of thyrotropin-releasing hormone and thyrotropin reserve in man. J Clin Invest. 1973 May; 52(5):1099-107. View in: PubMed

Estimation of the triodothyronine secretion rate in euthyroid man. J Clin Endocrinol Metab. 1972 Jul; 35(1):82-9. View in: PubMed

Metabolic clearance rates of diiodotyrosine in man. J Clin Endocrinol Metab. 1972 Apr; 34(4):666-70. View in: PubMed

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