Faculty

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Jorge Nieva, MD
Associate Professor of Clinical Medicine
Medicine
NOR 1441 Eastlake Ave Off Campus Los Angeles
+1 323 865 0421

Overview

Dr. Jorge Nieva graduated from the University of California, Irvine College of Medicine in 1997, trained in internal medicine at University of California, San Diego and in oncology and hematology at the Scripps Clinic. In 2003 he joined the faculty of the Scripps Research Institute and the medical staff of the Scripps Clinic in La Jolla, CA. While at Scripps, Dr. Nieva pioneered new technology for the detection of cancer cells in the peripheral blood and discoveries related to the fundamental mechanisms of the immune system.

Dr. Nieva was recruited to the Billings Clinic in Montana in 2007 where he served as department chair and was a program leader who established the multidisciplinary lung cancer and head/neck cancer clinics at the cancer center. While in Billings, Dr. Nieva led efforts to establish a research program in virus-delivered cancer gene therapy and immunotherapy. His teams were awarded certificates for excellence in the conduct of cancer clinical trials from the National Cancer Institute and the American Society of Clinical Oncology. Dr. Nieva returned to California, joining the faculty of the Keck School of Medicine in 2014.

Publications

A Randomized Phase II Study of Linsitinib (OSI-906) Versus Topotecan in Patients With Relapsed Small-Cell Lung Cancer. Oncologist. 2016 Oct; 21(10):1163-1164. View in: PubMed

Oncolytic viruses: perspectives on clinical development. Curr Opin Virol. 2015 Aug; 13:55-60. View in: PubMed

A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma. Oral Oncol. 2015 Apr; 51(4):376-82. View in: PubMed

Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer. J Thorac Oncol. 2014 Aug; 9(8):1111-9. View in: PubMed

Adrenal metastases in lung cancer: clinical implications of a mathematical model. J Thorac Oncol. 2014 Apr; 9(4):442-6. View in: PubMed

Entropy, complexity, and Markov diagrams for random walk cancer models. Sci Rep. 2014; 4:7558. View in: PubMed

Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients. Cancer. 2013 Jul 1; 119(13):2383-90. View in: PubMed

Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model. Cancer Res. 2013 May 1; 73(9):2760-9. View in: PubMed

An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer. PLoS One. 2013; 8(7):e67733. View in: PubMed

ERCC1 expression in circulating tumor cells (CTCs) using a novel detection platform correlates with progression-free survival (PFS) in patients with metastatic non-small-cell lung cancer (NSCLC) receiving platinum chemotherapy. Lung Cancer. 2012 Aug; 77(2):421-6. View in: PubMed

Fluid biopsy for solid tumors: a patient's companion for lifelong characterization of their disease. Future Oncol. 2012 Aug; 8(8):989-98. View in: PubMed

Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol. 2012 Feb; 9(1):016005. View in: PubMed

Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol. 2012 Feb; 9(1):016003. View in: PubMed

High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Phys Biol. 2012 Feb; 9(1):016004. View in: PubMed

Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol. 2012 Feb; 9(1):016001. View in: PubMed

A pilot study of long-acting octreotide for symptomatic malignant ascites. Oncology. 2012; 82(6):315-20. View in: PubMed

A stochastic Markov chain model to describe lung cancer growth and metastasis. PLoS One. 2012; 7(4):e34637. View in: PubMed

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature. 2011 Sep 1; 477(7362):99-102. View in: PubMed

Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53. Chem Biol. 2011 Jul 29; 18(7):920-7. View in: PubMed

Cytomorphology of circulating colorectal tumor cells:a small case series. J Oncol. 2010; 2010:861341. View in: PubMed

Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type. Arch Pathol Lab Med. 2009 Sep; 133(9):1468-71. View in: PubMed

The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo. Chem Commun (Camb). 2009 Jun 7; (21):3098-100. View in: PubMed

Purification and characterization of sideroblasts from patients with acquired and hereditary sideroblastic anaemia. Br J Haematol. 2008 Nov; 143(3):446-50. View in: PubMed

Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation. Biochemistry. 2008 Jul 22; 47(29):7695-705. View in: PubMed

Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients. Thromb Res. 2008; 122(5):604-9. View in: PubMed

Understanding hairy cell leukemia genetics. Leuk Lymphoma. 2007 Apr; 48(4):653-4. View in: PubMed

Case study of the morphologic variation of circulating tumor cells. Hum Pathol. 2007 Mar; 38(3):514-9. View in: PubMed

The clinical significance of circulating tissue factor in prostate cancer. Thromb Haemost. 2007 Mar; 97(3):329-30. View in: PubMed

AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med. 2006 Oct 19; 355(16):1672-81. View in: PubMed

Use of optophoresis as an in vitro predictor of cell response to chemotherapy for chronic lymphocytic leukemia. Leuk Lymphoma. 2006 Oct; 47(10):2194-202. View in: PubMed

Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B. Biochemistry. 2006 Jun 13; 45(23):7162-70. View in: PubMed

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol. 2006 May; 2(5):249-53. View in: PubMed

High speed detection of circulating tumor cells. Biosens Bioelectron. 2006 Apr 15; 21(10):1893-9. View in: PubMed

Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway. Immunol Lett. 2006 Feb 28; 103(1):33-8. View in: PubMed

SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor. Br J Haematol. 2005 Jun; 129(6):791-4. View in: PubMed

The antibody-catalyzed water oxidation pathway--a new chemical arm to immune defense? Trends Biochem Sci. The antibody-catalyzed water oxidation pathway--a new chemical arm to immune defense? Trends Biochem Sci. 2004 May; 29(5):274-8. View in: PubMed

Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):4752-7. View in: PubMed

Cladribine activity in systemic mast cell disease: application of biochemistry in the modern era of molecular biology. Leuk Res. 2004 Feb; 28(2):113-4. View in: PubMed

Evidence for ozone formation in human atherosclerotic arteries. Science. 2003 Nov 7; 302(5647):1053-6. View in: PubMed

Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia. Blood. 2003 Aug 1; 102(3):810-3. View in: PubMed

Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science. 2002 Dec 13; 298(5601):2195-9. View in: PubMed

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