Faculty

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Joseph August Church, MD
Professor of Clinical Pediatrics
Pediatrics
CHL Mail Stop 75 Off Campus Los Angeles
+1 323 361 2501

Publications

Wasserman RL, Melamed I, Stein MR, Engl W, Sharkhawy M, Leibl H, Puck J, Rubinstein A, Kobrynski L, Gupta S, Grant AJ, Ratnayake A, Richmond WG, Church J, Yel L, Gelmont D. Long-Term Tolerability, Safety, and Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Human Immunoglobulin for Primary Immunodeficiency. J Clin Immunol. 2016 Aug; 36(6):571-82. View in: PubMed

Heimall J, Chen J, Church JA, Griffin R, Melamed I, Kleiner GI. Pharmacokinetics, Safety, and Tolerability of Subcutaneous Immune Globulin Injection (Human), 10 % Caprylate/Chromatography Purified (GAMUNEX®-C) in Pediatric Patients with Primary Immunodeficiency Disease. J Clin Immunol. 2016 Aug; 36(6):600-9. View in: PubMed

Sheibani S, Cohen R, Kane S, Dubinsky M, Church JA, Mahadevan U. The Effect of Maternal Peripartum Anti-TNFa Use on Infant Immune Response. Dig Dis Sci. 2016 Jun; 61(6):1622-7. View in: PubMed

Aguilera-Sandoval CR, Yang OO, Jojic N, Lovato P, Chen DY, Boechat MI, Cooper P, Zuo J, Ramirez C, Belzer M, Church JA, Krogstad P. Supranormal thymic output up to 2 decades after HIV-1 infection. AIDS. 2016 Mar 13; 30(5):701-11. View in: PubMed

Iqbal Z, Wilson NE, Keller MA, Michalik DE, Church JA, Nielsen-Saines K, Deville J, Souza R, Brecht ML, Thomas MA. Pilot Assessment of Brain Metabolism in Perinatally HIV-Infected Youths Using Accelerated 5D Echo Planar J-Resolved Spectroscopic Imaging. PLoS One. 2016; 11(9):e0162810. View in: PubMed

Holzinger D, Fassl SK, de Jager W, Lohse P, Röhrig UF, Gattorno M, Omenetti A, Chiesa S, Schena F, Austermann J, Vogl T, Kuhns DB, Holland SM, Rodríguez-Gallego C, López-Almaraz R, Arostegui JI, Colino E, Roldan R, Fessatou S, Isidor B, Poignant S, Ito K, Epple HJ, Bernstein JA, Jeng M, Frankovich J, Lionetti G, Church JA, Ong PY, LaPlant M, Abinun M, Skinner R, Bigley V, Sachs UJ, Hinze C, Hoppenreijs E, Ehrchen J, Foell D, Chae JJ, Ombrello A, Aksentijevich I, Sunderkoetter C, Roth J. Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. J Allergy Clin Immunol. 2015 Nov; 136(5):1337-45. View in: PubMed

Wang JC, Ross L, Mahon LW, Owen R, Hemmat M, Wang BT, El Naggar M, Kopita KA, Randolph LM, Chase JM, Matas Aguilera MJ, Siles JL, Church JA, Hauser N, Shen JJ, Jones MC, Wierenga KJ, Jiang Z, Haddadin M, Boyar FZ, Anguiano A, Strom CM, Sahoo T. Regions of homozygosity identified by oligonucleotide SNP arrays: evaluating the incidence and clinical utility. Eur J Hum Genet. 2015 May; 23(5):663-71. View in: PubMed

Saez-Llorens X, Castaño E, Rathore M, Church J, Deville J, Gaur A, Estripeaut D, White K, Arterburn S, Enejosa JV, Cheng AK, Chuck SL, Rhee MS. A Randomized, Open-Label Study of the Safety and Efficacy of Switching Stavudine or Zidovudine to Tenofovir Disoproxil Fumarate in HIV-1-infected Children With Virologic Suppression. Pediatr Infect Dis J. 2015 Apr; 34(4):376-82. View in: PubMed

Patel JP, Puck JM, Srinivasan R, Brown C, Sunderam U, Kundu K, Brenner SE, Gatti RA, Church JA. Nijmegen Breakage Syndrome Detected by Newborn Screening for T Cell Receptor Excision Circles (TRECs). J Clin Immunol. 2015 Feb; 35(2):227-33. View in: PubMed

Adam E, Church JA. Antibody Levels to Bordetella pertussis and Neisseria meningitidis in Immunodeficient Patients Receiving Immunoglobulin Replacement Therapy. J Clin Immunol. 2015 Feb; 35(2):213-7. View in: PubMed

Church JA. Vectored Immunoprophylaxis Protects Humanized Mice From Mucosal HIV Transmission. Pediatrics. 2014 Nov; 134 Suppl 3:S184-5. View in: PubMed

Church JA. Absence of Detectible HIV-1 Viremia After Treatment Cessation in an Infant. Pediatrics. 2014 Nov; 134 Suppl 3:S183-4. View in: PubMed

Church JA. Cell Death by Pyroptosis Drives CD4 T-Cell Depletion in HIV-1 Infection. Pediatrics. 2014 Nov; 134 Suppl 3:S184. View in: PubMed

Adam E, Wang L, Herrington C, Bliss D, Church JA. Synchronous HIV/AIDS-related Epstein-Barr Virus-associated Smooth Muscle Tumors in a 20-year-old female. Pediatr Infect Dis J. 2014 Oct; 33(10):1055-6. View in: PubMed

Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan MJ, Cunningham-Rundles C, Dasu T, Dave N, De La Morena MT, Duffner U, Fong CT, Forbes L, Freedenberg D, Gelfand EW, Hale JE, Hanson IC, Hay BN, Hu D, Infante A, Johnson D, Kapoor N, Kay DM, Kohn DB, Lee R, Lehman H, Lin Z, Lorey F, Abdel-Mageed A, Manning A, McGhee S, Moore TB, Naides SJ, Notarangelo LD, Orange JS, Pai SY, Porteus M, Rodriguez R, Romberg N, Routes J, Ruehle M, Rubenstein A, Saavedra-Matiz CA, Scott G, Scott PM, Secord E, Seroogy C, Shearer WT, Siegel S, Silvers SK, Stiehm ER, Sugerman RW, Sullivan JL, Tanksley S, Tierce ML, Verbsky J, Vogel B, Walker R, Walkovich K, Walter JE, Wasserman RL, Watson MS, Weinberg GA, Weiner LB, Wood H, Yates AB, Puck JM. Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States. JAMA. 2014 Aug 20; 312(7):729-38. View in: PubMed

Dimitrova D, Ong PY, O'Gorman MR, Church JA. Major Histocompatibility Complex Class II Deficiency Complicated by Mycobacterium avium Complex in a Boy of Mixed Ethnicity. J Clin Immunol. 2014 Aug; 34(6):677-80. View in: PubMed

Menard L, Cantaert T, Chamberlain N, Tangye SG, Riminton S, Church JA, Klion A, Cunningham-Rundles C, Nichols KE, Meffre E. Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. J Allergy Clin Immunol. 2014 Apr; 133(4):1149-61. View in: PubMed

Reiff A, Bassuk AG, Church JA, Campbell E, Bing X, Ferguson PJ. Exome sequencing reveals RAG1 mutations in a child with autoimmunity and sterile chronic multifocal osteomyelitis evolving into disseminated granulomatous disease. J Clin Immunol. 2013 Nov; 33(8):1289-92. View in: PubMed

Kwan A, Church JA, Cowan MJ, Agarwal R, Kapoor N, Kohn DB, Lewis DB, McGhee SA, Moore TB, Stiehm ER, Porteus M, Aznar CP, Currier R, Lorey F, Puck JM. Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: results of the first 2 years. J Allergy Clin Immunol. 2013 Jul; 132(1):140-50. View in: PubMed

Acree SC, Tovar JP, Pattengale PK, Wang LL, Church JA, Gaynon PS, Cassarino DS. Subcutaneous Panniculitis-like T-cell lymphoma in two pediatric patients: an HIV-positive adolescent and a 4-month-old infant. Fetal Pediatr Pathol. 2013 Jun; 32(3):175-83. View in: PubMed

Kuo CY, Chase J, Garcia Lloret M, Stiehm ER, Moore T, Aguilera MJ, Lopez Siles J, Church JA. Newborn screening for severe combined immunodeficiency does not identify bare lymphocyte syndrome. J Allergy Clin Immunol. 2013 Jun; 131(6):1693-5. View in: PubMed

Mallott J, Kwan A, Church J, Gonzalez-Espinosa D, Lorey F, Tang LF, Sunderam U, Rana S, Srinivasan R, Brenner SE, Puck J. Newborn screening for SCID identifies patients with ataxia telangiectasia. J Clin Immunol. 2013 Apr; 33(3):540-9. View in: PubMed

Sarma MK, Nagarajan R, Keller MA, Kumar R, Nielsen-Saines K, Michalik DE, Deville J, Church JA, Thomas MA. Regional brain gray and white matter changes in perinatally HIV-infected adolescents. Neuroimage Clin. 2013; 4:29-34. View in: PubMed

Chase JM, Holland SM, Greenberg DE, Marshall-Batty K, Zelazny AM, Church JA. Acidomonas methanolica-associated necrotizing lymphadenitis in a patient with chronic granulomatous disease. J Clin Immunol. 2012 Dec; 32(6):1193-6. View in: PubMed

Wang T, Ong P, Roscioli T, Cliffe ST, Church JA. Hepatic veno-occlusive disease with immunodeficiency (VODI): First reported case in the U. S. and identification of a unique mutation in Sp110. Clin Immunol. 2012 Nov; 145(2):102-7. View in: PubMed

Cliffe ST, Bloch DB, Suryani S, Kamsteeg EJ, Avery DT, Palendira U, Church JA, Wainstein BK, Trizzino A, Lefranc G, Akatcherian C, Megarbané A, Gilissen C, Moshous D, Reichenbach J, Misbah S, Salzer U, Abinun M, Ong PY, Stepensky P, Ruga E, Ziegler JB, Wong M, Tangye SG, Lindeman R, Buckley MF, Roscioli T. Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome. J Allergy Clin Immunol. 2012 Sep; 130(3):735-742. e6. View in: PubMed

Wasserman RL, Church JA, Stein M, Moy J, White M, Strausbaugh S, Schroeder H, Ballow M, Harris J, Melamed I, Elkayam D, Lumry W, Suez D, Rehman SM. Safety, Efficacy and Pharmacokinetics of a New 10% Liquid Intravenous Immunoglobulin (IVIG) in Patients with Primary Immunodeficiency. J Clin Immunol. 2012 Aug; 32(4):663-9. View in: PubMed

Zuo J, Suen J, Wong A, Lewis M, Ayub A, Belzer M, Church J, Yang OO, Krogstad P. Functional Analysis of HIV Type 1 Nef Gene Variants from Adolescent and Adult Survivors of Perinatal Infection. AIDS Res Hum Retroviruses. 2012 May; 28(5):486-92. View in: PubMed

Ong PY, Ferdman RM, Church JA. Association of microbial IgE sensitizations with asthma in young children with atopic dermatitis. Ann Allergy Asthma Immunol. 2012 Mar; 108(3):212-3. View in: PubMed

Wasserman RL, Melamed I, Nelson RP, Knutsen AP, Fasano MB, Stein MR, Rojavin MA, Church JA. Pharmacokinetics of subcutaneous IgPro20 in patients with primary immunodeficiency. Clin Pharmacokinet. 2011 Jun 1; 50(6):405-14. View in: PubMed

Parekh C, Hofstra T, Church JA, Coates TD. Hemophagocytic lymphohistiocytosis in children with chronic granulomatous disease. Pediatr Blood Cancer. 2011 Mar; 56(3):460-2. View in: PubMed

Keller MD, Petersen M, Ong P, Church J, Risma K, Burham J, Jain A, Stiehm ER, Hanson EP, Uzel G, Deardorff MA, Orange JS. Hypohidrotic Ectodermal Dysplasia and Immunodeficiency with Coincident NEMO and EDA Mutations. Front Immunol. 2011; 2:61. View in: PubMed

Sukumaran S, Marzan K, Shaham B, Church JA. A child with x-linked agammaglobulinemia and enthesitis-related arthritis. Int J Rheumatol. 2011; 2011:175973. View in: PubMed

Zuo J, Church J, Belzer M, Kitchen C, Ank B, Schmid I, Krogstad P. Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy. AIDS Res Hum Retroviruses. 2010 Jun; 26(6):681-4. View in: PubMed

Cho C, Ferdman RM, Church JA, Ong PY. Skin-deep clues to a complex disease. Ann Allergy Asthma Immunol. 2010 Jan; 104(1):93-4. View in: PubMed

Wasserman RL, Church JA, Peter HH, Sleasman JW, Melamed I, Stein MR, Bichler J. Pharmacokinetics of a new 10% intravenous immunoglobulin in patients receiving replacement therapy for primary immunodeficiency. Eur J Pharm Sci. 2009 Jun 28; 37(3-4):272-8. View in: PubMed

Stein MR, Nelson RP, Church JA, Wasserman RL, Borte M, Vermylen C, Bichler J. Safety and efficacy of Privigen, a novel 10% liquid immunoglobulin preparation for intravenous use, in patients with primary immunodeficiencies. J Clin Immunol. 2009 Jan; 29(1):137-44. View in: PubMed

Ong PY, Patel M, Ferdman RM, Dunaway T, Church JA. Association of staphylococcal superantigen-specific immunoglobulin e with mild and moderate atopic dermatitis. J Pediatr. 2008 Dec; 153(6):803-6. View in: PubMed

Ong PY, Ferdman RM, Dunaway T, Church JA, Inderlied CB. Down-regulation of atopic dermatitis-associated serum chemokines by wet-wrap treatment: a pilot study. Ann Allergy Asthma Immunol. 2008 Mar; 100(3):286-7. View in: PubMed

Wiznia A, Church J, Emmanuel P, Eppes S, Rowell L, Evans C, Bertasso A. Safety and efficacy of enfuvirtide for 48 weeks as part of an optimized antiretroviral regimen in pediatric human immunodeficiency virus 1-infected patients. Pediatr Infect Dis J. 2007 Sep; 26(9):799-805. View in: PubMed

Webber EC, Church J, Rand TH, Shah AJ. Leukocyte adhesion deficiency in a female patient without delayed umbilical cord separation. J Paediatr Child Health. 2007 May; 43(5):406-8. View in: PubMed

Fletcher CV, DeVille JG, Samson PM, Moye JH, Church JA, Spiegel HM, Palumbo P, Fenton T, Smith ME, Graham B, Kraimer JM, Shearer WT. Nonlinear pharmacokinetics of high-dose recombinant fusion protein CD4-IgG2 (PRO 542) observed in HIV-1-infected children. J Allergy Clin Immunol. 2007 Mar; 119(3):747-50. View in: PubMed

Ferdman RM, Ong PY, Church JA. Pectin anaphylaxis and possible association with cashew allergy. Ann Allergy Asthma Immunol. 2006 Dec; 97(6):759-60. View in: PubMed

Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Dubinsky MC. Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1255-8. View in: PubMed

Ferdman RM, Church JA. Denial of insurance authorization at a subspecialty office as a cause of missed opportunities for influenza vaccination in children with asthma. Arch Pediatr Adolesc Med. 2006 Sep; 160(9):987-8. View in: PubMed

Shearer WT, DeVille JG, Samson PM, Moye JH, Fletcher CV, Church JA, Spiegel HM, Palumbo P, Fenton T, Smith ME, Graham B, Kraimer JM, Olson WC. Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140). J Allergy Clin Immunol. 2006 Aug; 118(2):518-21. View in: PubMed

Ferdman RM, Church JA. Mixed-up nuts: identification of peanuts and tree nuts by children. Ann Allergy Asthma Immunol. 2006 Jul; 97(1):73-7. View in: PubMed

Church JA, Leibl H, Stein MR, Melamed IR, Rubinstein A, Schneider LC, Wasserman RL, Pavlova BG, Birthistle K, Mancini M, Fritsch S, Patrone L, Moore-Perry K, Ehrlich HJ. Efficacy, safety and tolerability of a new 10% liquid intravenous immune globulin [IGIV 10%] in patients with primary immunodeficiency. J Clin Immunol. 2006 Jul; 26(4):388-95. View in: PubMed

Armenian SH, Han JY, Dunaway TM, Church JA. Safety and immunogenicity of live varicella virus vaccine in children with human immunodeficiency virus type 1. Pediatr Infect Dis J. 2006 Apr; 25(4):368-70. View in: PubMed

Lee JC, Boechat MI, Belzer M, Church JA, De Ville J, Nielsen K, Weston S, Geng Y, Dunaway T, Kitchen C, Krogstad PA. Thymic volume, T-cell populations, and parameters of thymopoiesis in adolescent and adult survivors of HIV infection acquired in infancy. AIDS. 2006 Mar 21; 20(5):667-74. View in: PubMed

Church JA. A pediatric genetic disorder diagnosed in adulthood. PLoS Med. 2006 Jan; 3(1):e15. View in: PubMed

Lestini BJ, Church JA. Trichosporon pullulans as a complication of chronic granulomatous disease in a patient undergoing immunosuppressive therapy for inflammatory bowel disease. Pediatr Infect Dis J. 2006 Jan; 25(1):87-9. View in: PubMed

Yang OO, Church J, Kitchen CM, Kilpatrick R, Ali A, Geng Y, Killian MS, Sabado RL, Ng H, Suen J, Bryson Y, Jamieson BD, Krogstad P. Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins. J Virol. 2005 Dec; 79(24):15368-75. View in: PubMed

Pitukcheewanont P, Safani D, Church J, Gilsanz V. Bone measures in HIV-1 infected children and adolescents: disparity between quantitative computed tomography and dual-energy X-ray absorptiometry measurements. Osteoporos Int. 2005 Nov; 16(11):1393-6. View in: PubMed

Podsakoff GM, Engel BC, Carbonaro DA, Choi C, Smogorzewska EM, Bauer G, Selander D, Csik S, Wilson K, Betts MR, Koup RA, Nabel GJ, Bishop K, King S, Schmidt M, von Kalle C, Church JA, Kohn DB. Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells. Mol Ther. 2005 Jul; 12(1):77-86. View in: PubMed

Han JY, Rosenzweig SD, Church JA, Holland SM, Ross LA. Variable presentation of disseminated nontuberculous mycobacterial infections in a family with an interferon-gamma receptor mutation. Clin Infect Dis. 2004 Sep 15; 39(6):868-70. View in: PubMed

Church JA, Hughes M, Chen J, Palumbo P, Mofenson LM, Delora P, Smith E, Wiznia A, Hawkins E, Sista P, Cunningham CK. Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children. Pediatr Infect Dis J. 2004 Aug; 23(8):713-8. View in: PubMed

Wakim M, Shah A, Arndt PA, Garratty G, Weinberg K, Hofstra T, Church J. Successful anti-CD20 monoclonal antibody treatment of severe autoimmune hemolytic anemia due to warm reactive IgM autoantibody in a child with common variable immunodeficiency. Am J Hematol. 2004 Jun; 76(2):152-5. View in: PubMed

Church JA. Oxandrolone treatment of childhood hereditary angioedema. Ann Allergy Asthma Immunol. 2004 Mar; 92(3):377-8. View in: PubMed

Ferdman RM, Wakim M, Church JA, Hofstra TC, Thomas D, Genyk YS. Rapid intravenous desensitization to antithymocyte globulin in a patient with aplastic anemia. Transplantation. 2004 Jan 27; 77(2):321-3. View in: PubMed

Soy D, Aweeka FT, Church JA, Cunningham CK, Palumbo P, Kosel BW, Sheiner LB. Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships. Clin Pharmacol Ther. 2003 Dec; 74(6):569-80. View in: PubMed

Purdy KW, Heckenlively JR, Church JA, Keller MA. Progressive outer retinal necrosis caused by varicella-zoster virus in children with acquired immunodeficiency syndrome. Pediatr Infect Dis J. 2003 Apr; 22(4):384-6. View in: PubMed

Pham T, Belzer M, Church JA, Kitchen C, Wilson CM, Douglas SD, Geng Y, Silva M, Mitchell RM, Krogstad P. Assessment of thymic activity in human immunodeficiency virus-negative and -positive adolescents by real-time PCR quantitation of T-cell receptor rearrangement excision circles. Clin Diagn Lab Immunol. 2003 Mar; 10(2):323-8. View in: PubMed

Church JA. Reversible leukoencephalopathy in a patient with nucleoside analogue-associated mitochondrial DNA depletion and metabolic disease. AIDS. 2002 Nov 22; 16(17):2366-7. View in: PubMed

Church JA, Cunningham C, Hughes M, Palumbo P, Mofenson LM, Delora P, Smith E, Wiznia A, Purdue L, Hawkins E, Sista P. Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children. Pediatr Infect Dis J. 2002 Jul; 21(7):653-9. View in: PubMed

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