Faculty

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Joseph August Church, MD
Professor of Clinical Pediatrics
Pediatrics
CHL Mail Stop 75 Off Campus Los Angeles
+1 323 361 2501

Publications

Pharmacokinetics, Safety, and Tolerability of Subcutaneous Immune Globulin Injection (Human), 10 % Caprylate/Chromatography Purified (GAMUNEX®-C) in Pediatric Patients with Primary Immunodeficiency Disease. J Clin Immunol. 2016 Aug; 36(6):600-9. View in: PubMed

Long-Term Tolerability, Safety, and Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Human Immunoglobulin for Primary Immunodeficiency. J Clin Immunol. 2016 Aug; 36(6):571-82. View in: PubMed

The Effect of Maternal Peripartum Anti-TNFa Use on Infant Immune Response. Dig Dis Sci. 2016 Jun; 61(6):1622-7. View in: PubMed

Supranormal thymic output up to 2 decades after HIV-1 infection. AIDS. 2016 Mar 13; 30(5):701-11. View in: PubMed

Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. J Allergy Clin Immunol. 2015 Nov; 136(5):1337-45. View in: PubMed

Regions of homozygosity identified by oligonucleotide SNP arrays: evaluating the incidence and clinical utility. Eur J Hum Genet. 2015 May; 23(5):663-71. View in: PubMed

A Randomized, Open-Label Study of the Safety and Efficacy of Switching Stavudine or Zidovudine to Tenofovir Disoproxil Fumarate in HIV-1-infected Children With Virologic Suppression. Pediatr Infect Dis J. 2015 Apr; 34(4):376-82. View in: PubMed

Antibody Levels to Bordetella pertussis and Neisseria meningitidis in Immunodeficient Patients Receiving Immunoglobulin Replacement Therapy. J Clin Immunol. 2015 Feb; 35(2):213-7. View in: PubMed

Nijmegen Breakage Syndrome Detected by Newborn Screening for T Cell Receptor Excision Circles (TRECs). J Clin Immunol. 2015 Feb; 35(2):227-33. View in: PubMed

Clinical characterization of int22h1/int22h2-mediated Xq28 duplication/deletion: new cases and literature review. BMC Med Genet. 2015; 16(1):12. View in: PubMed

Vectored Immunoprophylaxis Protects Humanized Mice From Mucosal HIV Transmission. Pediatrics. 2014 Nov; 134 Suppl 3:S184-5. View in: PubMed

Cell Death by Pyroptosis Drives CD4 T-Cell Depletion in HIV-1 Infection. Pediatrics. 2014 Nov; 134 Suppl 3:S184. View in: PubMed

Absence of Detectible HIV-1 Viremia After Treatment Cessation in an Infant. Pediatrics. 2014 Nov; 134 Suppl 3:S183-4. View in: PubMed

Synchronous HIV/AIDS-related Epstein-Barr Virus-associated Smooth Muscle Tumors in a 20-year-old female. Pediatr Infect Dis J. 2014 Oct; 33(10):1055-6. View in: PubMed

Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States. JAMA. 2014 Aug 20; 312(7):729-38. View in: PubMed

Major Histocompatibility Complex Class II Deficiency Complicated by Mycobacterium avium Complex in a Boy of Mixed Ethnicity. J Clin Immunol. 2014 Aug; 34(6):677-80. View in: PubMed

Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. J Allergy Clin Immunol. 2014 Apr; 133(4):1149-61. View in: PubMed

Exome sequencing reveals RAG1 mutations in a child with autoimmunity and sterile chronic multifocal osteomyelitis evolving into disseminated granulomatous disease. J Clin Immunol. 2013 Nov; 33(8):1289-92. View in: PubMed

Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: results of the first 2 years. J Allergy Clin Immunol. 2013 Jul; 132(1):140-50. View in: PubMed

Subcutaneous Panniculitis-like T-cell lymphoma in two pediatric patients: an HIV-positive adolescent and a 4-month-old infant. Fetal Pediatr Pathol. 2013 Jun; 32(3):175-83. View in: PubMed

Newborn screening for severe combined immunodeficiency does not identify bare lymphocyte syndrome. J Allergy Clin Immunol. 2013 Jun; 131(6):1693-5. View in: PubMed

Newborn screening for SCID identifies patients with ataxia telangiectasia. J Clin Immunol. 2013 Apr; 33(3):540-9. View in: PubMed

Regional brain gray and white matter changes in perinatally HIV-infected adolescents. Neuroimage Clin. 2013; 4:29-34. View in: PubMed

Acidomonas methanolica-associated necrotizing lymphadenitis in a patient with chronic granulomatous disease. J Clin Immunol. 2012 Dec; 32(6):1193-6. View in: PubMed

Hepatic veno-occlusive disease with immunodeficiency (VODI): First reported case in the U. S. and identification of a unique mutation in Sp110. Clin Immunol. 2012 Nov; 145(2):102-7. View in: PubMed

Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome. J Allergy Clin Immunol. 2012 Sep; 130(3):735-742. e6. View in: PubMed

Safety, Efficacy and Pharmacokinetics of a New 10% Liquid Intravenous Immunoglobulin (IVIG) in Patients with Primary Immunodeficiency. J Clin Immunol. 2012 Aug; 32(4):663-9. View in: PubMed

Functional Analysis of HIV Type 1 Nef Gene Variants from Adolescent and Adult Survivors of Perinatal Infection. AIDS Res Hum Retroviruses. 2012 May; 28(5):486-92. View in: PubMed

Association of microbial IgE sensitizations with asthma in young children with atopic dermatitis. Ann Allergy Asthma Immunol. 2012 Mar; 108(3):212-3. View in: PubMed

Pharmacokinetics of subcutaneous IgPro20 in patients with primary immunodeficiency. Clin Pharmacokinet. 2011 Jun 1; 50(6):405-14. View in: PubMed

Hemophagocytic lymphohistiocytosis in children with chronic granulomatous disease. Pediatr Blood Cancer. 2011 Mar; 56(3):460-2. View in: PubMed

Hypohidrotic Ectodermal Dysplasia and Immunodeficiency with Coincident NEMO and EDA Mutations. Front Immunol. 2011; 2:61. View in: PubMed

A child with x-linked agammaglobulinemia and enthesitis-related arthritis. Int J Rheumatol. 2011; 2011:175973. View in: PubMed

Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy. AIDS Res Hum Retroviruses. 2010 Jun; 26(6):681-4. View in: PubMed

Skin-deep clues to a complex disease. Ann Allergy Asthma Immunol. 2010 Jan; 104(1):93-4. View in: PubMed

Pharmacokinetics of a new 10% intravenous immunoglobulin in patients receiving replacement therapy for primary immunodeficiency. Eur J Pharm Sci. 2009 Jun 28; 37(3-4):272-8. View in: PubMed

Safety and efficacy of Privigen, a novel 10% liquid immunoglobulin preparation for intravenous use, in patients with primary immunodeficiencies. J Clin Immunol. 2009 Jan; 29(1):137-44. View in: PubMed

Association of staphylococcal superantigen-specific immunoglobulin e with mild and moderate atopic dermatitis. J Pediatr. 2008 Dec; 153(6):803-6. View in: PubMed

Down-regulation of atopic dermatitis-associated serum chemokines by wet-wrap treatment: a pilot study. Ann Allergy Asthma Immunol. 2008 Mar; 100(3):286-7. View in: PubMed

Safety and efficacy of enfuvirtide for 48 weeks as part of an optimized antiretroviral regimen in pediatric human immunodeficiency virus 1-infected patients. Pediatr Infect Dis J. 2007 Sep; 26(9):799-805. View in: PubMed

Leukocyte adhesion deficiency in a female patient without delayed umbilical cord separation. J Paediatr Child Health. 2007 May; 43(5):406-8. View in: PubMed

Nonlinear pharmacokinetics of high-dose recombinant fusion protein CD4-IgG2 (PRO 542) observed in HIV-1-infected children. J Allergy Clin Immunol. 2007 Mar; 119(3):747-50. View in: PubMed

Pectin anaphylaxis and possible association with cashew allergy. Ann Allergy Asthma Immunol. 2006 Dec; 97(6):759-60. View in: PubMed

Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1255-8. View in: PubMed

Denial of insurance authorization at a subspecialty office as a cause of missed opportunities for influenza vaccination in children with asthma. Arch Pediatr Adolesc Med. 2006 Sep; 160(9):987-8. View in: PubMed

Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140). J Allergy Clin Immunol. 2006 Aug; 118(2):518-21. View in: PubMed

Efficacy, safety and tolerability of a new 10% liquid intravenous immune globulin [IGIV 10%] in patients with primary immunodeficiency. J Clin Immunol. 2006 Jul; 26(4):388-95. View in: PubMed

Mixed-up nuts: identification of peanuts and tree nuts by children. Ann Allergy Asthma Immunol. 2006 Jul; 97(1):73-7. View in: PubMed

Safety and immunogenicity of live varicella virus vaccine in children with human immunodeficiency virus type 1. Pediatr Infect Dis J. 2006 Apr; 25(4):368-70. View in: PubMed

Thymic volume, T-cell populations, and parameters of thymopoiesis in adolescent and adult survivors of HIV infection acquired in infancy. AIDS. 2006 Mar 21; 20(5):667-74. View in: PubMed

A pediatric genetic disorder diagnosed in adulthood. PLoS Med. 2006 Jan; 3(1):e15. View in: PubMed

Trichosporon pullulans as a complication of chronic granulomatous disease in a patient undergoing immunosuppressive therapy for inflammatory bowel disease. Pediatr Infect Dis J. 2006 Jan; 25(1):87-9. View in: PubMed

Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins. J Virol. 2005 Dec; 79(24):15368-75. View in: PubMed

Bone measures in HIV-1 infected children and adolescents: disparity between quantitative computed tomography and dual-energy X-ray absorptiometry measurements. Osteoporos Int. 2005 Nov; 16(11):1393-6. View in: PubMed

Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells. Mol Ther. 2005 Jul; 12(1):77-86. View in: PubMed

Variable presentation of disseminated nontuberculous mycobacterial infections in a family with an interferon-gamma receptor mutation. Clin Infect Dis. 2004 Sep 15; 39(6):868-70. View in: PubMed

Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children. Pediatr Infect Dis J. 2004 Aug; 23(8):713-8. View in: PubMed

Successful anti-CD20 monoclonal antibody treatment of severe autoimmune hemolytic anemia due to warm reactive IgM autoantibody in a child with common variable immunodeficiency. Am J Hematol. 2004 Jun; 76(2):152-5. View in: PubMed

Oxandrolone treatment of childhood hereditary angioedema. Ann Allergy Asthma Immunol. 2004 Mar; 92(3):377-8. View in: PubMed

Rapid intravenous desensitization to antithymocyte globulin in a patient with aplastic anemia. Transplantation. 2004 Jan 27; 77(2):321-3. View in: PubMed

Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships. Clin Pharmacol Ther. 2003 Dec; 74(6):569-80. View in: PubMed

Progressive outer retinal necrosis caused by varicella-zoster virus in children with acquired immunodeficiency syndrome. Pediatr Infect Dis J. 2003 Apr; 22(4):384-6. View in: PubMed

Assessment of thymic activity in human immunodeficiency virus-negative and -positive adolescents by real-time PCR quantitation of T-cell receptor rearrangement excision circles. Clin Diagn Lab Immunol. 2003 Mar; 10(2):323-8. View in: PubMed

Reversible leukoencephalopathy in a patient with nucleoside analogue-associated mitochondrial DNA depletion and metabolic disease. AIDS. 2002 Nov 22; 16(17):2366-7. View in: PubMed

Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children. Pediatr Infect Dis J. 2002 Jul; 21(7):653-9. View in: PubMed

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