Faculty

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Julie E. Lang, MD
Associate Professor of Clinical Surgery
Director, Breast Cancer Program, Department of Surgery
Surgery
HCC 514 Health Sciences Campus Los Angeles
+1 323 442 6229

Overview

Julie Lang, MD, FACS is an Associate Professor at the Keck School of Medicine of USC. She earned her medical degree from the University of North Carolina, Chapel Hill. She then went on to complete a Surgery residency and a postdoctoral research fellowship in breast cancer research at the University of California, San Francisco. She completed her breast surgical oncology fellowship at the UT-MD Anderson Cancer Center in 2007. She served as the Director of Breast Surgical Oncology at the Arizona Cancer Center for 5 years, then joined the faculty of USC in 2012. Dr. Lang is an expert in the field of breast surgical oncology, with strong expertise in both clinical care and research in the field of breast cancer. She is experienced with advanced breast surgical techniques, such as skin sparing, nipple sparing mastectomies, and coordinating reconstructive surgery with colleagues in Plastic Surgery. Her research focuses on circulating tumor cells, clinical trials, locally advanced/inflammatory breast cancer and radiation-induced sarcoma. Dr. Lang is an avid breast cancer researcher and leads the Breast Surgical Oncology Translational Research Laboratory at the Norris Comprehensive Cancer Center. Dr. Lang is very patient centered and strives to utilize technology and evidenced based medicine to the benefit of her patients. She has published numerous peer reviewed articles and book chapters on the topic of breast cancer.

Publications

Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ, Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med. 2016 Jul 7; 375(1):23-34. View in: PubMed

Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ, Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med. 2016 Jul 7; 375(1):23-34. View in: PubMed

Park JW, Liu MC, Yee D, Yau C, van 't Veer LJ, Symmans WF, Paoloni M, Perlmutter J, Hylton NM, Hogarth M, DeMichele A, Buxton MB, Chien AJ, Wallace AM, Boughey JC, Haddad TC, Chui SY, Kemmer KA, Kaplan HG, Isaacs C, Nanda R, Tripathy D, Albain KS, Edmiston KK, Elias AD, Northfelt DW, Pusztai L, Moulder SL, Lang JE, Viscusi RK, Euhus DM, Haley BB, Khan QJ, Wood WC, Melisko M, Schwab R, Helsten T, Lyandres J, Davis SE, Hirst GL, Sanil A, Esserman LJ, Berry DA. Adaptive Randomization of Neratinib in Early Breast Cancer. N Engl J Med. 2016 Jul 7; 375(1):11-22. View in: PubMed

Park JW, Liu MC, Yee D, Yau C, van 't Veer LJ, Symmans WF, Paoloni M, Perlmutter J, Hylton NM, Hogarth M, DeMichele A, Buxton MB, Chien AJ, Wallace AM, Boughey JC, Haddad TC, Chui SY, Kemmer KA, Kaplan HG, Isaacs C, Nanda R, Tripathy D, Albain KS, Edmiston KK, Elias AD, Northfelt DW, Pusztai L, Moulder SL, Lang JE, Viscusi RK, Euhus DM, Haley BB, Khan QJ, Wood WC, Melisko M, Schwab R, Helsten T, Lyandres J, Davis SE, Hirst GL, Sanil A, Esserman LJ, Berry DA. Adaptive Randomization of Neratinib in Early Breast Cancer. N Engl J Med. 2016 Jul 7; 375(1):11-22. View in: PubMed

Forte VA, Barrak DK, Elhodaky M, Tung L, Snow A, Lang JE. The potential for liquid biopsies in the precision medical treatment of breast cancer. Cancer Biol Med. 2016 Mar; 13(1):19-40. View in: PubMed

O'Kelly Priddy CM, Forte VA, Lang JE. The importance of surgical margins in breast cancer. J Surg Oncol. 2016 Mar; 113(3):256-63. View in: PubMed

López AM, Pruthi S, Boughey JC, Perloff M, Hsu CH, Lang JE, Ley M, Frank D, Taverna JA, Chow HH. Double-Blind, Randomized Trial of Alternative Letrozole Dosing Regimens in Postmenopausal Women with Increased Breast Cancer Risk. Cancer Prev Res (Phila). 2016 Feb; 9(2):142-8. View in: PubMed

Ring A, Mineyev N, Zhu W, Park E, Lomas C, Punj V, Yu M, Barrak D, Forte V, Porras T, Tripathy D, Lang JE. EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low. Oncotarget. 2015 Dec 29; 6(42):44623-34. View in: PubMed

Wu T, Harder BG, Wong PK, Lang JE, Zhang DD. Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy? Mol Carcinog. 2015 Nov; 54(11):1494-502. View in: PubMed

Cummins T, Yoon C, Choi H, Eliahoo P, Kim HH, Yamashita MW, Hovanessian-Larsen LJ, Lang JE, Sener SF, Vallone J, Martin SE, Kirk Shung K. High-frequency ultrasound imaging for breast cancer biopsy guidance. J Med Imaging (Bellingham). 2015 Oct; 2(4):047001. View in: PubMed

Poole BB, Wecsler JS, Sheth P, Sener SF, Wang L, Larsen L, Tripathy D, Lang JE. Malignancy rates after surgical excision of discordant breast biopsies. J Surg Res. 2015 May 1; 195(1):152-7. View in: PubMed

Wecsler JS, Tereffe W, Pedersen RC, Sieffert MR, Mack WJ, Cui H, Russell CA, Woods RR, Viscusi RK, Sener SF, Lang JE. Lymph node status in inflammatory breast cancer. Breast Cancer Res Treat. 2015 May; 151(1):113-20. View in: PubMed

Lang J, Zhu W, Nokes B, Sheth G, Novak P, Fuchs L, Watts G, Futscher B, Mineyev N, Ring A, LeBeau L, Nagle R, Cranmer L. Characterization of a novel radiation-induced sarcoma cell line. J Surg Oncol. 2015 May; 111(6):669-82. View in: PubMed

Miller JA, Pappan K, Thompson PA, Want EJ, Siskos AP, Keun HC, Wulff J, Hu C, Lang JE, Chow HH. Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention. Cancer Prev Res (Phila). 2015 Jan; 8(1):86-93. View in: PubMed

Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang JE, Molinolo AA, Leduc R, Marsault E, Boerner J, List K. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015; 6:6776. View in: PubMed

Lang JE, Scott JH, Wolf DM, Novak P, Punj V, Magbanua MJ, Zhu W, Mineyev N, Haqq CM, Crothers JR, Esserman LJ, Tripathy D, van 't Veer L, Park JW. Expression profiling of circulating tumor cells in metastatic breast cancer. Breast Cancer Res Treat. 2015 Jan; 149(1):121-31. View in: PubMed

Miller JA, Pappan K, Thompson PA, Want EJ, Siskos AP, Keun HC, Wulff J, Hu C, Lang JE, Chow HH. Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention. Cancer Prev Res (Phila). 2015 Jan; 8(1):86-93. View in: PubMed

Lang JE, Wecsler JS, Press MF, Tripathy D. Molecular markers for breast cancer diagnosis, prognosis and targeted therapy. J Surg Oncol. 2015 Jan; 111(1):81-90. View in: PubMed

Davis GB, Lang JE, Peric M, Yang H, Artenstein D, Chan LS, Schooler WG, Carey JN. Breast reconstruction satisfaction rates at a large county hospital. Ann Plast Surg. 2014 May; 72 Suppl 1:S61-5. View in: PubMed

Lang JE, Summers DE, Cui H, Carey JN, Viscusi RK, Hurst CA, Waer AL, Ley ML, Sener SF, Vijayasekaran A. Trends in post-mastectomy reconstruction: a SEER database analysis. J Surg Oncol. 2013 Sep; 108(3):163-8. View in: PubMed

Lang JE, Tereffe W, Mitchell MP, Rao R, Feng L, Meric-Bernstam F, Bedrosian I, Kuerer HM, Hunt KK, Hortobagyi GN, Babiera GV. Primary tumor extirpation in breast cancer patients who present with stage IV disease is associated with improved survival. Ann Surg Oncol. 2013 Jun; 20(6):1893-9. View in: PubMed

Miller JA, Lang JE, Ley M, Nagle R, Hsu CH, Thompson PA, Cordova C, Waer A, Chow HH. Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer. Cancer Prev Res (Phila). 2013 Jun; 6(6):577-84. View in: PubMed

Nokes B, Apel M, Jones C, Brown G, Lang JE. Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications. J Surg Res. 2013 May; 181(2):262-71. View in: PubMed

Nokes BT, Cunliffe HE, Lafleur B, Mount DW, Livingston RB, Futscher BW, Lang JE. In Vitro Assessment of the Inflammatory Breast Cancer Cell Line SUM 149: Discovery of 2 Single Nucleotide Polymorphisms in the RNase L Gene. J Cancer. 2013; 4(2):104-16. View in: PubMed

Sheth GR, Cranmer LD, Smith BD, Grasso-Lebeau L, Lang JE. Radiation-induced sarcoma of the breast: a systematic review. Oncologist. 2012; 17(3):405-18. View in: PubMed

Liu LC, Lang JE, Lu Y, Roe D, Hwang SE, Ewing CA, Esserman LJ, Morita E, Treseler P, Leong SP. Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients: a meta-analysis and single-institution experience. Cancer. 2011 Jan 15; 117(2):250-8. View in: PubMed

Klein RL, Brown AR, Gomez-Castro CM, Chambers SK, Cragun JM, Grasso-Lebeau L, Lang JE. Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: a case report and literature review. J Cancer. 2010; 1:27-31. View in: PubMed

Klein RL, Brown AR, Gomez-Castro CM, Chambers SK, Cragun JM, Grasso-Lebeau L, Lang JE. Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: a case report and literature review. J Cancer. 2010; 1:27-31. View in: PubMed

Lang JE, Liu LC, Lu Y, Jenkins T, Hwang SE, Esserman LJ, Ewing CA, Alvarado M, Morita E, Treseler P, Leong SP. Prognostic implications of positive nonsentinel lymph nodes removed during selective sentinel lymphadenectomy for breast cancer. Breast J. 2009 May-Jun; 15(3):242-6. View in: PubMed

Lang JE, Mosalpuria K, Cristofanilli M, Krishnamurthy S, Reuben J, Singh B, Bedrosian I, Meric-Bernstam F, Lucci A. HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer. Breast Cancer Res Treat. 2009 Feb; 113(3):501-7. View in: PubMed

Lang JE, Magbanua MJ, Scott JH, Makrigiorgos GM, Wang G, Federman S, Esserman LJ, Park JW, Haqq CM. A comparison of RNA amplification techniques at sub-nanogram input concentration. BMC Genomics. 2009; 10:326. View in: PubMed

Liu LC, Lang JE, Jenkins T, Lu Y, Ewing CA, Hwang SE, Sokol S, Alvarado M, Esserman LJ, Morita E, Treseler P, Leong SP. Is it necessary to harvest additional lymph nodes after resection of the most radioactive sentinel lymph node in breast cancer? J Am Coll Surg. 2008 Dec; 207(6):853-8. View in: PubMed

Lang JE, Kuerer HM. Breast ductal secretions: clinical features, potential uses, and possible applications. Cancer Control. 2007 Oct; 14(4):350-9. View in: PubMed

Lang JE, Hall CS, Singh B, Lucci A. Significance of micrometastasis in bone marrow and blood of operable breast cancer patients: research tool or clinical application? Expert Rev Anticancer Ther. 2007 Oct; 7(10):1463-72. View in: PubMed

Lang JE, Kuerer HM. Breast ductal secretions: clinical features, potential uses, and possible applications. Cancer Control. 2007 Oct; 14(4):350-9. View in: PubMed

Lang JE, Babiera GV. Locoregional Resection in Stage IV breast cancer: tumor biology, molecular and clinical perspectives. Surg Clin North Am. 2007 Apr; 87(2):527-38, xi-xii. View in: PubMed

Lang JE, Esserman LJ, Ewing CA, Rugo HS, Lane KT, Leong SP, Hwang ES. Accuracy of selective sentinel lymphadenectomy after neoadjuvant chemotherapy: effect of clinical node status at presentation. J Am Coll Surg. 2004 Dec; 199(6):856-62. View in: PubMed

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