Faculty

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Kasper S. Wang, MD
Associate Professor of Surgery (Clinical Scholar)
Pediatrics
CHL MailStop72 Off Campus Los Angeles
+1 323 361 2338

Overview

Dr. Wang's academic interest focuses on biliary atresia. Biliary atresia is a disease of infants where the bile ducts are damaged due to unclear causes. As a consequence of the damage, bile is unable to flow from the liver and progressive liver damage occurs. Biliary atresia is the most common indication for pediatric liver transplantation. Dr. Wang is the Principal Investigator for an NIH funded U01 grant for CHLA focusing on biliary atresia and other liver diseases of infants and children. The grant enables CHLA to participate in the Childhood Liver Disease Research and Education Network (ChiLDREN) which is a consortium of 15 of the top children's hospitals in the U.S. and Canada joined to studies rare but lethal pediatric liver diseases. To date, nearly 1500 patients with biliary atresia have been enrolled in number studies and clinical trials through ChiLDREN. Currently enrollment in a prospective randomized double blinded placebo controlled study on the efficacy of corticosteroids in the treatment of patients with biliary atresia after Kasai portoenterostomy is closed. Unblinding of data will occur in 2013 to be followed by publication of observations. In addition to involvement in ChiLDREN, Dr. Wang heads a research program focusing on the molecular events involved in biliary atresia. His research lab focuses on the signaling pathways regulating liver stem/progenitor cells during liver organogenesis and a variety of liver damage such as that incurred by biliary atresia.

Publications

Zagory JA, Nguyen MV, Dietz W, Mavila N, Haldeman A, Grishin A, Wang KS. Toll-like receptor 3 mediates PROMININ-1 expressing cell expansion in biliary atresia via Transforming Growth Factor-Beta. J Pediatr Surg. 2016 Jun; 51(6):917-22. View in: PubMed

Lua I, Li Y, Zagory JA, Wang KS, French SW, Sévigny J, Asahina K. Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers. J Hepatol. 2016 May; 64(5):1137-46. View in: PubMed

Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ. Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J Pediatr. 2016 Mar; 170:211-217. e2. View in: PubMed

Wang KS. Newborn Screening for Biliary Atresia. Pediatrics. 2015 Dec; 136(6):e1663-9. View in: PubMed

Kamath BM, Chen Z, Romero R, Fredericks EM, Alonso EM, Arnon R, Heubi J, Hertel PM, Karpen SJ, Loomes KM, Murray KF, Rosenthal P, Schwarz KB, Subbarao G, Teckman JH, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Magee JC. Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome. J Pediatr. 2015 Aug; 167(2):390-396. e3. View in: PubMed

Zagory JA, Nguyen MV, Wang KS. Recent advances in the pathogenesis and management of biliary atresia. Curr Opin Pediatr. 2015 Jun; 27(3):389-94. View in: PubMed

Hypothermia and neonatal encephalopathy. Pediatrics. 2014 Jun; 133(6):1146-50. View in: PubMed

Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ. Use of Corticosteroids After Hepatoportoenterostomy for Bile Drainage in Infants With Biliary Atresia: The START Randomized Clinical Trial. JAMA. 2014 May 7; 311(17):1750-9. View in: PubMed

Mavila N, James D, Shivakumar P, Nguyen MV, Utley S, Mak K, Wu A, Zhou S, Wang L, Vendyres C, Groff M, Asahina K, Wang KS. Expansion of PROMININ-1-expressing cells in association with fibrosis of biliary atresia. Hepatology. 2014 May 3. View in: PubMed

Utley S, James D, Mavila N, Nguyen MV, Vendryes C, Salisbury SM, Phan J, Wang KS. Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent ß-catenin activation. J Hepatol. 2014 May; 60(5):1002-9. View in: PubMed

Immersion in water during labor and delivery. Pediatrics. 2014 Apr; 133(4):758-61. View in: PubMed

Goodhue CJ, Wang KS. Persistent hyperbilirubinemia in a newborn. J Pediatr Health Care. 2014 Mar-Apr; 28(2):172-6. View in: PubMed

Lua I, James D, Wang J, Wang KS, Asahina K. Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014 Feb 1. View in: PubMed

Kumar P. Use of inhaled nitric oxide in preterm infants. Pediatrics. 2014 Jan; 133(1):164-70. View in: PubMed

Polin RA, Carlo WA. Surfactant replacement therapy for preterm and term neonates with respiratory distress. Pediatrics. 2014 Jan; 133(1):156-63. View in: PubMed

Respiratory support in preterm infants at birth. Pediatrics. 2014 Jan; 133(1):171-4. View in: PubMed

Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC. Extrahepatic anomalies in infants with biliary atresia: results of a large prospective north american multicenter study. Hepatology. 2013 Nov; 58(5):1724-31. View in: PubMed

Short SS, Papillon S, Hunter CJ, Stanley P, Kerkar N, Wang L, Azen C, Wang K. Percutaneous liver biopsy: pathologic diagnosis and complications in children. J Pediatr Gastroenterol Nutr. 2013 Nov; 57(5):644-8. View in: PubMed

Jensen AR, Short SS, Anselmo DM, Torres MB, Frykman PK, Shin CE, Wang K, Nguyen NX. Laparoscopic versus open treatment of congenital duodenal obstruction: multicenter short-term outcomes analysis. J Laparoendosc Adv Surg Tech A. 2013 Oct; 23(10):876-80. View in: PubMed

Sundaram SS, Alonso EM, Haber B, Magee JC, Fredericks E, Kamath B, Kerkar N, Rosenthal P, Shepherd R, Limbers C, Varni JW, Robuck P, Sokol RJ. Health related quality of life in patients with biliary atresia surviving with their native liver. J Pediatr. 2013 Oct; 163(4):1052-7. e2. View in: PubMed

Behnke M, Smith VC. Prenatal substance abuse: short- and long-term effects on the exposed fetus. Pediatrics. 2013 Mar; 131(3):e1009-24. View in: PubMed

Kimberlin DW, Baley J. Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Pediatrics. 2013 Feb; 131(2):383-6. View in: PubMed

Papillon S, Goodhue CJ, Zmora O, Sharma SS, Wells WJ, Ford HR, Upperman JS, Wang KS, Bushman GA, Kim R, Pierce JR. Congenital heart disease and heterotaxy: upper gastrointestinal fluoroscopy can be misleading and surgery in an asymptomatic patient is not beneficial. J Pediatr Surg. 2013 Jan; 48(1):164-9. View in: PubMed

Short SS, Frykman PK, Nguyen N, Liu Q, Berel D, Wang KS. Laparoscopic common bile duct exploration in children is associated with decreased cost and length of stay: results of a two-center analysis. J Pediatr Surg. 2013 Jan; 48(1):215-20. View in: PubMed

Wang KS. Assessment and management of inguinal hernia in infants. Pediatrics. 2012 Oct; 130(4):768-73. View in: PubMed

Levels of neonatal care. Pediatrics. 2012 Sep; 130(3):587-97. View in: PubMed

Stamp LA, Braxton DR, Wu J, Akopian V, Hasegawa K, Chandrasoma PT, Hawes SM, McLean C, Petrovic LM, Wang K, Pera MF. The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin. Stem Cells. 2012 Sep; 30(9):1999-2009. View in: PubMed

Polin RA. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012 May; 129(5):1006-15. View in: PubMed

Hudak ML, Tan RC. Neonatal drug withdrawal. Pediatrics. 2012 Feb; 129(2):e540-60. View in: PubMed

Mavila N, James D, Utley S, Cu N, Coblens O, Mak K, Rountree CB, Kahn M, Wang KS. Fibroblast growth factor receptor-mediated activation of AKT-ß-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells. PLoS One. 2012; 7(11):e50401. View in: PubMed

Bhutani VK. Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2011 Oct; 128(4):e1046-52. View in: PubMed

Superina R, Magee JC, Brandt ML, Healey PJ, Tiao G, Ryckman F, Karrer FM, Iyer K, Fecteau A, West K, Burns RC, Flake A, Lee H, Lowell JA, Dillon P, Colombani P, Ricketts R, Li Y, Moore J, Wang KS. The anatomic pattern of biliary atresia identified at time of Kasai hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant-free survival. Ann Surg. 2011 Oct; 254(4):577-85. View in: PubMed

Policy statement—Recommendations for the prevention of perinatal group B streptococcal (GBS) disease. Pediatrics. 2011 Sep; 128(3):611-6. View in: PubMed

Postnatal glucose homeostasis in late-preterm and term infants. Pediatrics. 2011 Mar; 127(3):575-9. View in: PubMed

Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82. View in: PubMed

Berg T, DeLanghe S, Al Alam D, Utley S, Estrada J, Wang KS. ß-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis. J Surg Res. 2010 Dec; 164(2):276-85. View in: PubMed

Watterberg KL. Policy statement--postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. Pediatrics. 2010 Oct; 126(4):800-8. View in: PubMed

Guner YS, Emami CN, Chokshi NK, Wang K, Shin CE. Inversion herniotomy: a laparoscopic technique for female inguinal hernia repair. J Laparoendosc Adv Surg Tech A. 2010 Jun; 20(5):481-4. View in: PubMed

Petrosyan M, Hunter C, Estrada J, Guner Y, Qureshi F, Stein J, Ford HR, Wang K, Nguyen N. Subcutaneous fixation of gastrostomy tube is superior to temporary fixation. J Laparoendosc Adv Surg Tech A. 2010 Mar; 20(2):207-9. View in: PubMed

Tai CC, Sala FG, Ford HR, Wang KS, Li C, Minoo P, Grikscheit TC, Bellusci S. Wnt5a knock-out mouse as a new model of anorectal malformation. J Surg Res. 2009 Oct; 156(2):278-82. View in: PubMed

Advanced practice in neonatal nursing. Pediatrics. 2009 Jun; 123(6):1606-7. View in: PubMed

Tai CC, Curtis JL, Sala FG, Del Moral PM, Chokshi N, Kanard RJ, Al Alam D, Wang J, Burns RC, Ford HR, Grishin A, Wang KS, Bellusci S. Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. Dev Dyn. 2009 Feb; 238(2):294-301. View in: PubMed

Tai CC, Curtis JL, Szmuszkovicz JR, Horn MV, Ford HR, Woo MS, Wang KS. Abdominal involvement in pediatric heart and lung transplant recipients with posttransplant lymphoproliferative disease increases the risk of mortality. J Pediatr Surg. 2008 Dec; 43(12):2174-7. View in: PubMed

Estrada JJ, Petrosyan M, Hunter CJ, Lee SL, Anselmo DM, Grikscheit TC, Stein JE, Wang KS, Ford HR, Shaul DB. Preservation of extracorporeal tissue in closing gastroschisis augments intestinal length. J Pediatr Surg. 2008 Dec; 43(12):2213-5. View in: PubMed

Speer AL, Schofield DE, Wang KS, Shin CE, Stein JE, Shaul DB, Mahour GH, Ford HR. Contemporary management of lipoblastoma. J Pediatr Surg. 2008 Jul; 43(7):1295-300. View in: PubMed

Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97. View in: PubMed

Sala FG, Curtis JL, Veltmaat JM, Del Moral PM, Le LT, Fairbanks TJ, Warburton D, Ford H, Wang K, Burns RC, Bellusci S. Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol. 2006 Nov 15; 299(2):373-85. View in: PubMed

del Moral PM, De Langhe SP, Sala FG, Veltmaat JM, Tefft D, Wang K, Warburton D, Bellusci S. Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev Biol. 2006 May 1; 293(1):77-89. View in: PubMed

Warburton D, Bellusci S, De Langhe S, Del Moral PM, Fleury V, Mailleux A, Tefft D, Unbekandt M, Wang K, Shi W. Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. View in: PubMed

Wang KS, Skarsgard ED. Left-sided gastroschisis associated with situs inversus. J Pediatr Surg. 2004 Dec; 39(12):1883-4. View in: PubMed

Wang KS, Cahill JL, Skarsgard ED. Omphalocele, colonic atresia, and Hirschsprung's disease: an unusual cluster of malformations in a single patient. Pediatr Surg Int. 2001 Mar; 17(2-3):218-20. View in: PubMed

Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C126-34. View in: PubMed

Wang KS, Ma T, Filiz F, Verkman AS, Bastidas JA. Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G463-70. View in: PubMed

Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA. Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G448-53. View in: PubMed

Wang KS, Edelstein PS. Revenge of the conjoined twin: a giant presacral recurrence in a patient born with an attached, well-differentiated teratoma. Surgery. 1999 Nov; 126(5):980-3. View in: PubMed

Wang KS, Albanese C, Dada F, Skarsgard ED. Papillary cystic neoplasm of the pancreas: a report of three pediatric cases and literature review. J Pediatr Surg. 1998 Jun; 33(6):842-5. View in: PubMed

Gingalewski C, Wang K, Clemens MG, De Maio A. Posttranscriptional regulation of connexin 32 expression in liver during acute inflammation. J Cell Physiol. 1996 Feb; 166(2):461-7. View in: PubMed

Wang K, Deutschman CS, Clemens MG, De Maio A. Reciprocal expression of phosphoenolpyruvate carboxykinase and acute phase genes during acute inflammation. Shock. 1995 Mar; 3(3):204-9. View in: PubMed

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