Faculty

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Kenneth Raymond Hallows, MD, PhD
Professor of Medicine
Director of The Usc/Ukro Kidney Research Center
Chief, Division of Nephrology
Medicine
MMR 1333 San Pablo Street Off Campus Los Angeles

Overview

Dr. Hallows is studying the metabolic control of kidney epithelial salt and water transport mechanisms with relevance to hypertension, acute kidney injury and chronic kidney disease. He is also studying the role of metabolic changes in autosomal dominant polycystic kidney disease and other kidney diseases at various levels.

After completing his undergraduate training at Brown University, Dr. Hallows earned his PhD and MD degrees from the University of Rochester. He then went on to complete residency in internal medicine and then a fellowship in nephrology at the Hospital of the University of Pennsylvania. After spending a year as an instructor at the University of Pennsylvania, Dr. Hallows moved to the University of Pittsburgh as an assistant professor, then associate professor of medicine, before moving to the Keck School of Medicine of USC in 2015.

Awards

American Physiological Society: Lazaro J. Mandel Young Investigator Award, 2009

American Society of Nephrology: Carl W. Gottschalk Research Scholar Grantee, 2006

American Society of Nephrology: Fellow, 2004

University of Pennsylvania: J. Russell Elkinton Renal Fellow Teaching Award, 1999-2000

National Kidney Foundation: Renal Fellow Research Forum Prize, 1999

Alpha Omega Alpha: National Medical Honor Society, 1994

University of Rochester : William F. Neuman Award in Biophysics, 1992

University of Rochester: Edward F. Adolph Prize in Physiology, 1988

University of Rochester: Walle J.H. Nauta Award in Neural Sciences, 1988

Brown University: Susan Colver Rosenberger Prize in Biology, 1987

Brown University: CBS Merit Scholarship, 1983-1987

Publications

Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 Jun 12. View in: PubMed

Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. View in: PubMed

Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 Nov 01; 311(5):F890-F900. View in: PubMed

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 Oct 26; 6:35952. View in: PubMed

Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 Jun 1; 310(11):F1216-28. View in: PubMed

Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015 Sep 17; 14(18):2914-23. View in: PubMed

Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 1; 309(5):F414-28. View in: PubMed

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep 1; 125(9):3433-48. View in: PubMed

Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. View in: PubMed

Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. View in: PubMed

A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. View in: PubMed

Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. View in: PubMed

Hemodialysis for the treatment of severe accidental hypothermia. Semin Dial. 2014 May-Jun; 27(3):295-7. View in: PubMed

Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014; 18(5):501. View in: PubMed

AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 1; 305(7):F943-56. View in: PubMed

Opening lines of communication in the distal nephron. J Clin Invest. 2013 Oct 1; 123(10):4139-41. View in: PubMed

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60. View in: PubMed

Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. View in: PubMed

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 1; 305(5):F679-90. View in: PubMed

Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019. View in: PubMed

Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012 Sep 28; 287(40):33389-400. View in: PubMed

AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. View in: PubMed

Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40. View in: PubMed

Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. View in: PubMed

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2462-7. View in: PubMed

CFTR regulation by phosphorylation. Methods Mol Biol. 2011; 741:471-88. View in: PubMed

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. View in: PubMed

SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. View in: PubMed

PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 6; 285(32):24676-85. View in: PubMed

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83. View in: PubMed

Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 9; 285(28):21671-8. View in: PubMed

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. View in: PubMed

AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84. View in: PubMed

Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. View in: PubMed

Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. View in: PubMed

AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101. View in: PubMed

AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. View in: PubMed

Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. View in: PubMed

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Jan 2; 284(1):150-7. View in: PubMed

Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 2008 Oct; 19(10):1845-54. View in: PubMed

Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. View in: PubMed

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 8; 281(36):26159-69. View in: PubMed

Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem. 2006 Feb 17; 281(7):4231-41. View in: PubMed

Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71. View in: PubMed

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem. 2005 May 6; 280(18):17608-16. View in: PubMed

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308. View in: PubMed

Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem. 2003 Jan 10; 278(2):998-1004. View in: PubMed

Yeast two-hybrid identification and analysis of protein interactions with CFTR. Methods Mol Med. 2002; 70:365-81. View in: PubMed

Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000 Jun; 105(12):1711-21. View in: PubMed

The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000 Apr; 319(4):240-4. View in: PubMed

Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation. J Cell Physiol. 1996 Apr; 167(1):60-71. View in: PubMed

Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72. View in: PubMed

Control of intracellular pH during regulatory volume decrease in HL-60 cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66. View in: PubMed

Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56. View in: PubMed

Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology. 1992 Mar-Jun; 29(2-3):295-309. View in: PubMed

Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61. View in: PubMed

Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate. Radiat Res. 1988 Jun; 114(3):579-88. View in: PubMed

Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells. Radiat Res. 1988 Jan; 113(1):191-8. View in: PubMed

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