Postdoctoral fellow with expertise in innate immunity, immune signaling and gene regulation, neuroinflammation, neurodegenation and cognitive decline in animal models of Alzheimer's disease, molecular biology, bioinformatics, and next generation sequencing.
My primary research focus has been to explore the logic of innate immune transcriptional regulation with an emphasis on pathways that control the selective expression of key pro-inflammatory genes. Many pro-inflammatory genes that undergo rapidly induced transcription as part of the innate immune response can also be aberrantly expressed and drive multiple disease pathologies, spanning the realm from autoimmune diseases to cancer to diseases of aging, such as Alzheimer’s disease. Many complex diseases have key inflammatory components that provide an avenue for treatment if we can rebalance the underlying inflammatory condition.
Guillot-Sestier MV, Doty KR, Town T. Innate Immunity Fights Alzheimer's Disease. Trends Neurosci. 2015 Nov; 38(11):674-81. View in: PubMed
Doty KR, Guillot-Sestier MV, Town T. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive? Brain Res. 2015 Aug 18; 1617:155-73. View in: PubMed
Guillot-Sestier MV, Doty KR, Gate D, Rodriguez J, Leung BP, Rezai-Zadeh K, Town T. Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology. Neuron. 2015 Feb 4; 85(3):534-48. View in: PubMed
Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Kamada N, Hisamatsu T, Hansen JJ, Doty KR, Pope SD, Smale ST, Hibi T, Rothman PB, Kashiwada M, Plevy SE. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J Immunol. 2011 Apr 15; 186(8):4649-55. View in: PubMed
Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10; 138(1):114-28. View in: PubMed