Faculty

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Kevin Verne Lemley, MD, PhD
Professor of Pediatrics (Clinical Scholar)
Pediatrics
CHL Mail Stop 40 Off Campus Los Angeles
+1 323 361 2102

Overview

My main research interests are in podocyte pathobiology and stereologic methods. My clinical interests are in diabetic kidney disease, nephrotic syndrome, genetic kidney diseases. My health systems interests are in the use of clinical pathways/protocols, outcomes assessment and quality audit, and lean systems.

Publications

Saulnier PJ, Wheelock KM, Howell S, Weil EJ, Tanamas SK, Knowler WC, Lemley KV, Mauer M, Yee B, Nelson RG, Beisswenger PJ. Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes. Diabetes. 2016 Dec; 65(12):3744-3753. View in: PubMed

Lemley KV, Faul C, Schramm K, Meyers K, Kaskel F, Dell KM, Gipson DS, Gibson K, Trachtman H. The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome. Pediatrics. 2016 Jul; 138(1). View in: PubMed

Wheelock KM, Jaiswal M, Martin CL, Fufaa GD, Weil EJ, Lemley KV, Yee B, Feldman E, Brosius FC, Knowler WC, Nelson RG, Pop-Busui R. Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes. J Diabetes Complications. 2016 Jul; 30(5):873-9. View in: PubMed

Lemley KV. Glomerular pathology and the progression of chronic kidney disease. Am J Physiol Renal Physiol. 2016 Jun 1; 310(11):F1385-8. View in: PubMed

Sampson MG, Robertson CC, Martini S, Mariani LH, Lemley KV, Gillies CE, Otto EA, Kopp JB, Randolph A, Vega-Warner V, Eichinger F, Nair V, Gipson DS, Cattran DC, Johnstone DB, O'Toole JF, Bagnasco SM, Song PX, Barisoni L, Troost JP, Kretzler M, Sedor JR. Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects. J Am Soc Nephrol. 2016 Mar; 27(3):814-23. View in: PubMed

Fufaa GD, Weil EJ, Lemley KV, Knowler WC, Brosius FC, Yee B, Mauer M, Nelson RG. Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes. Clin J Am Soc Nephrol. 2016 Feb 5; 11(2):254-61. View in: PubMed

Gipson DS, Troost JP, Lafayette RA, Hladunewich MA, Trachtman H, Gadegbeku CA, Sedor JR, Holzman LB, Moxey-Mims MM, Perumal K, Kaskel FJ, Nelson PJ, Tuttle KR, Bagnasco SM, Hogan MC, Dell KM, Appel GB, Lieske JC, Ilori TO, Sethna CB, Fervenza FC, Hogan SL, Nachman PH, Rosenberg AZ, Greenbaum LA, Meyers KE, Hewitt SM, Choi MJ, Kopp JB, Zhdanova O, Hodgin JB, Johnstone DB, Adler SG, Avila-Casado C, Neu AM, Hingorani SR, Lemley KV, Nast CC, Brady TM, Barisoni-Thomas L, Fornoni A, Jennette JC, Cattran DC, Palmer MB, Gibson KL, Reich HN, Mokrzycki MH, Sambandam KK, Zilleruelo GE, Licht C, Sampson MG, Song P, Mariani LH, Kretzler M. Complete Remission in the Nephrotic Syndrome Study Network. Clin J Am Soc Nephrol. 2016 Jan 7; 11(1):81-9. View in: PubMed

Pavkov ME, Weil EJ, Fufaa GD, Nelson RG, Lemley KV, Knowler WC, Niewczas MA, Krolewski AS. Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int. 2016 Jan; 89(1):226-34. View in: PubMed

Lemley KV, Bagnasco SM, Nast CC, Barisoni L, Conway CM, Hewitt SM, Song PX. Morphometry Predicts Early GFR Change in Primary Proteinuric Glomerulopathies: A Longitudinal Cohort Study Using Generalized Estimating Equations. PLoS One. 2016; 11(6):e0157148. View in: PubMed

Nast CC, Lemley KV, Hodgin JB, Bagnasco S, Avila-Casado C, Hewitt SM, Barisoni L. Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes. Semin Nephrol. 2015 May; 35(3):266-78. View in: PubMed

Lemley KV, Mak RH. Nephrotic syndrome: Efficacy of rituximab in challenging nephrotic syndrome. Nat Rev Nephrol. 2015 May; 11(5):257-8. View in: PubMed

Kriz W, Lemley KV. A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD. J Am Soc Nephrol. 2015 Feb; 26(2):258-69. View in: PubMed

Uy N, Graf L, Lemley KV, Kaskel F. Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. Pediatr Res. 2015 Jan; 77(1-2):252-5. View in: PubMed

Mammen C, Matsell DG, Lemley KV. The importance of clinical pathways and protocols in pediatric nephrology. Pediatr Nephrol. 2014 Oct; 29(10):1903-14. View in: PubMed

Lemley KV. An unusual case of hypercalcemia in a patient with renal insufficiency: Question. Pediatr Nephrol. 2014 Sep; 29(9):1529-30. View in: PubMed

Lemley KV. LMX1B mutations with nails and kneecaps: a new paradigm? Nephrol Dial Transplant. 2014 Jan; 29(1):9-12. View in: PubMed

Weil EJ, Fufaa G, Jones LI, Lovato T, Lemley KV, Hanson RL, Knowler WC, Bennett PH, Yee B, Myers BD, Nelson RG. Effect of losartan on prevention and progression of early diabetic nephropathy in American Indians with type 2 diabetes. Diabetes. 2013 Sep; 62(9):3224-31. View in: PubMed

Barisoni L, Nast CC, Jennette JC, Hodgin JB, Herzenberg AM, Lemley KV, Conway CM, Kopp JB, Kretzler M, Lienczewski C, Avila-Casado C, Bagnasco S, Sethi S, Tomaszewski J, Gasim AH, Hewitt SM. Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE). Clin J Am Soc Nephrol. 2013 Aug; 8(8):1449-59. View in: PubMed

Lemley KV, Bertram JF, Nicholas SB, White K. Estimation of glomerular podocyte number: a selection of valid methods. J Am Soc Nephrol. 2013 Jul; 24(8):1193-202. View in: PubMed

Pavkov ME, Knowler WC, Hanson RL, Williams DE, Lemley KV, Myers BD, Nelson RG. Comparison of serum cystatin C, serum creatinine, measured GFR, and estimated GFR to assess the risk of kidney failure in American Indians with diabetic nephropathy. Am J Kidney Dis. 2013 Jul; 62(1):33-41. View in: PubMed

Jennifer Weil E, Lemley KV, Myers BD, Nelson RG. The authors reply. Kidney Int. 2013 Jun; 83(6):1203. View in: PubMed

Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PX, Barisoni L, Sampson MG, Kopp JB, Lemley KV, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KE, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M. Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int. 2013 Apr; 83(4):749-56. View in: PubMed

Kriz W, Shirato I, Nagata M, LeHir M, Lemley KV. The podocyte's response to stress: the enigma of foot process effacement. Am J Physiol Renal Physiol. 2013 Feb 15; 304(4):F333-47. View in: PubMed

Da Sacco S, Lemley KV, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L. A novel source of cultured podocytes. PLoS One. 2013; 8(12):e81812. View in: PubMed

Weil EJ, Lemley KV, Mason CC, Yee B, Jones LI, Blouch K, Lovato T, Richardson M, Myers BD, Nelson RG. Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy. Kidney Int. 2012 Nov; 82(9):1010-7. View in: PubMed

Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley KV, De Filippo RE, Perin L. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. View in: PubMed

Pavkov ME, Knowler WC, Lemley KV, Mason CC, Myers BD, Nelson RG. Early renal function decline in type 2 diabetes. Clin J Am Soc Nephrol. 2012 Jan; 7(1):78-84. View in: PubMed

Lemley KV. Protecting podocytes: how good do we need to be? Kidney Int. 2012 Jan; 81(1):9-11. View in: PubMed

Lemley KV. Pediatrics: Extracellular volume in children with chronic kidney disease. Nat Rev Nephrol. 2011 Jul; 7(7):366-8. View in: PubMed

Weil EJ, Lemley KV, Yee B, Lovato T, Richardson M, Myers BD, Nelson RG. Podocyte detachment in type 2 diabetic nephropathy. Am J Nephrol. 2011; 33 Suppl 1:21-4. View in: PubMed

Lemley KV. When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetes. Pediatr Nephrol. 2010 Oct; 25(10):2021-34. View in: PubMed

Lemley KV. Pediatrics: how 'minimal' are the adult consequences of childhood MCNS? Nat Rev Nephrol. 2010 Feb; 6(2):70-1. View in: PubMed

Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010; 5(2):e9357. View in: PubMed

Lemley KV. Kidney disease in nail-patella syndrome. Pediatr Nephrol. 2009 Dec; 24(12):2345-54. View in: PubMed

Lemley KV. Pediatric nephrology: Estimating GFR in children: Schwartz redux. Nat Rev Nephrol. 2009 Jun; 5(6):310-1. View in: PubMed

Sanchez-Niño MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley KV, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A. The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol. 2009 Feb; 20(2):353-62. View in: PubMed

Lemley KV. Diabetes and chronic kidney disease: lessons from the Pima Indians. Pediatr Nephrol. 2008 Nov; 23(11):1933-40. View in: PubMed

Lemley KV. Yet more ways to skin a cat: nephrin mutations outside the neonatal period. J Am Soc Nephrol. 2008 Oct; 19(10):1837-8. View in: PubMed

Lemley KV, Lafayette RA, Derby G, Blouch KL, Anderson L, Efron B, Myers BD. Prediction of early progression in recently diagnosed IgA nephropathy. Nephrol Dial Transplant. 2008 Jan; 23(1):213-22. View in: PubMed

Lemley KV. An introduction to biomarkers: applications to chronic kidney disease. Pediatr Nephrol. 2007 Nov; 22(11):1849-59. View in: PubMed

Lemley KV. Neonatal nephrotic presentation of a child with heterozygous NPHS1 mutation. Pediatr Nephrol. 2006 Jun; 21(6):864-6. View in: PubMed

Lemley KV. Can theophylline prevent the development of renal dysfunction in neonates with severe asphyxia? Nat Clin Pract Nephrol. 2006 Apr; 2(4):196-7. View in: PubMed

Lemley KV, Boothroyd DB, Blouch KL, Nelson RG, Jones LI, Olshen RA, Myers BD. Modeling GFR trajectories in diabetic nephropathy. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F863-70. View in: PubMed

Lemley K. Proteinuria or peptiduria: where's the beef? J Lab Clin Med. 2005 May; 145(5):228-30. View in: PubMed

Higgins JP, Wang L, Kambham N, Montgomery K, Mason V, Vogelmann SU, Lemley KV, Brown PO, Brooks JD, van de Rijn M. Gene expression in the normal adult human kidney assessed by complementary DNA microarray. Mol Biol Cell. 2004 Feb; 15(2):649-56. View in: PubMed

Hoang K, Tan JC, Derby G, Blouch KL, Masek M, Ma I, Lemley KV, Myers BD. Determinants of glomerular hypofiltration in aging humans. Kidney Int. 2003 Oct; 64(4):1417-24. View in: PubMed

Vogelmann SU, Nelson WJ, Myers BD, Lemley KV. Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol. 2003 Jul; 285(1):F40-8. View in: PubMed

Lynch SK, Lemley KV, Polak MJ. The effect of dopamine on glomerular filtration rate in normotensive, oliguric premature neonates. Pediatr Nephrol. 2003 Jul; 18(7):649-52. View in: PubMed

Hogg RJ, Furth S, Lemley KV, Portman R, Schwartz GJ, Coresh J, Balk E, Lau J, Levin A, Kausz AT, Eknoyan G, Levey AS. National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification. Pediatrics. 2003 Jun; 111(6 Pt 1):1416-21. View in: PubMed

Lemley KV. A basis for accelerated progression of diabetic nephropathy in Pima Indians. Kidney Int Suppl. 2003 Feb; (83):S38-42. View in: PubMed

Nagata M, Tomari S, Kanemoto K, Usui J, Lemley KV. Podocytes, parietal cells, and glomerular pathology: the role of cell cycle proteins. Pediatr Nephrol. 2003 Jan; 18(1):3-8. View in: PubMed

Lemley KV, Lafayette RA, Safai M, Derby G, Blouch K, Squarer A, Myers BD. Podocytopenia and disease severity in IgA nephropathy. Kidney Int. 2002 Apr; 61(4):1475-85. View in: PubMed

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