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Kevin Verne Lemley, MD, PhD
Professor of Pediatrics (Clinical Scholar)
CHL Mail Stop 40 Off Campus Los Angeles
+1 323 361 2102


My main research interests are in podocyte pathobiology and stereologic methods. My clinical interests are in diabetic kidney disease, nephrotic syndrome, genetic kidney diseases. My health systems interests are in the use of clinical pathways/protocols, outcomes assessment and quality audit, and lean systems.


Combined use of electron microscopy and intravital imaging captures morphological and functional features of podocyte detachment. Pflugers Arch. 2017 Aug; 469(7-8):965-974. View in: PubMed

Potential relevance of shear stress for slit diaphragm and podocyte function. Kidney Int. 2017 Jun; 91(6):1283-1286. View in: PubMed

Mechanical challenges to the glomerular filtration barrier: adaptations and pathway to sclerosis. Pediatr Nephrol. 2017 Mar; 32(3):405-417. View in: PubMed

Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant. 2017 02 27. View in: PubMed

Fetal Serum ß2-Microglobulin and Postnatal Renal Function in Lower Urinary Tract Obstruction Treated with Vesicoamniotic Shunt. Fetal Diagn Ther. 2017; 42(1):17-27. View in: PubMed

Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes. Diabetes. 2016 Dec; 65(12):3744-3753. View in: PubMed

Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes. J Diabetes Complications. 2016 Jul; 30(5):873-9. View in: PubMed

The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome. Pediatrics. 2016 Jul; 138(1). View in: PubMed

Glomerular pathology and the progression of chronic kidney disease. Am J Physiol Renal Physiol. 2016 Jun 01; 310(11):F1385-8. View in: PubMed

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects. J Am Soc Nephrol. 2016 Mar; 27(3):814-23. View in: PubMed

Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes. Clin J Am Soc Nephrol. 2016 Feb 05; 11(2):254-61. View in: PubMed

Complete Remission in the Nephrotic Syndrome Study Network. Clin J Am Soc Nephrol. 2016 Jan 07; 11(1):81-9. View in: PubMed

Morphometry Predicts Early GFR Change in Primary Proteinuric Glomerulopathies: A Longitudinal Cohort Study Using Generalized Estimating Equations. PLoS One. 2016; 11(6):e0157148. View in: PubMed

Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int. 2016 Jan; 89(1):226-34. View in: PubMed

Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes. Semin Nephrol. 2015 May; 35(3):266-78. View in: PubMed

Nephrotic syndrome: Efficacy of rituximab in challenging nephrotic syndrome. Nat Rev Nephrol. 2015 May; 11(5):257-8. View in: PubMed

A potential role for mechanical forces in the detachment of podocytes and the progression of CKD. J Am Soc Nephrol. 2015 Feb; 26(2):258-69. View in: PubMed

Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. Pediatr Res. 2015 Jan; 77(1-2):252-5. View in: PubMed

The importance of clinical pathways and protocols in pediatric nephrology. Pediatr Nephrol. 2014 Oct; 29(10):1903-14. View in: PubMed

An unusual case of hypercalcemia in a patient with renal insufficiency. Pediatr Nephrol. 2014 Sep; 29(9):1529-33. View in: PubMed

LMX1B mutations with nails and kneecaps: a new paradigm? Nephrol Dial Transplant. LMX1B mutations with nails and kneecaps: a new paradigm? Nephrol Dial Transplant. 2014 Jan; 29(1):9-12. View in: PubMed

Effect of losartan on prevention and progression of early diabetic nephropathy in American Indians with type 2 diabetes. Diabetes. 2013 Sep; 62(9):3224-31. View in: PubMed

Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE). Clin J Am Soc Nephrol. 2013 Aug; 8(8):1449-59. View in: PubMed

Comparison of serum cystatin C, serum creatinine, measured GFR, and estimated GFR to assess the risk of kidney failure in American Indians with diabetic nephropathy. Am J Kidney Dis. 2013 Jul; 62(1):33-41. View in: PubMed

Estimation of glomerular podocyte number: a selection of valid methods. J Am Soc Nephrol. 2013 Jul; 24(8):1193-202. View in: PubMed

The authors reply. Kidney Int. 2013 Jun; 83(6):1203. View in: PubMed

Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int. 2013 Apr; 83(4):749-56. View in: PubMed

The podocyte's response to stress: the enigma of foot process effacement. Am J Physiol Renal Physiol. 2013 Feb 15; 304(4):F333-47. View in: PubMed

A novel source of cultured podocytes. PLoS One. 2013; 8(12):e81812. View in: PubMed

Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy. Kidney Int. 2012 Nov; 82(9):1010-7. View in: PubMed

Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. View in: PubMed

Protecting podocytes: how good do we need to be? Kidney Int. Protecting podocytes: how good do we need to be? Kidney Int. 2012 Jan; 81(1):9-11. View in: PubMed

Early renal function decline in type 2 diabetes. Clin J Am Soc Nephrol. 2012 Jan; 7(1):78-84. View in: PubMed

Pediatrics: Extracellular volume in children with chronic kidney disease. Nat Rev Nephrol. 2011 May 24; 7(7):366-8. View in: PubMed

Podocyte detachment in type 2 diabetic nephropathy. Am J Nephrol. 2011; 33 Suppl 1:21-4. View in: PubMed

When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetes. Pediatr Nephrol. 2010 Oct; 25(10):2021-34. View in: PubMed

Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010 Feb 24; 5(2):e9357. View in: PubMed

Pediatrics: how 'minimal' are the adult consequences of childhood MCNS? Nat Rev Nephrol. Pediatrics: how 'minimal' are the adult consequences of childhood MCNS? Nat Rev Nephrol. 2010 Feb; 6(2):70-1. View in: PubMed

Kidney disease in nail-patella syndrome. Pediatr Nephrol. 2009 Dec; 24(12):2345-54. View in: PubMed

Pediatric nephrology: Estimating GFR in children: Schwartz redux. Nat Rev Nephrol. 2009 Jun; 5(6):310-1. View in: PubMed

The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol. 2009 Feb; 20(2):353-62. View in: PubMed

Diabetes and chronic kidney disease: lessons from the Pima Indians. Pediatr Nephrol. 2008 Nov; 23(11):1933-40. View in: PubMed

Yet more ways to skin a cat: nephrin mutations outside the neonatal period. J Am Soc Nephrol. 2008 Oct; 19(10):1837-8. View in: PubMed

Prediction of early progression in recently diagnosed IgA nephropathy. Nephrol Dial Transplant. 2008 Jan; 23(1):213-22. View in: PubMed

An introduction to biomarkers: applications to chronic kidney disease. Pediatr Nephrol. 2007 Nov; 22(11):1849-59. View in: PubMed

Neonatal nephrotic presentation of a child with heterozygous NPHS1 mutation. Pediatr Nephrol. 2006 Jun; 21(6):864-6. View in: PubMed

Can theophylline prevent the development of renal dysfunction in neonates with severe asphyxia? Nat Clin Pract Nephrol. Can theophylline prevent the development of renal dysfunction in neonates with severe asphyxia? Nat Clin Pract Nephrol. 2006 Apr; 2(4):196-7. View in: PubMed

Modeling GFR trajectories in diabetic nephropathy. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F863-70. View in: PubMed

Proteinuria or peptiduria: where's the beef? J Lab Clin Med. Proteinuria or peptiduria: where's the beef? J Lab Clin Med. 2005 May; 145(5):228-30. View in: PubMed

Gene expression in the normal adult human kidney assessed by complementary DNA microarray. Mol Biol Cell. 2004 Feb; 15(2):649-56. View in: PubMed

Determinants of glomerular hypofiltration in aging humans. Kidney Int. 2003 Oct; 64(4):1417-24. View in: PubMed

Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol. 2003 Jul; 285(1):F40-8. View in: PubMed

The effect of dopamine on glomerular filtration rate in normotensive, oliguric premature neonates. Pediatr Nephrol. 2003 Jul; 18(7):649-52. View in: PubMed

National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification. Pediatrics. 2003 Jun; 111(6 Pt 1):1416-21. View in: PubMed

A basis for accelerated progression of diabetic nephropathy in Pima Indians. Kidney Int Suppl. 2003 Feb; (83):S38-42. View in: PubMed

Podocytes, parietal cells, and glomerular pathology: the role of cell cycle proteins. Pediatr Nephrol. 2003 Jan; 18(1):3-8. View in: PubMed

Podocytopenia and disease severity in IgA nephropathy. Kidney Int. 2002 Apr; 61(4):1475-85. View in: PubMed

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