Faculty

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Kian Kani, PhD
Assistant Professor of Research Medicine
Medicine
CSC 240 Off Campus Los Angeles
+1 323 442 2539

Overview

Cancer has been traditionally classified based on the organ site of origin; breast cancer is different from prostate cancer which is distinct from lung cancer and so on. Over the past several years however, cancer research has introduced reclassification of tumors based on the signaling pathway(s) that causes malignant transformation. As a result, medical oncologists can prescribe drugs that specifically target the aberrant signaling pathway irrespective of the location of the tumor.

Modern cancer therapeutics have therefore become “targeted” rather than “systemic.” This has brought upon a significant paradigm shift in medical treatment decisions and spurred oncology research to identify biomarkers indicative of signaling pathway activation. The Kani research group utilizes state-of-the-art proteomic techniques in order to identify and characterize novel cancer biomarkers. Our work focuses on the androgen receptor and human epidermal growth factor receptor signaling axes in prostate, lung, breast, ovarian, and pancreatic cancers. Our goal is to enhance patient outcome by empowering medical oncologist with tools and knowledge necessary for personalized medicine.

Awards

European Molecular Biology Organization: Travel Award, 2009

Department of Biological Chemistry, UCLA: David Sigman Award, 2003

Human Proteome Organization: Outstanding Poster Award, 2008

Thomas Cook Rewards and Recognition Award

University of Hartford: Summa Cum Laude, 1996

University of Hartford: Gengras Academic Scholarship, 1994

University of Hartford: award conferred by, 1996

is primary position

European Molecular Biology Organization: award conferred by, 2009

Human Proteome Organization: award conferred by, 2008

European Molecular Biology Organization: award or honor for, 2009

Department of Biological Chemistry, UCLA: award or honor for, 2003

Human Proteome Organization: award or honor for, 2008

University of Hartford: award or honor for, 1994

award or honor for

University of Hartford: award or honor for, 1996

University of Hartford: full name, 1996

University of Hartford: full name, 1994

Department of Biological Chemistry, UCLA: full name, 2003

full name

European Molecular Biology Organization: full name, 2009

Human Proteome Organization: full name, 2008

European Molecular Biology Organization: person in primary position, 2009

Human Proteome Organization: person in primary position, 2008

person in primary position

University of Hartford: person in primary position, 1996

University of Hartford: person in primary position, 1994

Department of Biological Chemistry, UCLA: person in primary position, 2003

Department of Biological Chemistry, UCLA: last name, 2003

Human Proteome Organization: last name, 2008

University of Hartford: last name, 1996

last name

University of Hartford: last name, 1994

European Molecular Biology Organization: last name, 2009

Human Proteome Organization: HR job title, 2008

University of Hartford: HR job title, 1994

European Molecular Biology Organization: HR job title, 2009

HR job title

University of Hartford: HR job title, 1996

Department of Biological Chemistry, UCLA: HR job title, 2003

University of Hartford: position in department, 1996

Human Proteome Organization: position in department, 2008

Department of Biological Chemistry, UCLA: position in department, 2003

European Molecular Biology Organization: position in department, 2009

position in department

University of Hartford: position in department, 1994

University of Hartford: sort order, 1994

European Molecular Biology Organization: sort order, 2009

sort order

University of Hartford: sort order, 1996

Department of Biological Chemistry, UCLA: sort order, 2003

Human Proteome Organization: sort order, 2008

Human Proteome Organization: Assistant Professor, 2008

University of Hartford: Assistant Professor, 1994

Assistant Professor

Department of Biological Chemistry, UCLA: Assistant Professor, 2003

University of Hartford: Assistant Professor, 1996

European Molecular Biology Organization: Assistant Professor, 2009

Human Proteome Organization: email address, 2008

University of Hartford: email address, 1996

Department of Biological Chemistry, UCLA: email address, 2003

email address

University of Hartford: email address, 1994

European Molecular Biology Organization: email address, 2009

Department of Biological Chemistry, UCLA: start date, 2003

start date

Human Proteome Organization: start date, 2008

European Molecular Biology Organization: start date, 2009

University of Hartford: start date, 1994

University of Hartford: start date, 1996

University of Hartford: type, 1996

University of Hartford: type, 1994

type

European Molecular Biology Organization: type, 2009

University of Hartford: workplace homepage, 1994

workplace homepage

European Molecular Biology Organization: workplace homepage, 2009

Department of Biological Chemistry, UCLA: workplace homepage, 2003

Human Proteome Organization: workplace homepage, 2008

University of Hartford: workplace homepage, 1996

European Molecular Biology Organization: Kani, Kian, 2009

Kani, Kian

University of Hartford: Kani, Kian, 1994

Department of Biological Chemistry, UCLA: Kani, Kian, 2003

University of Hartford: Kani, Kian, 1996

Human Proteome Organization: Kani, Kian, 2008

Faculty Rank

University of Hartford: award conferred by, 1994

Department of Biological Chemistry, UCLA: award conferred by, 2003

European Molecular Biology Organization: Faculty Rank, 2009

University of Hartford: Faculty Rank, 1996

University of Hartford: Faculty Rank, 1994

Department of Biological Chemistry, UCLA: Faculty Rank, 2003

Human Proteome Organization: Faculty Rank, 2008

Human Proteome Organization: is primary position, 2008

University of Hartford: is primary position, 1996

University of Hartford: is primary position, 1994

Department of Biological Chemistry, UCLA: is primary position, 2003

European Molecular Biology Organization: is primary position, 2009

University of Hartford: preferred title, 1994

Department of Biological Chemistry, UCLA: preferred title, 2003

Human Proteome Organization: preferred title, 2008

University of Hartford: preferred title, 1996

European Molecular Biology Organization: preferred title, 2009

preferred title

Agent

University of Hartford: Agent, 1994

European Molecular Biology Organization: Agent, 2009

University of Hartford: Agent, 1996

Department of Biological Chemistry, UCLA: Agent, 2003

University of Hartford: first name, 1994

first name

University of Hartford: first name, 1996

European Molecular Biology Organization: first name, 2009

Human Proteome Organization: first name, 2008

Assistant Professor of Research Medicine

Department of Biological Chemistry, UCLA: Assistant Professor of Research Medicine, 2003

Human Proteome Organization: Assistant Professor of Research Medicine, 2008

University of Hartford: Assistant Professor of Research Medicine, 1994

European Molecular Biology Organization: Assistant Professor of Research Medicine, 2009

University of Hartford: Assistant Professor of Research Medicine, 1996

University of Hartford: Person ID, 1996

University of Hartford: Person ID, 1994

Department of Biological Chemistry, UCLA: Person ID, 2003

Person ID

Human Proteome Organization: Person ID, 2008

European Molecular Biology Organization: Person ID, 2009

Organization

University of Hartford: Organization, 1996

European Molecular Biology Organization: Organization, 2009

Department of Biological Chemistry, UCLA: Organization, 2003

Human Proteome Organization: Organization, 2008

University of Hartford: Organization, 1994

University of Hartford: has faculty rank, 1996

Department of Biological Chemistry, UCLA: has faculty rank, 2003

has faculty rank

European Molecular Biology Organization: has faculty rank, 2009

University of Hartford: has faculty rank, 1994

Human Proteome Organization: has faculty rank, 2008

European Molecular Biology Organization: Medicine, 2009

Human Proteome Organization: Medicine, 2008

Medicine

Department of Biological Chemistry, UCLA: Medicine, 2003

University of Hartford: Keck School of Medicine of USC, 1996

Human Proteome Organization: Keck School of Medicine of USC, 2008

Keck School of Medicine of USC

European Molecular Biology Organization: Keck School of Medicine of USC, 2009

University of Hartford: Keck School of Medicine of USC, 1994

Department of Biological Chemistry, UCLA: Keck School of Medicine of USC, 2003

Human Proteome Organization: Agent, 2008

University of Hartford: Position, 1994

European Molecular Biology Organization: Position, 2009

University of Hartford: Position, 1996

Human Proteome Organization: Position, 2008

Position

Department of Biological Chemistry, UCLA: Position, 2003

Publications

Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells. Endocr Relat Cancer. 2017 Apr; 24(4):157-170. View in: PubMed

Quantitative Proteomics Using SILAC. Methods Mol Biol. 2017; 1550:171-184. View in: PubMed

Simulation of the Protein-Shedding Kinetics of a Fully Vascularized Tumor. Cancer Inform. 2015; 14:163-75. View in: PubMed

Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. Prostate. 2013 Feb 15; 73(3):306-15. View in: PubMed

A cross-platform toolkit for mass spectrometry and proteomics. Nat Biotechnol. 2012 Oct 10; 30(10):918-20. View in: PubMed

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13237-42. View in: PubMed

Quantitative Proteomic Profiling Identifies Protein Correlates to EGFR Kinase Inhibition. Mol Cancer Ther. 2012 May; 11(5):1071-81. View in: PubMed

Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays. Methods Mol Biol. 2012; 795:233-53. View in: PubMed

Model-based discovery of circulating biomarkers. Methods Mol Biol. 2011; 728:87-107. View in: PubMed

Impact of protein stability, cellular localization, and abundance on proteomic detection of tumor-derived proteins in plasma. PLoS One. 2011; 6(7):e23090. View in: PubMed

Precursor-ion mass re-estimation improves peptide identification on hybrid instruments. J Proteome Res. 2008 Sep; 7(9):4031-9. View in: PubMed

The N-terminal domains of neuregulin 1 confer signal attenuation. J Biol Chem. 2006 Sep 15; 281(37):27306-16. View in: PubMed

The extracellular domains of ErbB3 retain high ligand binding affinity at endosome pH and in the locked conformation. Biochemistry. 2005 Dec 6; 44(48):15842-57. View in: PubMed

Oligomers of ERBB3 have two distinct interfaces that differ in their sensitivity to disruption by heregulin. J Biol Chem. 2005 Mar 4; 280(9):8238-47. View in: PubMed

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