Faculty

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Kinji Asahina, PhD
Associate Professor of Research Pathology
Pathology
MMR 402 Health Sciences Campus Los Angeles
+1 323 442 3120

Publications

Lua I, Li Y, Zagory JA, Wang KS, French SW, Sévigny J, Asahina K. Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers. J Hepatol. 2016 May; 64(5):1137-46. View in: PubMed

Lua I, Asahina K. The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration. Gut Liver. 2016 Mar 23; 10(2):166-76. View in: PubMed

Li Y, Lua I, French SW, Asahina K. Role of TGF-ß signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15; 310(4):G262-72. View in: PubMed

He L, Gubbins J, Peng Z, Medina V, Fei F, Asahina K, Wang J, Kahn M, Rountree CB, Stiles BL. Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8. View in: PubMed

Lua I, Li Y, Pappoe LS, Asahina K. Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis. Am J Pathol. 2015 Dec; 185(12):3258-73. View in: PubMed

Li Y, Lua I, Asahina K. MACS Isolation and Culture of Mouse Liver Mesothelial Cells. Bio Protoc. 2015 Jul 5; 3(13). View in: PubMed

Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug 1; 124(8):3566-78. View in: PubMed

Mavila N, James D, Shivakumar P, Nguyen MV, Utley S, Mak K, Wu A, Zhou S, Wang L, Vendyres C, Groff M, Asahina K, Wang KS. Expansion of PROMININ-1-expressing cells in association with fibrosis of biliary atresia. Hepatology. 2014 May 3. View in: PubMed

Lua I, James D, Wang J, Wang KS, Asahina K. Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014 Feb 1. View in: PubMed

Yin C, Evason KJ, Asahina K, Stainier DY. Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest. 2013 May 1; 123(5):1902-10. View in: PubMed

Li Y, Wang J, Asahina K. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2324-9. View in: PubMed

Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang CC, Tsukamoto H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor ? in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81. View in: PubMed

Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H. Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration. J Biol Chem. 2012 Mar 23; 287(13):10355-67. View in: PubMed

Asahina K. Hepatic stellate cell progenitor cells. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:80-4. View in: PubMed

Tsukamoto H, Zhu NL, Wang J, Asahina K, Machida K. Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. View in: PubMed

Ozeki R, Kakinuma S, Asahina K, Shimizu-Saito K, Arii S, Tanaka Y, Teraoka H. Hepatic stellate cells mediate differentiation of dendritic cells from monocytes. J Med Dent Sci. 2012; 59(1):43-52. View in: PubMed

DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. View in: PubMed

Tsukamoto H, Zhu NL, Asahina K, Mann DA, Mann J. Epigenetic cell fate regulation of hepatic stellate cells. Hepatol Res. 2011 Jul; 41(7):675-82. View in: PubMed

Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. View in: PubMed

Shikanai M, Asahina K, Iseki S, Teramoto K, Nishida T, Shimizu-Saito K, Ota M, Eto K, Teraoka H. A novel method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver. Biochem Biophys Res Commun. 2009 Apr 3; 381(2):276-82. View in: PubMed

Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov HM, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. View in: PubMed

Gaucher G, Asahina K, Wang J, Leroux JC. Effect of poly(N-vinyl-pyrrolidone)-block-poly(D,L-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticles. Biomacromolecules. 2009 Feb 9; 10(2):408-16. View in: PubMed

Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 3; 106(5):1548-53. View in: PubMed

Fujimori H, Asahina K, Shimizu-Saito K, Ikeda R, Tanaka Y, Teramoto K, Morita I, Teraoka H. Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells. J Hepatol. 2008 Jun; 48(6):962-73. View in: PubMed

Ikeda R, Nishida T, Watanabe F, Shimizu-Saito K, Asahina K, Horikawa S, Teraoka H. Involvement of CCAAT/enhancer binding protein-beta (C/EBPbeta) in epigenetic regulation of mouse methionine adenosyltransferase 1A gene expression. Int J Biochem Cell Biol. 2008; 40(9):1956-69. View in: PubMed

Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, Tsukamoto H. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. View in: PubMed

Irie T, Asahina K, Shimizu-Saito K, Teramoto K, Arii S, Teraoka H. Hepatic progenitor cells in the mouse extrahepatic bile duct after a bile duct ligation. Stem Cells Dev. 2007 Dec; 16(6):979-87. View in: PubMed

Masaki H, Nishida T, Kitajima S, Asahina K, Teraoka H. Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. J Biol Chem. 2007 Nov 9; 282(45):33034-42. View in: PubMed

Kida Y, Asahina K, Inoue K, Kawada N, Yoshizato K, Wake K, Sato T. Characterization of vitamin A-storing cells in mouse fibrous kidneys using Cygb/STAP as a marker of activated stellate cells. Arch Histol Cytol. 2007 Jul; 70(2):95-106. View in: PubMed

Kida Y, Asahina K, Teraoka H, Gitelman I, Sato T. Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney. J Histochem Cytochem. 2007 Jul; 55(7):661-73. View in: PubMed

Ogawa T, Tateno C, Asahina K, Fujii H, Kawada N, Obara M, Yoshizato K. Identification of vitamin A-free cells in a stellate cell-enriched fraction of normal rat liver as myofibroblasts. Histochem Cell Biol. 2007 Feb; 127(2):161-74. View in: PubMed

Kakinuma S, Asahina K, Okamura K, Teramoto K, Tateno C, Yoshizato K, Tanaka Y, Yasumizu T, Sakamoto N, Watanabe M, Teraoka H. Human cord blood cells transplanted into chronically damaged liver exhibit similar characteristics to functional hepatocytes. Transplant Proc. 2007 Jan-Feb; 39(1):240-3. View in: PubMed

Asahina K, Teramoto K, Teraoka H. Embryonic stem cells: hepatic differentiation and regenerative medicine for the treatment of liver disease. Curr Stem Cell Res Ther. 2006 May; 1(2):139-56. View in: PubMed

Asahina K, Shiokawa M, Ueki T, Yamasaki C, Aratani A, Tateno C, Yoshizato K. Multiplicative mononuclear small hepatocytes in adult rat liver: their isolation as a homogeneous population and localization to periportal zone. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1160-7. View in: PubMed

Sakasai R, Shinohe K, Ichijima Y, Okita N, Shibata A, Asahina K, Teraoka H. Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells. 2006 Mar; 11(3):237-46. View in: PubMed

Okamura K, Asahina K, Fujimori H, Ozeki R, Shimizu-Saito K, Tanaka Y, Teramoto K, Arii S, Takase K, Kataoka M, Soeno Y, Tateno C, Yoshizato K, Teraoka H. Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver. Histochem Cell Biol. 2006 Mar; 125(3):247-57. View in: PubMed

Ichijima Y, Sakasai R, Okita N, Asahina K, Mizutani S, Teraoka H. Phosphorylation of histone H2AX at M phase in human cells without DNA damage response. Biochem Biophys Res Commun. 2005 Oct 28; 336(3):807-12. View in: PubMed

Emoto K, Tateno C, Hino H, Amano H, Imaoka Y, Asahina K, Asahara T, Yoshizato K. Efficient in vivo xenogeneic retroviral vector-mediated gene transduction into human hepatocytes. Hum Gene Ther. 2005 Oct; 16(10):1168-74. View in: PubMed

Kumashiro Y, Asahina K, Ozeki R, Shimizu-Saito K, Tanaka Y, Kida Y, Inoue K, Kaneko M, Sato T, Teramoto K, Arii S, Teraoka H. Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable source. Transplantation. 2005 Mar 15; 79(5):550-7. View in: PubMed

Kumashiro Y, Teramoto K, Shimizu-Saito K, Asahina K, Teraoka H, Arii S. Isolation of hepatocyte-like cells from mouse embryoid body cells. Transplant Proc. 2005 Jan-Feb; 37(1):299-300. View in: PubMed

Teramoto K, Asahina K, Kumashiro Y, Kakinuma S, Chinzei R, Shimizu-Saito K, Tanaka Y, Teraoka H, Arii S. Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cells. J Hepatobiliary Pancreat Surg. 2005; 12(3):196-202. View in: PubMed

Teramoto K, Hara Y, Kumashiro Y, Chinzei R, Tanaka Y, Shimizu-Saito K, Asahina K, Teraoka H, Arii S. Teratoma formation and hepatocyte differentiation in mouse liver transplanted with mouse embryonic stem cell-derived embryoid bodies. Transplant Proc. 2005 Jan-Feb; 37(1):285-6. View in: PubMed

Asahina K, Fujimori H, Shimizu-Saito K, Kumashiro Y, Okamura K, Tanaka Y, Teramoto K, Arii S, Teraoka H. Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells. Genes Cells. 2004 Dec; 9(12):1297-308. View in: PubMed

Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, Tachibana A, Soeno Y, Asahina K, Hino H, Asahara T, Yokoi T, Furukawa T, Yoshizato K. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol. 2004 Sep; 165(3):901-12. View in: PubMed

Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M, Yoshizato K. Characterization of human stellate cell activation-associated protein and its expression in human liver. Biochim Biophys Acta. 2002 Sep 27; 1577(3):471-5. View in: PubMed

Asahina K, Sato H, Yamasaki C, Kataoka M, Shiokawa M, Katayama S, Tateno C, Yoshizato K. Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Am J Pathol. 2002 Jun; 160(6):2191-205. View in: PubMed

Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem. 2001 Jul 6; 276(27):25318-23. View in: PubMed

Utoh R, Asahina K, Suzuki K, Kotani K, Obara M, Yoshizato K. Developmentally and regionally regulated participation of epidermal cells in the formation of collagen lamella of anuran tadpole skin. Dev Growth Differ. 2000 Dec; 42(6):571-80. View in: PubMed

Oomizu S, Sahuc F, Asahina K, Inamatsu M, Matsuzaki T, Sasaki M, Obara M, Yoshizato K. Kdap, a novel gene associated with the stratification of the epithelium. Gene. 2000 Oct 3; 256(1-2):19-27. View in: PubMed

Asahina K, Obara M, Yoshizato K. Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb. Dev Dyn. 1999 Sep; 216(1):59-71. View in: PubMed

Asahina K, Utoh R, Obara M, Yoshizato K. Cell-type specific and thyroid hormone-dependent expression of genes of alpha1(I) and alpha2(I) collagen in intestine during amphibian metamorphosis. Matrix Biol. 1999 Feb; 18(1):89-103. View in: PubMed

Asahina K, Oofusa K, Obara M, Yoshizato K. Cloning and characterization of the full length cDNA encoding alpha2 type I collagen of bullfrog Rana catesbeiana. Gene. 1997 Jul 31; 194(2):283-9. View in: PubMed

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