Faculty

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Kinji Asahina, PhD
Associate Professor of Research Pathology
Pathology
MMR 402 Health Sciences Campus Los Angeles
+1 323 442 3120

Publications

The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration. Gut Liver. 2016 Mar 23; 10(2):166-76. View in: PubMed

Role of TGF-ß signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15; 310(4):G262-72. View in: PubMed

Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8. View in: PubMed

Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis. Am J Pathol. 2015 Dec; 185(12):3258-73. View in: PubMed

MACS Isolation and Culture of Mouse Liver Mesothelial Cells. Bio Protoc. 2015 Jul 5; 3(13). View in: PubMed

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug 1; 124(8):3566-78. View in: PubMed

Expansion of PROMININ-1-expressing cells in association with fibrosis of biliary atresia. Hepatology. 2014 May 3. View in: PubMed

Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014 Feb 1. View in: PubMed

Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest. 2013 May 1; 123(5):1902-10. View in: PubMed

Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2324-9. View in: PubMed

Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor ? in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81. View in: PubMed

Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration. J Biol Chem. 2012 Mar 23; 287(13):10355-67. View in: PubMed

Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. View in: PubMed

Hepatic stellate cell progenitor cells. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:80-4. View in: PubMed

Hepatic stellate cells mediate differentiation of dendritic cells from monocytes. J Med Dent Sci. 2012; 59(1):43-52. View in: PubMed

15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. View in: PubMed

Epigenetic cell fate regulation of hepatic stellate cells. Hepatol Res. 2011 Jul; 41(7):675-82. View in: PubMed

Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. View in: PubMed

A novel method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver. Biochem Biophys Res Commun. 2009 Apr 3; 381(2):276-82. View in: PubMed

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. View in: PubMed

Effect of poly(N-vinyl-pyrrolidone)-block-poly(D,L-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticles. Biomacromolecules. 2009 Feb 9; 10(2):408-16. View in: PubMed

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 3; 106(5):1548-53. View in: PubMed

Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells. J Hepatol. 2008 Jun; 48(6):962-73. View in: PubMed

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. View in: PubMed

Involvement of CCAAT/enhancer binding protein-beta (C/EBPbeta) in epigenetic regulation of mouse methionine adenosyltransferase 1A gene expression. Int J Biochem Cell Biol. 2008; 40(9):1956-69. View in: PubMed

Hepatic progenitor cells in the mouse extrahepatic bile duct after a bile duct ligation. Stem Cells Dev. 2007 Dec; 16(6):979-87. View in: PubMed

Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. J Biol Chem. 2007 Nov 9; 282(45):33034-42. View in: PubMed

Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney. J Histochem Cytochem. 2007 Jul; 55(7):661-73. View in: PubMed

Characterization of vitamin A-storing cells in mouse fibrous kidneys using Cygb/STAP as a marker of activated stellate cells. Arch Histol Cytol. 2007 Jul; 70(2):95-106. View in: PubMed

Identification of vitamin A-free cells in a stellate cell-enriched fraction of normal rat liver as myofibroblasts. Histochem Cell Biol. 2007 Feb; 127(2):161-74. View in: PubMed

Human cord blood cells transplanted into chronically damaged liver exhibit similar characteristics to functional hepatocytes. Transplant Proc. 2007 Jan-Feb; 39(1):240-3. View in: PubMed

Embryonic stem cells: hepatic differentiation and regenerative medicine for the treatment of liver disease. Curr Stem Cell Res Ther. 2006 May; 1(2):139-56. View in: PubMed

Multiplicative mononuclear small hepatocytes in adult rat liver: their isolation as a homogeneous population and localization to periportal zone. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1160-7. View in: PubMed

Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver. Histochem Cell Biol. 2006 Mar; 125(3):247-57. View in: PubMed

Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells. 2006 Mar; 11(3):237-46. View in: PubMed

Sakasai R, Shinohe K, Ichijima Y, Okita N, Shibata A, Asahina K, Teraoka H. Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylataon of replicatign protein A2 in response to repdication-mediated DNA double-strand breaks. Genes Cells. 2006 Mar; 11(3):237-46. 4/prns:informatignResourceReferefce>. View in: PubMed

Phosphorylation of histone H2AX at M phase in human cells without DNA damage response. Biochem Biophys Res Commun. 2005 Oct 28; 336(3):807-12. View in: PubMed

Efficient in vivo xenogeneic retroviral vector-mediated gene transduction into human hepatocytes. Hum Gene Ther. 2005 Oct; 16(10):1168-74. View in: PubMed

Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable source. Transplantation. 2005 Mar 15; 79(5):550-7. View in: PubMed

Isolation of hepatocyte-like cells from mouse embryoid body cells. Transplant Proc. 2005 Jan-Feb; 37(1):299-300. View in: PubMed

Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cells. J Hepatobiliary Pancreat Surg. 2005; 12(3):196-202. View in: PubMed

Teratoma formation and hepatocyte differentiation in mouse liver transplanted with mouse embryonic stem cell-derived embryoid bodies. Transplant Proc. 2005 Jan-Feb; 37(1):285-6. View in: PubMed

Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells. Genes Cells. 2004 Dec; 9(12):1297-308. View in: PubMed

Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol. 2004 Sep; 165(3):901-12. View in: PubMed

Characterization of human stellate cell activation-associated protein and its expression in human liver. Biochim Biophys Acta. 2002 Sep 27; 1577(3):471-5. View in: PubMed

Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Am J Pathol. 2002 Jun; 160(6):2191-205. View in: PubMed

Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem. 2001 Jul 6; 276(27):25318-23. View in: PubMed

Developmentally and regionally regulated participation of epidermal cells in the formation of collagen lamella of anuran tadpole skin. Dev Growth Differ. 2000 Dec; 42(6):571-80. View in: PubMed

Kdap, a novel gene associated with the stratification of the epithelium. Gene. 2000 Oct 3; 256(1-2):19-27. View in: PubMed

Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb. Dev Dyn. 1999 Sep; 216(1):59-71. View in: PubMed

Cell-type specific and thyroid hormone-dependent expression of genes of alpha1(I) and alpha2(I) collagen in intestine during amphibian metamorphosis. Matrix Biol. 1999 Feb; 18(1):89-103. View in: PubMed

Cloning and characterization of the full length cDNA encoding alpha2 type I collagen of bullfrog Rana catesbeiana. Gene. 1997 Jul 31; 194(2):283-9. View in: PubMed

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