Faculty

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Laurie D. De Leve, MD, PhD
Professor of Medicine
Senior Associate Chair For Scientific Affairs, Department of Medicine
Medicine
HMR 603 Off Campus Los Angeles
+1 323 442 3248

Overview

Dr. DeLeve's clinical interests include general gastroenterology, colon cancer screening, irritable bowel syndrome, drug-induced liver disease. Her research interests include the role of liver sinusoidal endothelial cell in liver injury recovery and liver fibrosis and drug-induced liver injury.

Born in New York City and raised in the Netherlands, Dr. DeLeve obtained a PhD in Pharmacology from the University of Toronto after receiving her medical degree from the Erasmus University of Rotterdam. Following her residency at the University of Michigan and fellowship at UCLA, Dr. DeLeve joined the Keck School of Medicine as an Assistant Professor in 1990.

Awards

Alpha Omega Alpha: Teaching Award, 2005

USC: Mellon Mentoring Award for Faculty Mentoring Faculty, 2015

Western Society for Clinical Investigation: Outstanding Investigator Award, 2008

Publications

DeLeve LD, Wang X, Wang L. VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2016 May 1; 310(9):G739-46. View in: PubMed

DeLeve LD. Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 2015 May; 61(5):1740-6. View in: PubMed

Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Control Release. 2014 Oct 10; 191:15-23. View in: PubMed

DeLeve LD. Liver sinusoidal endothelial cells and liver regeneration. J Clin Invest. 2013 May 1; 123(5):1861-6. View in: PubMed

Tallman MS, McDonald GB, DeLeve LD, Baer MR, Cook MN, Graepel GJ, Kollmer C. Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice. Int J Hematol. 2013 Apr; 97(4):456-64. View in: PubMed

Wang L, Wang X, Wang L, Chiu JD, van de Ven G, Gaarde WA, Deleve LD. Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology. 2012 Dec; 143(6):1555-1563. e2. View in: PubMed

Wang L, Wang X, Xie G, Wang L, Hill CK, Deleve LD. Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J Clin Invest. 2012 Apr 2; 122(4):1567-73. View in: PubMed

Xie G, Wang X, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA, Deleve LD. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 2012 Apr; 142(4):918-927. e6. View in: PubMed

DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. View in: PubMed

Warren A, Cogger VC, Fraser R, Deleve LD, McCuskey RS, Le Couteur DG. The effects of old age on hepatic stellate cells. Curr Gerontol Geriatr Res. 2011; 2011:439835. View in: PubMed

Xie G, Wang L, Wang X, Wang L, DeLeve LD. Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1204-10. View in: PubMed

Cogger VC, McNerney GP, Nyunt T, DeLeve LD, McCourt P, Smedsrød B, Le Couteur DG, Huser TR. Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. J Struct Biol. 2010 Sep; 171(3):382-8. View in: PubMed

Harb R, Xie G, Lutzko C, Guo Y, Wang X, Hill CK, Kanel GC, DeLeve LD. Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology. 2009 Aug; 137(2):704-12. View in: PubMed

DeLeve LD, Valla DC, Garcia-Tsao G. Vascular disorders of the liver. Hepatology. 2009 May; 49(5):1729-64. View in: PubMed

DeLeve LD, Wang X, Kanel GC, Atkinson RD, McCuskey RS. Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 2008 Oct; 173(4):993-1001. View in: PubMed

Deleve LD, Wang X, Guo Y. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology. 2008 Sep; 48(3):920-30. View in: PubMed

Deleve LD. Sinusoidal obstruction syndrome. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):101-3. View in: PubMed

DeLeve LD. Hepatic microvasculature in liver injury. Semin Liver Dis. 2007 Nov; 27(4):390-400. View in: PubMed

DeLeve LD, Wang X, McCuskey MK, McCuskey RS. Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates. Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1187-9. View in: PubMed

McCuskey RS, Bethea NW, Wong J, McCuskey MK, Abril ER, Wang X, Ito Y, DeLeve LD. Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol. 2005 Mar; 42(3):371-7. View in: PubMed

DeLeve LD, Wang X, Hu L, McCuskey MK, McCuskey RS. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G757-63. View in: PubMed

Adams PC, Arthur MJ, Boyer TD, DeLeve LD, Di Bisceglie AM, Hall M, Levin TR, Provenzale D, Seeff L. Screening in liver disease: report of an AASLD clinical workshop. Hepatology. 2004 May; 39(5):1204-12. View in: PubMed

DeLeve LD, Wang X, Kanel GC, Ito Y, Bethea NW, McCuskey MK, Tokes ZA, Tsai J, McCuskey RS. Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology. 2003 Oct; 38(4):900-8. View in: PubMed

Deleve LD, Wang X, Tsai J, Kanel G, Strasberg S, Tokes ZA. Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology. 2003 Sep; 125(3):882-90. View in: PubMed

DeLeve LD, Ito Y, Bethea NW, McCuskey MK, Wang X, McCuskey RS. Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6):G1045-52. View in: PubMed

Kumar S, DeLeve LD, Kamath PS, Tefferi A. Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. Mayo Clin Proc. 2003 May; 78(5):589-98. View in: PubMed

DeLeve LD. Vascular liver diseases. Curr Gastroenterol Rep. 2003 Feb; 5(1):63-70. View in: PubMed

Poreddy V, DeLeve LD. Hepatic circulatory diseases associated with chronic myeloid disorders. Clin Liver Dis. 2002 Nov; 6(4):909-31. View in: PubMed

DeLeve LD, Shulman HM, McDonald GB. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis. 2002 Feb; 22(1):27-42. View in: PubMed

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