Faculty

Back to Index
Laurie D. De Leve, MD, PhD
Professor of Medicine
Senior Associate Chair For Scientific Affairs, Department of Medicine
Medicine
HMR 603 Health Sciences Campus Los Angeles
+1 323 442 3248

Overview

Dr. DeLeve's clinical interests include general gastroenterology, colon cancer screening, irritable bowel syndrome, drug-induced liver disease. Her research interests include the role of liver sinusoidal endothelial cell in liver injury recovery and liver fibrosis and drug-induced liver injury.

Born in New York City and raised in the Netherlands, Dr. DeLeve obtained a PhD in Pharmacology from the University of Toronto after receiving her medical degree from the Erasmus University of Rotterdam. Following her residency at the University of Michigan and fellowship at UCLA, Dr. DeLeve joined the Keck School of Medicine as an Assistant Professor in 1990.

Awards

USC: Mellon Mentoring Award for Faculty Mentoring Faculty, 2015

Western Society for Clinical Investigation: Outstanding Investigator Award, 2008

Alpha Omega Alpha: Teaching Award, 2005

Publications

VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2016 May 1; 310(9):G739-46. View in: PubMed

Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 2015 May; 61(5):1740-6. View in: PubMed

An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Control Release. 2014 Oct 10; 191:15-23. View in: PubMed

Liver sinusoidal endothelial cells and liver regeneration. J Clin Invest. 2013 May 1; 123(5):1861-6. View in: PubMed

Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice. Int J Hematol. 2013 Apr; 97(4):456-64. View in: PubMed

Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology. 2012 Dec; 143(6):1555-1563. e2. View in: PubMed

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J Clin Invest. 2012 Apr 2; 122(4):1567-73. View in: PubMed

Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 2012 Apr; 142(4):918-927. e6. View in: PubMed

15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. View in: PubMed

The effects of old age on hepatic stellate cells. Curr Gerontol Geriatr Res. 2011; 2011:439835. View in: PubMed

Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1204-10. View in: PubMed

Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. J Struct Biol. 2010 Sep; 171(3):382-8. View in: PubMed

Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology. 2009 Aug; 137(2):704-12. View in: PubMed

Vascular disorders of the liver. Hepatology. 2009 May; 49(5):1729-64. View in: PubMed

Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 2008 Oct; 173(4):993-1001. View in: PubMed

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology. 2008 Sep; 48(3):920-30. View in: PubMed

Sinusoidal obstruction syndrome. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):101-3. View in: PubMed

Hepatic microvasculature in liver injury. Semin Liver Dis. 2007 Nov; 27(4):390-400. View in: PubMed

Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates. Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1187-9. View in: PubMed

Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol. 2005 Mar; 42(3):371-7. View in: PubMed

Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G757-63. View in: PubMed

Screening in liver disease: report of an AASLD clinical workshop. Hepatology. 2004 May; 39(5):1204-12. View in: PubMed

Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology. 2003 Oct; 38(4):900-8. View in: PubMed

Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology. 2003 Sep; 125(3):882-90. View in: PubMed

Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6):G1045-52. View in: PubMed

Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. Mayo Clin Proc. 2003 May; 78(5):589-98. View in: PubMed

Vascular liver diseases. Curr Gastroenterol Rep. 2003 Feb; 5(1):63-70. View in: PubMed

Hepatic circulatory diseases associated with chronic myeloid disorders. Clin Liver Dis. 2002 Nov; 6(4):909-31. View in: PubMed

Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis. 2002 Feb; 22(1):27-42. View in: PubMed

Hepatic venoocclusive disease: a major complication of hematopoietic stem cell transplantation in cancer patients. Tumori. 2001 Mar-Apr; 87(2):S27-9. View in: PubMed

Role of oxidative stress and glutathione in busulfan toxicity in cultured murine hepatocytes. Pharmacology. 2000 Apr; 60(3):143-54. View in: PubMed

Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology. 2000 Feb; 31(2):428-34. View in: PubMed

Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology. 1999 Jun; 29(6):1779-91. View in: PubMed

Glutathione defense in non-parenchymal cells. Semin Liver Dis. 1998; 18(4):403-13. View in: PubMed

Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 9; 53(9):1339-45. View in: PubMed

Effect of decreased glutathione levels in hereditary glutathione synthetase deficiency on dibromoethane-induced genotoxicity in human fibroblasts. Mutat Res. 1997 Mar 17; 389(2-3):291-7. View in: PubMed

Dinitrochlorobenzene is genotoxic by sister chromatid exchange in human skin fibroblasts. Mutat Res. 1996 Nov 4; 371(1-2):105-8. View in: PubMed

Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology. 1996 Oct; 24(4):830-7. View in: PubMed

Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology. 1996 Mar; 23(3):589-99. View in: PubMed

Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. View in: PubMed

Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A. J Pharmacol Exp Ther. 1995 Apr; 273(1):545-53. View in: PubMed

Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense. J Pharmacol Exp Ther. 1994 Mar; 268(3):1261-70. View in: PubMed

Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991 Dec; 52(3):287-305. View in: PubMed

Importance and regulation of hepatic glutathione. Semin Liver Dis. 1990 Nov; 10(4):251-66. View in: PubMed

Beta-blockade disappearance rate predicts beta-adrenergic hypersensitivity. Clin Pharmacol Ther. 1989 Sep; 46(3):279-90. View in: PubMed

Plasma concentration-response relationships of two formulations of propranolol. J Clin Pharmacol. 1985 Apr; 25(3):182-6. View in: PubMed

Nonselective beta-blockade enhances pressor responsiveness to epinephrine, norepinephrine, and angiotensin II in normal man. Clin Pharmacol Ther. 1984 Apr; 35(4):461-6. View in: PubMed

Nonselective beta-receptor stimulation and blockade and left ventricular function. Clin Pharmacol Ther. 1983 Nov; 34(5):570-5. View in: PubMed

Powered bySC CTSI