Faculty

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Leo Mascarenhas, MD
Associate Professor of Clinical Pediatrics
Section Head, Oncology
Director Solid Tumor Program
Director of Clinical Trials office
Pediatrics
CHL 4650 W Sunset Boulevard Off Campus Los Angeles
+1 323 361 2529

Overview

Leo Mascarenhas, MD is director of the Clinical Trials Office in the Children’s Center for Cancer and Blood Diseases and Principal Investigator for the National Cancer Institute funded Children’s Oncology Group grant at Children’s Hospital Los Angeles. He is an associate professor of Clinical Pediatrics at the Keck School of Medicine of the University of Southern California.

Childhood cancer is the leading cause of disease-related death in pediatrics in the United States. Dr. Mascarenhas and his team's research focuses on developmental therapeutics for patients with bone and soft tissue sarcomas. Despite the remarkable progress made in the treatment of childhood cancer in the last four decades, improved therapies are still needed for our patients with a poor prognosis and less toxic therapies for those destined to survive. This can be accomplished only through basic, translational and clinical research.

Publications

Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1. J Clin Oncol. 2017 Mar 24; JCO2016717579. View in: PubMed

Comparison of self-report and electronic monitoring of 6MP intake in childhood ALL: A Children's Oncology Group study. Blood. 2017 Feb 02. View in: PubMed

Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2016 Mar; 63(3):493-8. View in: PubMed

Pediatric phase I trial of oral sorafenib and topotecan in refractory or recurrent pediatric solid malignancies. Cancer Med. 2016 Feb; 5(2):294-303. View in: PubMed

Pilot Feasibility Study of Comprehensive Pulmonary Evaluation Following Lung Radiation Therapy. J Pediatr Hematol Oncol. 2015 Oct; 37(7):e412-8. View in: PubMed

Zoledronic Acid for the Treatment of Children With Refractory Central Giant Cell Granuloma. J Pediatr Hematol Oncol. 2015 Aug; 37(6):e399-401. View in: PubMed

Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma. J Pediatr Hematol Oncol. 2015 Aug; 37(6):e356-60. View in: PubMed

Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation. Pediatr Pulmonol. 2015 Jun; 50(6):596-603. View in: PubMed

Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study. JAMA Oncol. 2015 Jun 1; 1(3):287-95. View in: PubMed

Hepatoblastoma in a patient with methylmalonic aciduria. Am J Med Genet A. 2015 Mar; 167(3):635-8. View in: PubMed

Sarcomas. Pediatr Clin North Am. 2015 Feb; 62(1):179-200. View in: PubMed

Oxaliplatin and Doxorubicin for relapsed or refractory high-risk neuroblastoma. Pediatr Hematol Oncol. 2015 Feb; 32(1):26-31. View in: PubMed

Is INI1-retained small cell undifferentiated histology in hepatoblastoma unfavorable? Hum Pathol. Is INI1-retained small cell undifferentiated histology in hepatoblastoma unfavorable? Hum Pathol. 2015 Jan 14. View in: PubMed

Effect of neoadjuvant chemotherapy on resectability of stage III and IV hepatoblastoma. Br J Surg. 2015 Jan; 102(1):108-13. View in: PubMed

Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors. Clin Cancer Res. 2014 Dec 15; 20(24):6314-23. View in: PubMed

De novo congenital melanoma: analysis of 2 cases with array comparative genomic hybridization. Am J Dermatopathol. 2014 Nov; 36(11):915-9. View in: PubMed

Pulmonary function abnormalities in childhood cancer survivors treated with bleomycin. Pediatr Blood Cancer. 2014 Sep; 61(9):1679-84. View in: PubMed

High dose alkylator therapy for extracranial malignant rhabdoid tumors in children. Pediatr Blood Cancer. 2014 Aug; 61(8):1357-61. View in: PubMed

Hepatoblastoma and hypoplastic kidneys: A new association. Pediatr Blood Cancer. 2014 Aug; 61(8):1476-8. View in: PubMed

Successful treatment of recurrent metastatic nasopharyngeal carcinoma with oxaliplatin and Doxorubicin. J Pediatr Hematol Oncol. 2014 Jul; 36(5):e307-9. View in: PubMed

Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. View in: PubMed

Carnitine and cardiac dysfunction in childhood cancer survivors treated with anthracyclines. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1109-14. View in: PubMed

Nuclear protein in testis midline carcinoma misdiagnosed as adamantinoma. J Clin Oncol. 2014 May 20; 32(15):e57-60. View in: PubMed

Treatment of multiply relapsed wilms tumor with vincristine, irinotecan, temozolomide and bevacizumab. Pediatr Blood Cancer. 2014 Apr; 61(4):756-9. View in: PubMed

Hepatoblastoma in a 15-month-old female with trisomy 13. Am J Med Genet A. 2014 Feb; 164(2):472-5. View in: PubMed

Inflammatory myofibroblastic tumors in childhood. Pediatr Hematol Oncol. 2013 Oct; 30(7):640-5. View in: PubMed

Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 1; 86(5):942-8. View in: PubMed

A phase I study of oxaliplatin and doxorubicin in pediatric patients with relapsed or refractory extracranial non-hematopoietic solid tumors. Pediatr Blood Cancer. 2013 Jul; 60(7):1103-7. View in: PubMed

Ewing sarcoma of the tibia mimicking fibrous dysplasia. J Pediatr Orthop B. 2013 May; 22(3):222-7. View in: PubMed

Orthopaedic case of the month: A 14-year-old boy with a medial thigh soft tissue mass. Clin Orthop Relat Res. 2013 May; 471(5):1433-8. View in: PubMed

A phase I study of vincristine, irinotecan, temozolomide and bevacizumab (vitb) in pediatric patients with relapsed solid tumors. PLoS One. 2013; 8(7):e68416. View in: PubMed

Tumor necrosis predicts survival following neo-adjuvant chemotherapy for hepatoblastoma. Pediatr Blood Cancer. 2012 Sep; 59(3):493-8. View in: PubMed

Pleuropulmonary Blastoma: A Single-institution Experience. J Pediatr Hematol Oncol. 2012 Jul; 34(5):e182-5. View in: PubMed

Correlation of long-term pulmonary injury with radiation dose distribution in childhood cancer survivors. Pract Radiat Oncol. 2012 Jul-Sep; 2(3):237-40. View in: PubMed

Nonadherence to Oral Mercaptopurine and Risk of Relapse in Hispanic and Non-Hispanic White Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group. J Clin Oncol. 2012 Jun 10; 30(17):2094-101. View in: PubMed

Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011 Dec 1; 57(6):939-42. View in: PubMed

Gorham's disease and diffuse lymphangiomatosis in children and adolescents. Pediatr Blood Cancer. 2011 Apr; 56(4):667-70. View in: PubMed

Expanded Access Through Cancer Trials Support Unit to Children's Oncology Group Sarcoma Trial AEWS1031 for Adolescents and Young Adults. J Adolesc Young Adult Oncol. 2011 Mar; 1(1):61-3. View in: PubMed

Randomized phase II window trial of two schedules of irinotecan with vincristine in patients with first relapse or progression of rhabdomyosarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2010 Oct 20; 28(30):4658-63. View in: PubMed

Recurrent and refractory giant cell tumor of the jaw. J Craniofac Surg. 2009 Nov; 20(6):2245-8. View in: PubMed

Effect of time to resumption of chemotherapy after definitive surgery on prognosis for non-metastatic osteosarcoma. J Bone Joint Surg Am. 2009 Mar 1; 91(3):604-12. View in: PubMed

Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2008 Sep; 51(3):334-8. View in: PubMed

Invasive diagnostic procedures for pulmonary infiltrates in pediatric hematopoietic stem cell transplant recipients. Pediatr Transplant. 2007 Nov; 11(7):736-42. View in: PubMed

Extracranial malignant rhabdoid tumors in childhood: the Childrens Hospital Los Angeles experience. Cancer. 2007 Nov 1; 110(9):2061-6. View in: PubMed

Treatment of infantile choriocarcinoma of the liver. Pediatr Blood Cancer. 2007 Jul; 49(1):99-102. View in: PubMed

Severe methotrexate toxicity precipitated by intravenous radiographic contrast. J Pediatr Hematol Oncol. 2007 Jul; 29(7):496-9. View in: PubMed

Evaluation of persistent pulmonary infiltrates in pediatric oncology patients. Pediatr Blood Cancer. 2007 Feb; 48(2):165-72. View in: PubMed

Transient myeloproliferative disorder in a phenotypically normal infant with i(21q) mosaicism. Cancer Genet Cytogenet. 2002 Jul 15; 136(2):138-40. View in: PubMed

Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage- colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses. Blood. 2000 Aug 15; 96(4):1317-26. View in: PubMed

Gene delivery to human B-precursor acute lymphoblastic leukemia cells. Blood. 1998 Nov 15; 92(10):3537-45. View in: PubMed

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