Faculty

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Linda S. Sher, MD
Professor of Clinical Surgery
Vice Chair, HSC Irb
Division Chief, Clinical Research
Surgery
HCC 200 Health Sciences Campus Los Angeles
+1 323 442 5908

Overview

Dr. Sher is a Professor of Clinical Surgery and Director of Clinical Research in the Division of Hepatobiliary Surgery and Abdominal Organ Transplantation at Keck School of Medicine of USC. After completing her medical school education and surgical residency at Mount Sinai School of Medicine in New York, Dr. Sher undertook her fellowship training in Liver and Kidney Transplantation at the University of Pittsburgh. Following her fellowship in 1988, Dr. Sher was involved in the establishment of two liver transplant programs in Los Angeles prior to joining the USC program in 2001.

Dr. Sher has participated in and overseen over 50 research projects and is currently very active in the development of the clinical and basic science research components of the USC Abdominal Organ Transplantation Program. She has numerous publications on immunosuppression, chronic rejection, disease recurrence, infection, and prophylaxis and hepatobiliary surgery. Dr. Sher is one of the original editors of Current Opinion in Organ Transplantation and has endeavored over the years to provide the reader with an up to date overview of the entire field of organ transplantation.

Awards

Southeastern Surgical Congress: Society Membership, 1996-2014

American Liver Foundation: Society Membership, 1995-2014

International Liver Transplantation Society: Society Membership, 1993-2014

American Society of Transplant Surgeons: Society Membership, 1993-2014

American College of Surgeons : Society Membership, 1992-2014

International Transplantation Society: Society Membership, 1991-2014

Western Association for Transplant Surgeons: Society Membership , 1990-2014

Los Angeles Surgical Society: Society Membership, 1990-2014

American Association for the Study of Liver Diseases: Society Membership , 1990-2014

United Liver Association: Society Membership, 1990-1997

American Society of Transplantation: Society Membership , 1989-2014

University of Pittsburgh: Fellowship, 1986-1988

Mount Sinai Hospital: Fellowship, 1982-1983

American Medical Association: Society Membership , 1981-2014

Publications

Complicated gallstone disease: diagnosis and management of Mirizzi syndrome. Surg Endosc. 2016 Sep 01. View in: PubMed

TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice. Gastroenterology. 2016 Mar; 150(3):707-19. View in: PubMed

Fibrin Sealant Patch (TachoSil) vs Oxidized Regenerated Cellulose Patch (Surgicel Original) for the Secondary Treatment of Local Bleeding in Patients Undergoing Hepatic Resection: A Randomized Controlled Trial. J Am Coll Surg. 2016 Mar; 222(3):261-8. View in: PubMed

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism. Cell Metab. 2016 Jan 12; 23(1):206-19. View in: PubMed

A multicenter study of 30 days complications after deceased donor liver transplantation in the model for end-stage liver disease score era. Liver Transpl. 2015 Sep; 21(9):1160-8. View in: PubMed

Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables. J Surg Oncol. 2015 Aug; 112(2):125-32. View in: PubMed

Phase II study of avatrombopag in thrombocytopenic patients with cirrhosis undergoing an elective procedure. J Hepatol. 2014 Dec; 61(6):1253-9. View in: PubMed

Imaging Appearance in Acute Liver Failure: Correlation with Clinical and Pathology Findings. Dig Dis Sci. 2014 Apr 2. View in: PubMed

Suicide attempts in major depressed patients with personality disorder. Suicide Life Threat Behav. 2014 Apr; 44(2):155-66. View in: PubMed

Impact of living with bipolar patients: Making sense of caregivers' burden. World J Psychiatry. 2014 Mar 22; 4(1):1-12. View in: PubMed

Bipolar disorder, testosterone administration, and homicide: A case report. Int J Psychiatry Clin Pract. 2014 Mar 16. View in: PubMed

Do testosterone and brain-derived neurotrophic factor interactions play a role in the pathophysiology of suicidal behavior? Aust N Z J Psychiatry. Do testosterone and brain-derived neurotrophic factor interactions play a role in the pathophysiology of suicidal behavior? Aust N Z J Psychiatry. 2014 Mar; 48(3):290-1. View in: PubMed

Testosterone and homicidal behavior. Aust N Z J Psychiatry. 2014 Mar; 48(3):290. View in: PubMed

Alcohol, testosterone and suicide. Aust N Z J Psychiatry. 2014 Feb 24; 48(7):688-689. View in: PubMed

Cortisol response to cosyntropin administration in military veterans with or without posttraumatic stress disorder. Psychoneuroendocrinology. 2014 Feb; 40:151-8. View in: PubMed

Sociodemographic and clinical differences between suicide ideators and attempters: a study of mood disordered patients 50 years and older. Suicide Life Threat Behav. 2014 Feb; 44(1):34-45. View in: PubMed

The impact of periventricular white matter lesions in patients with bipolar disorder type I. CNS Spectr. 2014 Jan 10; 1-12. View in: PubMed

Psychiatric pathology and suicide risk in patients with cancer. J Psychosoc Oncol. 2014; 32(4):383-95. View in: PubMed

Predictive factors of neurological complications and one-month mortality after liver transplantation. Front Neurol. 2014; 5:275. View in: PubMed

Suicidal behavior in military veterans and health care professionals. Aust N Z J Psychiatry. 2013 Dec 23; 48(6):589. View in: PubMed

Combined dexamethasone suppression-corticotrophin-releasing hormone stimulation test in medication-free major depression and healthy volunteers. J Affect Disord. 2013 Dec; 151(3):1108-12. View in: PubMed

Posttraumatic stress disorder and suicide risk among veterans: a literature review. J Nerv Ment Dis. 2013 Sep; 201(9):802-12. View in: PubMed

Psychological autopsy studies: past, present, and future. Aust N Z J Psychiatry. 2013 Sep; 47(9):884. View in: PubMed

Epidemiology of suicide in bipolar disorders: a systematic review of the literature. Bipolar Disord. 2013 Aug; 15(5):457-90. View in: PubMed

Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: a critical review. World J Biol Psychiatry. 2013 Aug; 14(6):412-31. View in: PubMed

Calcineurin inhibitor-free mycophenolate mofetil/sirolimus maintenance in liver transplantation: the randomized spare-the-nephron trial. Liver Transpl. 2013 Jul; 19(7):675-89. View in: PubMed

Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells. J Clin Invest. 2013 Jul 1; 123(7):2832-49. View in: PubMed

Renal function at two years in liver transplant patients receiving everolimus: results of a randomized, multicenter study. Am J Transplant. 2013 Jul; 13(7):1734-45. View in: PubMed

Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013 Jun 27; 368(26):2455-66. View in: PubMed

High and low testosterone levels may be associated with suicidal behavior in young and older men, respectively. Aust N Z J Psychiatry. 2013 May; 47(5):492-3. View in: PubMed

Killing in combat and suicide risk. Eur Psychiatry. 2013 May; 28(4):261. View in: PubMed

Suicidal Behavior and Neurological Illnesses. J Depress Anxiety. 2013 Apr 18; Suppl 9(1). View in: PubMed

Mortality following treatment for cannabis use disorders: predictors and causes. J Subst Abuse Treat. 2013 Apr; 44(4):400-6. View in: PubMed

Cognitive effects of quetiapine in a patient with dementia with Lewy bodies. Psychogeriatrics. 2013 Mar; 13(1):52-7. View in: PubMed

Outcomes after liver transplantation in patients achieving a model for end-stage liver disease score of 40 or higher. Transplantation. 2013 Feb 15; 95(3):507-12. View in: PubMed

Educating medical professionals about suicide prevention among military veterans. Int J Adolesc Med Health. 2013; 25(3):187-91. View in: PubMed

Military sexual trauma as a determinant in the development of mental and physical illness in male and female veterans. Int J Adolesc Med Health. 2013; 25(3):269-74. View in: PubMed

Dating violence and suicidal behavior in adolescents. Int J Adolesc Med Health. 2013; 25(3):257-61. View in: PubMed

Low testosterone levels may be associated with suicidal behavior in older men while high testosterone levels may be related to suicidal behavior in adolescents and young adults: a hypothesis. Int J Adolesc Med Health. 2013; 25(3):263-8. View in: PubMed

Child sexual abuse and the pathophysiology of suicide in adolescents and adults. Int J Adolesc Med Health. 2013; 25(3):201-5. View in: PubMed

Bullying, psychiatric pathology and suicidal behavior. Int J Adolesc Med Health. 2013; 25(3):295-9. View in: PubMed

Education of health professionals about adolescent psychiatry. Int J Adolesc Med Health. 2013; 25(3):185-6. View in: PubMed

Sleep, psychiatric disorders and suicide. J Psychiatr Res. 2013 Jan; 47(1):135. View in: PubMed

Does the physician density affect suicide rates among adolescents and young adults? Int J Adolesc Med Health. Does the physician density affect suicide rates among adolescents and young adults? Int J Adolesc Med Health. 2013; 25(3):315-21. View in: PubMed

The underexamined association between posttraumatic stress disorder, medical illness and suicidal behavior. Int J Adolesc Med Health. 2013; 25(3):279-82. View in: PubMed

Suicidal behavior in Indian adolescents. Int J Adolesc Med Health. 2013; 25(3):207-12. View in: PubMed

Educating health care trainees and professionals about suicide prevention in depressed adolescents. Int J Adolesc Med Health. 2013; 25(3):221-9. View in: PubMed

Ecstasy use and serotonin syndrome: a neglected danger to adolescents and young adults prescribed selective serotonin reuptake inhibitors. Int J Adolesc Med Health. 2013; 25(3):193-9. View in: PubMed

Buprenorphine in the treatment of non-suicidal self-injury: a case series and discussion of the literature. Int J Adolesc Med Health. 2013; 25(3):323-30. View in: PubMed

Prevention of suicidal behavior in adolescents with post-traumatic stress disorder. Int J Adolesc Med Health. 2013; 25(3):283-93. View in: PubMed

Prolactin and thyroid hormone levels are associated with suicide attempts in psychiatric patients. Psychiatry Res. 2012 Dec 30; 200(2-3):389-94. View in: PubMed

Stimulant substitution in methamphetamine dependence. Aust N Z J Psychiatry. 2012 Dec; 46(12):1201-2. View in: PubMed

The epidemiology of chemical eye exposures reported to the Victorian Poisons Information Centre. Eur J Emerg Med. 2012 Dec; 19(6):389-94. View in: PubMed

Early onset of action and sleep-improving effect are crucial in decreasing suicide risk: the role of quetiapine XR in the treatment of unipolar and bipolar depression. Riv Psichiatr. 2012 Nov-Dec; 47(6):489-97. View in: PubMed

Electrodiagnostic evaluation of compressive nerve injuries of the upper extremities. Orthop Clin North Am. 2012 Oct; 43(4):409-16. View in: PubMed

Testosterone levels in suicide attempters with bipolar disorder. J Psychiatr Res. 2012 Oct; 46(10):1267-71. View in: PubMed

Relieving the pruritus of atopic dermatitis: a meta-analysis. Acta Derm Venereol. 2012 Sep; 92(5):455-61. View in: PubMed

How does subjective experience of pain relate to psychopathology among psychiatric patients? Gen Hosp Psychiatry. How does subjective experience of pain relate to psychopathology among psychiatric patients? Gen Hosp Psychiatry. 2012 Sep-Oct; 34(5):534-40. View in: PubMed

Intra-aortic balloon pump for hemodynamic support in hepatobiliary surgery: report of a case. Surg Today. 2012 Aug; 42(8):793-6. View in: PubMed

Hypothalamic-pituitary-adrenal axis dysfunction as a neurobiological correlate of emotion dysregulation in adolescent suicide. World J Pediatr. 2012 Aug; 8(3):197-206. View in: PubMed

The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behavior. Neurosci Res. 2012 Jul; 73(3):179-90. View in: PubMed

Post-traumatic stress disorder, associated medical illnesses, and suicidal behavior: plenty of room for new research. Aust N Z J Psychiatry. 2012 Jul; 46(7):684. View in: PubMed

Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care. Int J Psychiatry Clin Pract. 2012 Jun; 16(2):77-84. View in: PubMed

Results of live donor liver transplantation in patients with hepatitic C virus infection: the HCV 3 trial experience. Clin Transplant. 2012 May; 26(3):502-9. View in: PubMed

Suicidal behavior in war veterans. Expert Rev Neurother. 2012 May; 12(5):611-24. View in: PubMed

Educating health care professionals about suicide prevention. Aust N Z J Psychiatry. 2012 May; 46(5):481-2. View in: PubMed

Decreased suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors: an open study. Psychiatry Res. 2012 Apr 30; 196(2-3):261-6. View in: PubMed

Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial. Am J Transplant. 2012 Mar; 12(3):694-705. View in: PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. View in: PubMed

Testosterone and suicidal behavior. Expert Rev Neurother. 2012 Mar; 12(3):257-9. View in: PubMed

Cyclothymic-depressive-anxious temperament pattern is related to suicide risk in 346 patients with major mood disorders. J Affect Disord. 2012 Feb; 136(3):405-11. View in: PubMed

What should we tell medical students and residents about euthanasia and assisted suicide? Aust N Z J Psychiatry. What should we tell medical students and residents about euthanasia and assisted suicide? Aust N Z J Psychiatry. 2012 Feb; 46(2):87-91. View in: PubMed

Posttraumatic stress disorder, depression, and suicide in veterans. Cleve Clin J Med. 2012 Feb; 79(2):92-7. View in: PubMed

Mometasone furoate/formoterol reduces asthma deteriorations and improves lung function. Eur Respir J. 2012 Feb; 39(2):279-89. View in: PubMed

Adolescent suicide in New York City: plenty of room for new research. Int J Adolesc Med Health. 2012; 24(2):99-104. View in: PubMed

Teaching medical professionals and trainees about adolescent suicide prevention: five key problems. Int J Adolesc Med Health. 2012; 24(2):121-3. View in: PubMed

Can cannabis increase the suicide risk in psychosis? A critical review. Can cannabis increase the suicide risk in psychosis? A critical review. Curr Pharm Des. 2012; 18(32):5165-87. View in: PubMed

Partial androgen deficiency, depression, and testosterone supplementation in aging men. Int J Endocrinol. 2012; 2012:280724. View in: PubMed

Suicide prevention in older men: do medical professionals know enough? Aust N Z J Psychiatry. Suicide prevention in older men: do medical professionals know enough? Aust N Z J Psychiatry. 2011 Dec; 45(12):1094. View in: PubMed

A randomized, multicenter study comparing steroid-free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C. Liver Transpl. 2011 Dec; 17(12):1394-403. View in: PubMed

Teaching health care professionals about suicide safety planning. Psychiatr Danub. 2011 Dec; 23(4):396-7. View in: PubMed

Teaching medical professionals about suicide prevention: what's missing? QJM. Teaching medical professionals about suicide prevention: what's missing? QJM. 2011 Nov; 104(11):1005-8. View in: PubMed

Teaching medical staff in general hospitals about suicide prevention. J Formos Med Assoc. 2011 Oct; 110(10):664; author reply 665. View in: PubMed

Treatment of suicide attempters with bipolar disorder: a randomized clinical trial comparing lithium and valproate in the prevention of suicidal behavior. Am J Psychiatry. 2011 Oct; 168(10):1050-6. View in: PubMed

Brain-derived neurotrophic factor and suicidal behavior in adolescents. World J Pediatr. 2011 Aug; 7(3):197-8. View in: PubMed

Preventing suicide among returning combat veterans: a moral imperative. Mil Med. 2011 Jun; 176(6):601-2. View in: PubMed

Towards a model of suicidal behavior among physicians. Rev Bras Psiquiatr. 2011 Jun; 33(2):111-2. View in: PubMed

Alcohol consumption and later risk of hospitalization with psychiatric disorders: prospective cohort study. Psychiatry Res. 2011 May 15; 187(1-2):214-9. View in: PubMed

Brain-derived neurotrophic factor and suicidal behavior. QJM. 2011 May; 104(5):455-8. View in: PubMed

Is it possible to predict suicide? Aust N Z J Psychiatry. Is it possible to predict suicide? Aust N Z J Psychiatry. 2011 Apr; 45(4):341. View in: PubMed

Mortality among individuals with cannabis, cocaine, amphetamine, MDMA, and opioid use disorders: a nationwide follow-up study of Danish substance users in treatment. Drug Alcohol Depend. 2011 Apr 1; 114(2-3):134-9. View in: PubMed

Immunogenicity and safety of a combined diphtheria, tetanus, 5-component acellular pertussis, inactivated poliomyelitis, Haemophilus type b conjugate vaccine when administered concurrently with a pneumococcal conjugate vaccine: a randomized, open-label, phase 3 study. Vaccine. 2011 Mar 3; 29(11):2212-21. View in: PubMed

Brain-derived neurotrophic factor and suicidal behavior in patients with posttraumatic stress disorder. Rev Bras Psiquiatr. 2011 Mar; 33(1):105-6. View in: PubMed

Removal of a large hepatic neuroendocrine tumor causing Budd-Chiari syndrome using a median sternotomy approach in conjunction with a midline laparotomy incision. Am Surg. 2011 Feb; 77(2):E27-9. View in: PubMed

Brain stimulation in posttraumatic stress disorder. Eur J Psychotraumatol. 2011; 2. View in: PubMed

The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior. Int J Adolesc Med Health. 2011; 23(3):181-5. View in: PubMed

Transcranial magnetic stimulation and the treatment of suicidality. Expert Rev Neurother. 2010 Dec; 10(12):1781-4. View in: PubMed

Post-industrialized societies and impulsivity. Med Hypotheses. 2010 Dec; 75(6):679. View in: PubMed

Impulsivity: current and future trends in pharmacological treatment. Expert Rev Neurother. 2010 Sep; 10(9):1367-9. View in: PubMed

New scientific evidence supports the concept of post-traumatic mood disorder and an association of post-traumatic mood disorder with completed suicide. Med Hypotheses. 2010 Aug; 75(2):271-2. View in: PubMed

Suicidal behavior in adolescents with post-traumatic stress disorder. Minerva Pediatr. 2010 Aug; 62(4):363-70. View in: PubMed

Neurobiology of suicidal behavior in post-traumatic stress disorder. Expert Rev Neurother. 2010 Aug; 10(8):1233-5. View in: PubMed

Twenty-six-week efficacy and safety study of mometasone furoate/formoterol 200/10 microg combination treatment in patients with persistent asthma previously receiving medium-dose inhaled corticosteroids. Allergy Asthma Proc. 2010 Jul-Aug; 31(4):269-79. View in: PubMed

Secondary prevention of suicide. PLoS Med. 2010 Jun; 7(6):e1000271. View in: PubMed

Immigration, mental health and suicidal behavior. Med Hypotheses. 2010 Jun; 74(6):966-7. View in: PubMed

Suicidal behavior and alcohol abuse. Int J Environ Res Public Health. 2010 Apr; 7(4):1392-431. View in: PubMed

Is disturbed sleep a clinically useful marker to determine the suicide risk in patients with posttraumatic stress disorder? Isr J Psychiatry Relat Sci. Is disturbed sleep a clinically useful marker to determine the suicide risk in patients with posttraumatic stress disorder? Isr J Psychiatry Relat Sci. 2010; 47(2):153-4. View in: PubMed

Short exposure to light treatment improves depression scores in patients with seasonal affective disorder: A brief report. Int J Disabil Hum Dev. 2009 Jul; 8(3):283-286. View in: PubMed

Blood-management programs: a clinical and administrative model with program implementation strategies. Perm J. 2009; 13(1):18-28. View in: PubMed

Intraoperative umbilical herniorrhaphy during liver transplantation. Surgery. 2008 Mar; 143(3):451-2. View in: PubMed

Ischemic mass effect from biliary surgical clips. J Laparoendosc Adv Surg Tech A. 2008 Feb; 18(1):84-7. View in: PubMed

Living related donor nephrectomy in transfusion refusing donors. Transpl Int. 2007 Jun; 20(6):490-6. View in: PubMed

Impact of a transfusion-free program on non-Jehovah's Witness patients undergoing liver transplantation. Arch Surg. 2006 Sep; 141(9):913-7. View in: PubMed

Extended pancreatectomy with resection of the celiac axis: the modified Appleby operation. Am J Surg. 2006 Sep; 192(3):330-5. View in: PubMed

Predictors of employment after liver transplantation. Clin Transplant. 2006 Jul-Aug; 20(4):490-5. View in: PubMed

Gallstone-induced inflammatory fibrosis: a relentless clinical course of retained gallstones after laparoscopic cholecystectomy. Am Surg. 2006 Apr; 72(4):303-6. View in: PubMed

Pancreaticoduodenectomy in adults with congenital intestinal rotation disorders. Pancreas. 2005 Nov; 31(4):413-5. View in: PubMed

Transfusion free surgery: single institution experience of 27 consecutive liver transplants in Jehovah's Witnesses. J Am Coll Surg. 2005 Sep; 201(3):412-7. View in: PubMed

Transfusion-free techniques in pediatric live donor liver transplantation. J Pediatr Gastroenterol Nutr. 2005 Apr; 40(4):521-3. View in: PubMed

Comparison of a new fibrin sealant with standard topical hemostatic agents. Arch Surg. 2004 Nov; 139(11):1148-54. View in: PubMed

Live donor liver transplantation without blood products: strategies developed for Jehovah's Witnesses offer broad application. Ann Surg. 2004 Aug; 240(2):350-7. View in: PubMed

Live donor liver transplantation: staging hepatectomy in a Jehovah's Witness recipient. J Hepatobiliary Pancreat Surg. 2004; 11(3):211-4. View in: PubMed

Left portahepatic shunt: a novel technique to decrease excessive portal venous inflow during live donor liver transplantation. J Am Coll Surg. 2003 Dec; 197(6):1056-7. View in: PubMed

Characteristics and management of splenic artery aneurysm in liver transplant candidates and recipients. Am Surg. 2003 Nov; 69(11):933-40. View in: PubMed

Comparison of outcomes in noncomplicated and in higher-risk donors after standard versus hand-assisted laparoscopic nephrectomy. Am Surg. 2003 Sep; 69(9):771-8. View in: PubMed

Cadaveric organ donor recruitment at Los Angeles County Hospital: improvement after formation of a structured clinical, educational and administrative service. Clin Transplant. 2003; 17 Suppl 9:52-7. View in: PubMed

Histologic evaluation and treatment outcome after sequential radiofrequency ablation and hepatic resection for primary and metastatic tumors. Am Surg. 2002 Dec; 68(12):1038-43. View in: PubMed

Phase I safety and pharmacokinetic studies of brequinar sodium after single ascending oral doses in stable renal, hepatic, and cardiac allograft recipients. J Clin Pharmacol. 1997 Dec; 37(12):1121-8. View in: PubMed

Immunosuppression: now we have choices. Hepatology. 1995 Sep; 22(3):996-7. View in: PubMed

WHICH LIVER-DESEASE PATIENTS NEED A TRANSPLANT?: Organ replacement has come into its own as a treatment for end-stage liver disease. A team of experts from two leading transplant centers reviews current indications, survival rates, and methods of evaluating candidates for operation. Hosp Rec Study. 1988 Jun; 10(6):62-79. View in: PubMed

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