Faculty

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Luanda Grazette, MD
Associate Professor of Clinical Medicine
Medicine
HCC 322 Health Sciences Campus Los Angeles
+1 323 442 6130

Overview

Dr. Luanda Grazette completed her undergraduate studies at the University of Alabama and went on to Harvard to earn her Medical Degree and Masters Degree in Public Health. She then completed her internship and residency at Massachusetts General Hospital in Boston followed by Fellowship training in Clinical Cardiology at Emory University. After completing her fellowship, Dr. Grazette returned to Massachusetts General Hospital for additional training in Heart Failure and Transplantation and Heart Failure Research and then remained on staff as a Physician-Scientist.

Her experience with follow-up care of transplant patients, supervision of students and fellows, and management of pre- and post-transplant patients in critical care settings and inpatient consultation makes her a tremendous asset to USC. In addition to her clinical responsibilities, Dr. Grazette engaged in active clinical and translational research investigating the basic mechanisms of cardiac toxicity, plasticty and survival. Dr Grazette has also served as a Medical Director of Global Clinical Research for Amgen where she overseeing early and late stage clinical trials. Myocardial plasticity and the potential for recovery remain the focus of her clinical and research activities.

Awards

National Institute of Health: K01 Mentored Faculty Development Award, 2000-2005

Publications

Yoon AJ, Sohn J, Grazette L, Fong MW, Bowdish ME. Pan-Cardiac Cycle Fixed Mitral Valve Opening in an LVAD Patient Presenting with Hemorrhagic Shock. Echocardiography. 2016 Apr; 33(4):644-646. View in: PubMed

Fung E, Fong MW, Correa AJ, Yoon AJ, Grazette LP. Fulminant eosinophilic myocarditis following ICD implantation in a patient with undisclosed nickel allergy. Int J Cardiol. 2016 Jan 15; 203:1018-9. View in: PubMed

King K, Grazette LP, Paltoo DN, McDevitt JT, Sia SK, Barrett PM, Apple FS, Gurbel PA, Weissleder R, Leeds H, Iturriaga EJ, Rao A, Adhikari B, Desvigne-Nickens P, Galis ZS, Libby P. Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group. JACC Basic Transl Sci. 2016 Jan-Feb; 1(1-2):73-86. View in: PubMed

Chaudhry MA, Correa A, Lee C, Yoon A, Grazette L, Saremi F, Fong MW. Modern day management of giant cell myocarditis. Int J Cardiol. 2015 Jan 15; 178:82-4. View in: PubMed

Samelson EJ, Miller PD, Christiansen C, Daizadeh NS, Grazette L, Anthony MS, Egbuna O, Wang A, Siddhanti SR, Cheung AM, Franchimont N, Kiel DP. RANKL Inhibition With Denosumab Does Not Influence 3-Year Progression of Aortic Calcification or Incidence of Adverse Cardiovascular Events in Postmenopausal Women With Osteoporosis and High Cardiovascular Risk. J Bone Miner Res. 2014 Feb; 29(2):450-7. View in: PubMed

Fong MW, Grazette L, Cesario D, Cao M, Saxon L. Treatment of ventricular tachycardia in patients with heart failure. Curr Cardiol Rep. 2011 Jun; 13(3):203-9. View in: PubMed

Bone HG, Bolognese MA, Yuen CK, Kendler DL, Miller PD, Yang YC, Grazette L, San Martin J, Gallagher JC. Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass. J Clin Endocrinol Metab. 2011 Apr; 96(4):972-80. View in: PubMed

Kerkelä R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, Van Etten RA, Alroy J, Durand JB, Force T. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006 Aug; 12(8):908-16. View in: PubMed

Smith RN, Brousaides N, Grazette L, Saidman S, Semigran M, Disalvo T, Madsen J, Dec GW, Perez-Atayde AR, Collins AB. C4d deposition in cardiac allografts correlates with alloantibody. J Heart Lung Transplant. 2005 Sep; 24(9):1202-10. View in: PubMed

Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24. View in: PubMed

Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings BA, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 2005 Aug; 115(8):2128-38. View in: PubMed

Grazette LP, Rosenzweig A. Role of apoptosis in heart failure. Heart Fail Clin. 2005 Jul; 1(2):251-61. View in: PubMed

Grazette LP, Boecker W, Matsui T, Semigran M, Force TL, Hajjar RJ, Rosenzweig A. Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J Am Coll Cardiol. 2004 Dec 7; 44(11):2231-8. View in: PubMed

Boecker W, Bernecker OY, Wu JC, Zhu X, Sawa T, Grazette L, Rosenzweig A, del Monte F, Schmidt U, Hajjar RJ. Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter. Mol Imaging. 2004 Apr; 3(2):69-75. View in: PubMed

Smith RN, Chang Y, Houser S, Dec GW, Grazette L. Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections. Transplantation. 2002 Jun 27; 73(12):1928-32. View in: PubMed

Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, Molkentin JD. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation. 2001 Feb 6; 103(5):670-7. View in: PubMed

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