Faculty

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Lucio Comai, PhD
Professor of Molecular Microbiology & Immunology
Director of Bsl 3 Laboratory
Molecular Microbiology and Immunology
CSC 264 2250 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 3950

Overview

Dr. Comai received his Ph.D.in Biochemistry in 1990 from the University of California, Davis and completed his postdoctoral training at University of California, Berkeley. He joined the faculty of the Keck School of Medicine in 1995 and became a member of the Institute for Genetic Medicine in 2005.

Publications

The Werner syndrome helicase coordinates sequential strand displacement and FEN1-mediated flap cleavage during Polymerase d elongation. Mol Cell Biol. 2016 Nov 14. View in: PubMed

Recent advances in understanding the role of lamins in health and disease. F1000Res. 2016; 5:2536. View in: PubMed

Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. Sci Rep. 2016; 6:30999. View in: PubMed

Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation. EBioMedicine. 2015 Sep; 2(9):1034-47. View in: PubMed

Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms. Sci Rep. 2015; 5:9042. View in: PubMed

Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell. 2014 Apr; 13(2):367-78. View in: PubMed

A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012 Aug; 4(8):567-77. View in: PubMed

RNA splicing is responsive to MBNL1 dose. PLoS One. 2012; 7(11):e48825. View in: PubMed

Lamin A, farnesylation and aging. Exp Cell Res. 2012 Jan 1; 318(1):1-7. View in: PubMed

Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011 Nov 4; 286(44):38427-38. View in: PubMed

RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. EMBO Rep. 2011 Jul; 12(7):735-42. View in: PubMed

Cell cycle-regulated association between the Werner syndrome protein and its molecular partners. Cell Cycle. 2011 Jun 15; 10(12):2038-40. View in: PubMed

Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY). 2011 Apr; 3(4):395-406. View in: PubMed

Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res. 2011 Feb 1; 317(3):319-29. View in: PubMed

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 2010 Dec 1; 185(11):6985-98. View in: PubMed

Processing of human telomeres by the Werner syndrome protein. Cell Cycle. 2010 Aug 15; 9(16):3137-8. View in: PubMed

Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 2009 Aug 11; 48(31):7525-32. View in: PubMed

Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. Aging (Albany NY). 2009 Mar; 1(3):289-302. View in: PubMed

Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal. 2009; 9:1449-62. View in: PubMed

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype. Aging Cell. 2008 Jun; 7(3):355-67. View in: PubMed

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol. 2008 Mar; 28(6):1892-904. View in: PubMed

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol. 2008 Jan 14; 180(1):67-81. View in: PubMed

Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. PLoS One. 2008; 3(12):e3968. View in: PubMed

Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor. Am J Physiol Cell Physiol. 2007 May; 292(5):C1617-24. View in: PubMed

Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. View in: PubMed

CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Nucleic Acids Res. 2006; 34(17):4752-66. View in: PubMed

Direct regulation of rRNA transcription by fibroblast growth factor 2. Mol Cell Biol. 2005 Nov; 25(21):9419-26. View in: PubMed

Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription. J Gen Virol. 2005 Aug; 86(Pt 8):2315-22. View in: PubMed

PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. Mol Cell Biol. 2005 Aug; 25(16):6899-911. View in: PubMed

MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem. 2005 Feb 18; 280(7):5773-80. View in: PubMed

A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis. Nucleic Acids Res. 2005; 33(21):6861-7. View in: PubMed

The Werner syndrome protein at the crossroads of DNA repair and apoptosis. Mech Ageing Dev. 2004 Aug; 125(8):521-8. View in: PubMed

Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem. 2004 Apr 2; 279(14):13659-67. View in: PubMed

Mechanism of RNA polymerase I transcription. Adv Protein Chem. 2004; 67:123-55. View in: PubMed

Coimmunoprecipitation assay for the detection of kinase-substrate interactions. Methods Mol Biol. 2003; 218:277-84. View in: PubMed

The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Curr Biol. 2002 Dec 23; 12(24):2142-6. View in: PubMed

Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res. 2002 Sep 1; 30(17):3653-61. View in: PubMed

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