Faculty

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Lynda Kay McGinnis, PhD
Assistant Professor of Research Obstetrics & Gynecology
Obstetrics & Gynecology
NTT 1441 Eastlake Blvd Health Sciences Campus Los Angeles
+1 323 865 3013

Publications

Hung WT, Christenson LK, McGinnis LK. Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion. Biol Reprod. 2015 Sep 30. View in: PubMed

McGinnis LK, Luense LJ, Christenson LK. MicroRNA in Ovarian Biology and Disease. Cold Spring Harb Perspect Med. 2015 May 18. View in: PubMed

McGinnis LK, Kinsey WH. Role of focal adhesion kinase in oocyte-follicle communication. Mol Reprod Dev. 2015 Feb; 82(2):90-102. View in: PubMed

Warren BD, Kinsey WK, McGinnis LK, Christenson LK, Jasti S, Stevens AM, Petroff BK, Petroff MG. Ovarian autoimmune disease: clinical concepts and animal models. Cell Mol Immunol. 2014 Nov; 11(6):510-21. View in: PubMed

McGinnis LK, Pelech S, Kinsey WH. Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis. Mol Reprod Dev. 2014 Oct; 81(10):928-45. View in: PubMed

Luo J, McGinnis LK, Carlton C, Beggs HE, Kinsey WH. PTK2b function during fertilization of the mouse oocyte. Biochem Biophys Res Commun. 2014 Aug 1; 450(3):1212-7. View in: PubMed

Albertini DF, McGinnis LK. A catalyst for change in reproductive science: John D. Biggers as a mentor’s mentor. J Assist Reprod Genet. 2013 Aug; 30(8):979-94. View in: PubMed

McGinnis LK, Luo J, Kinsey WH. Protein tyrosine kinase signaling in the mouse oocyte cortex during sperm-egg interactions and anaphase resumption. Mol Reprod Dev. 2013 Apr; 80(4):260-72. View in: PubMed

McGinnis LK, Limback SD, Albertini DF. Signaling modalities during oogenesis in mammals. Curr Top Dev Biol. 2013; 102:227-42. View in: PubMed

Jasti S, Warren BD, McGinnis LK, Kinsey WH, Petroff BK, Petroff MG. The autoimmune regulator prevents premature reproductive senescence in female mice. Biol Reprod. 2012 Apr; 86(4):110. View in: PubMed

McGinnis LK, Carroll DJ, Kinsey WH. Protein tyrosine kinase signaling during oocyte maturation and fertilization. Mol Reprod Dev. 2011 Oct-Nov; 78(10-11):831-45. View in: PubMed

McGinnis LK, Hong X, Christenson LK, Kinsey WH. Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes. Mol Reprod Dev. 2011 Jan; 78(1):33-47. View in: PubMed

McGinnis LK, Albertini DF. Dynamics of protein phosphorylation during meiotic maturation. J Assist Reprod Genet. 2010 Apr; 27(4):169-82. View in: PubMed

Duffy DM, McGinnis LK, Vandevoort CA, Christenson LK. Mammalian oocytes are targets for prostaglandin E2 (PGE2) action. Reprod Biol Endocrinol. 2010; 8:131. View in: PubMed

Luo J, McGinnis LK, Kinsey WH. Role of Fyn kinase in oocyte developmental potential. Reprod Fertil Dev. 2010; 22(6):966-76. View in: PubMed

Luo J, McGinnis LK, Kinsey WH. Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex. Mol Reprod Dev. 2009 Sep; 76(9):819-31. View in: PubMed

Elmoazzen HY, Lee GY, Li MW, McGinnis LK, Lloyd KC, Toner M, Biggers JD. Further optimization of mouse spermatozoa evaporative drying techniques. Cryobiology. 2009 Aug; 59(1):113-5. View in: PubMed

Rodrigues P, Limback D, McGinnis LK, Plancha CE, Albertini DF. Multiple mechanisms of germ cell loss in the perinatal mouse ovary. Reproduction. 2009 Apr; 137(4):709-20. View in: PubMed

McGinnis LK, Kinsey WH, Albertini DF. Functions of Fyn kinase in the completion of meiosis in mouse oocytes. Dev Biol. 2009 Mar 15; 327(2):280-7. View in: PubMed

Hong X, Luense LJ, McGinnis LK, Nothnick WB, Christenson LK. Dicer1 is essential for female fertility and normal development of the female reproductive system. Endocrinology. 2008 Dec; 149(12):6207-12. View in: PubMed

Rodrigues P, Limback D, McGinnis LK, Plancha CE, Albertini DF. Oogenesis: Prospects and challenges for the future. J Cell Physiol. 2008 Aug; 216(2):355-65. View in: PubMed

McGinnis LK, Albertini DF, Kinsey WH. Localized activation of Src-family protein kinases in the mouse egg. Dev Biol. 2007 Jun 1; 306(1):241-54. View in: PubMed

Li MW, Biggers JD, Elmoazzen HY, Toner M, McGinnis L, Lloyd KC. Long-term storage of mouse spermatozoa after evaporative drying. Reproduction. 2007 May; 133(5):919-29. View in: PubMed

Biggers JD, McGinnis LK, Lawitts JA. One-step versus two-step culture of mouse preimplantation embryos: is there a difference? Hum Reprod. 2005 Dec; 20(12):3376-84. View in: PubMed

McGinnis LK, Zhu L, Lawitts JA, Bhowmick S, Toner M, Biggers JD. Mouse sperm desiccated and stored in trehalose medium without freezing. Biol Reprod. 2005 Oct; 73(4):627-33. View in: PubMed

Summers MC, McGinnis LK, Lawitts JA, Biggers JD. Mouse embryo development following IVF in media containing either L-glutamine or glycyl-L-glutamine. Hum Reprod. 2005 May; 20(5):1364-71. View in: PubMed

Biggers JD, McGinnis LK, Lawitts JA. Enhanced effect of glycyl-L-glutamine on mouse preimplantation embryos in vitro. Reprod Biomed Online. 2004 Jul; 9(1):59-69. View in: PubMed

Biggers JD, McGinnis LK, Summers MC. Discrepancies between the effects of glutamine in cultures of preimplantation mouse embryos. Reprod Biomed Online. 2004 Jul; 9(1):70-3. View in: PubMed

Li MW, McGinnis L, Zhu L, Lawitts J, Biggers J, Lloyd KC. Intracytoplasmic sperm injection (ICSI) enables rescue of valuable mutant mouse strains. Comp Med. 2003 Jun; 53(3):265-9. View in: PubMed

Bhowmick S, Zhu L, McGinnis L, Lawitts J, Nath BD, Toner M, Biggers J. Desiccation tolerance of spermatozoa dried at ambient temperature: production of fetal mice. Biol Reprod. 2003 May; 68(5):1779-86. View in: PubMed

Biggers JD, McGinnis LK. Evidence that glucose is not always an inhibitor of mouse preimplantation development in vitro. Hum Reprod. 2001 Jan; 16(1):153-163. View in: PubMed

Summers MC, McGinnis LK, Lawitts JA, Raffin M, Biggers JD. IVF of mouse ova in a simplex optimized medium supplemented with amino acids. Hum Reprod. 2000 Aug; 15(8):1791-801. View in: PubMed

Biggers JD, McGinnis LK, Raffin M. Amino acids and preimplantation development of the mouse in protein-free potassium simplex optimized medium. Biol Reprod. 2000 Jul; 63(1):281-93. View in: PubMed

Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999 Oct; 19(10):7237-44. View in: PubMed

Kreidberg JA, Natoli TA, McGinnis L, Donovan M, Biggers JD, Amstutz A. Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct. Mol Reprod Dev. 1999 Apr; 52(4):366-75. View in: PubMed

Biggers JD, Summers MC, McGinnis LK. Polyvinyl alcohol and amino acids as substitutes for bovine serum albumin in culture media for mouse preimplantation embryos. Hum Reprod Update. 1997 Mar-Apr; 3(2):125-35. View in: PubMed

Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 1996 Dec 5; 384(6608):470-4. View in: PubMed

Johnson LD, Albertini DF, McGinnis LK, Biggers JD. Chromatin organization, meiotic status and meiotic competence acquisition in mouse oocytes from cultured ovarian follicles. J Reprod Fertil. 1995 Jul; 104(2):277-84. View in: PubMed

Youngs CR, Ford SP, McGinnis LK, Anderson LH. Investigations into the control of litter size in swine: I. Comparative studies on in vitro development of Meishan and Yorkshire preimplantation embryos. J Anim Sci. 1993 Jun; 71(6):1561-5. View in: PubMed

McGinnis LK, Youngs CR. In vitro development of ovine embryos in CZB medium. Theriogenology. 1992 Mar; 37(3):559-69. View in: PubMed

DiGiacomo RF, McGinnis LK, Studer E, Evermann JF. Failure of embryo transfer to transmit BLV in a dairy herd. Vet Rec. 1990 Nov 3; 127(18):456. View in: PubMed

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