Faculty

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M. Elizabeth Fini, PhD
Professor of Cell & Neurobiology
Director, Institute For Genetic Medicine
Cell and Neurobiology
CSC 135K 2250 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 7732

Overview

In March 2008, Dr. Fini moved to the Keck School of Medicine at USC to assume her current position as director of USC's Institute for Genetic Medicine and Vice Dean for Research at the Keck School of Medicine of USC.

Her current research areas include: Repair and Regeneration in the Corneal Stroma, Maintenance of Ocular Surface Integrity, Ocular Surface Infection, and Glaucoma Outflow Deficiency.

A native of Boston, Dr. Fini earned her doctoral degree at Dartmouth College and did post-doctoral training at Dartmouth Medical School and Massachusetts Institute of Technology. Her first independent faculty position was at Harvard Medical School, with her lab located at the Massachusetts General Hospital and the Schepens Eye Research Institute. From there she was recruited to Tufts-New England Medical Center Medicine as the Jules & Doris Stein Research to Prevent Blindness Professor. She rose to director of research and founded the Tufts Center for Vision Research. In 2002 she was recruited to the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, where she was appointed as scientific director for the Evelyn F. & William L. McKnight Vision Research Center, vice chair for research, and the Walter G. Ross Chair in Ophthalmic Research.

The Fini lab maintains two long-term project grants from the National Eye Institute’s cornea program: “Repair & Regeneration in the Corneal Stroma” (EY09828) and “Maintenance of Ocular Surface Integrity” (EY12651). Leveraging from these grants over the years and extending resources through other funding mechanisms and collaboration, the lab has contributed in a number of other areas, including repair & regeneration in the skin, tadpole tail remodeling, and eye development. The Matrix Metalloproteinase (MMP) family of tissue remodeling enzymes has been an important focus. The group has been interested in basic mechanisms of MMP role and gene regulation. Discoveries are then applied to the cornea and other models of repair, regeneration, and disease.

Publications

Fini ME, Bauskar A, Jeong S, Wilson MR. Clusterin in the eye: An old dog with new tricks at the ocular surface. Exp Eye Res. 2016 Jun; 147:57-71. View in: PubMed

Salamanna F, Maglio M, Borsari V, Giavaresi G, Aldini NN, Fini M. Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease. J Cell Physiol. 2016 Mar; 231(3):521-30. View in: PubMed

Veronesi F, Della Bella E, Torricelli P, Pagani S, Fini M. Effect of adipose-derived mesenchymal stromal cells on tendon healing in aging and estrogen deficiency: an in vitro co-culture model. Cytotherapy. 2015 Nov; 17(11):1536-44. View in: PubMed

Kheirandish M, Faezi ST, Paragomi P, Akhlaghi M, Gharibdoost F, Shahali A, Fini ME, Akbarian M. Prevalence and severity of depression and anxiety in patients with systemic lupus erythematosus: An epidemiologic study in Iranian patients. Mod Rheumatol. 2015 May; 25(3):405-9. View in: PubMed

Jeong S, Patel N, Edlund CC, Hartiala J, Hazelett D, Itakura T, Wu PC, Avery RL, Davis J, Flynn HW, Lalwani G, Puliafito CA, Wafapoor H, Hijikata M, Keicho N, Gao XA, Argueso P, Allayee H, Coetzee GA, Pletcher MT, Conti DV, Schwartz SG, Eaton AM, Fini ME. Identification of a Novel Mucin Gene HCG22 Associated with Steroid-Induced Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Mar 26. View in: PubMed

Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME. Expression and Functional Role of Orphan Receptor GPR158 in Prostate Cancer Growth and Progression. PLoS One. 2015; 10(2):e0117758. View in: PubMed

Wu PC, Tsai CL, Gordon GM, Jeong S, Itakura T, Patel N, Shi S, Fini ME. Chondrogenesis in scleral stem/progenitor cells and its association with form-deprived myopia in mice. Mol Vis. 2015; 21:138-47. View in: PubMed

Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46):8131-8141. View in: PubMed

Farè S, Torricelli P, Giavaresi G, Bertoldi S, Alessandrino A, Villa T, Fini M, Tanzi MC, Freddi G. In vitro study on silk fibroin textile structure for anterior cruciate ligament regeneration. Mater Sci Eng C Mater Biol Appl. 2013 Oct; 33(7):3601-8. View in: PubMed

LaGier AJ, Gordon GM, Katzman LR, Vasiliou V, Fini ME. Mechanisms for PDGF, a serum cytokine, stimulating loss of corneal keratocyte crystallins. Cornea. 2013 Sep; 32(9):1269-75. View in: PubMed

Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME. GPR158, an Orphan Member of G Protein-Coupled Receptor Family C: Glucocorticoid-Stimulated Expression and Novel Nuclear Role. PLoS One. 2013; 8(2):e57843. View in: PubMed

Jiang M, Wu PC, Fini ME, Tsai CL, Itakura T, Zhang X, Jiao S. Single-Shot Dimension Measurements of the Mouse Eye Using SD-OCT. Ophthalmic Surg Lasers Imaging. 2012 May 1; 43(3):252-6. View in: PubMed

Jeong S, Ledee DR, Gordon GM, Itakura T, Patel N, Martin A, Fini ME. Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation. Am J Pathol. 2012 May; 180(5):2028-39. View in: PubMed

Boanini E, Torricelli P, Fini M, Sima F, Serban N, Mihailescu IN, Bigi A. Magnesium and strontium doped octacalcium phosphate thin films by matrix assisted pulsed laser evaporation. J Inorg Biochem. 2012 Feb; 107(1):65-72. View in: PubMed

Santos AR, Corredor RG, Obeso BA, Trakhtenberg EF, Wang Y, Ponmattam J, Dvoriantchikova G, Ivanov D, Shestopalov VI, Goldberg JL, Fini ME, Bajenaru ML. ß1 Integrin-Focal Adhesion Kinase (FAK) Signaling Modulates Retinal Ganglion Cell (RGC) Survival. PLoS One. 2012; 7(10):e48332. View in: PubMed

Tsai CL, Wu PC, Fini ME, Shi S. Identification of multipotent stem/progenitor cells in murine sclera. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5481-7. View in: PubMed

Gordon GM, Austin JS, Sklar AL, Feuer WJ, LaGier AJ, Fini ME. Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing. J Cell Physiol. 2011 Jun; 226(6):1461-70. View in: PubMed

Gordon GM, Moradshahi N, Jeong S, Lane C, Fini ME. A novel mechanism of increased infections in contact lens wearers. Invest Ophthalmol Vis Sci. 2011; 52(12):9188-94. View in: PubMed

Indelicato M, Pucci B, Schito L, Reali V, Aventaggiato M, Mazzarino MC, Stivala F, Fini M, Russo MA, Tafani M. Role of hypoxia and autophagy in MDA-MB-231 invasiveness. J Cell Physiol. 2010 May; 223(2):359-68. View in: PubMed

Fournié PR, Gordon GM, Dawson DG, Malecaze FJ, Edelhauser HF, Fini ME. Correlation between epithelial ingrowth and basement membrane remodeling in human corneas after laser-assisted in situ keratomileusis. Arch Ophthalmol. 2010 Apr; 128(4):426-36. View in: PubMed

Zhang J, Lu JP, Suter DM, Krause KH, Fini ME, Chen B, Lu Q. Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Exp Cell Res. 2010 Apr 1; 316(6):1070-81. View in: PubMed

Pucci B, Indelicato M, Paradisi V, Reali V, Pellegrini L, Aventaggiato M, Karpinich NO, Fini M, Russo MA, Farber JL, Tafani M. ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of Bax translocation in HeLa Cells. J Cell Biochem. 2009 Dec 1; 108(5):1166-74. View in: PubMed

Gordon GM, Ledee DR, Feuer WJ, Fini ME. Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells. J Cell Physiol. 2009 Nov; 221(2):402-11. View in: PubMed

Ledee DR, Iovieno A, Miller D, Mandal N, Diaz M, Fell J, Fini ME, Alfonso EC. Molecular identification of t4 and t5 genotypes in isolates from acanthamoeba keratitis patients. J Clin Microbiol. 2009 May; 47(5):1458-62. View in: PubMed

Oechsler RA, Feilmeier MR, Ledee DR, Miller D, Diaz MR, Fini ME, Fell JW, Alfonso EC. Utility of molecular sequence analysis of the ITS rRNA region for identification of Fusarium spp. from ocular sources. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2230-6. View in: PubMed

Jung JC, Wang PX, Zhang G, Ezura Y, Fini ME, Birk DE. Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation. Cell Tissue Res. 2009 Apr; 336(1):79-89. View in: PubMed

Gerzenstein SM, Pletcher MT, Cervino AC, Tsinoremas NF, Young B, Puliafito CA, Fini ME, Schwartz SG. Glucocorticoid receptor polymorphisms and intraocular pressure response to intravitreal triamcinolone acetonide. Ophthalmic Genet. 2008 Dec; 29(4):166-70. View in: PubMed

Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini ME, Li D, Lu Q. Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008 May 2; 369(2):414-20. View in: PubMed

Fournié PR, Gordon GM, Dawson DG, Edelhauser HF, Fini ME. Correlations of long-term matrix metalloproteinase localization in human corneas after successful laser-assisted in situ keratomileusis with minor complications at the flap margin. Arch Ophthalmol. 2008 Feb; 126(2):162-70. View in: PubMed

Bassett EA, Pontoriero GF, Feng W, Marquardt T, Fini ME, Williams T, West-Mays JA. Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development. Mol Cell Biol. 2007 Nov; 27(21):7497-510. View in: PubMed

Jung JC, Huh MI, Fini ME. Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma. J Cell Biochem. 2007 Oct 1; 102(2):453-62. View in: PubMed

Huh MI, Lee YM, Seo SK, Kang BS, Chang Y, Lee YS, Fini ME, Kang SS, Jung JC. Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development. J Cell Biochem. 2007 Aug 1; 101(5):1222-37. View in: PubMed

Jockovich ME, Bajenaru ML, Piña Y, Suarez F, Feuer W, Fini ME, Murray TG. Retinoblastoma tumor vessel maturation impacts efficacy of vessel targeting in the LH(BETA)T(AG) mouse model. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2476-82. View in: PubMed

LaGier AJ, Yoo SH, Alfonso EC, Meiners S, Fini ME. Inhibition of human corneal epithelial production of fibrotic mediator TGF-beta2 by basement membrane-like extracellular matrix. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1061-71. View in: PubMed

Bargagna-Mohan P, Mohan R, Russo L, Kochevar IE, Fini ME. Cell lines and transgenic mice expressing a matrix metalloproteinase-9 promoter-driven reporter gene: potential for assay of ultraviolet light effects and light-inhibiting compounds. Cutan Ocul Toxicol. 2007; 26(4):383-97. View in: PubMed

Mukherjee R, Mingoia JT, Bruce JA, Austin JS, Stroud RE, Escobar GP, McClister DM, Allen CM, Alfonso-Jaume MA, Fini ME, Lovett DH, Spinale FG. Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2216-28. View in: PubMed

Zhang X, Schroeder A, Callahan EM, Coyle BM, Wang N, Erickson KA, Schuman JS, Fini ME. Constitutive signalling pathway activity in trabecular meshwork cells from glaucomatous eyes. Exp Eye Res. 2006 Jun; 82(6):968-73. View in: PubMed

Ouyang J, Shen YC, Yeh LK, Li W, Coyle BM, Liu CY, Fini ME. Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2397-407. View in: PubMed

Fini ME, Stramer BM. How the cornea heals: cornea-specific repair mechanisms affecting surgical outcomes. Cornea. 2005 Nov; 24(8 Suppl):S2-S11. View in: PubMed

Chintala SK, Wang N, Diskin S, Mattox C, Kagemann L, Fini ME, Schuman JS. Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs. Exp Eye Res. 2005 Oct; 81(4):429-36. View in: PubMed

Stramer BM, Austin JS, Roberts AB, Fini ME. Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3. J Cell Physiol. 2005 Apr; 203(1):226-32. View in: PubMed

Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. View in: PubMed

Stramer BM, Fini ME. Uncoupling keratocyte loss of corneal crystallin from markers of fibrotic repair. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4010-5. View in: PubMed

Jung JC, West-Mays JA, Stramer BM, Byrne MH, Scott S, Mody MK, Sadow PM, Krane SM, Fini ME. Activity and expression of Xenopus laevis matrix metalloproteinases: identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals. J Cell Physiol. 2004 Oct; 201(1):155-64. View in: PubMed

Stramer BM, Kwok MG, Farthing-Nayak PJ, Jung JC, Fini ME, Nayak RC. Monoclonal antibody (3G5)-defined ganglioside: cell surface marker of corneal keratocytes. Invest Ophthalmol Vis Sci. 2004 Mar; 45(3):807-12. View in: PubMed

Johnson C, Sung HJ, Lessner SM, Fini ME, Galis ZS. Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Circ Res. 2004 Feb 6; 94(2):262-8. View in: PubMed

Sivak JM, West-Mays JA, Yee A, Williams T, Fini ME. Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Mol Cell Biol. 2004 Jan; 24(1):245-57. View in: PubMed

Newsom RS, Austin JS, Fini ME, Reichel E. Large spot endolaser for retinal photocoagulation and transvitreal thermotherapy. Ophthalmic Surg Lasers Imaging. 2004 Jan-Feb; 35(1):26-30. View in: PubMed

Stramer BM, Zieske JD, Jung JC, Austin JS, Fini ME. Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4237-46. View in: PubMed

Berryhill BL, Kane B, Stramer BM, Fini ME, Hassell JR. Increased SPARC accumulation during corneal repair. Exp Eye Res. 2003 Jul; 77(1):85-92. View in: PubMed

Wang N, Chintala SK, Fini ME, Schuman JS. Ultrasound activates the TM ELAM-1/IL-1/NF-kappaB response: a potential mechanism for intraocular pressure reduction after phacoemulsification. Invest Ophthalmol Vis Sci. 2003 May; 44(5):1977-81. View in: PubMed

West-Mays JA, Sivak JM, Papagiotas SS, Kim J, Nottoli T, Williams T, Fini ME. Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation. 2003 Apr; 71(3):206-16. View in: PubMed

Surgucheva IG, Sivak JM, Fini ME, Palazzo RE, Surguchov AP. Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys. 2003 Feb 1; 410(1):167-76. View in: PubMed

Chintala SK, Zhang X, Austin JS, Fini ME. Deficiency in matrix metalloproteinase gelatinase B (MMP-9) protects against retinal ganglion cell death after optic nerve ligation. J Biol Chem. 2002 Dec 6; 277(49):47461-8. View in: PubMed

Wang X, Mori T, Jung JC, Fini ME, Lo EH. Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J Neurotrauma. 2002 May; 19(5):615-25. View in: PubMed

Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52. View in: PubMed

Jung JC, Leco KJ, Edwards DR, Fini ME. Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption. Dev Dyn. 2002 Mar; 223(3):402-13. View in: PubMed

Hargrave SL, Jung JC, Fini ME, Gelender H, Cather C, Guidera A, Udell I, Fisher S, Jester JV, Bowman RW, McCulley JP, Cavanagh HD. Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis. Ophthalmology. 2002 Feb; 109(2):343-50. View in: PubMed

Mohan R, Chintala SK, Jung JC, Villar WV, McCabe F, Russo LA, Lee Y, McCarthy BE, Wollenberg KR, Jester JV, Wang M, Welgus HG, Shipley JM, Senior RM, Fini ME. Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem. 2002 Jan 18; 277(3):2065-72. View in: PubMed

Fini ME, Slaugenhaupt SA. Enzymatic mechanisms in corneal ulceration with specific reference to familial dysautonomia: potential for genetic approaches. Adv Exp Med Biol. 2002; 506(Pt A):629-39. View in: PubMed

Sivak JM, Fini ME. MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology. Prog Retin Eye Res. 2002 Jan; 21(1):1-14. View in: PubMed

Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 1; 21(19):7724-32. View in: PubMed

Asahi M, Sumii T, Fini ME, Itohara S, Lo EH. Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport. 2001 Sep 17; 12(13):3003-7. View in: PubMed

Stramer BM, Cook JR, Fini ME, Taylor A, Obin M. Induction of the ubiquitin-proteasome pathway during the keratocyte transition to the repair fibroblast phenotype. Invest Ophthalmol Vis Sci. 2001 Jul; 42(8):1698-706. View in: PubMed

Göke MN, Cook JR, Kunert KS, Fini ME, Gipson IK, Podolsky DK. Trefoil peptides promote restitution of wounded corneal epithelial cells. Exp Cell Res. 2001 Apr 1; 264(2):337-44. View in: PubMed

Wang N, Chintala SK, Fini ME, Schuman JS. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med. 2001 Mar; 7(3):304-9. View in: PubMed

Kupferman ME, Fini ME, Muller WJ, Weber R, Cheng Y, Muschel RJ. Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression. Am J Pathol. 2000 Dec; 157(6):1777-83. View in: PubMed

Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab. 2000 Dec; 20(12):1681-9. View in: PubMed

Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000 Sep 15; 20(18):7037-42. View in: PubMed

Sivak JM, Mohan R, Rinehart WB, Xu PX, Maas RL, Fini ME. Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev Biol. 2000 Jun 1; 222(1):41-54. View in: PubMed

Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, Raizman MB, Fini ME. Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000 Apr 7; 275(14):10405-12. View in: PubMed

Cook JR, Mody MK, Fini ME. Failure to activate transcription factor NF-kappaB in corneal stromal cells (keratocytes). Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3122-31. View in: PubMed

Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999 Jul; 18(4):529-51. View in: PubMed

West-Mays JA, Cook JR, Sadow PM, Mullady DK, Bargagna-Mohan P, Strissel KJ, Fini ME. Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. Invest Ophthalmol Vis Sci. 1999 Apr; 40(5):887-96. View in: PubMed

Bargagna-Mohan P, Strissel KJ, Fini ME. Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha. Invest Ophthalmol Vis Sci. 1999 Mar; 40(3):784-9. View in: PubMed

Mohan R, Rinehart WB, Bargagna-Mohan P, Fini ME. Gelatinase B/lacZ transgenic mice, a model for mapping gelatinase B expression during developmental and injury-related tissue remodeling. J Biol Chem. 1998 Oct 2; 273(40):25903-14. View in: PubMed

Fini ME, Cook JR, Mohan R. Proteolytic mechanisms in corneal ulceration and repair. Arch Dermatol Res. 1998 Jul; 290 Suppl:S12-23. View in: PubMed

Fitch J, Fini ME, Beebe DC, Linsenmayer TF. Collagen type IX and developmentally regulated swelling of the avian primary corneal stroma. Dev Dyn. 1998 May; 212(1):27-37. View in: PubMed

Strissel KJ, Girard MT, West-Mays JA, Rinehart WB, Cook JR, Brinckerhoff CE, Fini ME. Role of serum amyloid A as an intermediate in the IL-1 and PMA-stimulated signaling pathways regulating expression of rabbit fibroblast collagenase. Exp Cell Res. 1997 Dec 15; 237(2):275-87. View in: PubMed

Strissel KJ, Tessier MJ, Shams NB, Grabbe S, Gross J, Fini ME. Frog PNKT-4B cells express specific extracellular matrix-degrading enzymes and cytokines correlated with an invasive phenotype. J Exp Zool. 1997 Jul 1; 278(4):201-14. View in: PubMed

West-Mays JA, Sadow PM, Tobin TW, Strissel KJ, Cintron C, Fini ME. Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop. Invest Ophthalmol Vis Sci. 1997 Jun; 38(7):1367-79. View in: PubMed

Strissel KJ, Rinehart WB, Fini ME. Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Invest Ophthalmol Vis Sci. 1997 Feb; 38(2):546-52. View in: PubMed

Fini ME, Strissel KJ, West-Mays JA. Perspectives on eye development. Dev Genet. 1997; 20(3):175-85. View in: PubMed

Fini ME, Parks WC, Rinehart WB, Girard MT, Matsubara M, Cook JR, West-Mays JA, Sadow PM, Burgeson RE, Jeffrey JJ, Raizman MB, Krueger RR, Zieske JD. Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol. 1996 Oct; 149(4):1287-302. View in: PubMed

Rada JA, Fini ME, Hassell JR. Regionalized growth patterns of young chicken corneas. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2060-7. View in: PubMed

West-Mays JA, Strissel KJ, Sadow PM, Fini ME. Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):6768-72. View in: PubMed

Fini ME, Girard MT, Matsubara M, Bartlett JD. Unique regulation of the matrix metalloproteinase, gelatinase B. Invest Ophthalmol Vis Sci. 1995 Mar; 36(3):622-33. View in: PubMed

Strissel KJ, Rinehart WB, Fini ME. A corneal epithelial inhibitor of stromal cell collagenase synthesis identified as TGF-beta 2. Invest Ophthalmol Vis Sci. 1995 Jan; 36(1):151-62. View in: PubMed

Fini ME, Bartlett JD, Matsubara M, Rinehart WB, Mody MK, Girard MT, Rainville M. The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription. J Biol Chem. 1994 Nov 18; 269(46):28620-8. View in: PubMed

Fini ME, Strissel KJ, Girard MT, Mays JW, Rinehart WB. Interleukin 1 alpha mediates collagenase synthesis stimulated by phorbol 12-myristate 13-acetate. J Biol Chem. 1994 Apr 15; 269(15):11291-8. View in: PubMed

Ando H, Twining SS, Yue BY, Zhou X, Fini ME, Kaiya T, Higginbotham EJ, Sugar J. MMPs and proteinase inhibitors in the human aqueous humor. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3541-8. View in: PubMed

Girard MT, Matsubara M, Kublin C, Tessier MJ, Cintron C, Fini ME. Stromal fibroblasts synthesize collagenase and stromelysin during long-term tissue remodeling. J Cell Sci. 1993 Apr; 104 ( Pt 4):1001-11. View in: PubMed

Fini ME, Yue BY, Sugar J. Collagenolytic/gelatinolytic metalloproteinases in normal and keratoconus corneas. Curr Eye Res. 1992 Sep; 11(9):849-62. View in: PubMed

Fini ME, Girard MT, Matsubara M. Collagenolytic/gelatinolytic enzymes in corneal wound healing. Acta Ophthalmol Suppl. 1992; (202):26-33. View in: PubMed

Fini ME, Girard MT. Non-coordinate regulation of metalloproteinase gene expression in cornea. Matrix Suppl. 1992; 1:203-4. View in: PubMed

Matsubara M, Zieske JD, Fini ME. Mechanism of basement membrane dissolution preceding corneal ulceration. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3221-37. View in: PubMed

Fini ME, Cui TY, Mouldovan A, Grobelny D, Galardy RE, Fisher SJ. An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium. Invest Ophthalmol Vis Sci. 1991 Oct; 32(11):2997-3001. View in: PubMed

Matsubara M, Girard MT, Kublin CL, Cintron C, Fini ME. Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea. Dev Biol. 1991 Oct; 147(2):425-39. View in: PubMed

Girard MT, Matsubara M, Fini ME. Transforming growth factor-beta and interleukin-1 modulate metalloproteinase expression by corneal stromal cells. Invest Ophthalmol Vis Sci. 1991 Aug; 32(9):2441-54. View in: PubMed

Fini ME, Girard MT. The pattern of metalloproteinase expression by corneal fibroblasts is altered by passage in cell culture. J Cell Sci. 1990 Oct; 97 ( Pt 2):373-83. View in: PubMed

Fini ME, Girard MT. Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Invest Ophthalmol Vis Sci. 1990 Sep; 31(9):1779-88. View in: PubMed

Fini ME, Bendena WG, Pardue ML. Unusual behavior of the cytoplasmic transcript of hsr omega: an abundant, stress-inducible RNA that is translated but yields no detectable protein product. J Cell Biol. 1989 Jun; 108(6):2045-57. View in: PubMed

Fini ME, Karmilowicz MJ, Ruby PL, Beeman AM, Borges KA, Brinckerhoff CE. Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase. Arthritis Rheum. 1987 Nov; 30(11):1254-64. View in: PubMed

Fini ME, Plucinska IM, Mayer AS, Gross RH, Brinckerhoff CE. A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix. Biochemistry. 1987 Sep 22; 26(19):6156-65. View in: PubMed

Brinckerhoff CE, Ruby PL, Austin SD, Fini ME, White HD. Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. J Clin Invest. 1987 Feb; 79(2):542-6. View in: PubMed

Fini ME, Gross RH, Brinckerhoff CE. Characterization of rabbit genes for synovial cell collagenase. Arthritis Rheum. 1986 Nov; 29(11):1301-15. View in: PubMed

Fini ME, Austin SD, Holt PT, Ruby PL, Gross RH, White HD, Brinckerhoff CE. Homology between exon-containing portions of rabbit genomic clones for synovial cell collagenase and human foreskin and synovial cell mRNAs. Coll Relat Res. 1986 Jul; 6(3):239-48. View in: PubMed

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