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M. Elizabeth Fini, PhD
Professor of Cell & Neurobiology
Director, Institute For Genetic Medicine
Cell and Neurobiology
CSC 135K 2250 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 7732


Repair, Regeneration and the Tissue Response to Stress

The Fini Lab is best known for innovative contributions to our understanding of eye diseases. For many years, the research focus was on the Matrix Metalloproteinase (MMP) gene family. MMP genes encode a family of neutral proteinases that serve as central players in development and normal tissue maintenance. They are also important mediators of pathophysiology in a multitude of disorders.

The first MMP publication in 1960 described activity of collagenase, now known as MMP1. A small group of labs advanced the field slowly over the next 25 years using biochemical approaches, identifying several related enzymes. The field expanded dramatically once recombinant DNA technologies entered the biomedical research scene. The search string “Matrix Metalloproteinase” now brings up more than 48,000 papers on PubMed.

As a trainee, Dr. Fini was centrally involved in expansion of the MMP field, cloning genes for collagenase (MMP1) and stromelysin (MMP3). In her first faculty position, she began work on gelatinase A (MMP2) and gelatinase B (MMP9). Her lab cloned the MMP9 gene and pioneered many of the early studies characterizing MMP9 gene transcriptional regulation during development, and under various conditions of stress. The lab has also contributed to our knowledge of biological and disease roles for MMP1 and MMP9, including in corneal repair, remodeling and ulceration, maintenance of the corneal epithelium, glaucoma, eye development, cancer, brain trauma, and angiogenesis. Investigation of these MMP roles led to the lab's broader research focus in the area of repair, regeneration, and the tissue response to stress.

Dr. Fini relocated to USC in 2008. After a five year stint in senior administration, she launched the lab in new directions. Research is now focused on molecules that emerged from broad-based molecular and genomic screens, with practical application to the treatment of dry eye, ocular hypertension, and prostate cancer. The lab is currently supported by NIH R01 EY026479 and R41 EY025890.


Pagani S, Torricelli P, Veronesi F, Salamanna F, Cepollaro S, Fini M. An Advanced Tri-culture Model to Evaluate the Dynamic Interplay Among Osteoblasts, Osteoclasts and Endothelial Cells. J Cell Physiol. 2017 Feb 27. View in: PubMed

Della Bella E, Pagani S, Giavaresi G, Capelli I, Comai G, Donadei C, Cappuccilli M, La Manna G, Fini M. Uremic Serum Impairs Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stromal Cells. J Cell Physiol. 2016 Dec 14. View in: PubMed

Salamanna F, Borsari V, Brogini S, Torricelli P, Cepollaro S, Cadossi M, Fini M. A Human 3D In Vitro Model to Assess the Relationship Between Osteoporosis and Dissemination to Bone of Breast Cancer Tumor Cells. J Cell Physiol. 2016 Dec 07. View in: PubMed

Perrone AM, Livi A, Fini M, Bondioli E, Concetti S, Morganti AG, Contedini F, De Iaco P. A surgical multi-layer technique for pelvic reconstruction after total exenteration using a combination of pedicled omental flap, human acellular dermal matrix and autologous adipose derived cells. Gynecol Oncol Rep. 2016 Nov; 18:36-39. View in: PubMed

Veronesi F, Dallari D, Sabbioni G, Carubbi C, Martini L, Fini M. Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration Via Adenosine A2A Receptor Involvement: A Mini-Review. J Cell Physiol. 2016 Oct 28. View in: PubMed

Fini ME, Schwartz SG, Gao X, Jeong S, Patel N, Itakura T, Price MO, Price FW, Varma R, Stamer WD. Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. Prog Retin Eye Res. 2016 Sep 22. View in: PubMed

Fini ME, Bauskar A, Jeong S, Wilson MR. Clusterin in the eye: An old dog with new tricks at the ocular surface. Exp Eye Res. 2016 Jun; 147:57-71. View in: PubMed

Veronesi F, Della Bella E, Cepollaro S, Brogini S, Martini L, Fini M. Novel therapeutic targets in osteoarthritis: Narrative review on knock-out genes involved in disease development in mouse animal models. Cytotherapy. 2016 May; 18(5):593-612. View in: PubMed

Brilliant MH, Vaziri K, Connor TB, Schwartz SG, Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ, Kishor KS, Flynn HW, Moshfeghi AA, Moshfeghi DM, Fini ME, McKay BS. Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. Am J Med. 2016 Mar; 129(3):292-8. View in: PubMed

Gordon GM, LaGier AJ, Ponchel C, Bauskar A, Itakura T, Jeong S, Patel N, Fini ME. A cell-based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair. Wound Repair Regen. 2016 Jan; 24(1):89-99. View in: PubMed

Ongaro A, Pellati A, Setti S, Masieri FF, Aquila G, Fini M, Caruso A, De Mattei M. Electromagnetic fields counteract IL-1ß activity during chondrogenesis of bovine mesenchymal stem cells. J Tissue Eng Regen Med. 2015 Dec; 9(12):E229-38. View in: PubMed

Jeong S, Patel N, Edlund CC, Hartiala J, Hazelett D, Itakura T, Wu PC, Avery RL, Davis J, Flynn HW, Lalwani G, Puliafito CA, Wafapoor H, Hijikata M, Keicho N, Gao XA, Argueso P, Allayee H, Coetzee GA, Pletcher MT, Conti DV, Schwartz SG, Eaton AM, Fini ME. Identification of a Novel Mucin Gene HCG22 Associated with Steroid-Induced Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Mar 26. View in: PubMed

Wu PC, Tsai CL, Gordon GM, Jeong S, Itakura T, Patel N, Shi S, Fini ME. Chondrogenesis in scleral stem/progenitor cells and its association with form-deprived myopia in mice. Mol Vis. 2015; 21:138-47. View in: PubMed

Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME. Expression and Functional Role of Orphan Receptor GPR158 in Prostate Cancer Growth and Progression. PLoS One. 2015; 10(2):e0117758. View in: PubMed

Itakura T, Peters DM, Fini ME. Glaucomatous MYOC mutations activate the IL-1/NF-?B inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells. Mol Vis. 2015; 21:1071-84. View in: PubMed

Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46):8131-8141. View in: PubMed

LaGier AJ, Gordon GM, Katzman LR, Vasiliou V, Fini ME. Mechanisms for PDGF, a serum cytokine, stimulating loss of corneal keratocyte crystallins. Cornea. 2013 Sep; 32(9):1269-75. View in: PubMed

Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME. GPR158, an Orphan Member of G Protein-Coupled Receptor Family C: Glucocorticoid-Stimulated Expression and Novel Nuclear Role. PLoS One. 2013; 8(2):e57843. View in: PubMed

Jiang M, Wu PC, Fini ME, Tsai CL, Itakura T, Zhang X, Jiao S. Single-Shot Dimension Measurements of the Mouse Eye Using SD-OCT. Ophthalmic Surg Lasers Imaging. 2012 May 1; 43(3):252-6. View in: PubMed

Jeong S, Ledee DR, Gordon GM, Itakura T, Patel N, Martin A, Fini ME. Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation. Am J Pathol. 2012 May; 180(5):2028-39. View in: PubMed

Santos AR, Corredor RG, Obeso BA, Trakhtenberg EF, Wang Y, Ponmattam J, Dvoriantchikova G, Ivanov D, Shestopalov VI, Goldberg JL, Fini ME, Bajenaru ML. ß1 Integrin-Focal Adhesion Kinase (FAK) Signaling Modulates Retinal Ganglion Cell (RGC) Survival. PLoS One. 2012; 7(10):e48332. View in: PubMed

Tsai CL, Wu PC, Fini ME, Shi S. Identification of multipotent stem/progenitor cells in murine sclera. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5481-7. View in: PubMed

Gordon GM, Austin JS, Sklar AL, Feuer WJ, LaGier AJ, Fini ME. Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing. J Cell Physiol. 2011 Jun; 226(6):1461-70. View in: PubMed

Gordon GM, Moradshahi N, Jeong S, Lane C, Fini ME. A novel mechanism of increased infections in contact lens wearers. Invest Ophthalmol Vis Sci. 2011; 52(12):9188-94. View in: PubMed

Fournié PR, Gordon GM, Dawson DG, Malecaze FJ, Edelhauser HF, Fini ME. Correlation between epithelial ingrowth and basement membrane remodeling in human corneas after laser-assisted in situ keratomileusis. Arch Ophthalmol. 2010 Apr; 128(4):426-36. View in: PubMed

Zhang J, Lu JP, Suter DM, Krause KH, Fini ME, Chen B, Lu Q. Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Exp Cell Res. 2010 Apr 1; 316(6):1070-81. View in: PubMed

Fournie P, Gordon G, Ledee DR, Roberts CJ, Fini ME. The Corneal Stroma: Shape, Structure, and Biomechanical Properties. Corneal Surgery (Brightbill FS, McDonnell PJ, McGhee CNJ, and Serdarevic O, eds). 2010. View in: PubMed

Gordon, GM and Fini ME. Encyclopedia of the Eye (Darlene A. Dartt, ed). Corneal epithelium: wound healing junctions, attachment to stroma receptors, matrix metalloproteinases, intracellular communications. 2010; 1:456-462. View in: PubMed

Fini ME (ed). Vertebrate Eye Development. Results and Problems in Cell Differentiation book series. 2010. View in: PubMed

Schwartz SG, Fini ME. Pharmacogenomics for the Retina Specialist. Retina Today. 2010; (Jul/Aug):71-72. View in: PubMed

Gordon GM, Ledee DR, Feuer WJ, Fini ME. Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells. J Cell Physiol. 2009 Nov; 221(2):402-11. View in: PubMed

Ledee DR, Iovieno A, Miller D, Mandal N, Diaz M, Fell J, Fini ME, Alfonso EC. Molecular identification of t4 and t5 genotypes in isolates from acanthamoeba keratitis patients. J Clin Microbiol. 2009 May; 47(5):1458-62. View in: PubMed

Oechsler RA, Feilmeier MR, Ledee DR, Miller D, Diaz MR, Fini ME, Fell JW, Alfonso EC. Utility of molecular sequence analysis of the ITS rRNA region for identification of Fusarium spp. from ocular sources. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2230-6. View in: PubMed

Jung JC, Wang PX, Zhang G, Ezura Y, Fini ME, Birk DE. Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation. Cell Tissue Res. 2009 Apr; 336(1):79-89. View in: PubMed

Ayala-Haedo J, Schwartz SG, Kishor KS, Fini, ME. Pharmacogenomics of Ophthalmic Beta Blockers. International Journal of Medical and Biological Frontiers. 2009; (14):139-152. View in: PubMed

Gerzenstein SM, Pletcher MT, Cervino AC, Tsinoremas NF, Young B, Puliafito CA, Fini ME, Schwartz SG. Glucocorticoid receptor polymorphisms and intraocular pressure response to intravitreal triamcinolone acetonide. Ophthalmic Genet. 2008 Dec; 29(4):166-70. View in: PubMed

Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini ME, Li D, Lu Q. Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008 May 2; 369(2):414-20. View in: PubMed

Fournié PR, Gordon GM, Dawson DG, Edelhauser HF, Fini ME. Correlations of long-term matrix metalloproteinase localization in human corneas after successful laser-assisted in situ keratomileusis with minor complications at the flap margin. Arch Ophthalmol. 2008 Feb; 126(2):162-70. View in: PubMed

Schwartz SG, Ayala-Haedo J, Kishor KS, Fini ME (2008). Pharmacogenomics of Open-Angle Glaucoma. Current Pharmacogenomics and Personalized Medicine, 6: 121-125. 2008. View in: PubMed

Bassett EA, Pontoriero GF, Feng W, Marquardt T, Fini ME, Williams T, West-Mays JA. Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development. Mol Cell Biol. 2007 Nov; 27(21):7497-510. View in: PubMed

Jung JC, Huh MI, Fini ME. Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma. J Cell Biochem. 2007 Oct 1; 102(2):453-62. View in: PubMed

Huh MI, Lee YM, Seo SK, Kang BS, Chang Y, Lee YS, Fini ME, Kang SS, Jung JC. Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development. J Cell Biochem. 2007 Aug 1; 101(5):1222-37. View in: PubMed

Jockovich ME, Bajenaru ML, Piña Y, Suarez F, Feuer W, Fini ME, Murray TG. Retinoblastoma tumor vessel maturation impacts efficacy of vessel targeting in the LH(BETA)T(AG) mouse model. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2476-82. View in: PubMed

LaGier AJ, Yoo SH, Alfonso EC, Meiners S, Fini ME. Inhibition of human corneal epithelial production of fibrotic mediator TGF-beta2 by basement membrane-like extracellular matrix. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1061-71. View in: PubMed

Bargagna-Mohan P, Mohan R, Russo L, Kochevar IE, Fini ME. Cell lines and transgenic mice expressing a matrix metalloproteinase-9 promoter-driven reporter gene: potential for assay of ultraviolet light effects and light-inhibiting compounds. Cutan Ocul Toxicol. 2007; 26(4):383-97. View in: PubMed

Mukherjee R, Mingoia JT, Bruce JA, Austin JS, Stroud RE, Escobar GP, McClister DM, Allen CM, Alfonso-Jaume MA, Fini ME, Lovett DH, Spinale FG. Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2216-28. View in: PubMed

Zhang X, Schroeder A, Callahan EM, Coyle BM, Wang N, Erickson KA, Schuman JS, Fini ME. Constitutive signalling pathway activity in trabecular meshwork cells from glaucomatous eyes. Exp Eye Res. 2006 Jun; 82(6):968-73. View in: PubMed

Ouyang J, Shen YC, Yeh LK, Li W, Coyle BM, Liu CY, Fini ME. Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2397-407. View in: PubMed

Fini ME, Stramer BM. How the cornea heals: cornea-specific repair mechanisms affecting surgical outcomes. Cornea. 2005 Nov; 24(8 Suppl):S2-S11. View in: PubMed

Chintala SK, Wang N, Diskin S, Mattox C, Kagemann L, Fini ME, Schuman JS. Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs. Exp Eye Res. 2005 Oct; 81(4):429-36. View in: PubMed

Stramer BM, Austin JS, Roberts AB, Fini ME. Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3. J Cell Physiol. 2005 Apr; 203(1):226-32. View in: PubMed

Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. View in: PubMed

Stramer BM, Fini ME. Uncoupling keratocyte loss of corneal crystallin from markers of fibrotic repair. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4010-5. View in: PubMed

Jung JC, West-Mays JA, Stramer BM, Byrne MH, Scott S, Mody MK, Sadow PM, Krane SM, Fini ME. Activity and expression of Xenopus laevis matrix metalloproteinases: identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals. J Cell Physiol. 2004 Oct; 201(1):155-64. View in: PubMed

Stramer BM, Kwok MG, Farthing-Nayak PJ, Jung JC, Fini ME, Nayak RC. Monoclonal antibody (3G5)-defined ganglioside: cell surface marker of corneal keratocytes. Invest Ophthalmol Vis Sci. 2004 Mar; 45(3):807-12. View in: PubMed

Johnson C, Sung HJ, Lessner SM, Fini ME, Galis ZS. Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Circ Res. 2004 Feb 6; 94(2):262-8. View in: PubMed

Newsom RS, Austin JS, Fini ME, Reichel E. Large spot endolaser for retinal photocoagulation and transvitreal thermotherapy. Ophthalmic Surg Lasers Imaging. 2004 Jan-Feb; 35(1):26-30. View in: PubMed

Sivak JM, West-Mays JA, Yee A, Williams T, Fini ME. Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Mol Cell Biol. 2004 Jan; 24(1):245-57. View in: PubMed

Stramer BM, Zieske JD, Jung JC, Austin JS, Fini ME. Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4237-46. View in: PubMed

Berryhill BL, Kane B, Stramer BM, Fini ME, Hassell JR. Increased SPARC accumulation during corneal repair. Exp Eye Res. 2003 Jul; 77(1):85-92. View in: PubMed

Wang N, Chintala SK, Fini ME, Schuman JS. Ultrasound activates the TM ELAM-1/IL-1/NF-kappaB response: a potential mechanism for intraocular pressure reduction after phacoemulsification. Invest Ophthalmol Vis Sci. 2003 May; 44(5):1977-81. View in: PubMed

West-Mays JA, Sivak JM, Papagiotas SS, Kim J, Nottoli T, Williams T, Fini ME. Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation. 2003 Apr; 71(3):206-16. View in: PubMed

Surgucheva IG, Sivak JM, Fini ME, Palazzo RE, Surguchov AP. Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys. 2003 Feb 1; 410(1):167-76. View in: PubMed

Chintala SK, Zhang X, Austin JS, Fini ME. Deficiency in matrix metalloproteinase gelatinase B (MMP-9) protects against retinal ganglion cell death after optic nerve ligation. J Biol Chem. 2002 Dec 6; 277(49):47461-8. View in: PubMed

Wang X, Mori T, Jung JC, Fini ME, Lo EH. Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J Neurotrauma. 2002 May; 19(5):615-25. View in: PubMed

Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52. View in: PubMed

Jung JC, Leco KJ, Edwards DR, Fini ME. Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption. Dev Dyn. 2002 Mar; 223(3):402-13. View in: PubMed

Hargrave SL, Jung JC, Fini ME, Gelender H, Cather C, Guidera A, Udell I, Fisher S, Jester JV, Bowman RW, McCulley JP, Cavanagh HD. Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis. Ophthalmology. 2002 Feb; 109(2):343-50. View in: PubMed

Mohan R, Chintala SK, Jung JC, Villar WV, McCabe F, Russo LA, Lee Y, McCarthy BE, Wollenberg KR, Jester JV, Wang M, Welgus HG, Shipley JM, Senior RM, Fini ME. Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem. 2002 Jan 18; 277(3):2065-72. View in: PubMed

Fini ME, Slaugenhaupt SA. Enzymatic mechanisms in corneal ulceration with specific reference to familial dysautonomia: potential for genetic approaches. Adv Exp Med Biol. 2002; 506(Pt A):629-39. View in: PubMed

Sivak JM, Fini ME. MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology. Prog Retin Eye Res. 2002 Jan; 21(1):1-14. View in: PubMed

Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 1; 21(19):7724-32. View in: PubMed

Asahi M, Sumii T, Fini ME, Itohara S, Lo EH. Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport. 2001 Sep 17; 12(13):3003-7. View in: PubMed

Stramer BM, Cook JR, Fini ME, Taylor A, Obin M. Induction of the ubiquitin-proteasome pathway during the keratocyte transition to the repair fibroblast phenotype. Invest Ophthalmol Vis Sci. 2001 Jul; 42(8):1698-706. View in: PubMed

Göke MN, Cook JR, Kunert KS, Fini ME, Gipson IK, Podolsky DK. Trefoil peptides promote restitution of wounded corneal epithelial cells. Exp Cell Res. 2001 Apr 1; 264(2):337-44. View in: PubMed

Wang N, Chintala SK, Fini ME, Schuman JS. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med. 2001 Mar; 7(3):304-9. View in: PubMed

Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab. 2000 Dec; 20(12):1681-9. View in: PubMed

Kupferman ME, Fini ME, Muller WJ, Weber R, Cheng Y, Muschel RJ. Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression. Am J Pathol. 2000 Dec; 157(6):1777-83. View in: PubMed

Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000 Sep 15; 20(18):7037-42. View in: PubMed

Sivak JM, Mohan R, Rinehart WB, Xu PX, Maas RL, Fini ME. Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev Biol. 2000 Jun 1; 222(1):41-54. View in: PubMed

Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, Raizman MB, Fini ME. Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000 Apr 7; 275(14):10405-12. View in: PubMed

Cook JR, Mody MK, Fini ME. Failure to activate transcription factor NF-kappaB in corneal stromal cells (keratocytes). Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3122-31. View in: PubMed

Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999 Jul; 18(4):529-51. View in: PubMed

West-Mays JA, Cook JR, Sadow PM, Mullady DK, Bargagna-Mohan P, Strissel KJ, Fini ME. Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. Invest Ophthalmol Vis Sci. 1999 Apr; 40(5):887-96. View in: PubMed

Bargagna-Mohan P, Strissel KJ, Fini ME. Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha. Invest Ophthalmol Vis Sci. 1999 Mar; 40(3):784-9. View in: PubMed

Mohan R, Rinehart WB, Bargagna-Mohan P, Fini ME. Gelatinase B/lacZ transgenic mice, a model for mapping gelatinase B expression during developmental and injury-related tissue remodeling. J Biol Chem. 1998 Oct 2; 273(40):25903-14. View in: PubMed

Fini ME, Cook JR, Mohan R. Proteolytic mechanisms in corneal ulceration and repair. Arch Dermatol Res. 1998 Jul; 290 Suppl:S12-23. View in: PubMed

Fitch J, Fini ME, Beebe DC, Linsenmayer TF. Collagen type IX and developmentally regulated swelling of the avian primary corneal stroma. Dev Dyn. 1998 May; 212(1):27-37. View in: PubMed

Matsubara M, Fini ME. Matrix Metalloproteinases in degradation and remodeling of the corneal epithelial basement membrane. Proceedings of the Kyoto Cornea Club. 1998. View in: PubMed

Fini, ME, Cook, JR, Mohan R, Brinckerhoff, CE. Regulation of Matrix Metalloproteinase gene expression. In: Parks W. , and Mecham, R. Matrix Metalloproteinases. 1998. View in: PubMed

Strissel KJ, Girard MT, West-Mays JA, Rinehart WB, Cook JR, Brinckerhoff CE, Fini ME. Role of serum amyloid A as an intermediate in the IL-1 and PMA-stimulated signaling pathways regulating expression of rabbit fibroblast collagenase. Exp Cell Res. 1997 Dec 15; 237(2):275-87. View in: PubMed

Strissel KJ, Tessier MJ, Shams NB, Grabbe S, Gross J, Fini ME. Frog PNKT-4B cells express specific extracellular matrix-degrading enzymes and cytokines correlated with an invasive phenotype. J Exp Zool. 1997 Jul 1; 278(4):201-14. View in: PubMed

West-Mays JA, Sadow PM, Tobin TW, Strissel KJ, Cintron C, Fini ME. Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop. Invest Ophthalmol Vis Sci. 1997 Jun; 38(7):1367-79. View in: PubMed

Strissel KJ, Rinehart WB, Fini ME. Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Invest Ophthalmol Vis Sci. 1997 Feb; 38(2):546-52. View in: PubMed

Fini ME, Strissel KJ, West-Mays JA. Perspectives on eye development. Dev Genet. 1997; 20(3):175-85. View in: PubMed

Williams JM, Fini ME, Cousins SW, Pepose JS. In: Krachmer JH, Mannis MJ, and Holland EJ, eds. The Cornea. Volume I: Fundamentals of Cornea and External Disease. Corneal responses to infection. 1997; 129-162. View in: PubMed

Fini ME, Parks WC, Rinehart WB, Girard MT, Matsubara M, Cook JR, West-Mays JA, Sadow PM, Burgeson RE, Jeffrey JJ, Raizman MB, Krueger RR, Zieske JD. Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol. 1996 Oct; 149(4):1287-302. View in: PubMed

Rada JA, Fini ME, Hassell JR. Regionalized growth patterns of young chicken corneas. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2060-7. View in: PubMed

Fini ME, Cook JR, Rinehart WB, Sadow PM, Strissel KJ, West-Mays JA. Molecular mechanisms initiating the gene expression program for corneal repair. Advances in Cornea Research: Selected Transactions of the World Corneal Congress (Lass J, ed). 1996. View in: PubMed

West-Mays JA, Strissel KJ, Sadow PM, Fini ME. Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):6768-72. View in: PubMed

Fini ME, Girard MT, Matsubara M, Bartlett JD. Unique regulation of the matrix metalloproteinase, gelatinase B. Invest Ophthalmol Vis Sci. 1995 Mar; 36(3):622-33. View in: PubMed

Strissel KJ, Rinehart WB, Fini ME. A corneal epithelial inhibitor of stromal cell collagenase synthesis identified as TGF-beta 2. Invest Ophthalmol Vis Sci. 1995 Jan; 36(1):151-62. View in: PubMed

Fini ME, Bartlett JD, Matsubara M, Rinehart WB, Mody MK, Girard MT, Rainville M. The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription. J Biol Chem. 1994 Nov 18; 269(46):28620-8. View in: PubMed

Fini ME, Strissel KJ, Girard MT, Mays JW, Rinehart WB. Interleukin 1 alpha mediates collagenase synthesis stimulated by phorbol 12-myristate 13-acetate. J Biol Chem. 1994 Apr 15; 269(15):11291-8. View in: PubMed

Ando H, Twining SS, Yue BY, Zhou X, Fini ME, Kaiya T, Higginbotham EJ, Sugar J. MMPs and proteinase inhibitors in the human aqueous humor. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3541-8. View in: PubMed

Girard MT, Matsubara M, Kublin C, Tessier MJ, Cintron C, Fini ME. Stromal fibroblasts synthesize collagenase and stromelysin during long-term tissue remodeling. J Cell Sci. 1993 Apr; 104 ( Pt 4):1001-11. View in: PubMed

Fini ME, Yue BY, Sugar J. Collagenolytic/gelatinolytic metalloproteinases in normal and keratoconus corneas. Curr Eye Res. 1992 Sep; 11(9):849-62. View in: PubMed

Fini ME, Girard MT, Matsubara M. Collagenolytic/gelatinolytic enzymes in corneal wound healing. Acta Ophthalmol Suppl. 1992; (202):26-33. View in: PubMed

Fini ME, Girard MT. Non-coordinate regulation of metalloproteinase gene expression in cornea. Matrix Suppl. 1992; 1:203-4. View in: PubMed

Matsubara M, Zieske JD, Fini ME. Mechanism of basement membrane dissolution preceding corneal ulceration. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3221-37. View in: PubMed

Fini ME, Cui TY, Mouldovan A, Grobelny D, Galardy RE, Fisher SJ. An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium. Invest Ophthalmol Vis Sci. 1991 Oct; 32(11):2997-3001. View in: PubMed

Matsubara M, Girard MT, Kublin CL, Cintron C, Fini ME. Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea. Dev Biol. 1991 Oct; 147(2):425-39. View in: PubMed

Girard MT, Matsubara M, Fini ME. Transforming growth factor-beta and interleukin-1 modulate metalloproteinase expression by corneal stromal cells. Invest Ophthalmol Vis Sci. 1991 Aug; 32(9):2441-54. View in: PubMed

Fini ME, Girard MT. The pattern of metalloproteinase expression by corneal fibroblasts is altered by passage in cell culture. J Cell Sci. 1990 Oct; 97 ( Pt 2):373-83. View in: PubMed

Fini ME, Girard MT. Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Invest Ophthalmol Vis Sci. 1990 Sep; 31(9):1779-88. View in: PubMed

Pardue ML, Bendena WG, Fini ME, Garbe JC, Hogan NC, Traverse KL. Hsr-omega, a novel gene encoded in a Drosophila heat shock puff. The Biological Bulletin. 1990; 179:77-86. View in: PubMed

Fini ME, Bendena WG, Pardue ML. Unusual behavior of the cytoplasmic transcript of hsr omega: an abundant, stress-inducible RNA that is translated but yields no detectable protein product. J Cell Biol. 1989 Jun; 108(6):2045-57. View in: PubMed

Brinckerhoff CE, Fini ME. In: Olsen B, Nimmi ME, eds. Collagen: Volume IV, Molecular Biology. Molecular cloning of collagenase and activator/stromelysin: members of a coordinately regulated gene family of metalloproteinases important in the modulation of connective tissue metabolism. 1989; 65-86. View in: PubMed

Bendena WG, Fini ME, Garbe JC, Kidder GM, Lakhotia SC, Pardue ML. Hsr-omega: a different sort of heat shock locus. In: Pardue ML, Lindquist S, Ferimisco J, eds. Stress-Induced Proteins. (Proceedings of the UCLA Symposium). 1988; 3-14. View in: PubMed

Fini ME, Karmilowicz MJ, Ruby PL, Beeman AM, Borges KA, Brinckerhoff CE. Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase. Arthritis Rheum. 1987 Nov; 30(11):1254-64. View in: PubMed

Fini ME, Plucinska IM, Mayer AS, Gross RH, Brinckerhoff CE. A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix. Biochemistry. 1987 Sep 22; 26(19):6156-65. View in: PubMed

Brinckerhoff CE, Ruby PL, Austin SD, Fini ME, White HD. Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. J Clin Invest. 1987 Feb; 79(2):542-6. View in: PubMed

Brinckerhoff CE, Fini ME, Ruby PL, Plucinska IM, Borges KM, Karmilowicz MJ . Coordinate regulation of metalloproteinase gene expression in synovial cells. In: Sen A, Thornhill T, eds. Development and Diseases of Cartilage and Bone Matrix. (Proceedings of the UCLA Symposium). 1987; 299-217. View in: PubMed

Fini ME, Gross RH, Brinckerhoff CE. Characterization of rabbit genes for synovial cell collagenase. Arthritis Rheum. 1986 Nov; 29(11):1301-15. View in: PubMed

Fini ME, Austin SD, Holt PT, Ruby PL, Gross RH, White HD, Brinckerhoff CE. Homology between exon-containing portions of rabbit genomic clones for synovial cell collagenase and human foreskin and synovial cell mRNAs. Coll Relat Res. 1986 Jul; 6(3):239-48. View in: PubMed

Osteen RE, Fini ME, Wilson RE. The relationship of body temperature to the efficacy of chemotherapy against systemic metastases from B16 melanoma. Journal of Surgical Research. 1984; 37:139-144. View in: PubMed

Fini ME, Sicard RE. Limb regeneration of the adult newt (Notophthalmus viridescens) in the absence of the spleen. Wilhelm Roux's Archives of Developmental Biology. 1980; (189):77-79. View in: PubMed

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