Faculty

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Marc J. Weigensberg, MD
Associate Professor of Clinical Pediatrics
Pediatrics
IRD 105 2020 Zonal Avenue Off Campus Los Angeles
+1 323 226 5604

Overview

Dr. Weigensberg holds an appointment as Associate Professor of Clinical Pediatrics in the Department of Pediatrics, USC Keck School of Medicine, and is the Director of Pediatric Endocrinology at Los Angeles County + USC Medical Center. He has a major interest in mind-body medicine and was certified in Interactive Guided ImagerySM through the Academy for Guided Imagery, Mill Valley, CA in 1999. Dr. Weigensberg received his medical school training at the University of Chicago Pritzker School of Medicine, and completed his pediatric residency and pediatric endocrinology fellowship training at Children’s Memorial Hospital, Northwestern University in Chicago. He was formerly on faculty at the University of Illinois School of Medicine.

Dr. Weigensberg’s major research interest is in the interaction of psychological and physiological factors in the expression of metabolic disease in children and adolescents, particularly the role played by the body’s stress-response system in diabetes and metabolic disease risk. He is an integral clinical investigator in the USC Childhood Obesity Research Center, where he has served as Clinical Co-Principal Investigator (Co-PI) and Co-Investigator (Co-I) for multiple lifestyle interventions and other metabolic studies involving diabetes and chronic disease risk in overweight children and adolescents. He is Principle Investigator for the “Imagine Health” study, funded by the National Center for Complementary and Alternative Medicine, which developed and pilot-tested an innovative lifestyle intervention using guided imagery for Latino adolescents. He is currently Co-I on two projects of the USC Center for Transdisciplinary Research on Energetics and Cancer (USC C-TREC), as well as PI and Co-I for two separate projects in the USC National Center on Minority Health and Health Disparities (NCMHD) Center of Excellence in Minority Health in African American and Hispanic Children.

Publications

Clinical and Psychosocial Outcomes of a Structured Transition Program Among Young Adults With Type 1 Diabetes. J Adolesc Health. 2017 Feb; 60(2):212-218. View in: PubMed

Effects of air pollution exposure on glucose metabolism in Los Angeles minority children. Pediatr Obes. 2016 Dec 06. View in: PubMed

Associations among sugar sweetened beverage intake, visceral fat, and cortisol awakening response in minority youth. Physiol Behav. 2016 Dec 01; 167:188-193. View in: PubMed

Clinical and Psychosocial Outcomes of a Structured Transition Program Among Young Adults With Type 1 Diabetes. J Adolesc Health. 2016 Nov 23. View in: PubMed

The Role of Assimilating to the US Culture and the Relationship Between Neighborhood Ethnic Composition and Dietary Intake Among Hispanic Youth. J Racial Ethn Health Disparities. 2016 Oct 17. View in: PubMed

Saturation of subcutaneous adipose tissue expansion and accumulation of ectopic fat associated with metabolic dysfunction during late and post-pubertal growth. Int J Obes (Lond). 2016 Apr; 40(4):601-6. View in: PubMed

Comparing glycemic indicators of prediabetes: a prospective study of obese Latino Youth. Pediatr Diabetes. 2015 Dec; 16(8):640-3. View in: PubMed

Saturation of subcutaneous adipose tissue expansion and accumulation of ectopic fat associated with metabolic dysfunction during late and post-pubertal growth. Int J Obes (Lond). 2015 Oct 7. View in: PubMed

Effects of high-sugar and high-fiber meals on physical activity behaviors in Latino and African American adolescents. Obesity (Silver Spring). 2015 Sep; 23(9):1886-94. View in: PubMed

Let's Empower and Prepare (LEAP): Evaluation of a Structured Transition Program for Young Adults With Type 1 Diabetes. Diabetes Care. 2015 Aug; 38(8):1412-9. View in: PubMed

Temporal relationships between adipocytokines and diabetes risk in Hispanic adolescents with obesity. Obesity (Silver Spring). 2015 Jul; 23(7):1479-85. View in: PubMed

Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetol. 2015 Apr; 52(2):277-84. View in: PubMed

Changes in Bone Biomarkers, BMC, and Insulin Resistance Following a 10-Week Whole Body Vibration Exercise Program in Overweight Latino Boys. Int J Med Sci. 2015; 12(6):494-501. View in: PubMed

Built Environment Associations with Adiposity Parameters among Overweight and Obese Hispanic Youth. Prev Med Rep. 2015; 2:406-412. View in: PubMed

Challenges contributing to disrupted transition from paediatric to adult diabetes care in young adults with type 1 diabetes. Diabet Med. 2014 Dec; 31(12):1615-24. View in: PubMed

Vegetable consumption is linked to decreased visceral and liver fat and improved insulin resistance in overweight Latino youth. J Acad Nutr Diet. 2014 Nov; 114(11):1776-83. View in: PubMed

"We are all gonna get diabetic these days": the impact of a living legacy of type 2 diabetes on Hispanic young adults' diabetes care. Diabetes Educ. 2014 Sep-Oct; 40(5):648-58. View in: PubMed

Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetol. 2014 Aug 11. View in: PubMed

Double jeopardy: metabolic syndrome leads to increased sedentary behavior in peri-pubertal minority females. Pediatr Exerc Sci. 2014 Aug; 26(3):266-73. View in: PubMed

"We Are All Gonna Get Diabetic These Days": The Impact of a Living Legacy of Type 2 Diabetes on Hispanic Young Adults' Diabetes Care. Diabetes Educ. 2014 May 27. View in: PubMed

Meal skipping linked to increased visceral adipose tissue and triglycerides in overweight minority youth. Obesity (Silver Spring). 2014 May; 22(5):E77-84. View in: PubMed

Double Jeopardy: Metabolic Syndrome Leads to Increased Sedentary Behavior in Peri-Pubertal Minority Females. Pediatr Exerc Sci. 2014 Apr 10. View in: PubMed

Fast-food restaurants, park access, and insulin resistance among Hispanic youth. Am J Prev Med. 2014 Apr; 46(4):378-87. View in: PubMed

Vegetable Consumption Is Linked to Decreased Visceral and Liver Fat and Improved Insulin Resistance in Overweight Latino Youth. J Acad Nutr Diet. 2014 Mar 27. View in: PubMed

Modifying influence of dietary sugar in the relationship between cortisol and visceral adipose tissue in minority youth. Obesity (Silver Spring). 2014 Feb; 22(2):474-81. View in: PubMed

Imagine HEALTH: results from a randomized pilot lifestyle intervention for obese Latino adolescents using Interactive Guided ImagerySM. BMC Complement Altern Med. 2014 Jan 17; 14:28. View in: PubMed

Imagine HEALTH: results from a randomized pilot lifestyle intervention for obese Latino adolescents using Interactive Guided ImagerySM. BMC Complement Altern Med. 2014; 14(1):28. View in: PubMed

Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children. Obesity (Silver Spring). 2013 Dec; 21(12):E790-7. View in: PubMed

Temporal relationship between insulin sensitivity and the pubertal decline in physical activity in peripubertal Hispanic and African American females. Diabetes Care. 2013 Nov; 36(11):3739-45. View in: PubMed

Liver fat has a stronger association with risk factors for type 2 diabetes in African-American compared with Hispanic adolescents. J Clin Endocrinol Metab. 2013 Sep; 98(9):3748-54. View in: PubMed

Disclosure of psychosocial stressors affecting diabetes care among uninsured young adults with Type 1 diabetes. Diabet Med. 2013 Sep; 30(9):1140-4. View in: PubMed

Blunted nocturnal cortisol rise is associated with higher carotid artery intima-media thickness (CIMT) in overweight African American and Latino youth. Psychoneuroendocrinology. 2013 Sep; 38(9):1658-67. View in: PubMed

Eating breakfast more frequently is cross-sectionally associated with greater physical activity and lower levels of adiposity in overweight Latina and African American girls. Am J Clin Nutr. 2013 Aug; 98(2):275-81. View in: PubMed

One-hour glucose during an oral glucose challenge prospectively predicts ß-cell deterioration and prediabetes in obese Hispanic youth. Diabetes Care. 2013 Jun; 36(6):1681-6. View in: PubMed

Ectopic fat deposition in prediabetic overweight and obese minority adolescents. J Clin Endocrinol Metab. 2013 Mar; 98(3):1115-21. View in: PubMed

Leptin predicts a decline in moderate to vigorous physical activity in minority female children at risk for obesity. Pediatr Obes. 2013 Feb; 8(1):70-7. View in: PubMed

Adherence decision making in the everyday lives of emerging adults with type 1 diabetes. Patient Prefer Adherence. 2013; 7:709-18. View in: PubMed

Physical activity is related to insulin sensitivity in children and adolescents, independent of adiposity: a review of the literature. Diabetes Metab Res Rev. 2012 Jul 2; 28(5):395-408. View in: PubMed

Physical activity is related to insulin sensitivity in children and adolescents, independent of adiposity: a review of the literature. Diabetes Metab Res Rev. 2012 Jul; 28(5):395-408. View in: PubMed

Health-related quality of life in adolescents with or at risk for type 2 diabetes mellitus. J Pediatr. 2012 Jun; 160(6):911-7. View in: PubMed

Hemoglobin A1c above threshold level is associated with decreased ß-cell function in overweight Latino youth. J Pediatr. 2012 May; 160(5):751-6. View in: PubMed

CRP is related to higher leptin levels in minority peripubertal females regardless of adiposity levels. Obesity (Silver Spring). 2012 Mar; 20(3):512-6. View in: PubMed

Effects of a randomized maintenance intervention on adiposity and metabolic risk factors in overweight minority adolescents. Pediatr Obes. 2012 Feb; 7(1):16-27. View in: PubMed

Physical activity, sedentary behavior, and the metabolic syndrome in minority youth. Med Sci Sports Exerc. 2011 Dec; 43(12):2307-13. View in: PubMed

Improving insulin resistance in obese youth: choose your measures wisely. Int J Pediatr Obes. 2011 Jun; 6(2-2):e290-6. View in: PubMed

Subclinical atherosclerosis in Latino youth: progression of carotid intima-media thickness and its relationship to cardiometabolic risk factors. J Pediatr. 2011 Jun; 158(6):935-40. View in: PubMed

Relationships between IGF-1 and IGFBP-1 and adiposity in obese African-American and Latino adolescents. Obesity (Silver Spring). 2011 May; 19(5):933-8. View in: PubMed

Stress and abdominal fat: preliminary evidence of moderation by the cortisol awakening response in Hispanic peripubertal girls. Obesity (Silver Spring). 2011 May; 19(5):946-52. View in: PubMed

Fasting indicators of insulin sensitivity: effects of ethnicity and pubertal status. Diabetes Care. 2011 Apr; 34(4):994-9. View in: PubMed

Pubertal changes of insulin sensitivity, acute insulin response, and ß-cell function in overweight Latino youth. J Pediatr. 2011 Mar; 158(3):442-6. View in: PubMed

Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care. 2011 Feb; 34(2):485-90. View in: PubMed

Physical inactivity, but not sedentary behavior or energy intake, is associated with higher fat mass in Latina and African American girls. Ethn Dis. 2011; 21(4):458-61. View in: PubMed

Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents. Diabetes. 2010 Dec; 59(12):3127-30. View in: PubMed

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption. Am J Clin Nutr. 2010 Dec; 92(6):1522-7. View in: PubMed

Interventions for improving metabolic risk in overweight Latino youth. Int J Pediatr Obes. 2010 Oct; 5(5):451-5. View in: PubMed

Cortisol is negatively associated with insulin sensitivity in overweight Latino youth. J Clin Endocrinol Metab. 2010 Oct; 95(10):4729-35. View in: PubMed

Ethnic differences in insulin action in obese African-American and Latino adolescents. J Clin Endocrinol Metab. 2010 Aug; 95(8):4048-51. View in: PubMed

Insulin sensitivity as an independent predictor of fat mass gain in Hispanic adolescents. Diabetes Care. 2009 Nov; 32(11):2114-5. View in: PubMed

Persistence of the metabolic syndrome over 3 annual visits in overweight Hispanic children: association with progressive risk for type 2 diabetes. J Pediatr. 2009 Oct; 155(4):535-41. View in: PubMed

Persistence of the metabolic syndrome and its influence on carotid artery intima media thickness in overweight Latino children. Atherosclerosis. 2009 Oct; 206(2):594-8. View in: PubMed

Association of breakfast skipping with visceral fat and insulin indices in overweight Latino youth. Obesity (Silver Spring). 2009 Aug; 17(8):1528-33. View in: PubMed

Randomized control trial to improve adiposity and insulin resistance in overweight Latino adolescents. Obesity (Silver Spring). 2009 Aug; 17(8):1542-8. View in: PubMed

Aerobic and strength training reduces adiposity in overweight Latina adolescents. Med Sci Sports Exerc. 2009 Jul; 41(7):1494-503. View in: PubMed

A high-sugar/low-fiber meal compared with a low-sugar/high-fiber meal leads to higher leptin and physical activity levels in overweight Latina females. J Am Diet Assoc. 2009 Jun; 109(6):1058-63. View in: PubMed

Type 2 diabetes in children and adolescents. Lancet. 2009 May 23; 373(9677):1743-4. View in: PubMed

Reduction in risk factors for type 2 diabetes mellitus in response to a low-sugar, high-fiber dietary intervention in overweight Latino adolescents. Arch Pediatr Adolesc Med. 2009 Apr; 163(4):320-7. View in: PubMed

Acute effects of stress-reduction Interactive Guided Imagery(SM) on salivary cortisol in overweight Latino adolescents. J Altern Complement Med. 2009 Mar; 15(3):297-303. View in: PubMed

Birth weight and body composition in overweight Latino youth: a longitudinal analysis. Obesity (Silver Spring). 2008 Nov; 16(11):2524-8. View in: PubMed

Persistence of pre-diabetes in overweight and obese Hispanic children: association with progressive insulin resistance, poor beta-cell function, and increasing visceral fat. Diabetes. 2008 Nov; 57(11):3007-12. View in: PubMed

Cardiorespiratory fitness and physical activity in youth with type 2 diabetes. Pediatr Diabetes. 2008 Oct; 9(5):460-3. View in: PubMed

Adiponectin and leptin are independently associated with insulin sensitivity, but not with insulin secretion or beta-cell function in overweight Hispanic adolescents. Horm Metab Res. 2008 Oct; 40(10):708-12. View in: PubMed

Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children. J Pediatr Endocrinol Metab. 2008 Sep; 21(9):855-64. View in: PubMed

Combined association of maternal and paternal family history of diabetes with plasma leptin and adiponectin in overweight Hispanic children. Diabet Med. 2008 Sep; 25(9):1043-8. View in: PubMed

Dietary intake and the metabolic syndrome in overweight Latino children. J Am Diet Assoc. 2008 Aug; 108(8):1355-9. View in: PubMed

Low prevalence of pediatric type 2 diabetes: where's the epidemic? J Pediatr. Low prevalence of pediatric type 2 diabetes: where's the epidemic? J Pediatr. 2008 Jun; 152(6):753-5. View in: PubMed

Association between the metabolic syndrome and serum cortisol in overweight Latino youth. J Clin Endocrinol Metab. 2008 Apr; 93(4):1372-8. View in: PubMed

Associations of dietary sugar and glycemic index with adiposity and insulin dynamics in overweight Latino youth. Am J Clin Nutr. 2007 Nov; 86(5):1331-8. View in: PubMed

Parental history and risk of type 2 diabetes in overweight Latino adolescents: a longitudinal analysis. Diabetes Care. 2007 Oct; 30(10):2700-5. View in: PubMed

Leptin-to-adiponectin ratio as independent predictor of insulin sensitivity during growth in overweight Hispanic youth. J Endocrinol Invest. 2007 Jul-Aug; 30(7):RC13-6. View in: PubMed

Reduction in added sugar intake and improvement in insulin secretion in overweight latina adolescents. Metab Syndr Relat Disord. 2007 Jun; 5(2):183-93. View in: PubMed

Adiponectin independently predicts metabolic syndrome in overweight Latino youth. J Clin Endocrinol Metab. 2007 May; 92(5):1809-13. View in: PubMed

Influence of breastfeeding on obesity and type 2 diabetes risk factors in Latino youth with a family history of type 2 diabetes. Diabetes Care. 2007 Apr; 30(4):784-9. View in: PubMed

Frequency of hypoglycaemia during the intravenous glucose tolerance test in overweight children. Int J Pediatr Obes. 2007; 2(2):122-5. View in: PubMed

Feasibility of a home-based versus classroom-based nutrition intervention to reduce obesity and type 2 diabetes in Latino youth. Int J Pediatr Obes. 2007; 2(1):22-30. View in: PubMed

Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc. 2006 Jul; 38(7):1208-15. View in: PubMed

Acculturation is Associated With Higher VO2max in Overweight Hispanic Children. Pediatr Exerc Sci. 2006 Mar; 18(1):89-100. View in: PubMed

Deterioration of insulin sensitivity and beta-cell function in overweight Hispanic children during pubertal transition: a longitudinal assessment. Int J Pediatr Obes. 2006; 1(3):139-45. View in: PubMed

Longitudinal changes in insulin sensitivity, insulin secretion, and beta-cell function during puberty. J Pediatr. 2006 Jan; 148(1):16-22. View in: PubMed

Cardiovascular fitness and physical activity in children with and without impaired glucose tolerance. Int J Obes (Lond). 2006 Jan; 30(1):45-9. View in: PubMed

Predicting abdominal adipose tissue in overweight Latino youth. Int J Pediatr Obes. 2006; 1(4):210-6. View in: PubMed

Insulin sensitivity, insulin secretion and beta-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes. Int J Obes (Lond). 2005 Dec; 29(12):1471-7. View in: PubMed

The relation of sugar intake to beta cell function in overweight Latino children. Am J Clin Nutr. 2005 Nov; 82(5):1004-10. View in: PubMed

Decreased beta-cell function in overweight Latino children with impaired fasting glucose. Diabetes Care. 2005 Oct; 28(10):2519-24. View in: PubMed

Dietary fat intake and insulin resistance in black and white children. Obes Res. 2005 Sep; 13(9):1630-7. View in: PubMed

Cardiovascular fitness and the metabolic syndrome in overweight latino youths. Med Sci Sports Exerc. 2005 Jun; 37(6):922-8. View in: PubMed

Pediatric obesity and insulin resistance: chronic disease risk and implications for treatment and prevention beyond body weight modification. Annu Rev Nutr. 2005; 25:435-68. View in: PubMed

Relation between acanthosis nigricans and insulin sensitivity in overweight Hispanic children at risk for type 2 diabetes. Diabetes Care. 2004 Jun; 27(6):1412-6. View in: PubMed

Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes. J Clin Endocrinol Metab. 2004 Jan; 89(1):207-12. View in: PubMed

The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab. 2004 Jan; 89(1):108-13. View in: PubMed

Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth. Obes Res. 2004 Jan; 12(1):77-85. View in: PubMed

Association between insulin sensitivity and post-glucose challenge plasma insulin values in overweight Latino youth. Diabetes Care. 2003 Jul; 26(7):2094-9. View in: PubMed

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