Faculty

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Marcel E Nimni, PhD
Professor of Surgery
Surgery
EDM 191 Health Sciences Campus Los Angeles
+1 323 224 5067

Overview

Dr. Nimni is a Professor of Surgery, Biochemistry & Molecular Biology and Biomedical Engineering, and Director of Tissue Engineering Laboratories at the Keck School of Medicine of USC. His major areas of research activities include: Biochemistry of collagen: molecular structure, biosynthesis, mechanisms of crosslinking in soft tissues, bone and cartilage; interactions between connective tissues constituents, biochemical changes in degenerative diseases. Cell culture. Hydrophobic interactions involved in the self-assembly of macromolecules. Biochemistry of vascular tissues. Trans-dermal drug delivery. Mechanism of bone formation and dystrophic calcification. Osteogenesis: decline of osteoprogenitor cells with age. Collagen derived bioprosthesis. Growth factors (TGF-B, BMP’s and others). Bone and cartilage repair. Sulfur amino acids and glutathione: relationship to tissue repair.

Publications

Hoang BX, Shaw DG, Han B, Fang JY, Nimni M. Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. J Pain Palliat Care Pharmacother. 2015 Sep; 29(3):276-80. View in: PubMed

Hoang BX, Han B, Shaw DG, Nimni M. Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer. Eur J Cancer Prev. 2015 Aug 27. View in: PubMed

Tan S, Fang JY, Yang Z, Nimni ME, Han B. The synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiation. Biomaterials. 2014 Jul; 35(20):5294-306. View in: PubMed

Han B, Yang Z, Fang JY, Kuwahara K, Nimni M, Thanasukarn J, Tayag C. The effects of heparin binding proteins in platelet releasate on bone formation. Tissue Eng Part A. 2014 Apr; 20(7-8):1263-70. View in: PubMed

Fang J, Yang Z, Tan S, Tayag C, Nimni ME, Urata M, Han B. Injectable gel graft for bone defect repair. Regen Med. 2014 Jan; 9(1):41-51. View in: PubMed

Tian M, Yang Z, Kuwahara K, Nimni ME, Wan C, Han B. Delivery of demineralized bone matrix powder using a thermogelling chitosan carrier. Acta Biomater. 2012 Feb; 8(2):753-62. View in: PubMed

Montes LF, Nimni M. Topical griseofulvin in dermatophytoses. Skinmed. 2011 Mar-Apr; 9(2):134-5. View in: PubMed

Kuwahara K, Yang Z, Slack GC, Nimni ME, Han B. Cell delivery using an injectable and adhesive transglutaminase-gelatin gel. Tissue Eng Part C Methods. 2010 Aug; 16(4):609-18. View in: PubMed

Han B, Woodell-May J, Ponticiello M, Yang Z, Nimni M. The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J Bone Joint Surg Am. 2009 Jun; 91(6):1459-70. View in: PubMed

Yeh TT, Wen ZH, Lee HS, Lee CH, Yang Z, Jean YH, Wu SS, Nimni ME, Han B. Intra-articular injection of collagenase induced experimental osteoarthritis of the lumbar facet joint in rats. Eur Spine J. 2008 May; 17(5):734-42. View in: PubMed

Han B, Yang Z, Nimni M. Effects of gamma irradiation on osteoinduction associated with demineralized bone matrix. J Orthop Res. 2008 Jan; 26(1):75-82. View in: PubMed

Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007; 4:24. View in: PubMed

Kim S, Nimni ME, Yang Z, Han B. Chitosan/gelatin-based films crosslinked by proanthocyanidin. J Biomed Mater Res B Appl Biomater. 2005 Nov; 75(2):442-50. View in: PubMed

Han B, Yang Z, Nimni M. Effects of moisture and temperature on the osteoinductivity of demineralized bone matrix. J Orthop Res. 2005 Jul; 23(4):855-61. View in: PubMed

Han B, Nimni ME. Transdermal delivery of amino acids and antioxidants enhance collagen synthesis: in vivo and in vitro studies. Connect Tissue Res. 2005; 46(4-5):251-7. View in: PubMed

Han B, Tang B, Nimni ME. Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix. J Orthop Res. 2003 Jul; 21(4):648-54. View in: PubMed

Han B, Jaurequi J, Tang BW, Nimni ME. Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A. 2003 Apr 1; 65(1):118-24. View in: PubMed

Han B, Tang B, Nimni ME. Combined effects of phosphatidylcholine and demineralized bone matrix on bone induction. Connect Tissue Res. 2003; 44(3-4):160-6. View in: PubMed

Han B, Perelman N, Tang B, Hall F, Shors EC, Nimni ME. Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with Type I collagen enhance osteogenesis in a rat cranial defect model. J Orthop Res. 2002 Jul; 20(4):747-55. View in: PubMed

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