Faculty

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Marcel E Nimni, PhD
Professor of Surgery
Surgery
EDM 191 Health Sciences Campus Los Angeles
+1 323 224 5067

Overview

Dr. Nimni is a Professor of Surgery, Biochemistry & Molecular Biology and Biomedical Engineering, and Director of Tissue Engineering Laboratories at the Keck School of Medicine of USC. His major areas of research activities include: Biochemistry of collagen: molecular structure, biosynthesis, mechanisms of crosslinking in soft tissues, bone and cartilage; interactions between connective tissues constituents, biochemical changes in degenerative diseases. Cell culture. Hydrophobic interactions involved in the self-assembly of macromolecules. Biochemistry of vascular tissues. Trans-dermal drug delivery. Mechanism of bone formation and dystrophic calcification. Osteogenesis: decline of osteoprogenitor cells with age. Collagen derived bioprosthesis. Growth factors (TGF-B, BMP’s and others). Bone and cartilage repair. Sulfur amino acids and glutathione: relationship to tissue repair.

Publications

Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. J Pain Palliat Care Pharmacother. 2015 Sep; 29(3):276-80. View in: PubMed

Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer. Eur J Cancer Prev. 2015 Aug 27. View in: PubMed

The synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiation. Biomaterials. 2014 Jul; 35(20):5294-306. View in: PubMed

The effects of heparin binding proteins in platelet releasate on bone formation. Tissue Eng Part A. 2014 Apr; 20(7-8):1263-70. View in: PubMed

Injectable gel graft for bone defect repair. Regen Med. 2014 Jan; 9(1):41-51. View in: PubMed

Delivery of demineralized bone matrix powder using a thermogelling chitosan carrier. Acta Biomater. 2012 Feb; 8(2):753-62. View in: PubMed

Topical griseofulvin in dermatophytoses. Skinmed. 2011 Mar-Apr; 9(2):134-5. View in: PubMed

Cell delivery using an injectable and adhesive transglutaminase-gelatin gel. Tissue Eng Part C Methods. 2010 Aug; 16(4):609-18. View in: PubMed

The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J Bone Joint Surg Am. 2009 Jun; 91(6):1459-70. View in: PubMed

Intra-articular injection of collagenase induced experimental osteoarthritis of the lumbar facet joint in rats. Eur Spine J. 2008 May; 17(5):734-42. View in: PubMed

Effects of gamma irradiation on osteoinduction associated with demineralized bone matrix. J Orthop Res. 2008 Jan; 26(1):75-82. View in: PubMed

Are we getting enough sulfur in our diet? Nutr Metab (Lond). Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007; 4:24. View in: PubMed

Chitosan/gelatin-based films crosslinked by proanthocyanidin. J Biomed Mater Res B Appl Biomater. 2005 Nov; 75(2):442-50. View in: PubMed

Effects of moisture and temperature on the osteoinductivity of demineralized bone matrix. J Orthop Res. 2005 Jul; 23(4):855-61. View in: PubMed

Transdermal delivery of amino acids and antioxidants enhance collagen synthesis: in vivo and in vitro studies. Connect Tissue Res. 2005; 46(4-5):251-7. View in: PubMed

Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix. J Orthop Res. 2003 Jul; 21(4):648-54. View in: PubMed

Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A. 2003 Apr 1; 65(1):118-24. View in: PubMed

Combined effects of phosphatidylcholine and demineralized bone matrix on bone induction. Connect Tissue Res. 2003; 44(3-4):160-6. View in: PubMed

Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with Type I collagen enhance osteogenesis in a rat cranial defect model. J Orthop Res. 2002 Jul; 20(4):747-55. View in: PubMed

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