Faculty

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Mariana Carla Stern, PhD
Professor of Research Preventive Medicine and Urology
Preventive Medicine
NOR 5421A 1441 Eastlake Avenue Health Sciences Campus Los Angeles
+1 323 865 0811

Overview

Dr. Stern obtained her undergraduate training in Biology at the University of Buenos Aires, School of Sciences, in Argentina with a focus on molecular and evolutionary genetics. She obtained her PhD in Cancer Biology at the University of Texas-MD Anderson Cancer Center and pursued postdoctoral training in molecular epidemiology at the National Institutes of Environmental Health Sciences, National Institutes of Health. At USC, she is currently Director for the Molecular Epidemiology MS/PhD Program and teaches to undergraduates and graduate students enrolled in graduate programs in Preventive Medicine. Her overall research interests cut across the following main themes: diet and cancer, clinical epidemiology of prostate cancer, and cancer health disparities in Latino populations.

Publications

DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer. Cancer. 2017 Jun 22. View in: PubMed

Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biol. 2017 Jan 12; 18(1):3. View in: PubMed

Response to Conner et al. Re: "Cigarette Smoking and Breast Cancer Risk in Hispanic and Non-Hispanic White Women: The Breast Cancer Health Disparities Study". J Womens Health (Larchmt). 2017 Jan; 26(1):92-93. View in: PubMed

The Interaction Between Genetic Ancestry and Breast Cancer Risk Factors among Hispanic women: The Breast Cancer Health Disparities Study. Cancer Epidemiol Biomarkers Prev. 2016 Dec 08. View in: PubMed

Stomach cancer disparity among Korean Americans by tumor characteristics: comparison with non-Hispanic whites, Japanese Americans, South Koreans, and Japanese. Cancer Epidemiol Biomarkers Prev. 2016 Dec 01. View in: PubMed

Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients. Prostate. 2016 Oct; 76(14):1239-56. View in: PubMed

Red meat, poultry, and fish intake and breast cancer risk among Hispanic and Non-Hispanic white women: The Breast Cancer Health Disparities Study. Cancer Causes Control. 2016 Apr; 27(4):527-43. View in: PubMed

Disparities in colorectal cancer incidence among Latino subpopulations in California defined by country of origin. Cancer Causes Control. 2016 Feb; 27(2):147-55. View in: PubMed

Predictors of time to biochemical recurrence in a radical prostatectomy cohort within the PSA-era. Can Urol Assoc J. 2016 Jan-Feb; 10(1-2):E17-22. View in: PubMed

Variability in Cancer Risk and Outcomes Within US Latinos by National Origin and Genetic Ancestry. Curr Epidemiol Rep. 2016; 3:181-190. View in: PubMed

Interaction between Common Breast Cancer Susceptibility Variants, Genetic Ancestry, and Nongenetic Risk Factors in Hispanic Women. Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1731-8. View in: PubMed

Radical Prostatectomy or External Beam Radiation Therapy vs No Local Therapy for Survival Benefit in Metastatic Prostate Cancer: A SEER-Medicare Analysis. J Urol. 2015 Aug; 194(2):378-85. View in: PubMed

Meat intake, cooking methods, dietary carcinogens, and colorectal cancer risk: findings from the Colorectal Cancer Family Registry. Cancer Med. 2015 Jun; 4(6):936-52. View in: PubMed

Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history. Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):512-9. View in: PubMed

Body Size Throughout Adult Life Influences Postmenopausal Breast Cancer Risk among Hispanic Women: The Breast Cancer Health Disparities Study. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):128-37. View in: PubMed

MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: the breast cancer health disparities study. Nutr Cancer. 2015; 67(2):292-304. View in: PubMed

Overall and Abdominal Adiposity and Premenopausal Breast Cancer Risk among Hispanic Women: The Breast Cancer Health Disparities Study. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):138-47. View in: PubMed

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15. 33. Hum Mol Genet. 2014 Dec 15; 23(24):6616-33. View in: PubMed

Tobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Study. Cancer Med. 2014 Dec; 3(6):1644-55. View in: PubMed

Associations between CYP19A1 polymorphisms, Native American ancestry, and breast cancer risk and mortality: the Breast Cancer Health Disparities Study. Cancer Causes Control. 2014 Nov; 25(11):1461-71. View in: PubMed

The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease. Cancer Res. 2014 Oct 15; 74(20):5808-18. View in: PubMed

Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study. Cancer Causes Control. 2014 Sep; 25(9):1211-25. View in: PubMed

Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study. Breast Cancer Res Treat. 2014 Aug; 147(1):145-58. View in: PubMed

Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study. Carcinogenesis. 2014 Aug; 35(8):1750-9. View in: PubMed

Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis. 2014 Aug; 35(8):1737-44. View in: PubMed

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. Int J Cancer. 2014 Jul 15; 135(2):335-47. View in: PubMed

Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet. 2014 Mar 1; 23(5):1387-98. View in: PubMed

Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study. Int J Cancer. 2014 Jan 1; 134(1):125-35. View in: PubMed

Genetic variants and non-genetic factors predict circulating vitamin D levels in Hispanic and non-Hispanic White women: the Breast Cancer Health Disparities Study. Int J Mol Epidemiol Genet. 2014; 5(1):31-46. View in: PubMed

Genetic Ancestry and Risk of Mortality among U. S. Latinas with Breast Cancer. Cancer Res. 2013 Dec 15; 73(24):7243-53. View in: PubMed

Associations between genetic variants in the TGF-ß signaling pathway and breast cancer risk among Hispanic and non-Hispanic white women. Breast Cancer Res Treat. 2013 Sep; 141(2):287-97. View in: PubMed

Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study. Breast Cancer Res Treat. 2013 Aug; 140(3):587-601. View in: PubMed

Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women. Carcinogenesis. 2013 Aug; 34(8):1787-93. View in: PubMed

Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):937-45. View in: PubMed

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet. 2013 Apr; 45(4):385-91, 391e1-2. View in: PubMed

Genetic admixture and risk of hypertensive disorders of pregnancy among Latinas in Los Angeles County. Epidemiology. 2013 Mar; 24(2):285-94. View in: PubMed

Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: The breast cancer health disparities study. Int J Cancer. 2013 Feb 1; 134(3):629-44. View in: PubMed

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Hum Mol Genet. 2013 Jan 15; 22(2):408-15. View in: PubMed

Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. PLoS One. 2013; 8(8):e71211. View in: PubMed

Genetic variation in insulin pathway genes and distal colorectal adenoma risk. Int J Colorectal Dis. 2012 Dec; 27(12):1587-95. View in: PubMed

Red meat and poultry, cooking practices, genetic susceptibility and risk of prostate cancer: results from a multiethnic case-control study. Carcinogenesis. 2012 Nov; 33(11):2108-18. View in: PubMed

Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population. Carcinogenesis. 2012 Aug; 33(8):1512-21. View in: PubMed

Polymorphisms in carcinogen metabolism enzymes, fish intake, and risk of prostate cancer. Carcinogenesis. 2012 Jul; 33(7):1352-9. View in: PubMed

Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk. Int J Cancer. 2012 Apr 15; 130(8):1898-907. View in: PubMed

Fish intake, cooking practices, and risk of prostate cancer: results from a multi-ethnic case-control study. Cancer Causes Control. 2012 Mar; 23(3):405-20. View in: PubMed

Cigarette smoking and subtypes of bladder cancer. Int J Cancer. 2012 Feb 15; 130(4):896-901. View in: PubMed

A review of cancer in u. s. Hispanic populations. Cancer Prev Res (Phila). 2012 Feb; 5(2):150-63. View in: PubMed

Heterogeneity in genetic admixture across different regions of Argentina. PLoS One. 2012; 7(4):e34695. View in: PubMed

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet. 2011 Aug; 43(8):785-91. View in: PubMed

Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiology. Cancer Epidemiol Biomarkers Prev. 2011 Jun; 20(6):1156-70. View in: PubMed

Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study. Cancer Causes Control. 2011 Apr; 22(4):541-52. View in: PubMed

Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis. 2011 Feb; 32(2):197-202. View in: PubMed

Validation of genome-wide prostate cancer associations in men of African descent. Cancer Epidemiol Biomarkers Prev. 2011 Jan; 20(1):23-32. View in: PubMed

Meat consumption, cooking practices, meat mutagens, and risk of prostate cancer. Nutr Cancer. 2011; 63(4):525-37. View in: PubMed

Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study. Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3150-6. View in: PubMed

Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3167-73. View in: PubMed

Hypertension, diuretics and antihypertensives in relation to bladder cancer. Carcinogenesis. 2010 Nov; 31(11):1964-71. View in: PubMed

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010 Nov; 42(11):978-84. View in: PubMed

Use of folic acid-containing supplements after a diagnosis of colorectal cancer in the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev. 2010 Aug; 19(8):2023-34. View in: PubMed

Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3057-61. View in: PubMed

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009 Oct; 41(10):1116-21. View in: PubMed

Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Cancer Res. 2009 Sep 1; 69(17):6857-64. View in: PubMed

Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis. 2009 Mar; 30(3):472-9. View in: PubMed

Marine n-3 and saturated fatty acids in relation to risk of colorectal cancer in Singapore Chinese: a prospective study. Int J Cancer. 2009 Feb 1; 124(3):678-86. View in: PubMed

Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. J Nutrigenet Nutrigenomics. 2009; 2(6):273-9. View in: PubMed

Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev. 2008 Aug; 17(8):2052-61. View in: PubMed

DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2363-72. View in: PubMed

XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2384-90. View in: PubMed

DNA repair gene polymorphisms and probability of p53 mutation in bladder cancer. Mol Carcinog. 2006 Sep; 45(9):715-9. View in: PubMed

XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. Cancer Epidemiol Biomarkers Prev. 2005 Mar; 14(3):609-15. View in: PubMed

Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene. Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1279-84. View in: PubMed

XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2002 Oct; 11(10 Pt 1):1004-11. View in: PubMed

Genetic analyses of mouse skin tumor progression susceptibility using SENCAR inbred derived strains. Mol Carcinog. 2002 Sep; 35(1):13-20. View in: PubMed

DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2002 Sep; 11(9):939-43. View in: PubMed

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