Faculty

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Mark Krailo, PhD
Professor of Research Preventive Medicine
Preventive Medicine
SSB 302N 2001 N. Soto Street Health Sciences Campus Los Angeles
+1 323 442 8233

Awards

University of Windsor Entrance Award

Ontario Graduate Scholarship

National Research Council Postgraduate Scholarship

Ford Scholarship

Ontario Scholarship

Board of Governor's Award, University of Windsor

Publications

Variants in BAK1, SPRY4, and GAB2 are Associated with Pediatric Germ Cell Tumors: A Report from the Children's Oncology Group. Genes Chromosomes Cancer. 2017 Mar 13. View in: PubMed

Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children's Oncology Group. J Expo Sci Environ Epidemiol. 2017 Mar 08. View in: PubMed

Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group. J Clin Oncol. 2017 Feb 27; JCO2016676544. View in: PubMed

Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 study committee. Cancer. 2017 Feb 17. View in: PubMed

A novel prognostic model for osteosarcoma using circulating CXCL10 and FLT3LG. Cancer. 2017 Jan 01; 123(1):144-154. View in: PubMed

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2016 Nov 30. View in: PubMed

Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation. Br J Cancer. 2016 Nov 22. View in: PubMed

Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol. 2016 Nov 21. View in: PubMed

Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study. Neuro Oncol. 2016 Oct; 18(10):1442-50. View in: PubMed

Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group. Ann Surg Oncol. 2016 Oct; 23(11):3541-7. View in: PubMed

Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer. 2016 Oct; 63(10):1737-43. View in: PubMed

Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2016 Oct; 63(10):1771-9. View in: PubMed

Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward. J Clin Oncol. 2016 Sep 1; 34(25):3031-8. View in: PubMed

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort: A Children's Oncology Group Study. Ophthalmology. 2016 Aug; 123(8):1817-23. View in: PubMed

Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group. Clin Cancer Res. 2016 Jul 15; 22(14):3643-50. View in: PubMed

p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res. 2016 Jul 1; 76(13):4002-11. View in: PubMed

Can Big Data Shed Light on the Origins of Pediatric Cancer? Pediatrics. Can Big Data Shed Light on the Origins of Pediatric Cancer? Pediatrics. 2016 Jun; 137(6). View in: PubMed

Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2016 Mar; 63(3):493-8. View in: PubMed

Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group. J Surg Oncol. 2016 Mar; 113(4):351-4. View in: PubMed

Rapid Protocol Enrollment in Osteosarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2016 Feb; 63(2):370-1. View in: PubMed

Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. Cancer. 2016 Jan 15; 122(2):230-7. View in: PubMed

The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model. Eur J Cancer. 2016 Jan; 52:92-101. View in: PubMed

Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2016 Jan; 63(1):54-61. View in: PubMed

Identification of Discrete Prognostic Groups in Ewing Sarcoma. Pediatr Blood Cancer. 2016 Jan; 63(1):47-53. View in: PubMed

Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration. J Clin Oncol. 2015 Sep 20; 33(27):3018-28. View in: PubMed

Rare Tumors in Children: Progress Through Collaboration. J Clin Oncol. 2015 Sep 20; 33(27):3047-54. View in: PubMed

Impact of central surgical review in a study of malignant germ cell tumors. J Pediatr Surg. 2015 Sep; 50(9):1502-5. View in: PubMed

Phase 2 trial of sorafenib in children and young adults with refractory solid tumors: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Sep; 62(9):1562-6. View in: PubMed

Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group. J Immunother. 2015 Sep; 38(7):299-305. View in: PubMed

A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: a Children's Oncology Group study†. Neuro Oncol. 2015 Aug; 17(8):1132-8. View in: PubMed

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial. J Clin Oncol. 2015 Jul 10; 33(20):2279-87. View in: PubMed

Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group. J Pediatr Surg. 2015 Jun; 50(6):1000-3. View in: PubMed

Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 May; 62(5):759-65. View in: PubMed

Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children's Oncology Group. J Pathol Clin Res. 2015 Apr; 1(2):83-94. View in: PubMed

Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma-Associations with tumor phenotype and survival. Cancer. 2015 Mar 1; 121(5):697-707. View in: PubMed

Phase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: A report from the children's oncology group. Pediatr Blood Cancer. 2015 Mar; 62(3):440-4. View in: PubMed

A summary of the osteosarcoma banking efforts: A report from the Children's Oncology Group and the QuadW Foundation. Pediatr Blood Cancer. 2015 Mar; 62(3):450-5. View in: PubMed

Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: A report from the Children's Oncology Group. Cancer. 2015 Feb 1; 121(3):467-75. View in: PubMed

Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United kingdom and United States. J Clin Oncol. 2015 Jan 10; 33(2):195-201. View in: PubMed

Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status. Epigenetics. 2015 Jan 2; 10(1):31-9. View in: PubMed

Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children's Oncology Group Report. Sarcoma. 2015; 2015:927123. View in: PubMed

Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2014 Nov; 61(11):2018-23. View in: PubMed

The Children's Oncology Group Childhood Cancer Research Network (CCRN): Case catchment in the United States. Cancer. 2014 Oct 1; 120(19):3007-15. View in: PubMed

Reply to g. Mangili et Al and C. Lhommé et Al. J Clin Oncol. 2014 Sep 1; 32(25):2816-7. View in: PubMed

Congenital abnormalities and hepatoblastoma: A report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB). Am J Med Genet A. 2014 Sep; 164(9):2250-5. View in: PubMed

HER-2 expression is not prognostic in osteosarcoma; a Children's Oncology Group prospective biology study. Pediatr Blood Cancer. 2014 Sep; 61(9):1558-64. View in: PubMed

Toward a drug development path that targets metastatic progression in osteosarcoma. Clin Cancer Res. 2014 Aug 15; 20(16):4200-9. View in: PubMed

Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors. Oncologist. 2014 Jul; 19(7):689-92. View in: PubMed

Response to "High BMI at diagnosis is associated with inferior survival in patients with osteosarcoma". Pediatr Blood Cancer. 2014 May; 61(5):951. View in: PubMed

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. Pediatr Blood Cancer. 2014 Apr; 61(4):749-52. View in: PubMed

Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2014 Mar; 61(3):452-6. View in: PubMed

Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group. J Clin Oncol. 2014 Feb 10; 32(5):465-70. View in: PubMed

Clinical and Biochemical Function of Polymorphic NR0B1 GGAA-Microsatellites in Ewing Sarcoma: A Report from the Children's Oncology Group. PLoS One. 2014; 9(8):e104378. View in: PubMed

High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2013 Dec; 60(12):2042-6. View in: PubMed

Outcomes for patients with congenital hepatoblastoma. Pediatr Blood Cancer. 2013 Nov; 60(11):1817-25. View in: PubMed

Pilot study of cisplatin, etoposide, bleomycin, and escalating dose cyclophosphamide therapy for children with high risk germ cell tumors: a report of the children's oncology group (COG). Pediatr Blood Cancer. 2013 Oct; 60(10):1602-5. View in: PubMed

Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: a report from the children's oncology group. Cancer Epidemiol Biomarkers Prev. 2013 Oct; 22(10):1837-43. View in: PubMed

Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group. Eur J Cancer. 2013 Jul; 49(10):2384-91. View in: PubMed

Children's Oncology Group's 2013 blueprint for research: rare tumors. Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. View in: PubMed

Maternal pregnancy events and exposures and risk of hepatoblastoma: a Children's Oncology Group (COG) study. Cancer Epidemiol. 2013 Jun; 37(3):318-20. View in: PubMed

A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: A Children's Oncology Group (COG) Phase II study NCT00061893. Pediatr Blood Cancer. 2013 Mar; 60(3):409-14. View in: PubMed

Phase 2 trial of pemetrexed in children and adolescents with refractory solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer. 2013 Feb; 60(2):237-41. View in: PubMed

A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group. Front Oncol. 2013; 3:57. View in: PubMed

Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2012 Nov 20; 30(33):4148-54. View in: PubMed

"Accelerated ear-age": a new measure of chemotherapy-induced ototoxicity. Pediatr Blood Cancer. 2012 Nov; 59(5):947-9. View in: PubMed

Outcome for adolescent and young adult patients with osteosarcoma: A report from the Children's Oncology Group. Cancer. 2012 Sep 15; 118(18):4597-605. View in: PubMed

Phase II Trial of Trastuzumab in Combination With Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma With Human Epidermal Growth Factor Receptor 2 Overexpression: A Report From the Children's Oncology Group. J Clin Oncol. 2012 Jul 10; 30(20):2545-51. View in: PubMed

Parental infertility, infertility treatment and hepatoblastoma: a report from the Children's Oncology Group. Hum Reprod. 2012 Jun; 27(6):1649-56. View in: PubMed

Phase 2 clinical trial of intrathecal topotecan in children with refractory leptomeningeal leukemia: A Children's Oncology Group trial (P9962). Pediatr Blood Cancer. 2012 Mar; 58(3):362-5. View in: PubMed

A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children's Oncology Group. Eur J Cancer. 2012 Mar; 48(4):579-85. View in: PubMed

Phase I/II Trial and Pharmacokinetic Study of Cixutumumab in Pediatric Patients With Refractory Solid Tumors and Ewing Sarcoma: A Report From the Children's Oncology Group. J Clin Oncol. 2012 Jan 20; 30(3):256-62. View in: PubMed

Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: a Children's Oncology Group (COG) study. Int J Mol Epidemiol Genet. 2012; 3(4):286-93. View in: PubMed

Randomized Trial of Hydroxychloroquine for Newly Diagnosed Chronic Graft-versus-Host Disease in Children: A Children's Oncology Group Study. Biol Blood Marrow Transplant. 2012 Jan; 18(1):84-91. View in: PubMed

Treatment of hepatoblastoma: the North American cooperative group experience. Front Biosci (Elite Ed). 2012; 4:1717-23. View in: PubMed

Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011 Dec 1; 57(6):939-42. View in: PubMed

Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's Oncology Group Study ASCT0031. Biol Blood Marrow Transplant. 2011 Dec; 17(12):1804-13. View in: PubMed

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group. Cancer. 2011 Nov 1; 117(21):4966-76. View in: PubMed

Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group. J Clin Oncol. 2011 Aug 20; 29(24):3301-6. View in: PubMed

The Children's Oncology Group routinely applies "lack of efficacy" interim monitoring to its randomized clinical trials. Am J Bioeth. 2011 Mar; 11(3):18-9. View in: PubMed

Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group. Clin Cancer Res. 2011 Jan 1; 17(1):56-66. View in: PubMed

Infrequent tumor initiative of the Children's Oncology Group: initial lessons learned and their impact on future plans. J Clin Oncol. 2010 Nov 20; 28(33):5011-6. View in: PubMed

Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer. 2010 Oct; 55(4):629-38. View in: PubMed

A novel toxicity scoring system treating toxicity response as a quasi-continuous variable in Phase I clinical trials. Contemp Clin Trials. 2010 Sep; 31(5):473-82. View in: PubMed

A phase II trial and pharmacokinetic study of oxaliplatin in children with refractory solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer. 2010 Sep; 55(3):440-5. View in: PubMed

Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: effects on disease-free survival and immunomodulation. a report from the Children's Oncology Group. Clin Cancer Res. 2010 Aug 1; 16(15):4024-30. View in: PubMed

Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2010 Apr 20; 28(12):1989-94. View in: PubMed

Phase II trial of ixabepilone administered daily for five days in children and young adults with refractory solid tumors: a report from the children's oncology group. Clin Cancer Res. 2010 Jan 15; 16(2):750-4. View in: PubMed

Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group. Cancer. 2009 Dec 15; 115(24):5828-35. View in: PubMed

Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009 Dec; 53(6):1016-22. View in: PubMed

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group. Cancer. 2009 Nov 15; 115(22):5339-48. View in: PubMed

Phase II evaluation of intravenous vinorelbine (Navelbine) in recurrent or refractory pediatric malignancies: a Children's Oncology Group study. Pediatr Blood Cancer. 2009 Oct; 53(4):590-3. View in: PubMed

Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study. J Clin Oncol. 2009 May 20; 27(15):2536-41. View in: PubMed

Phase 1 study of oxaliplatin and irinotecan in pediatric patients with refractory solid tumors: a children's oncology group study. Cancer. 2009 Apr 15; 115(8):1765-75. View in: PubMed

Range and trend of expected toxicity level (ETL) in standard A + B designs: a report from the Children's Oncology Group. Contemp Clin Trials. 2009 Mar; 30(2):123-8. View in: PubMed

Effect of time to resumption of chemotherapy after definitive surgery on prognosis for non-metastatic osteosarcoma. J Bone Joint Surg Am. 2009 Mar 1; 91(3):604-12. View in: PubMed

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009 Mar; 52(3):324-7. View in: PubMed

Problems identified with phase II stopping rules that employ response and early-progression rates. J Clin Oncol. 2009 Feb 1; 27(4):646-7; author reply 647. View in: PubMed

Phase I study of ch14. 18 with granulocyte-macrophage colony-stimulating factor and interleukin-2 in children with neuroblastoma after autologous bone marrow transplantation or stem-cell rescue: a report from the Children's Oncology Group. J Clin Oncol. 2009 Jan 1; 27(1):85-91. View in: PubMed

Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study. J Clin Oncol. 2008 Oct 20; 26(30):4921-7. View in: PubMed

Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study. Neuro Oncol. 2008 Oct; 10(5):752-8. View in: PubMed

Progress in childhood cancer: 50 years of research collaboration, a report from the Children's Oncology Group. Semin Oncol. 2008 Oct; 35(5):484-93. View in: PubMed

Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2008 Sep; 51(3):334-8. View in: PubMed

Chemoimmunotherapy reinduction with epratuzumab in children with acute lymphoblastic leukemia in marrow relapse: a Children's Oncology Group Pilot Study. J Clin Oncol. 2008 Aug 1; 26(22):3756-62. View in: PubMed

Randomized comparison of every-two-week v. every-three-week chemotherapy in Ewing sarcoma family tumors (ESFT). J Clin Oncol. 2008 May 20; 26(15_suppl):10504. View in: PubMed

Risk of therapy related myelodysplasia and acute myeloid leukemia (t-MDS/AML) in children exposed to alkylating agents, anthracyclines, platinum compounds and epipodophyllotoxins: a report from Children's Oncology Group (COG). J Clin Oncol. 2008 May 20; 26(15_suppl):10005. View in: PubMed

Redefining the role of doxorubicin for the treatment of children with hepatoblastoma. J Clin Oncol. 2008 May 10; 26(14):2379-83. View in: PubMed

A Phase 1 and pharmacokinetic clinical trial of paclitaxel for the treatment of refractory leukemia in children: a Children's Oncology Group study. Pediatr Blood Cancer. 2008 Apr; 50(4):788-92. View in: PubMed

Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the Children's Oncology Group. Blood. 2008 Mar 15; 111(6):3276-85. View in: PubMed

Phase 2 study of docetaxel in the treatment of childhood refractory acute leukemias: a Children's Oncology Group report. Pediatr Blood Cancer. 2008 Mar; 50(3):533-6. View in: PubMed

Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. J Clin Oncol. 2008 Feb 1; 26(4):633-8. View in: PubMed

A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer. 2008 Feb; 50(2):254-8. View in: PubMed

Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2008 Jan 20; 26(3):399-405. View in: PubMed

Surgical resection of pulmonary metastatic lesions in children with hepatoblastoma. J Pediatr Surg. 2007 Dec; 42(12):2050-6. View in: PubMed

Treatment of metastatic Ewing sarcoma/primitive neuroectodermal tumor of bone: evaluation of increasing the dose intensity of chemotherapy--a report from the Children's Oncology Group. Pediatr Blood Cancer. 2007 Dec; 49(7):894-900. View in: PubMed

Phase II trial of irinotecan in children with refractory solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2007 Oct 10; 25(29):4622-7. View in: PubMed

Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group. Cancer. 2007 Oct 1; 110(7):1542-50. View in: PubMed

A phase I study of 90yttrium-ibritumomab-tiuxetan in children and adolescents with relapsed/refractory CD20-positive non-Hodgkin's lymphoma: a Children's Oncology Group study. Clin Cancer Res. 2007 Sep 15; 13(18 Pt 2):5652s-5660s. View in: PubMed

Analysis of biologic surrogate markers from a Children's Oncology Group Phase I trial of gefitinib in pediatric patients with solid tumors. Pediatr Blood Cancer. 2007 Sep; 49(3):352-7. View in: PubMed

Multiple drug resistance in osteogenic sarcoma: INT0133 from the Children's Oncology Group. J Clin Oncol. 2007 May 20; 25(15):2057-62. View in: PubMed

Phase I trial and pharmacokinetic study of pemetrexed in children with refractory solid tumors: the Children's Oncology Group. J Clin Oncol. 2007 Apr 20; 25(12):1505-11. View in: PubMed

Phase I Trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2007 Apr 20; 25(12):1512-8. View in: PubMed

Upfront window trial of topotecan in previously untreated children and adolescents with poor prognosis metastatic osteosarcoma: children's Cancer Group (CCG) 7943. Cancer. 2007 Apr 15; 109(8):1646-53. View in: PubMed

Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2007 Apr; 13(4):386-97. View in: PubMed

Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: a report from the Children's Oncology Group. Cancer Lett. 2007 Mar 18; 247(2):204-12. View in: PubMed

A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study. Clin Cancer Res. 2007 Mar 15; 13(6):1789-93. View in: PubMed

Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group. Blood. 2007 Jan 1; 109(1):46-51. View in: PubMed

Topotecan by 21-day continuous infusion in children with relapsed or refractory solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer. 2006 Nov; 47(6):790-4. View in: PubMed

Local control in pelvic Ewing sarcoma: analysis from INT-0091--a report from the Children's Oncology Group. J Clin Oncol. 2006 Aug 20; 24(24):3838-43. View in: PubMed

Phase I study of depsipeptide in pediatric patients with refractory solid tumors: a Children's Oncology Group report. J Clin Oncol. 2006 Aug 1; 24(22):3678-85. View in: PubMed

Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children's Oncology Group (CCG 09709). J Clin Oncol. 2006 Jul 20; 24(21):3423-30. View in: PubMed

Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma. J Clin Oncol. 2006 Jun 20; 24(18):2879-84. View in: PubMed

Phase II investigation of docetaxel in pediatric patients with recurrent solid tumors: a report from the Children's Oncology Group. Cancer. 2006 Apr 15; 106(8):1821-8. View in: PubMed

A phase I clinical trial of the hu14. 18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group. Clin Cancer Res. 2006 Mar 15; 12(6):1750-9. View in: PubMed

In utero exposure to female hormones and germ cell tumors in children. Cancer. 2006 Mar 1; 106(5):1169-77. View in: PubMed

Phase I evaluation of oral and intravenous vinorelbine in pediatric cancer patients: a report from the Children's Oncology Group. Clin Cancer Res. 2006 Jan 15; 12(2):516-22. View in: PubMed

Environmental exposure to residential pesticides, chemicals, dusts, fumes, and metals, and risk of childhood germ cell tumors. Int J Hyg Environ Health. 2006 Jan; 209(1):31-40. View in: PubMed

Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2005 Dec 20; 23(36):9179-86. View in: PubMed

A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed brainstem gliomas. Cancer. 2005 Nov 1; 104(9):1968-74. View in: PubMed

Parental occupational exposure to pesticides and childhood germ-cell tumors. Am J Epidemiol. 2005 Nov 1; 162(9):858-67. View in: PubMed

Phase 1 study of concurrent RMP-7 and carboplatin with radiotherapy for children with newly diagnosed brainstem gliomas. Cancer. 2005 Sep 15; 104(6):1281-7. View in: PubMed

Randomized comparison of antibiotics with and without granulocyte colony-stimulating factor in children with chemotherapy-induced febrile neutropenia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2005 Sep; 45(3):274-80. View in: PubMed

Phase I and pharmacokinetic study of gefitinib in children with refractory solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2005 Sep 1; 23(25):6172-80. View in: PubMed

Phase II evaluation of vinorelbine in recurrent pediatric malignancies. J Clin Oncol. 2005 Jun; 23(16_suppl):8521. View in: PubMed

Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group. J Clin Oncol. 2005 May 20; 23(15):3376-82. View in: PubMed

A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factor in children receiving ifosfamide, carboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: a Children's Oncology Group experience. Clin Cancer Res. 2005 Apr 1; 11(7):2644-50. View in: PubMed

Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children's Cancer Group (CCG) experience. Pediatr Blood Cancer. 2005 Apr; 44(4):338-47. View in: PubMed

Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J Clin Oncol. 2005 Mar 20; 23(9):2004-11. View in: PubMed

Risk of childhood germ cell tumors in association with parental smoking and drinking. Cancer. 2005 Mar 1; 103(5):1064-71. View in: PubMed

A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):672-7. View in: PubMed

Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: a Children's Oncology Group study (ADVL0015). J Clin Oncol. 2004 Dec 1; 22(23):4804-9. View in: PubMed

Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: results from a Children's Oncology Group phase 1 study. Blood. 2004 Nov 1; 104(9):2655-60. View in: PubMed

Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide--a Children's Cancer Group and Pediatric Oncology Group study. J Clin Oncol. 2004 Jul 15; 22(14):2873-6. View in: PubMed

Phase I trial and pharmacokinetics of gemcitabine in children with advanced solid tumors. J Clin Oncol. 2004 Jun 15; 22(12):2445-51. View in: PubMed

Phase I trial of tirapazamine and cyclophosphamide in children with refractory solid tumors: a pediatric oncology group study. J Clin Oncol. 2004 Apr 15; 22(8):1413-9. View in: PubMed

Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg. 2003 Oct; 238(4):563-7; discussion 567-8. View in: PubMed

Fibrolamellar hepatocellular carcinoma in children and adolescents. Cancer. 2003 Apr 15; 97(8):2006-12. View in: PubMed

Childhood cancer patients' access to cooperative group cancer programs: a population-based study. Cancer. 2003 Mar 1; 97(5):1339-45. View in: PubMed

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003 Feb 20; 348(8):694-701. View in: PubMed

Burkitt's and Burkitt-like lymphoma in children and adolescents: a review of the Children's Cancer Group experience. Br J Haematol. 2003 Feb; 120(4):660-70. View in: PubMed

Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. Clin Cancer Res. 2003 Feb; 9(2):837-44. View in: PubMed

A phase I study of topotecan as a radiosensitizer for brainstem glioma of childhood: first report of the Children's Cancer Group-0952. Neuro Oncol. 2003 Jan; 5(1):8-13. View in: PubMed

Phase I study of gemcitabine (difluorodeoxycytidine) in children with relapsed or refractory leukemia (CCG-0955): a report from the Children's Cancer Group. Leuk Lymphoma. 2002 Oct; 43(10):1945-50. View in: PubMed

Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study. J Clin Oncol. 2002 Jun 15; 20(12):2789-97. View in: PubMed

Long-term follow-up of short intensive multiagent chemotherapy without high-dose methotrexate ('Orange') in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: a children's cancer group report. Leukemia. 2002 Apr; 16(4):594-600. View in: PubMed

Ifosfamide, carboplatin and etoposide in children with poor-risk relapsed Wilms' tumor: a Children's Cancer Group report. Ann Oncol. 2002 Mar; 13(3):460-9. View in: PubMed

Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942. J Pediatr Hematol Oncol. 2002 Feb; 24(2):89-93. View in: PubMed

Comparison of long-term outcome of children and adolescents with disseminated non-lymphoblastic non-Hodgkin lymphoma treated with COMP or daunomycin-COMP: A report from the Children's Cancer Group. Med Pediatr Oncol. 2001 Nov; 37(5):432-41. View in: PubMed

High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis. J Clin Oncol. 2001 Jun 1; 19(11):2812-20. View in: PubMed

Phase I study of CI-958 in children and adolescents with recurrent solid tumors. Cancer. 2001 Mar 15; 91(6):1166-9. View in: PubMed

A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities. Clin Cancer Res. 2001 Jan; 7(1):58-67. View in: PubMed

Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: a children's cancer group report. J Pediatr Hematol Oncol. 2001 Jan; 23(1):30-8. View in: PubMed

Phase I study of chimeric human/murine anti-ganglioside G(D2) monoclonal antibody (ch14. 18) with granulocyte-macrophage colony-stimulating factor in children with neuroblastoma immediately after hematopoietic stem-cell transplantation: a Children's Cancer Group Study. J Clin Oncol. 2000 Dec 15; 18(24):4077-85. View in: PubMed

Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group. J Clin Oncol. 2000 Jul; 18(14):2665-75. View in: PubMed

A phase I dose escalation of combination chemotherapy with granulocyte-macrophage-colony stimulating factor in patients with neuroblastoma. Cancer. 2000 Jun 15; 88(12):2838-44. View in: PubMed

Ewing sarcoma of the rib: results of an intergroup study with analysis of outcome by timing of resection. J Thorac Cardiovasc Surg. 2000 Jun; 119(6):1154-61. View in: PubMed

Children's cancer group trials of interleukin-2 therapy to prevent relapse of acute myelogenous leukemia. Cancer J Sci Am. 2000 Feb; 6 Suppl 1:S39-44. View in: PubMed

Phase I study of topotecan administered as a 21-day continous infusion in children with recurrent solid tumors: a report from the Children's Cancer Group. Clin Cancer Res. 1999 Dec; 5(12):3956-62. View in: PubMed

A Phase I study of granulocyte-macrophage-colony stimulating factor/interleukin-3 fusion protein (PIXY321) following ifosfamide, carboplatin, and etoposide therapy for children with recurrent or refractory solid tumors: a report of the Children's Cancer Group. Cancer. 1998 Oct 1; 83(7):1449-60. View in: PubMed

A Phase II clinical trial of idarubicin administered to children with relapsed brain tumors. Cancer. 1998 Aug 15; 83(4):813-6. View in: PubMed

Feasibility, toxicity, and biologic response of interleukin-2 after consolidation chemotherapy for acute myelogenous leukemia: a report from the Children's Cancer Group. J Clin Oncol. 1998 Mar; 16(3):914-9. View in: PubMed

MOPP or radiation in addition to ABVD in the treatment of pathologically staged advanced Hodgkin's disease in children: results of the Children's Cancer Group Phase III Trial. J Clin Oncol. 1998 Mar; 16(3):897-906. View in: PubMed

Phase II trial of topotecan administered as 72-hour continuous infusion in children with refractory solid tumors: a collaborative Pediatric Branch, National Cancer Institute, and Children's Cancer Group Study. Clin Cancer Res. 1998 Feb; 4(2):357-60. View in: PubMed

Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a phase I/II study in pediatric patients with relapsed leukemias. The Children's Cancer Group. Clin Cancer Res. 1998 Jan; 4(1):45-52. View in: PubMed

Phase I/II study of idarubicin given with continuous infusion fludarabine followed by continuous infusion cytarabine in children with acute leukemia: a report from the Children's Cancer Group. J Clin Oncol. 1997 Aug; 15(8):2780-5. View in: PubMed

A phase II study of carboplatin as a treatment for children with acute leukemia recurring in bone marrow: a report of the Children's Cancer Group. Cancer. 1997 Jul 15; 80(2):311-6. View in: PubMed

A phase I/IB trial of murine monoclonal anti-GD2 antibody 14. G2a plus interleukin-2 in children with refractory neuroblastoma: a report of the Children's Cancer Group. Cancer. 1997 Jul 15; 80(2):317-33. View in: PubMed

Phase I trial of docetaxel administered as a 1-hour infusion in children with refractory solid tumors: a collaborative pediatric branch, National Cancer Institute and Children's Cancer Group trial. J Clin Oncol. 1997 Apr; 15(4):1538-43. View in: PubMed

Timing and magnitude of decline in alpha-fetoprotein levels in treated children with unresectable or metastatic hepatoblastoma are predictors of outcome: a report from the Children's Cancer Group. J Clin Oncol. 1997 Mar; 15(3):1190-7. View in: PubMed

Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group. J Clin Oncol. 1997 Jan; 15(1):76-84. View in: PubMed

A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study. Invest New Drugs. 1996; 13(4):337-42. View in: PubMed

Comparison of treatment regimens for pediatric lymphoblastic non-Hodgkin's lymphoma: a Childrens Cancer Group study. J Clin Oncol. 1995 Jun; 13(6):1368-76. View in: PubMed

An exploratory analysis of risk factors for childhood malignant germ-cell tumors: report from the Childrens Cancer Group (Canada, United States). Cancer Causes Control. 1995 May; 6(3):187-98. View in: PubMed

A phase II study of carboplatin in children with recurrent or progressive solid tumors. A report from the Childrens Cancer Group. Cancer. 1994 Feb 15; 73(4):1297-301. View in: PubMed

A phase I study of carboplatin in children with acute leukemia in bone marrow relapse. A report from the Childrens Cancer Group. Cancer. 1993 Aug 1; 72(3):917-22. View in: PubMed

Patterns of enrollment on cooperative group studies. An analysis of trends from the Los Angeles County Cancer Surveillance Program. Cancer. 1993 May 15; 71(10 Suppl):3325-30. View in: PubMed

Trends in patterns of treatment of childhood cancer in Los Angeles County. Cancer. 1993 May 15; 71(10 Suppl):3222-8. View in: PubMed

Treatment of pulmonary metastases of initial stage I hepatoblastoma in childhood. Report from the Childrens Cancer Group. Cancer. 1993 Feb 1; 71(3):859-64. View in: PubMed

Lack of significant activity of 2'-deoxycoformycin alone or in combination with adenine arabinoside in relapsed childhood acute lymphoblastic leukemia. A randomized phase II trial from the Childrens Cancer Study Group. Am J Clin Oncol. 1992 Dec; 15(6):490-3. View in: PubMed

Phase II trial of indicine N-oxide in relapsed acute leukemia of childhood. A report from the Childrens Cancer Study Group. Am J Clin Oncol. 1992 Apr; 15(2):135-40. View in: PubMed

The CCSG prospective study of venous access devices: an analysis of insertions and causes for removal. J Pediatr Surg. 1992 Feb; 27(2):155-63; discussion 163-4. View in: PubMed

13-cis-retinoic acid (NSC 122758) in the treatment of children with metastatic neuroblastoma unresponsive to conventional chemotherapy: report from the Childrens Cancer Study Group. Med Pediatr Oncol. 1992; 20(4):307-11. View in: PubMed

Determination of the maximum tolerated dose of idarubicin when used in a combination chemotherapy program of reinduction of childhood ALL at first marrow relapse and a preliminary assessment of toxicity compared to that of daunorubicin: a report from the Childrens Cancer Study Group. Med Pediatr Oncol. 1992; 20(2):124-9. View in: PubMed

Effective treatment of unresectable or metastatic hepatoblastoma with cisplatin and continuous infusion doxorubicin chemotherapy: a report from the Childrens Cancer Study Group. J Clin Oncol. 1991 Dec; 9(12):2167-76. View in: PubMed

Results of treatment of malignant germ cell tumors in 93 children: a report from the Childrens Cancer Study Group. J Clin Oncol. 1991 Oct; 9(10):1782-92. View in: PubMed

Pharmacology and phase I trial of high-dose oral leucovorin plus 5-fluorouracil in children with refractory cancer: a report from the Children's Cancer Study Group. Cancer Res. 1991 Sep 15; 51(18):4871-5. View in: PubMed

Carboplatin in childhood brain tumors. A Children's Cancer Study Group Phase II trial. Cancer. 1990 Dec 15; 66(12):2465-9. View in: PubMed

Plasma pharmacokinetics and cerebrospinal fluid concentrations of idarubicin and idarubicinol in pediatric leukemia patients: a Childrens Cancer Study Group report. Cancer Res. 1990 Oct 15; 50(20):6525-8. View in: PubMed

A phase II study of diaziquone in children with recurrent or progressive solid tumors. Report from the Childrens Cancer Study Group. Am J Pediatr Hematol Oncol. 1990; 12(3):301-5. View in: PubMed

Phase I/II study of bisantrene in childhood cancer: a report from the Childrens Cancer Study Group. Med Pediatr Oncol. 1988; 16(5):333-6. View in: PubMed

The effects of moderate physical activity on menstrual cycle patterns in adolescence: implications for breast cancer prevention. Br J Cancer. 1987 Jun; 55(6):681-5. View in: PubMed

Chronic effects of fractionated renal irradiation on the pharmacokinetics of intravenous methotrexate. Int J Radiat Oncol Biol Phys. 1987 May; 13(5):759-64. View in: PubMed

Use of unequal allocation in survival trials. Stat Med. 1987 Mar; 6(2):119-25. View in: PubMed

Phase II study of vindesine in the treatment of pediatric patients with solid tumors: a report from the Childrens Cancer Study Group. Cancer Treat Rep. 1986 Jun; 70(6):807-9. View in: PubMed

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