Faculty

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Mark Lee Barr, MD
Associate Professor of Surgery
Surgery
HCT 4300 Health Sciences Campus Los Angeles
+1 323 442 5849

Overview

Dr. Mark L. Barr obtained his medical degree from Mount Sinai School of Medicine in New York and completed 10 years of postgraduate residency at New York University and Columbia University, including a 2-year NIH-sponsored research fellowship in transplantation immunology. Dr. Barr is former President and current Chair of the Scientific Grants and Awards Committee of the International Society for Heart and Lung Transplantation (ISHLT) and is the Immediate Past Chair of the Thoracic Committee of the American Society of Transplant Surgeons (ASTS). He has served on the Board of Directors of both the ASTS and the American Society of Transplantation, and as the Program Chair for the Annual Scientific Meeting of Both the ISHLT and the American Transplant Congress. Dr. Barr actively serves on multiple governmental transplant-related oversight subcommittees under the auspices of the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (DHHS), including the Scientific Technical Advisory Committee of the Scientific Registry of Transplant Recipients. He is the incoming Chair of the Thoracic Committee for the United Network of Organ Sharing (UNOS). Dr. Barr has authored more than 150 peer-reviewed publications and book chapters in the fields of cardiothoracic surgery and heart and lung transplantation. He is a Deputy Editor of the American Journal of Transplantation. In addition, Dr. Barr is a standing reviewer for the Annals of Thoracic Surgery, the Journal of Heart and Lung Transplantation, the Journal of Thoracic and Cardiovascular Surgery, Lancet, and Transplantation. He maintains an active research program, funded by both federal and regional grant support, studying transplant immunology and Pulmonary physiology. He has served as a study section member for the NIAID, NHLBI, and NCRR of the National Institutes of Health.

Publications

Bowdish ME, Hui DS, Cleveland JD, Mack WJ, Sinha R, Ranjan R, Cohen RG, Baker CJ, Cunningham MJ, Barr ML, Starnes VA. A comparison of aortic valve replacement via an anterior right minithoracotomy with standard sternotomy: a propensity score analysis of 492 patients†. Eur J Cardiothorac Surg. 2016 Feb; 49(2):456-63. View in: PubMed

Greene CL, Barr ML, Schenkel FA, Worrell SG, Starnes VA, McFadden PM. Outcomes after pregnancy in living lobar lung transplantation. Transplantation. 2014 Oct 15; 98(7):692-4. View in: PubMed

Takabe W, Jen N, Ai L, Hamilton R, Wang S, Holmes K, Dharbandi F, Khalsa B, Bressler S, Barr ML, Li R, Hsiai TK. Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling. Antioxid Redox Signal. 2011 Sep 1; 15(5):1379-88. View in: PubMed

Yu F, Li R, Ai L, Edington C, Yu H, Barr M, Kim ES, Hsiai TK. Electrochemical impedance spectroscopy to assess vascular oxidative stress. Ann Biomed Eng. 2011 Jan; 39(1):287-96. View in: PubMed

Adler FR, Aurora P, Barker DH, Barr ML, Blackwell LS, Bosma OH, Brown S, Cox DR, Jensen JL, Kurland G, Nossent GD, Quittner AL, Robinson WM, Romero SL, Spencer H, Sweet SC, van der Bij W, Vermeulen J, Verschuuren EA, Vrijlandt EJ, Walsh W, Woo MS, Liou TG. Lung transplantation for cystic fibrosis. Proc Am Thorac Soc. 2009 Dec; 6(8):619-33. View in: PubMed

Palmer SL, Kelly PD, Schenkel FA, Barr ML. CT-guided tube pericardiostomy: a safe and effective technique in the management of postsurgical pericardial effusion. AJR Am J Roentgenol. 2009 Oct; 193(4):W314-20. View in: PubMed

Wu GD, Wang H, Zhu H, He Y, Barr ML, Klein AS. Genetic modulation of CD44 expression by intragraft fibroblasts. J Biochem. 2008 Nov; 144(5):571-80. View in: PubMed

Kawut SM, Lederer DJ, Keshavjee S, Wilt JS, Daly T, D'Ovidio F, Sonett JR, Arcasoy SM, Barr ML. Outcomes after lung retransplantation in the modern era. Am J Respir Crit Care Med. 2008 Jan 1; 177(1):114-20. View in: PubMed

Hsiai TK, Hwang J, Barr ML, Correa A, Hamilton R, Alavi M, Rouhanizadeh M, Cadenas E, Hazen SL. Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med. 2007 Feb 15; 42(4):519-29. View in: PubMed

Mitsuhashi N, Wu GD, Zhu H, Kearns-Jonker M, Cramer DV, Starnes VA, Barr ML. Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models. Mol Cell Biochem. 2007 Feb; 296(1-2):1-9. View in: PubMed

Kobashigawa JA, Starling RC, Mehra MR, Kormos RL, Bhat G, Barr ML, Sigouin CS, Kolesar J, Fitzsimmons W. Multicenter retrospective analysis of cardiovascular risk factors affecting long-term outcome of de novo cardiac transplant recipients. J Heart Lung Transplant. 2006 Sep; 25(9):1063-9. View in: PubMed

Barr ML, Belghiti J, Villamil FG, Pomfret EA, Sutherland DS, Gruessner RW, Langnas AN, Delmonico FL. A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines. Transplantation. 2006 May 27; 81(10):1373-85. View in: PubMed

Zhu H, Mitsuhashi N, Klein A, Barsky LW, Weinberg K, Barr ML, Demetriou A, Wu GD. The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells. 2006 Apr; 24(4):928-35. View in: PubMed

Zheng SG, Meng L, Wang JH, Watanabe M, Barr ML, Cramer DV, Gray JD, Horwitz DA. Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient. Int Immunol. 2006 Feb; 18(2):279-89. View in: PubMed

Watanabe M, Mencel RL, Cramer DV, Starnes VA, Barr ML. Transforming growth factor-beta/interleukin-2-induced regulatory CD4+ T cells prolong cardiac allograft survival in rats. J Heart Lung Transplant. 2005 Dec; 24(12):2153-9. View in: PubMed

Backhus LM, Sievers EM, Schenkel FA, Barr ML, Cohen RG, Smith MA, Starnes VA, Bremner RM. Pleural space problems after living lobar transplantation. J Heart Lung Transplant. 2005 Dec; 24(12):2086-90. View in: PubMed

Wu GD, Bowdish ME, Jin YS, Zhu H, Mitsuhashi N, Barsky LW, Barr ML. Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection. J Heart Lung Transplant. 2005 Dec; 24(12):2160-9. View in: PubMed

Wells WJ, Barr ML. The ethics of living donor lung transplantation. Thorac Surg Clin. 2005 Nov; 15(4):519-25. View in: PubMed

Barr ML, Schenkel FA, Bowdish ME, Starnes VA. Living donor lobar lung transplantation: current status and future directions. Transplant Proc. 2005 Nov; 37(9):3983-6. View in: PubMed

Barr ML, Kawut SM, Whelan TP, Girgis R, Böttcher H, Sonett J, Vigneswaran W, Follette DM, Corris PA. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV: recipient-related risk factors and markers. J Heart Lung Transplant. 2005 Oct; 24(10):1468-82. View in: PubMed

Barr ML, Bourge RC, Orens JB, McCurry KR, Ring WS, Hulbert-Shearon TE, Merion RM. Thoracic organ transplantation in the United States, 1994-2003. Am J Transplant. 2005 Apr; 5(4 Pt 2):934-49. View in: PubMed

Bowdish ME, Pessotto R, Barbers RG, Schenkel FA, Starnes VA, Barr ML. Long-term pulmonary function after living-donor lobar lung transplantation in adults. Ann Thorac Surg. 2005 Feb; 79(2):418-25. View in: PubMed

Bowdish ME, Barr ML. Living lobar lung transplantation. Respir Care Clin N Am. 2004 Dec; 10(4):563-79. View in: PubMed

Bowdish ME, Barr ML, Schenkel FA, Woo MS, Bremner RM, Horn MV, Baker CJ, Barbers RG, Wells WJ, Starnes VA. A decade of living lobar lung transplantation: perioperative complications after 253 donor lobectomies. Am J Transplant. 2004 Aug; 4(8):1283-8. View in: PubMed

Bowdish ME, Arcasoy SM, Wilt JS, Conte JV, Davis RD, Garrity ER, Hertz ML, Orens JB, Rosengard BR, Barr ML. Surrogate markers and risk factors for chronic lung allograft dysfunction. Am J Transplant. 2004 Jul; 4(7):1171-8. View in: PubMed

Nigro JJ, Schwartz DS, Bart RD, Bart CW, Lopez BM, Cunningham MJ, Barr ML, Bremner RM, Haddy SM, Wells WJ, Starnes VA. Neochordal repair of the posterior mitral leaflet. J Thorac Cardiovasc Surg. 2004 Feb; 127(2):440-7. View in: PubMed

Starnes VA, Bowdish ME, Woo MS, Barbers RG, Schenkel FA, Horn MV, Pessotto R, Sievers EM, Baker CJ, Cohen RG, Bremner RM, Wells WJ, Barr ML. A decade of living lobar lung transplantation: recipient outcomes. J Thorac Cardiovasc Surg. 2004 Jan; 127(1):114-22. View in: PubMed

Pierson RN, Barr ML, McCullough KP, Egan T, Garrity E, Jessup M, Murray S. Thoracic organ transplantation. Am J Transplant. 2004; 4 Suppl 9:93-105. View in: PubMed

Thompson JL, Ryan JA, Barr ML, Franc B, Starnes VA, Schwarz MA. Potential role for antiangiogenic proteins in the myocardial infarction repair process. J Surg Res. 2004 Jan; 116(1):156-64. View in: PubMed

Barr ML, Schenkel FA, Van Kirk A, Halbert RJ, Helderman JH, Hricik DE, Matas AJ, Pirsch JD, Siegal BR, Ferguson RM, Nordyke RJ. Determinants of quality of life changes among long-term cardiac transplant survivors: results from longitudinal data. J Heart Lung Transplant. 2003 Oct; 22(10):1157-67. View in: PubMed

Wu GD, Tuan TL, Bowdish ME, Jin YS, Starnes VA, Cramer DV, Barr ML. Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection. Transplantation. 2003 Aug 15; 76(3):609-14. View in: PubMed

Wells W, Malas M, Baker CJ, Quardt SM, Barr ML. Depopulated vena caval homograft: a new venous conduit. J Thorac Cardiovasc Surg. 2003 Aug; 126(2):498-503. View in: PubMed

Bowdish ME, Barr ML, Starnes VA. Living lobar transplantation. Chest Surg Clin N Am. 2003 Aug; 13(3):505-24. View in: PubMed

Barr ML. Photopheresis for the prevention and treatment of transplant rejection. J Cutan Med Surg. 2003 Jul-Aug; 7(4 Suppl):18-9. View in: PubMed

Hathaway D, Barr ML, Ghobrial RM, Rodrigue J, Bogner S, Prendergast MM, Subaiya I. The PORTEL registry: overview and selected findings. Prog Transplant. 2003 Jun; Suppl:3-13; quiz 16-7. View in: PubMed

Wu GD, Nolta JA, Jin YS, Barr ML, Yu H, Starnes VA, Cramer DV. Migration of mesenchymal stem cells to heart allografts during chronic rejection. Transplantation. 2003 Mar 15; 75(5):679-85. View in: PubMed

Grover FL, Barr ML, Edwards LB, Martinez FJ, Pierson RN, Rosengard BR, Murray S. Thoracic transplantation. Am J Transplant. 2003; 3 Suppl 4:91-102. View in: PubMed

Sritippayawan S, Keens TG, Horn MV, MacLaughlin EF, Barr ML, Starnes VA, Woo MS. Does lung growth occur when mature lobes are transplanted into children? Pediatr Transplant. 2002 Dec; 6(6):500-4. View in: PubMed

Haddy SM, Bremner RM, Moore-Jefferies EW, Thangathurai D, Schenkel FA, Barr ML, Starnes VA. Hyperinflation resulting in hemodynamic collapse following living donor lobar transplantation. Anesthesiology. 2002 Nov; 97(5):1315-7. View in: PubMed

Wu GD, Jin YS, Salazar R, Dai WD, Barteneva N, Barr ML, Barsky LW, Starnes VA, Cramer DV. Vascular endothelial cell apoptosis induced by anti-donor non-MHC antibodies: a possible injury pathway contributing to chronic allograft rejection. J Heart Lung Transplant. 2002 Nov; 21(11):1174-87. View in: PubMed

Matas AJ, Halbert RJ, Barr ML, Helderman JH, Hricik DE, Pirsch JD, Schenkel FA, Siegal BR, Liu H, Ferguson RM. Life satisfaction and adverse effects in renal transplant recipients: a longitudinal analysis. Clin Transplant. 2002 Apr; 16(2):113-21. View in: PubMed

Malas MB, Barr ML, Starnes VA, Shapiro S, Palmer S, Schwartz DS. Dyspnea lusoria: compression of the pulmonary artery by a Kommerell's diverticulum. Ann Thorac Surg. 2002 Jan; 73(1):312-3. View in: PubMed

Barr ML, Baker CJ, Schenkel FA, McLaughlin SN, Stouch BC, Starnes VA, Rose EA. Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation. Clin Transplant. 2000 Apr; 14(2):162-6. View in: PubMed

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