Faculty

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Mark S. Humayun, MD, PhD
University Professor of Ophthalmology
Cornelius J. Pings Chair in Biomedical Sciences
Director, Institute For Biomedical Therapeutics
Co Director USC Eye Institute
Director of Sensory Science Initiatives
Ophthalmology
HC4 6534B 1450 San Pablo Street Off Campus Los Angeles
+1 323 865 3092

Overview

Mark S. Humayun is internationally known for his work on the Argus II artificial retina implant intended to restore sight to the blind. His research projects focus on the treatment of the most debilitating and challenging eye diseases through advanced engineering. Leading a team of more than 30 faculty and 200 students from 15 different institutes, Humayun is focused on developing therapies for 1) retinal degenerations such as retinitis pigmentosa, 2) macular degenerations such as age-related macular degeneration, 3) retinovascular diseases such as vein occlusions, 4) diabetic retinopathy, as well as 5) glaucoma.

He received his BS from Georgetown University in 1984, his MD from Duke University in 1989, and his PhD from the University of North Carolina, Chapel Hill in 1994. He completed his ophthalmology residency at Duke Eye Center and fellowships in both vitreoretinal and retinovascular surgery at Johns Hopkins Hospital. He stayed on as faculty at Johns Hopkins where he rose to the rank of associate professor before moving to USC in 2001.

He has been voted as one of the Best Doctors in America and has received numerous research awards. He is the director of the National Science Foundation BioMimetic MicroElectronic Systems Engineering Research Center, as well as the director of the Department of Energy Artificial Retina Project.

Awards

Richard S. Ross Clinical Scientist Award

William and Mary Grieve Scholar's Award

Jules Stein Living tribute Award

Senior Honor Award of the Am. Soc. Retina Specialists

Strathmore's Who's Who Award

Best Doctors of America Award

R&D magazine: Innovator of the Year award, 2005

Castle Connolly Medical Ltd.: America's Top Doctors, 2011

R&D magazine: Innovator of the Year award, 2005

Castle Connolly Medical Ltd. : America's Top Doctors, 2011

Publications

Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. View in: PubMed

Falabella P, Stefanini FR, Lue JC, Pfister M, Reyes-Mckinley J, Koss MJ, Teixeira A, Schor P, Humayun MS. INTRAOCULAR PRESSURE CHANGES DURING VITRECTOMY USING CONSTELLATION VISION SYSTEM'S INTRAOCULAR PRESSURE CONTROL FEATURE. Retina. 2016 Jul; 36(7):1275-80. View in: PubMed

Yue L, Weiland JD, Roska B, Humayun MS. Retinal stimulation strategies to restore vision: Fundamentals and systems. Prog Retin Eye Res. 2016 Jul; 53:21-47. View in: PubMed

DeBoer CM, Lee JK, Wheelan BP, Cable C, Shi W, Tai YC, Humayun MS. Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon. IEEE Trans Biomed Eng. 2016 Jun; 63(6):1129-35. View in: PubMed

Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton DR, Humayun MS. Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. Invest Ophthalmol Vis Sci. 2016 May 1; 57(6):2877-87. View in: PubMed

Abdallah WF, Louie SG, Zhang Y, Rodgers KE, Sivok E, S diZerega G, Humayun MS. NorLeu3A(1-7) Accelerates Clear Corneal Full Thickness Wound Healing. Invest Ophthalmol Vis Sci. 2016 Apr 1; 57(4):2187-94. View in: PubMed

Brant Fernandes RA, Koss MJ, Falabella P, Stefanini FR, Maia M, Diniz B, Ribeiro R, Hu Y, Hinton D, Clegg DO, Chader G, Humayun MS. An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 1; 47(4):342-51. View in: PubMed

Murali K, Kang D, Nazari H, Scianmarello N, Cadenas E, Tai YC, Kashani A, Humayun M. Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016; 11(3):e0149961. View in: PubMed

Weitz AC, Nanduri D, Behrend MR, Gonzalez-Calle A, Greenberg RJ, Humayun MS, Chow RH, Weiland JD. Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration. Sci Transl Med. 2015 Dec 16; 7(318):318ra203. View in: PubMed

Yue L, Falabella P, Christopher P, Wuyyuru V, Dorn J, Schor P, Greenberg RJ, Weiland JD, Humayun MS. Ten-Year Follow-up of a Blind Patient Chronically Implanted with Epiretinal Prosthesis Argus I. Ophthalmology. 2015 Dec; 122(12):2545-2552. e1. View in: PubMed

Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani AH, Hinton DR, Humayun MS. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. View in: PubMed

Ho AC, Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Handa J, Barale PO, Sahel JA, Stanga PE, Hafezi F, Safran AB, Salzmann J, Santos A, Birch D, Spencer R, Cideciyan AV, de Juan E, Duncan JL, Eliott D, Fawzi A, Olmos de Koo LC, Brown GC, Haller JA, Regillo CD, Del Priore LV, Arditi A, Geruschat DR, Greenberg RJ. Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind. Ophthalmology. 2015 Aug; 122(8):1547-54. View in: PubMed

Yue L, Humayun MS. Monte Carlo analysis of the enhanced transcranial penetration using distributed near-infrared emitter array. J Biomed Opt. 2015 Aug 1; 20(8):88001. View in: PubMed

Murali K, Kashani AH, Humayun MS. Whole Vitreous Humor Dissection for Vitreodynamic Analysis. J Vis Exp. 2015; (99). View in: PubMed

Brant Fernandes RA, Diniz B, Falabella P, Ribeiro R, Teixeira AG, Magalhães O, Moraes N, Maia A, Farah ME, Maia M, Humayun MS. Fluidics comparison between dual pneumatic and spring return high-speed vitrectomy systems. Ophthalmic Surg Lasers Imaging Retina. 2015 Jan 1; 46(1):68-72. View in: PubMed

Kashani AH, Lopez Jaime GR, Saati S, Martin G, Varma R, Humayun MS. NONINVASIVE ASSESSMENT OF RETINAL VASCULAR OXYGEN CONTENT AMONG NORMAL AND DIABETIC HUMAN SUBJECTS: A Study Using Hyperspectral Computed Tomographic Imaging Spectroscopy. Retina. 2014 Sep; 34(9):1854-60. View in: PubMed

Chen K, Rowley AP, Weiland JD, Humayun MS. Elastic properties of human posterior eye. J Biomed Mater Res A. 2014 Jun; 102(6):2001-7. View in: PubMed

Weiland JD, Humayun MS. Retinal prosthesis. IEEE Trans Biomed Eng. 2014 May; 61(5):1412-24. View in: PubMed

Weitz AC, Behrend MR, Ahuja AK, Christopher P, Wei J, Wuyyuru V, Patel U, Greenberg RJ, Humayun MS, Chow RH, Weiland JD. Interphase gap as a means to reduce electrical stimulation thresholds for epiretinal prostheses. J Neural Eng. 2014 Feb; 11(1):016007. View in: PubMed

Pfister M, Lue JC, Stefanini FR, Falabella P, Dustin L, Koss MJ, Humayun MS. Comparison of Reaction Response Time between Hand and Foot Controlled Devices in Simulated Microsurgical Testing. Biomed Res Int. 2014; 2014:769296. View in: PubMed

Lu B, Tai YC, Humayun MS. Microdevice-based cell therapy for age-related macular degeneration. Dev Ophthalmol. 2014; 53:155-66. View in: PubMed

Stefanini FR, Maia M, Falabella P, Pfister M, Niemeyer M, Kashani AH, Humayun MS, Koss MJ. Profile of ocriplasmin and its potential in the treatment of vitreomacular adhesion. Clin Ophthalmol. 2014; 8:847-56. View in: PubMed

Monge M, Raj M, Nazari MH, Chang HC, Zhao Y, Weiland JD, Humayun MS, Tai YC, Emami A. A fully intraocular high-density self-calibrating epiretinal prosthesis. IEEE Trans Biomed Circuits Syst. 2013 Dec; 7(6):747-60. View in: PubMed

Ribeiro RM, Oregon A, Diniz B, Fernandes RB, Koss MJ, Charafeddin W, Hu Y, Thomas P, Thomas BB, Maia M, Chader GJ, Hinton DR, Humayun MS. In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance. Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):380-4. View in: PubMed

Diniz B, Thomas P, Thomas B, Ribeiro R, Hu Y, Brant R, Ahuja A, Zhu D, Liu L, Koss M, Maia M, Chader G, Hinton DR, Humayun MS. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci. 2013 Jul; 54(7):5087-96. View in: PubMed

Chen K, Lo YK, Yang Z, Weiland JD, Humayun MS, Liu W. A system verification platform for high-density epiretinal prostheses. IEEE Trans Biomed Circuits Syst. 2013 Jun; 7(3):326-37. View in: PubMed

Diniz B, Fernandes RB, Ribeiro RM, Lue JC, Teixeira AG, Magalhães O, Maia M, Humayun MS. Analysis of a 23-gauge ultra high-speed cutter with duty cycle control. Retina. 2013 May; 33(5):933-8. View in: PubMed

Ribeiro RM, Teixeira AG, Diniz B, Fernandes RB, Zhong Y, Kerns R, Humayun MS. Performance analysis of ultrahigh-speed vitreous cutter system. Retina. 2013 May; 33(5):928-32. View in: PubMed

da Cruz L, Coley BF, Dorn J, Merlini F, Filley E, Christopher P, Chen FK, Wuyyuru V, Sahel J, Stanga P, Humayun M, Greenberg RJ, Dagnelie G. The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss. Br J Ophthalmol. 2013 May; 97(5):632-6. View in: PubMed

Rohan JG, Citron YR, Durrell AC, Cheruzel LE, Gray HB, Grubbs RH, Humayun M, Engisch KL, Pikov V, Chow RH. Light-triggered modulation of cellular electrical activity by ruthenium diimine nanoswitches. ACS Chem Neurosci. 2013 Apr 17; 4(4):585-93. View in: PubMed

Weitz AC, Behrend MR, Lee NS, Klein RL, Chiodo VA, Hauswirth WW, Humayun MS, Weiland JD, Chow RH. Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators. J Neurophysiol. 2013 Apr; 109(7):1979-88. View in: PubMed

Alkin Z, Kashani AH, López-Jaime GR, Ruiz García H, Humayun MS, Sadda SR. Quantitative analysis of retinal structures using spectral domain optical coherence tomography in normal rabbits. Curr Eye Res. 2013 Feb; 38(2):299-304. View in: PubMed

Diniz B, Ribeiro RM, Fernandes RB, Lue JC, Teixeira AG, Maia M, Humayun MS. Fluidics in a dual pneumatic ultra high-speed vitreous cutter system. Ophthalmologica. 2013; 229(1):15-20. View in: PubMed

Abdallah WF, Olmos de Koo LC, Abdulkader MM, Barnett C, Chader GJ, Humayun MS. High-resolution OCT: an innovative tool for posterior segment imaging. Ophthalmic Surg Lasers Imaging. 2012 Nov-Dec; 43(6 Suppl):S123-34. View in: PubMed

Arana LA, Pinto AT, Chader GJ, Barbosa JD, Morales S, Moreira AT, Maia M, Humayun MS. Fluorescein angiography, optical coherence tomography, and histopathologic findings in a VEGF(165) animal model of retinal angiogenesis. Graefes Arch Clin Exp Ophthalmol. 2012 Oct; 250(10):1421-8. View in: PubMed

Lu B, Zhu D, Hinton D, Humayun MS, Tai YC. Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells. Biomed Microdevices. 2012 Aug; 14(4):659-67. View in: PubMed

Fernandes RA, Diniz B, Ribeiro R, Humayun M. Artificial vision through neuronal stimulation. Neurosci Lett. 2012 Jun 25; 519(2):122-8. View in: PubMed

Xie J, Wang GJ, Yow L, Humayun MS, Weiland JD, Cela CJ, Jadvar H, Lazzi G, Dhrami-Gavazi E, Tsang SH. Preservation of retinotopic map in retinal degeneration. Exp Eye Res. 2012 May; 98:88-96. View in: PubMed

Weiland JD, Faraji B, Greenberg RJ, Humayun MS, Shellock FG. Assessment of MRI issues for the Argus II Retinal Prosthesis. Magn Reson Imaging. 2012 Apr; 30(3):382-9. View in: PubMed

Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE, Cideciyan AV, Duncan JL, Eliott D, Filley E, Ho AC, Santos A, Safran AB, Arditi A, Del Priore LV, Greenberg RJ. Interim Results from the International Trial of Second Sight's Visual Prosthesis. Ophthalmology. 2012 Apr; 119(4):779-88. View in: PubMed

Jaime GR, Kashani AH, Saati S, Martin G, Chader G, Humayun MS. Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion. PLoS One. 2012; 7(11):e50179. View in: PubMed

Abdallah WF, Patel H, Grant EG, Diniz B, Chader GJ, Humayun MS. Evaluation of ultrasound-assisted thrombolysis using custom liposomes in a model of retinal vein occlusion. Invest Ophthalmol Vis Sci. 2012; 53(11):6920-7. View in: PubMed

Hu Y, Liu L, Lu B, Zhu D, Ribeiro R, Diniz B, Thomas PB, Ahuja AK, Hinton DR, Tai YC, Hikita ST, Johnson LV, Clegg DO, Thomas BB, Humayun MS. A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Res. 2012; 48(4):186-91. View in: PubMed

Nanduri D, Fine I, Horsager A, Boynton GM, Humayun MS, Greenberg RJ, Weiland JD. Frequency and amplitude modulation have different effects on the percepts elicited by retinal stimulation. Invest Ophthalmol Vis Sci. 2012; 53(1):205-14. View in: PubMed

Ray A, Chan LL, Gonzalez A, Humayun MS, Weiland JD. Impedance as a method to sense proximity at the electrode-retina interface. IEEE Trans Neural Syst Rehabil Eng. 2011 Dec; 19(6):696-9. View in: PubMed

Weiland JD, Cho AK, Humayun MS. Retinal prostheses: current clinical results and future needs. Ophthalmology. 2011 Nov; 118(11):2227-37. View in: PubMed

Behrend MR, Ahuja AK, Humayun MS, Chow RH, Weiland JD. Resolution of the epiretinal prosthesis is not limited by electrode size. IEEE Trans Neural Syst Rehabil Eng. 2011 Aug; 19(4):436-42. View in: PubMed

Xie J, Wang GJ, Yow L, J Cela C, Humayun MS, Weiland JD, Lazzi G, Jadvar H. Modeling and percept of transcorneal electrical stimulation in humans. IEEE Trans Biomed Eng. 2011 Jul; 58(7):1932-9. View in: PubMed

Eng JG, Agrawal RN, Tozer KR, Ross-Cisneros FN, Dagnelie G, Greenberg RJ, Chader GJ, Weiland JD, Rao NA, Sadun AA, Humayun MS. Morphometric analysis of optic nerves and retina from an end-stage retinitis pigmentosa patient with an implanted active epiretinal array. Invest Ophthalmol Vis Sci. 2011 Jun; 52(7):4610-6. View in: PubMed

Chan LL, Lee EJ, Humayun MS, Weiland JD. Both electrical stimulation thresholds and SMI-32-immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina. J Neurophysiol. 2011 Jun; 105(6):2687-97. View in: PubMed

Matsuoka N, Teixeira A, Lue JC, Fang S, Kerns R, Bhadri P, Humayun M. Performance analysis of millennium vitreous enhancer™ system. Ophthalmic Surg Lasers Imaging. 2011 Mar-Apr; 42(3):162-7. View in: PubMed

Abdallah W, Ameri H, Barron E, Chader GJ, Greenbaum E, Hinton DR, Humayun MS. Vitreal oxygenation in retinal ischemia reperfusion. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1035-42. View in: PubMed

Kashani AH, Kirkman E, Martin G, Humayun MS. Hyperspectral computed tomographic imaging spectroscopy of vascular oxygen gradients in the rabbit retina in vivo. PLoS One. 2011; 6(9):e24482. View in: PubMed

Lima LH, Deboer C, McCormick M, Kerns R, Bhadri P, Humayun MS. A new dual port cutter system for vitrectomy surgery. Retina. 2010 Oct; 30(9):1515-9. View in: PubMed

Teixeira A, Chong L, Matsuoka N, Rowley A, Lue JC, McCormick M, Kerns R, Humayun M. Novel method to quantify traction in a vitrectomy procedure. Br J Ophthalmol. 2010 Sep; 94(9):1226-9. View in: PubMed

Teixeira A, Chong L, Matsuoka N, Arana L, Lue JC, McCormick M, Kerns R, Bhadri P, Humayun M. An experimental protocol of the model to quantify traction applied to the retina by vitreous cutters. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4181-6. View in: PubMed

Teixeira A, Chong LP, Matsuoka N, Arana L, Kerns R, Bhadri P, Humayun M. Vitreoretinal traction created by conventional cutters during vitrectomy. Ophthalmology. 2010 Jul; 117(7):1387-92. e2. View in: PubMed

Matsuoka N, Paeng DG, Chen R, Ameri H, Abdallah W, Zhou Q, Fawzi A, Shung KK, Humayun M. Ultrasonic Doppler measurements of blood flow velocity of rabbit retinal vessels using a 45-MHz needle transducer. Graefes Arch Clin Exp Ophthalmol. 2010 May; 248(5):675-80. View in: PubMed

Saati S, Agrawal RN, Louie S, Chader GJ, Humayun MS. Effect of multiple injections of small divided doses vs single injection of intravitreal bevacizumab on retinal neovascular model in rabbits. Graefes Arch Clin Exp Ophthalmol. 2010 Apr; 248(4):457-66. View in: PubMed

Saati S, Lo R, Li PY, Meng E, Varma R, Humayun MS. Mini drug pump for ophthalmic use. Curr Eye Res. 2010 Mar; 35(3):192-201. View in: PubMed

Abdallah W, Fawzi A, Patel H, Dagliyan G, Matsuoka N, Grant E, Humayun M. Blood velocity measurement in the posterior segment of the rabbit eye using combined spectral Doppler and power Doppler ultrasound. Graefes Arch Clin Exp Ophthalmol. 2010 Jan; 248(1):93-101. View in: PubMed

Saati S, Lo R, Li PY, Meng E, Varma R, Humayun MS. Mini drug pump for ophthalmic use. Trans Am Ophthalmol Soc. 2009 Dec; 107:60-70. View in: PubMed

Greenwald SH, Horsager A, Humayun MS, Greenberg RJ, McMahon MJ, Fine I. Brightness as a function of current amplitude in human retinal electrical stimulation. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5017-25. View in: PubMed

Huang CC, Chen R, Tsui PH, Zhou Q, Humayun MS, Shung KK. Measurements of attenuation coefficient for evaluating the hardness of a cataract lens by a high-frequency ultrasonic needle transducer. Phys Med Biol. 2009 Oct 7; 54(19):5981-94. View in: PubMed

Lo R, Li PY, Saati S, Agrawal RN, Humayun MS, Meng E. A passive MEMS drug delivery pump for treatment of ocular diseases. Biomed Microdevices. 2009 Oct; 11(5):959-70. View in: PubMed

Tunc M, Yildirim U, Yuksel H, Cheng X, Humayun M, Ratner B. Conjunctival impression cytology by using a thermosensitive adhesive: polymerized N-isopropyl acrylamide. Cornea. 2009 Aug; 28(7):770-3. View in: PubMed

Ameri H, Ratanapakorn T, Ufer S, Eckhardt H, Humayun MS, Weiland JD. Toward a wide-field retinal prosthesis. J Neural Eng. 2009 Jun; 6(3):035002. View in: PubMed

Behrend MR, Ahuja AK, Humayun MS, Weiland JD, Chow RH. Selective labeling of retinal ganglion cells with calcium indicators by retrograde loading in vitro. J Neurosci Methods. 2009 May 15; 179(2):166-72. View in: PubMed

Caspi A, Dorn JD, McClure KH, Humayun MS, Greenberg RJ, McMahon MJ. Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant. Arch Ophthalmol. 2009 Apr; 127(4):398-401. View in: PubMed

Horsager A, Greenwald SH, Weiland JD, Humayun MS, Greenberg RJ, McMahon MJ, Boynton GM, Fine I. Predicting visual sensitivity in retinal prosthesis patients. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1483-91. View in: PubMed

Paeng DG, Chang JH, Chen R, Humayun MS, Shung KK. Feasibility of rotational scan ultrasound imaging by an angled high frequency transducer for the posterior segment of the eye. IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Mar; 56(3):676-80. View in: PubMed

Ray A, Colodetti L, Weiland JD, Hinton DR, Humayun MS, Lee EJ. Immunocytochemical analysis of retinal neurons under electrical stimulation. Brain Res. 2009 Feb 19; 1255:89-97. View in: PubMed

Greenbaum E, Humayun MS, Sanders CA, Close D, O'Neill HM, Evans BR. Metabolic prosthesis for oxygenation of ischemic tissue. IEEE Trans Biomed Eng. 2009 Feb; 56(2):528-31. View in: PubMed

Magalhaes O, Chong L, DeBoer C, Bhadri P, Kerns R, Barnes A, Fang S, Schor P, Humayun M. Guillotine performance: duty cycle analysis of vitrectomy systems. Retin Cases Brief Rep. 2009; 3(1):64-7. View in: PubMed

Weiland JD, Humayun MS, Eckhardt H, Ufer S, Laude L, Basinger B, Tai YC. A comparison of retinal prosthesis electrode array substrate materials. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4140-3. View in: PubMed

Parikh NJ, McIntosh BP, Tanguay AR, Humayun MS, Weiland JD. Biomimetic image processing for retinal prostheses: peripheral saliency cues. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4569-72. View in: PubMed

Humayun MS, Dorn JD, Ahuja AK, Caspi A, Filley E, Dagnelie G, Salzmann J, Santos A, Duncan J, daCruz L, Mohand-Said S, Eliott D, McMahon MJ, Greenberg RJ. Preliminary 6 month results from the Argus II epiretinal prosthesis feasibility study. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4566-8. View in: PubMed

Chader GJ, Weiland J, Humayun MS. Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Prog Brain Res. 2009; 175:317-32. View in: PubMed

Tunc M, Humayun M, Cheng X, Ratner BD. A reversible thermosensitive adhesive for retinal implants: in vivo experience with plasma-deposited poly(N-isopropyl acrylamide). Retina. 2008 Oct; 28(9):1338-43. View in: PubMed

Ameri H, Ratanapakorn T, Rao NA, Chader GJ, Humayun MS. Natural course of experimental retinal vein occlusion in rabbit; arterial occlusion following venous photothrombosis. Graefes Arch Clin Exp Ophthalmol. 2008 Oct; 246(10):1429-39. View in: PubMed

DeBoer C, Fang S, Lima LH, McCormick M, Bhadri P, Kerns R, Humayun M. Port geometry and its influence on vitrectomy. Retina. 2008 Oct; 28(8):1061-7. View in: PubMed

Lo R, Li PY, Saati S, Agrawal R, Humayun MS, Meng E. A refillable microfabricated drug delivery device for treatment of ocular diseases. Lab Chip. 2008 Jul; 8(7):1027-30. View in: PubMed

de Balthasar C, Patel S, Roy A, Freda R, Greenwald S, Horsager A, Mahadevappa M, Yanai D, McMahon MJ, Humayun MS, Greenberg RJ, Weiland JD, Fine I. Factors affecting perceptual thresholds in epiretinal prostheses. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2303-14. View in: PubMed

Ahuja AK, Behrend MR, Kuroda M, Humayun MS, Weiland JD. An in vitro model of a retinal prosthesis. IEEE Trans Biomed Eng. 2008 Jun; 55(6):1744-53. View in: PubMed

Lim TH, Humayun MS, Yoon YH, Kwon YH, Kim JG. The efficacy of retrobulbar block anesthesia only in pars plana vitrectomy and transconjunctival sutureless vitrectomy. Ophthalmic Surg Lasers Imaging. 2008 May-Jun; 39(3):191-5. View in: PubMed

Ahuja AK, Behrend MR, Whalen JJ, Humayun MS, Weiland JD. The dependence of spectral impedance on disc microelectrode radius. IEEE Trans Biomed Eng. 2008 Apr; 55(4):1457-60. View in: PubMed

Han S, Sarunic MV, Wu J, Humayun M, Yang C. Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspection. J Biomed Opt. 2008 Mar-Apr; 13(2):020505. View in: PubMed

Ameri H, Kim JG, Ratanapakorn T, Chader GJ, Humayun MS. Intravitreal and subretinal injection of tissue plasminogen activator (tPA) in the treatment of experimentally created retinal vein occlusion in rabbits. Retina. 2008 Feb; 28(2):350-5. View in: PubMed

Magalhaes O, Chong L, DeBoer C, Bhadri P, Kerns R, Barnes A, Fang S, Humayun M. Vitreous dynamics: vitreous flow analysis in 20-, 23-, and 25-gauge cutters. Retina. 2008 Feb; 28(2):236-41. View in: PubMed

Fang SY, DeBoer CM, Humayun MS. Performance analysis of new-generation vitreous cutters. Graefes Arch Clin Exp Ophthalmol. 2008 Jan; 246(1):61-7. View in: PubMed

Huang CC, Zhou Q, Ameri H, Wu da W, Sun L, Wang SH, Humayun MS, Shung KK. Determining the acoustic properties of the lens using a high-frequency ultrasonic needle transducer. Ultrasound Med Biol. 2007 Dec; 33(12):1971-7. View in: PubMed

Ameri H, Chader GJ, Kim JG, Sadda SR, Rao NA, Humayun MS. The effects of intravitreous bevacizumab on retinal neovascular membrane and normal capillaries in rabbits. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5708-15. View in: PubMed

Huang CC, Ameri H, Deboer C, Rowley AP, Xu X, Sun L, Wang SH, Humayun MS, Shung KK. Evaluation of lens hardness in cataract surgery using high-frequency ultrasonic parameters in vitro. Ultrasound Med Biol. 2007 Oct; 33(10):1609-16. View in: PubMed

Tunc M, Cheng X, Ratner BD, Meng E, Humayun M. Reversible thermosensitive glue for retinal implants. Retina. 2007 Sep; 27(7):938-42. View in: PubMed

Bhadri PR, Rowley AP, Khurana RN, Deboer CM, Kerns RM, Chong LP, Humayun MS. Evaluation of a stereoscopic camera-based three-dimensional viewing workstation for ophthalmic surgery. Am J Ophthalmol. 2007 May; 143(5):891-2. View in: PubMed

Yanai D, Weiland JD, Mahadevappa M, Greenberg RJ, Fine I, Humayun MS. Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa. Am J Ophthalmol. 2007 May; 143(5):820-827. View in: PubMed

Shah S, Hines A, Zhou D, Greenberg RJ, Humayun MS, Weiland JD. Electrical properties of retinal-electrode interface. J Neural Eng. 2007 Mar; 4(1):S24-9. View in: PubMed

Zhou Q, Xu X, Gottlieb EJ, Sun L, Cannata JM, Ameri H, Humayun MS, Han P, Shung KK. PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar; 54(3):668-75. View in: PubMed

Dagnelie G, Keane P, Narla V, Yang L, Weiland J, Humayun M. Real and virtual mobility performance in simulated prosthetic vision. J Neural Eng. 2007 Mar; 4(1):S92-101. View in: PubMed

Johnson WR, Wilson DW, Fink W, Humayun M, Bearman G. Snapshot hyperspectral imaging in ophthalmology. J Biomed Opt. 2007 Jan-Feb; 12(1):014036. View in: PubMed

Khurana RN, Chang YH, Barnes AC, Fujii GY, De Juan E, Humayun MS. A novel method to oxygenate intraocular irrigation fluids with an in-line oxygenator. Retina. 2007 Jan; 27(1):83-6. View in: PubMed

Javaheri M, Fujii GY, Rossi JV, Panzan CQ, Yanai D, Lakhanpal RR, Maia M, Khurana RN, Guven D, De Juan E, Humayun MS. Effect of oxygenated intraocular irrigation solutions on the electroretinogram after vitrectomy. Retina. 2007 Jan; 27(1):87-94. View in: PubMed

O'Hearn TM, Sadda SR, Weiland JD, Maia M, Margalit E, Humayun MS. Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina. Vision Res. 2006 Oct; 46(19):3198-204. View in: PubMed

Weiland JD, Humayun MS. Intraocular retinal prosthesis. Big steps to sight restoration. IEEE Eng Med Biol Mag. 2006 Sep-Oct; 25(5):60-6. View in: PubMed

Shyu JS, Maia M, Weiland JD, Ohearn T, Chen SJ, Margalit E, Suzuki S, Humayun MS. Electrical stimulation in isolated rabbit retina. IEEE Trans Neural Syst Rehabil Eng. 2006 Sep; 14(3):290-8. View in: PubMed

Ratanapakorn T, Ameri H, Humayun MS, Weiland JD. Enucleated eye model for intraocular retinal prosthesis implantation. Ophthalmic Surg Lasers Imaging. 2006 Jul-Aug; 37(4):341-3. View in: PubMed

Roizenblatt R, Weiland JD, Carcieri S, Qiu G, Behrend M, Humayun MS, Chow RH. Nanobiolistic delivery of indicators to the living mouse retina. J Neurosci Methods. 2006 May 15; 153(1):154-61. View in: PubMed

Xiao X, Wang J, Liu C, Carlisle JA, Mech B, Greenberg R, Guven D, Freda R, Humayun MS, Weiland J, Auciello O. In vitro and in vivo evaluation of ultrananocrystalline diamond for coating of implantable retinal microchips. J Biomed Mater Res B Appl Biomater. 2006 May; 77(2):273-81. View in: PubMed

Javaheri M, Hahn DS, Lakhanpal RR, Weiland JD, Humayun MS. Retinal prostheses for the blind. Ann Acad Med Singapore. 2006 Mar; 35(3):137-44. View in: PubMed

Lim JI, Walonker AF, Levin L, Mahmoud M, Sadda S, Flaxel CJ, Humayun M, deJuan E, Labree L. One-year results of a pilot study using oral 13-cis retinoic acid as a treatment for subfoveal predominantly occult choroidal neovascularization in patients with age-related macular degeneration. Retina. 2006 Mar; 26(3):314-21. View in: PubMed

Dagnelie G, Barnett D, Humayun MS, Thompson RW. Paragraph text reading using a pixelized prosthetic vision simulator: parameter dependence and task learning in free-viewing conditions. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1241-50. View in: PubMed

Wang G, Liu W, Sivaprakasam M, Zhou M, Weiland JD, Humayun MS. A dual band wireless power and data telemetry for retinal prosthesis. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:4392-5. View in: PubMed

Zhou M, Liu W, Wang G, Sivaprakasam M, Yuce MR, Weiland JD, Humayun MS. A transcutaneous data telemetry system tolerant to power telemetry interference. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:5884-7. View in: PubMed

Chen SJ, Mahadevappa M, Roizenblatt R, Weiland J, Humayun M. Neural responses elicited by electrical stimulation of the retina. Trans Am Ophthalmol Soc. 2006; 104:252-9. View in: PubMed

Güven D, Weiland JD, Maghribi M, Davidson JC, Mahadevappa M, Roizenblatt R, Qiu G, Krulevitz P, Wang X, Labree L, Humayun MS. Implantation of an inactive epiretinal poly(dimethyl siloxane) electrode array in dogs. Exp Eye Res. 2006 Jan; 82(1):81-90. View in: PubMed

Khurana RN, Fujii GY, Walsh AC, Humayun MS, de Juan E, Sadda SR. Rapid recurrence of geographic atrophy after full macular translocation for nonexudative age-related macular degeneration. Ophthalmology. 2005 Sep; 112(9):1586-91. View in: PubMed

Weiland JD, Humayun MS. Old idea, new technology. IEEE Eng Med Biol Mag. 2005 Sep-Oct; 24(5):12-3. View in: PubMed

Weiland JD, Humayun MS. A biomimetic retinal stimulating array. IEEE Eng Med Biol Mag. 2005 Sep-Oct; 24(5):14-21. View in: PubMed

Mahadevappa M, Weiland JD, Yanai D, Fine I, Greenberg RJ, Humayun MS. Perceptual thresholds and electrode impedance in three retinal prosthesis subjects. IEEE Trans Neural Syst Rehabil Eng. 2005 Jun; 13(2):201-6. View in: PubMed

Lakhanpal RR, Humayun MS, de Juan E, Lim JI, Chong LP, Chang TS, Javaheri M, Fujii GY, Barnes AC, Alexandrou TJ. Outcomes of 140 consecutive cases of 25-gauge transconjunctival surgery for posterior segment disease. Ophthalmology. 2005 May; 112(5):817-24. View in: PubMed

Lakhanpal RR, Javaheri M, Ruiz-Garcia H, De Juan E, Humayun MS. Transvitreal limited arteriovenous-crossing manipulation without vitrectomy for complicated branch retinal vein occlusion using 25-gauge instrumentation. Retina. 2005 Apr-May; 25(3):272-80. View in: PubMed

Güven D, Weiland JD, Fujii G, Mech BV, Mahadevappa M, Greenberg R, Roizenblatt R, Qiu G, Labree L, Wang X, Hinton D, Humayun MS. Long-term stimulation by active epiretinal implants in normal and RCD1 dogs. J Neural Eng. 2005 Mar; 2(1):S65-73. View in: PubMed

Yu DY, Cringle SJ, Su E, Yu PK, Humayun MS, Dorin G. Laser-induced changes in intraretinal oxygen distribution in pigmented rabbits. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):988-99. View in: PubMed

Sivaprakasam M, Liu W, Wang G, Weiland J, Humayun M. A programmable discharge circuitry with current limiting capability for a retinal prosthesis. Conf Proc IEEE Eng Med Biol Soc. 2005; 5:5234-7. View in: PubMed

Weiland JD, Liu W, Humayun MS. Retinal prosthesis. Annu Rev Biomed Eng. 2005; 7:361-401. View in: PubMed

Weiland J, Fink W, Humayun M, Liu W, Rodger D, Tai YC, Tarbell M. Progress towards a high-resolution retinal prosthesis. Conf Proc IEEE Eng Med Biol Soc. 2005; 7:7373-5. View in: PubMed

Wang G, Liu W, Sivaprakasam M, Zhou M, Weiland J, Humayun M. A wireless phase shift keying transmitter with q-independent phase transition time. Conf Proc IEEE Eng Med Biol Soc. 2005; 5:5238-41. View in: PubMed

Tameesh MK, Lakhanpal RR, Fujii GY, Javaheri M, Shelley TH, D'Anna S, Barnes AC, Margalit E, Farah M, De Juan E, Humayun MS. Retinal vein cannulation with prolonged infusion of tissue plasminogen activator (t-PA) for the treatment of experimental retinal vein occlusion in dogs. Am J Ophthalmol. 2004 Nov; 138(5):829-39. View in: PubMed

Panzan CQ, Güven D, Weiland JD, Lakhanpal RR, Javaheri M, de Juan E, Humayun MS. Retinal thickness in normal and RCD1 dogs using optical coherence tomography. Ophthalmic Surg Lasers Imaging. 2004 Nov-Dec; 35(6):485-93. View in: PubMed

Ng EW, Fujii GY, Au Eong KG, Reynolds SM, Melia BM, Kouzis AC, Humayun MS, de Juan E, Pieramici DJ. Macular translocation in patients with recurrent subfoveal choroidal neovascularization after laser photocoagulation for nonsubfoveal choroidal neovascularization. Ophthalmology. 2004 Oct; 111(10):1889-93. View in: PubMed

Johnson L, Perkins FK, O'Hearn T, Skeath P, Merritt C, Frieble J, Sadda S, Humayun M, Scribner D. Electrical stimulation of isolated retina with microwire glass electrodes. J Neurosci Methods. 2004 Aug 30; 137(2):265-73. View in: PubMed

Gosalia K, Weiland J, Humayun M, Lazzi G. Thermal elevation in the human eye and head due to the operation of a retinal prosthesis. IEEE Trans Biomed Eng. 2004 Aug; 51(8):1469-77. View in: PubMed

Suzuki S, Humayun MS, Weiland JD, Chen SJ, Margalit E, Piyathaisere DV, de Juan E. Comparison of electrical stimulation thresholds in normal and retinal degenerated mouse retina. Jpn J Ophthalmol. 2004 Jul-Aug; 48(4):345-9. View in: PubMed

Güven D, Panzan CQ, Humayun MS, De Juan E. Use of rotational sutures for limited retinal translocation: a new technique for superior limited macular translocation. Am J Ophthalmol. 2004 May; 137(5):901-7. View in: PubMed

Rossi JV, Verma D, Fujii GY, Lakhanpal RR, Wu SL, Humayun MS, De Juan E. Virtual vitreoretinal surgical simulator as a training tool. Retina. 2004 Apr; 24(2):231-6. View in: PubMed

Duh EJ, Yang HS, Haller JA, De Juan E, Humayun MS, Gehlbach P, Melia M, Pieramici D, Harlan JB, Campochiaro PA, Zack DJ. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Am J Ophthalmol. 2004 Apr; 137(4):668-74. View in: PubMed

Maia M, Haller JA, Pieramici DJ, Margalit E, de Juan E, Farah ME, Lakhanpal RR, Au Eong KG, Guven D, Humayun MS. Retinal pigment epithelial abnormalities after internal limiting membrane peeling guided by indocyanine green staining. Retina. 2004 Feb; 24(1):157-60. View in: PubMed

Maia M, Kellner L, de Juan E, Smith R, Farah ME, Margalit E, Lakhanpal RR, Grebe L, Au Eong KG, Humayun MS. Effects of indocyanine green injection on the retinal surface and into the subretinal space in rabbits. Retina. 2004 Feb; 24(1):80-91. View in: PubMed

Maia M, Margalit E, Lakhanpal R, Tso MO, Grebe R, Torres G, Au Eong KG, Farah ME, Fujii GY, Weiland J, de Juan E, D'Anna SA, Humayun MS. Effects of intravitreal indocyanine green injection in rabbits. Retina. 2004 Feb; 24(1):69-79. View in: PubMed

Parikh NJ, Weiland JD, Humayun MS, Shah SS, Mohile GS. DSP based image processing for retinal prosthesis. Conf Proc IEEE Eng Med Biol Soc. 2004; 2:1475-8. View in: PubMed

Shah S, Chu A, Zhou D, Greenberg R, Guven D, Humayun MS, Weiland JD. Intraocular impedance as a function of the position in the eye, electrode material and electrode size. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4169-71. View in: PubMed

Kazemi M, Basham E, Sivaprakasam M, Wang G, Rodger D, Weiland J, Tai YC, Liu W, Humayun M. A test microchip for evaluation of hermetic packaging technology for biomedical prosthetic implants. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4093-5. View in: PubMed

Fujii GY, De Juan E, Humayun MS, Sunness JS, Chang TS, Rossi JV. Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration. Am J Ophthalmol. 2003 Dec; 136(6):1067-78. View in: PubMed

Weiland JD, Humayun MS. Past, present, and future of artificial vision. Artif Organs. 2003 Nov; 27(11):961-2. View in: PubMed

Humayun MS, Weiland JD, Fujii GY, Greenberg R, Williamson R, Little J, Mech B, Cimmarusti V, Van Boemel G, Dagnelie G, de Juan E. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res. 2003 Nov; 43(24):2573-81. View in: PubMed

Thompson RW, Barnett GD, Humayun MS, Dagnelie G. Facial recognition using simulated prosthetic pixelized vision. Invest Ophthalmol Vis Sci. 2003 Nov; 44(11):5035-42. View in: PubMed

Hayes JS, Yin VT, Piyathaisere D, Weiland JD, Humayun MS, Dagnelie G. Visually guided performance of simple tasks using simulated prosthetic vision. Artif Organs. 2003 Nov; 27(11):1016-28. View in: PubMed

See RF, Humayun M, Rao NA. Bilateral neuroretinopathy with multiple retinal arterial aneurysms. Arch Ophthalmol. 2003 Aug; 121(8):1206-7. View in: PubMed

Lakhanpal RR, Yanai D, Weiland JD, Fujii GY, Caffey S, Greenberg RJ, de Juan E, Humayun MS. Advances in the development of visual prostheses. Curr Opin Ophthalmol. 2003 Jun; 14(3):122-7. View in: PubMed

Kent DL, Fujii GY, Pieramici DJ, Reynolds SM, Melia M, Rossi JV, Humayun MS, Caffey S, De Juan E. Angiographic characteristics in patients undergoing macular translocation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Retina. 2003 Apr; 23(2):152-8. View in: PubMed

Margalit E, Weiland JD, Clatterbuck RE, Fujii GY, Maia M, Tameesh M, Torres G, D'Anna SA, Desai S, Piyathaisere DV, Olivi A, de Juan E, Humayun MS. Visual and electrical evoked response recorded from subdural electrodes implanted above the visual cortex in normal dogs under two methods of anesthesia. J Neurosci Methods. 2003 Mar 15; 123(2):129-37. View in: PubMed

Piyathaisere DV, Margalit E, Chen SJ, Shyu JS, D'Anna SA, Weiland JD, Grebe RR, Grebe L, Fujii G, Kim SY, Greenberg RJ, De Juan E, Humayun MS. Heat effects on the retina. Ophthalmic Surg Lasers Imaging. 2003 Mar-Apr; 34(2):114-20. View in: PubMed

Fujii GY, de Juan E, Humayun MS, Chang TS. Limited macular translocation for the management of subfoveal choroidal neovascularization after photodynamic therapy. Am J Ophthalmol. 2003 Jan; 135(1):109-12. View in: PubMed

Fujii GY, de Juan E, Humayun MS. Improvements after sheathotomy for branch retinal vein occlusion documented by optical coherence tomography and scanning laser ophthalmoscope. Ophthalmic Surg Lasers Imaging. 2003 Jan-Feb; 34(1):49-52. View in: PubMed

Yanai D, Lakhanpal RR, Weiland JD, Mahadevappa M, Van Boemel G, Fujii GY, Greenberg R, Caffey S, de Juan E, Humayun MS. The value of preoperative tests in the selection of blind patients for a permanent microelectronic implant. Trans Am Ophthalmol Soc. 2003; 101:223-8; discussion 228-30. View in: PubMed

Fujii GY, Au Eong KG, Humayun MS, de Juan E. Limited macular translocation: current concepts. Ophthalmol Clin North Am. 2002 Dec; 15(4):425-36. View in: PubMed

Weiland JD, Anderson DJ, Humayun MS. In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodes. IEEE Trans Biomed Eng. 2002 Dec; 49(12 Pt 2):1574-9. View in: PubMed

Fujii GY, De Juan E, Humayun MS, Pieramici DJ, Chang TS, Awh C, Ng E, Barnes A, Wu SL, Sommerville DN. A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery. Ophthalmology. 2002 Oct; 109(10):1807-12; discussion 1813. View in: PubMed

Fujii GY, De Juan E, Humayun MS, Chang TS, Pieramici DJ, Barnes A, Kent D. Initial experience using the transconjunctival sutureless vitrectomy system for vitreoretinal surgery. Ophthalmology. 2002 Oct; 109(10):1814-20. View in: PubMed

Radner W, Sadda SR, Humayun MS, Suzuki S, de Juan E. Increased spontaneous retinal ganglion cell activity in rd mice after neural retinal transplantation. Invest Ophthalmol Vis Sci. 2002 Sep; 43(9):3053-8. View in: PubMed

Fujii GY, de Juan E, Sunness J, Humayun MS, Pieramici DJ, Chang TS. Patient selection for macular translocation surgery using the scanning laser ophthalmoscope. Ophthalmology. 2002 Sep; 109(9):1737-44. View in: PubMed

Margalit E, Maia M, Weiland JD, Greenberg RJ, Fujii GY, Torres G, Piyathaisere DV, O'Hearn TM, Liu W, Lazzi G, Dagnelie G, Scribner DA, de Juan E, Humayun MS. Retinal prosthesis for the blind. Surv Ophthalmol. 2002 Jul-Aug; 47(4):335-56. View in: PubMed

Fujii GY, de Juan E, Pieramici DJ, Humayun MS, Phillips S, Reynolds SM, Melia M, Schachat AP. Inferior limited macular translocation for subfoveal choroidal neovascularization secondary to age-related macular degeneration: 1-year visual outcome and recurrence report. Am J Ophthalmol. 2002 Jul; 134(1):69-74. View in: PubMed

An GJ, Asayama N, Humayun MS, Weiland J, Cao J, Kim SY, Grebe R, de Juan E, Sadda S. Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents. Curr Eye Res. 2002 Jan; 24(1):26-32. View in: PubMed

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