Faculty

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Meredith N. Braskie, PhD
Assistant Professor of Research Neurology
Neurology
STT 2001 N. SOTO Street Health Sciences Campus Los Angeles
+1 323 442 7246

Overview

My research focus is to evaluate how genetic and environmental risk factors for Alzheimer's disease (AD) relate to brain structure, function, and connectivity throughout adulthood, with an emphasis on cognitively intact adults and those with early mild cognitive impairment. We also seek to understand the biological mechanisms and signaling pathways that may contribute to or protect against AD-related changes, using relevant blood and cerebrospinal fluid measures, and multimodal imaging (structural and functional MRI, diffusion tensor imaging, and PET). When possible, we engage in collaborative research with laboratories investigating similar concepts in a wet lab environment.

Awards

Turken Award for Alzheimer’s Disease Research

Ruth L. Kirschstein National Research Service Award

Achievement Rewards for College Scientists (ARCS) fellowship

Ruth L Kirschstein National Research Service Award

Publications

Scott JA, Braskie MN, Tosun D, Thompson PM, Weiner M, DeCarli C, Carmichael OT. Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. Front Aging Neurosci. 2015; 7:221. View in: PubMed

Dennis EL, Jahanshad N, Braskie MN, Warstadt NM, Hibar DP, Kohannim O, Nir TM, McMahon KL, de Zubicaray GI, Montgomery GW, Martin NG, Toga AW, Wright MJ, Thompson PM. Obesity gene NEGR1 associated with white matter integrity in healthy young adults. Neuroimage. 2014 Nov 15; 102 Pt 2:548-57. View in: PubMed

Braskie MN, Boyle CP, Rajagopalan P, Gutman BA, Toga AW, Raji CA, Tracy RP, Kuller LH, Becker JT, Lopez OL, Thompson PM. Physical activity, inflammation, and volume of the aging brain. Neuroscience. 2014 Jul 25; 273:199-209. View in: PubMed

Braskie MN, Thompson PM. A focus on structural brain imaging in the Alzheimer's disease neuroimaging initiative. Biol Psychiatry. 2014 Apr 1; 75(7):527-33. View in: PubMed

Braskie MN, Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Thompson PM, Cummings JL, Bookheimer SY, Ringman JM. Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease. Hum Brain Mapp. 2013 Dec; 34(12):3308-19. View in: PubMed

Braskie MN, Kohannim O, Jahanshad N, Chiang MC, Barysheva M, Toga AW, Ringman JM, Montgomery GW, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Thompson PM. Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Neuroimage. 2013 Nov 15; 82:146-53. View in: PubMed

Braskie MN, Thompson PM. Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings. Trends Cogn Sci. 2013 Oct; 17(10):510-6. View in: PubMed

Lee GJ, Lu PH, Medina LD, Rodriguez-Agudelo Y, Melchor S, Coppola G, Braskie MN, Hua X, Apostolova LG, Leow AD, Thompson PM, Ringman JM. Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations. J Neurol Neurosurg Psychiatry. 2013 Feb; 84(2):154-62. View in: PubMed

Braskie MN, Toga AW, Thompson PM. Recent advances in imaging Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S313-27. View in: PubMed

Braskie MN, Jahanshad N, Toga AW, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Thompson PM. How a common variant in the growth factor receptor gene, NTRK1, affects white matter. Bioarchitecture. 2012 Sep 1; 2(5):181-4. View in: PubMed

Kohannim O, Jahanshad N, Braskie MN, Stein JL, Chiang MC, Reese AH, Hibar DP, Toga AW, McMahon KL, de Zubicaray GI, Medland SE, Montgomery GW, Martin NG, Wright MJ, Thompson PM. Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology. 2012 Aug; 37(9):2012-9. View in: PubMed

Protas HD, Kepe V, Hayashi KM, Klunder AD, Braskie MN, Ercoli L, Siddarth P, Bookheimer SY, Thompson PM, Small GW, Barrio JR, Huang SC. Prediction of cognitive decline based on hemispheric cortical surface maps of FDDNP PET. Neuroimage. 2012 Jul 16; 61(4):749-60. View in: PubMed

Braskie MN, Jahanshad N, Stein JL, Barysheva M, Johnson K, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults. J Neurosci. 2012 Apr 25; 32(17):5964-72. View in: PubMed

Klostermann EC, Braskie MN, Landau SM, O'Neil JP, Jagust WJ. Dopamine and frontostriatal networks in cognitive aging. Neurobiol Aging. 2012 Mar; 33(3):623. e15-24. View in: PubMed

Braskie MN, Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer SY, Ringman JM. Increased fMRI signal with age in familial Alzheimer's disease mutation carriers. Neurobiol Aging. 2012 Feb; 33(2):424. e11-21. View in: PubMed

Braskie MN, Landau SM, Wilcox CE, Taylor SD, O'Neil JP, Baker SL, Madison CM, Jagust WJ. Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults. Hum Brain Mapp. 2011 Jun; 32(6):947-61. View in: PubMed

Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 4; 31(18):6764-70. View in: PubMed

Ringman JM, Medina LD, Braskie M, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer S. Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task. Cereb Cortex. 2011 Apr; 21(4):877-83. View in: PubMed

Braskie MN, Ringman JM, Thompson PM. Neuroimaging measures as endophenotypes in Alzheimer's disease. Int J Alzheimers Dis. 2011; 2011:490140. View in: PubMed

Apostolova LG, Hwang KS, Medina LD, Green AE, Braskie MN, Dutton RA, Lai J, Geschwind DH, Cummings JL, Thompson PM, Ringman JM. Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2011; 32(2):118-25. View in: PubMed

Braskie MN, Klunder AD, Hayashi KM, Protas H, Kepe V, Miller KJ, Huang SC, Barrio JR, Ercoli LM, Siddarth P, Satyamurthy N, Liu J, Toga AW, Bookheimer SY, Small GW, Thompson PM. Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiol Aging. 2010 Oct; 31(10):1669-78. View in: PubMed

Braskie MN, Small GW, Bookheimer SY. Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging. 2010 Sep; 31(9):1532-42. View in: PubMed

Wilcox CE, Braskie MN, Kluth JT, Jagust WJ. Overeating Behavior and Striatal Dopamine with 6-[F]-Fluoro-L-m-Tyrosine PET. J Obes. 2010; 2010. View in: PubMed

Protas HD, Huang SC, Kepe V, Hayashi K, Klunder A, Braskie MN, Ercoli L, Bookheimer S, Thompson PM, Small GW, Barrio JR. FDDNP binding using MR derived cortical surface maps. Neuroimage. 2010 Jan 1; 49(1):240-8. View in: PubMed

Braskie MN, Small GW, Bookheimer SY. Entorhinal cortex structure and functional MRI response during an associative verbal memory task. Hum Brain Mapp. 2009 Dec; 30(12):3981-92. View in: PubMed

Braskie MN, Wilcox CE, Landau SM, O'Neil JP, Baker SL, Madison CM, Kluth JT, Jagust WJ. Relationship of striatal dopamine synthesis capacity to age and cognition. J Neurosci. 2008 Dec 24; 28(52):14320-8. View in: PubMed

Burggren AC, Zeineh MM, Ekstrom AD, Braskie MN, Thompson PM, Small GW, Bookheimer SY. Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers. Neuroimage. 2008 Jul 15; 41(4):1177-83. View in: PubMed

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