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Michael Noel Koss, MD
Professor of Pathology
HC4 1450 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 9620


Dr. Koss, a former officer in the United States Armed Forces, has co-authored over a hundred peer reviewed articles and numerous other non-peer reviewed articles, book chapters, letters to the editor, abstracts and four books. He has been invited to guest lecture across the globe and has been a co-investigator on two separate five-year research studies. Dr. Koss is a former Chairman of the Pulmonary and Mediastinal Pathology Department at the Armed Services Institute of Pathology and is currently a Professor of Pathology at the LAC+USC Medical Center.


Shigemitsu H, Orjioke N, Shriki JE, Varras J, Koss MN. A middle-aged man with cough, chest pain, and pulmonary artery filling defect. Chest. 2014 Feb 1; 145(2):407-10. View in: PubMed

Koss MN. Handling and interpretation of the medical renal biopsy. Methods Mol Biol. 2014; 1180:323-36. View in: PubMed

Stefanini FR, Badaró E, Falabella P, Koss M, Farah ME, Maia M. Anti-VEGF for the management of diabetic macular edema. J Immunol Res. 2014; 2014:632307. View in: PubMed

Diniz B, Thomas P, Thomas B, Ribeiro R, Hu Y, Brant R, Ahuja A, Zhu D, Liu L, Koss M, Maia M, Chader G, Hinton DR, Humayun MS. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci. 2013 Jul; 54(7):5087-96. View in: PubMed

Guinee DG, Franks TJ, Gerbino AJ, Murakami SS, Acree SC, Koss MN. Pulmonary nodular lymphoid hyperplasia (pulmonary pseudolymphoma): the significance of increased numbers of IgG4-positive plasma cells. Am J Surg Pathol. 2013 May; 37(5):699-709. View in: PubMed

Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, Lam S, Gazdar AF, Laird-Offringa IA. Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res. 2012 Jul; 22(7):1197-211. View in: PubMed

Barbers RG, Papanikolaou IC, Koss MN, Patel A, Katagihara E, Arenas M, Chan K, Azen CG, Sharma OP. Near fatal asthma: clinical and airway biopsy characteristics. Pulm Med. 2012; 2012:829608. View in: PubMed

Jacob N, Guo S, Mathian A, Koss MN, Gindea S, Putterman C, Jacob CO, Stohl W. B Cell and BAFF dependence of IFN-a-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice. J Immunol. 2011 Apr 15; 186(8):4984-93. View in: PubMed

Agrawal H, Jacob N, Carreras E, Bajana S, Putterman C, Turner S, Neas B, Mathian A, Koss MN, Stohl W, Kovats S, Jacob CO. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol. 2009 Nov 1; 183(9):6021-9. View in: PubMed

Shigemitsu H, Koss MN. IgG4-related interstitial lung disease: a new and evolving concept. Curr Opin Pulm Med. 2009 Sep; 15(5):513-6. View in: PubMed

Miller DC, Koss MN. Wegener granulomatosis presenting as epididymitis. Urology. 2009 Jun; 73(6):1225-6. View in: PubMed

Jacob N, Yang H, Pricop L, Liu Y, Gao X, Zheng SG, Wang J, Gao HX, Putterman C, Koss MN, Stohl W, Jacob CO. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J Immunol. 2009 Feb 15; 182(4):2532-41. View in: PubMed

Stohl W, Jacob N, Quinn WJ, Cancro MP, Gao H, Putterman C, Gao X, Pricop L, Koss MN. Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity. J Immunol. 2008 Jul 1; 181(1):833-41. View in: PubMed

Anglim PP, Galler JS, Koss MN, Hagen JA, Turla S, Campan M, Weisenberger DJ, Laird PW, Siegmund KD, Laird-Offringa IA. Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer. 2008; 7:62. View in: PubMed

Tsou JA, Galler JS, Wali A, Ye W, Siegmund KD, Groshen S, Laird PW, Turla S, Koss MN, Pass HI, Laird-Offringa IA. DNA methylation profile of 28 potential marker loci in malignant mesothelioma. Lung Cancer. 2007 Nov; 58(2):220-30. View in: PubMed

Ma Y, Gal A, Koss MN. The pathology of pulmonary sarcoidosis: update. Semin Diagn Pathol. 2007 Aug; 24(3):150-61. View in: PubMed

Lynch JP, Ma YL, Koss MN, White ES. Pulmonary sarcoidosis. Semin Respir Crit Care Med. 2007 Feb; 28(1):53-74. View in: PubMed

Tsou JA, Galler JS, Siegmund KD, Laird PW, Turla S, Cozen W, Hagen JA, Koss MN, Laird-Offringa IA. Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer. 2007; 6:70. View in: PubMed

Jacob CO, Pricop L, Putterman C, Koss MN, Liu Y, Kollaros M, Bixler SA, Ambrose CM, Scott ML, Stohl W. Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF. J Immunol. 2006 Aug 15; 177(4):2671-80. View in: PubMed

Schlesinger C, Koss MN. The organizing pneumonias : a critical review of current concepts and treatment. Treat Respir Med. 2006; 5(3):193-206. View in: PubMed

Cicciarelli J, Shah T, Koss M, Houston K, Narahghi R. Renal graft loss in recipients with at least one year of function and donor specific antibody (DSA). Clin Transpl. 2006; 539-40. View in: PubMed

Schlesinger C, Koss MN. The organizing pneumonias: an update and review. Curr Opin Pulm Med. 2005 Sep; 11(5):422-30. View in: PubMed

Stohl W, Xu D, Kim KS, Koss MN, Jorgensen TN, Deocharan B, Metzger TE, Bixler SA, Hong YS, Ambrose CM, Mackay F, Morel L, Putterman C, Kotzin BL, Kalled SL. BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus. Arthritis Rheum. 2005 Jul; 52(7):2080-91. View in: PubMed

Xia G, Kumar SR, Masood R, Koss M, Templeman C, Quinn D, Zhu S, Reddy R, Krasnoperov V, Gill PS. Up-regulation of EphB4 in mesothelioma and its biological significance. Clin Cancer Res. 2005 Jun 15; 11(12):4305-15. View in: PubMed

Marchevsky AM, Guintu R, Koss M, Fuller C, Houck W, McKenna RJ. Swyer-James (MacLeod) syndrome with placental transmogrification of the lung: a case report and review of the literature. Arch Pathol Lab Med. 2005 May; 129(5):686-9. View in: PubMed

Tsou JA, Shen LY, Siegmund KD, Long TI, Laird PW, Seneviratne CK, Koss MN, Pass HI, Hagen JA, Laird-Offringa IA. Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung. Lung Cancer. 2005 Feb; 47(2):193-204. View in: PubMed

Baydur A, Kanel G, Koss M. Tracheobronchomalacia and noninvasive ventilation revisited. Chest. 2004 Oct; 126(4):1390-2. View in: PubMed

Flieder DB, Koss MN. Nonspecific interstitial pneumonia: a provisional category of idiopathic interstitial pneumonia. Curr Opin Pulm Med. 2004 Sep; 10(5):441-6. View in: PubMed

Nakatani Y, Miyagi Y, Takemura T, Oka T, Yokoi T, Takagi M, Yokoyama S, Kashima K, Hara K, Yamada T, Nozawa A, Inayama Y, Sakamoto K, Ogawa N, Kitamura H, Resl M, Cho SH, Koss MN, Mark EJ. Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. Am J Surg Pathol. 2004 Jul; 28(7):921-7. View in: PubMed

Koss MN. Malignant and benign lymphoid lesions of the lung. Ann Diagn Pathol. 2004 Jun; 8(3):167-87. View in: PubMed

Zheng SG, Wang JH, Koss MN, Quismorio F, Gray JD, Horwitz DA. CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol. 2004 Feb 1; 172(3):1531-9. View in: PubMed

Jacob CO, Zang S, Li L, Ciobanu V, Quismorio F, Mizutani A, Satoh M, Koss M. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol. 2003 Aug 1; 171(3):1564-71. View in: PubMed

Müller C, Coffey TJ, Koss M, Teifke JP, Langhans W, Werling D. Lack of TNF alpha supports persistence of a plasmid encoding the bovine leukaemia virus in TNF(-/-) mice. Vet Immunol Immunopathol. 2003 Mar 20; 92(1-2):15-22. View in: PubMed

Ogino S, Franks TJ, Yong M, Koss MN. Extensive squamous metaplasia with cytologic atypia in diffuse alveolar damage mimicking squamous cell carcinoma: a report of 2 cases. Hum Pathol. 2002 Oct; 33(10):1052-4. View in: PubMed

Gal AA, Koss MN. The pathology of sarcoidosis. Curr Opin Pulm Med. 2002 Sep; 8(5):445-51. View in: PubMed

Schlesinger C, Koss MN. Bronchiolitis: update 2001. Curr Opin Pulm Med. 2002 Mar; 8(2):112-6. View in: PubMed

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