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Michael R Stallcup, PhD
Professor of Biochemistry & Molecular Biology
Biochemistry and Molecular Biology
NOR 6316 1441 Eastlake Avenue Health Sciences Campus Los Angeles
+1 323 865 3852


Michael R. Stallcup, Ph.D. received his B.A. at Yale University, his Ph.D. at the University of California at Berkeley, and did his postdoctoral training at the University of California at San Francisco. He began his career on the faculty at the University of South Carolina, joining USC in 1985 where he is a Professor in the Department of Biochemistry and Molecular Biology. He serves as co-leader with Dr. Peggy Farnham of the Epigenetics and Regulation Program. In his studies on transcriptional regulation by steroid hormone receptions, he is one of the leading researchers in discovering and characterizing coregulators. Specifically his research focuses on coregulators that help steroid receptors alter chromatin structure and recruit RNA polymerase to the target genes that are regulated by steroid hormones and their receptors. His lab discovered the first histone methyltransferase and was the first to demonstrate a role for histone methylation in transcriptional regulation. His lab is currently exploring the molecular mechanisms of coregulator action and the physiological roles of specific coregulators in cancer and inflammatory diseases.

Research Interests: Regulation of transcription by steroid hormones; molecular and physiological roles of transcriptional coregulators

Disease Models: cancer, inflammatory diseases


Yale University: Phi Beta Kappa, 1967

Yale University: Graduated Magna Cum Laude, 1969

National Science Foundation: Graduate Traineeship, 1969-1972

American Cancer Society: Postdoctoral Fellowship, 1974-1975

National Institutes of Health: National Research Service Award, 1977-1979

National Institutes of Health: Research Career Development Award, 1983-1988

Dept of Pathology, University of Southern California: R.S. Cleland Teaching Award (6 times), 1988-2003

Molecular Endocrinology: Editorial Board, 1990-1994

American Cancer Society: Chair, Tumor Biochemistry and Endocrinology Study Section, 1997-1998

Molecular Endocrinology: Editorial Board, 1999-2002

Keck School of Medicine, University of Southern California: Outstanding Gaduate Student Teaching Award, 2001

Journal of Biological Chemistry: Editorial Board, 2004-2009

Dept of Pathology, University of Southern California: Distinguished Service Award, 2006

National Institutes of Health, NIDDK: MERIT Award, 2008-2017

American Association for the Advancement of Science: Fellow, 2009

University of Southern California: USC Mellon Award for Excellence in Faculty Mentoring, 2010

National Institutes of Health: Chair, Molecular and Cellular Endocrinology Study Section, 2014-2016


Chodankar R, Wu DY, Gerke DS, Stallcup MR. Selective coregulator function and restriction of steroid receptor chromatin occupancy by hic-5. Mol Endocrinol. 2015 May; 29(5):716-29. View in: PubMed

Wu DY, Bittencourt D, Stallcup MR, Siegmund KD. Identifying differential transcription factor binding in ChIP-seq. Front Genet. 2015; 6:169. View in: PubMed

Ou CY, Chen TC, Lee JV, Wang JC, Stallcup MR. Coregulator Cell Cycle and Apoptosis Regulator 1 (CCAR1) Positively Regulates Adipocyte Differentiation through the Glucocorticoid Signaling Pathway. J Biol Chem. 2014 Jun 13; 289(24):17078-86. View in: PubMed

Chodankar R, Wu DY, Schiller BJ, Yamamoto KR, Stallcup MR. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4007-12. View in: PubMed

Jeong KW, Andreu-Vieyra C, You JS, Jones PA, Stallcup MR. Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression. Nucleic Acids Res. 2014 Feb 1; 42(4):2245-56. View in: PubMed

Schiller BJ, Chodankar R, Watson LC, Stallcup MR, Yamamoto KR. Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes. Genome Biol. 2014; 15(7):418. View in: PubMed

Wu DY, Ou CY, Chodankar R, Siegmund KD, Stallcup MR. Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators. Nucl Recept Signal. 2014; 12:e002. View in: PubMed

Bittencourt D, Lee BH, Gao L, Gerke DS, Stallcup MR. Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation. Epigenetics Chromatin. 2014; 7:27. View in: PubMed

Balasubramaniam S, Comstock CE, Ertel A, Jeong KW, Stallcup MR, Addya S, McCue PA, Ostrander WF, Augello MA, Knudsen KE. Aberrant BAF57 signaling facilitates prometastatic phenotypes. Clin Cancer Res. 2013 May 15; 19(10):2657-67. View in: PubMed

Hoang T, Fenne IS, Madsen A, Bozickovic O, Johannessen M, Bergsvåg M, Lien EA, Stallcup MR, Sagen JV, Moens U, Mellgren G. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 2013 Apr; 154(4):1513-27. View in: PubMed

Bittencourt D, Wu DY, Jeong KW, Gerke DS, Herviou L, Ianculescu I, Chodankar R, Siegmund KD, Stallcup MR. G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19673-8. View in: PubMed

Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, Stallcup MR. Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription. J Cell Biochem. 2012 Jul; 113(7):2406-14. View in: PubMed

Won Jeong K, Chodankar R, Purcell DJ, Bittencourt D, Stallcup MR. Gene-Specific Patterns of Coregulator Requirements by Estrogen Receptor-a in Breast Cancer Cells. Mol Endocrinol. 2012 Jun; 26(6):955-66. View in: PubMed

Ianculescu I, Wu DY, Siegmund KD, Stallcup MR. Selective Roles for cAMP Response Element-binding Protein Binding Protein and p300 Protein as Coregulators for Androgen-regulated Gene Expression in Advanced Prostate Cancer Cells. J Biol Chem. 2012 Feb 3; 287(6):4000-13. View in: PubMed

Sharma S, Gerke DS, Han HF, Jeong S, Stallcup MR, Jones PA, Liang G. Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells. Epigenetics Chromatin. 2012; 5(1):3. View in: PubMed

Purcell DJ, Jeong KW, Bittencourt D, Gerke DS, Stallcup MR. A Distinct Mechanism for Coactivator versus Corepressor Function by Histone Methyltransferase G9a in Transcriptional Regulation. J Biol Chem. 2011 Dec 9; 286(49):41963-71. View in: PubMed

Ji Yu E, Kim SH, Heo K, Ou CY, Stallcup MR, Kim JH. Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor {alpha} activity and co-activator synergy. Nucleic Acids Res. 2011 Sep 1; 39(16):6932-43. View in: PubMed

Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR. A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70. View in: PubMed

Lee YH, Stallcup MR. Roles of protein arginine methylation in DNA damage signaling pathways: Is CARM1 a life-or-death decision point? Cell Cycle. 2011 May 1; 10(9):1343-4. View in: PubMed

Lee YH, Bedford MT, Stallcup MR. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev. 2011 Jan 15; 25(2):176-88. View in: PubMed

Jeong KW, Kim K, Situ AJ, Ulmer TS, An W, Stallcup MR. Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011; 18(12):1358-65. View in: PubMed

Obianyo O, Causey CP, Osborne TC, Jones JE, Lee YH, Stallcup MR, Thompson PR. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14; 11(9):1219-23. View in: PubMed

Jeong KW, Lee YH, Stallcup MR. Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I. J Biol Chem. 2009 Oct 23; 284(43):29298-309. View in: PubMed

Ou CY, Kim JH, Yang CK, Stallcup MR. Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells. J Biol Chem. 2009 Jul 31; 284(31):20629-37. View in: PubMed

Lee YH, Stallcup MR. Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation. Mol Endocrinol. 2009 Apr; 23(4):425-33. View in: PubMed

Haiman CA, Garcia RR, Hsu C, Xia L, Ha H, Sheng X, Le Marchand L, Kolonel LN, Henderson BE, Stallcup MR, Greene GL, Press MF. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. BMC Cancer. 2009; 9:43. View in: PubMed

Khalid O, Baniwal SK, Purcell DJ, Leclerc N, Gabet Y, Stallcup MR, Coetzee GA, Frenkel B. Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer. Endocrinology. 2008 Dec; 149(12):5984-95. View in: PubMed

Kim JH, Yang CK, Heo K, Roeder RG, An W, Stallcup MR. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell. 2008 Aug 22; 31(4):510-9. View in: PubMed

Rao M, Casimiro MC, Lisanti MP, D'Amico M, Wang C, Shirley LA, Leader JE, Liu M, Stallcup M, Engel DA, Murphy DJ, Pestell RG. Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle. 2008 Mar 1; 7(5):647-55. View in: PubMed

Collins RE, Northrop JP, Horton JR, Lee DY, Zhang X, Stallcup MR, Cheng X. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol. 2008 Mar; 15(3):245-50. View in: PubMed

Yang CK, Kim JH, Ann DK, Stallcup MR. Differential regulation of the two transcriptional activation domains of the coiled-coil coactivator CoCoA by sumoylation. BMC Mol Biol. 2008; 9:12. View in: PubMed

Lee DY, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup MR. Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Mol Endocrinol. 2007 Jun; 21(6):1381-93. View in: PubMed

Chen YH, Yang CK, Xia M, Ou CY, Stallcup MR. Role of GAC63 in transcriptional activation mediated by beta-catenin. Nucleic Acids Res. 2007; 35(6):2084-92. View in: PubMed

Yang CK, Kim JH, Stallcup MR. Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin. Mol Endocrinol. 2006 Dec; 20(12):3251-62. View in: PubMed

Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup MR, Sato M, Thompson PR. Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry. 2006 Oct 3; 45(39):11727-36. View in: PubMed

Teyssier C, Ou CY, Khetchoumian K, Losson R, Stallcup MR. Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators. Mol Endocrinol. 2006 Jun; 20(6):1276-86. View in: PubMed

Chen YH, Beischlag TV, Kim JH, Perdew GH, Stallcup MR. Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. J Biol Chem. 2006 May 5; 281(18):12242-7. View in: PubMed

Lee DY, Northrop JP, Kuo MH, Stallcup MR. Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors. J Biol Chem. 2006 Mar 31; 281(13):8476-85. View in: PubMed

Yang CK, Kim JH, Li H, Stallcup MR. Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. J Biol Chem. 2006 Feb 10; 281(6):3389-97. View in: PubMed

Luo Y, Knuckley B, Lee YH, Stallcup MR, Thompson PR. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation. J Am Chem Soc. 2006 Feb 1; 128(4):1092-3. View in: PubMed

Kim JH, Yang CK, Stallcup MR. Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA. Nucleic Acids Res. 2006; 34(9):2736-50. View in: PubMed

Lee YH, Stallcup MR. Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription. Nucleic Acids Res. 2006; 34(18):5052-9. View in: PubMed

Kim JH, Lee MH, Kim BJ, Kim JH, Han SJ, Kim HY, Stallcup MR. Role of aspartate 351 in transactivation and active conformation of estrogen receptor alpha. J Mol Endocrinol. 2005 Dec; 35(3):449-64. View in: PubMed

Chen YH, Kim JH, Stallcup MR. GAC63, a GRIP1-dependent nuclear receptor coactivator. Mol Cell Biol. 2005 Jul; 25(14):5965-72. View in: PubMed

Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, Stallcup M, Merchant A, Galiano RD, Tomic-Canic M. Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol. 2005 Jul; 167(1):59-69. View in: PubMed

Teyssier C, Ma H, Emter R, Kralli A, Stallcup MR. Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev. 2005 Jun 15; 19(12):1466-73. View in: PubMed

Lee DY, Teyssier C, Strahl BD, Stallcup MR. Role of protein methylation in regulation of transcription. Endocr Rev. 2005 Apr; 26(2):147-70. View in: PubMed

Lee YH, Coonrod SA, Kraus WL, Jelinek MA, Stallcup MR. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A. 2005 Mar 8; 102(10):3611-6. View in: PubMed

Li YJ, Stallcup MR, Lai MM. Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication. J Virol. 2004 Dec; 78(23):13325-34. View in: PubMed

Kim JH, Stallcup MR. Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription. J Biol Chem. 2004 Nov 26; 279(48):49842-8. View in: PubMed

Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004 Oct 8; 306(5694):279-83. View in: PubMed

Guerrero-Santoro J, Yang L, Stallcup MR, DeFranco DB. Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation. J Cell Biochem. 2004 Jul 1; 92(4):810-9. View in: PubMed

Lee YH, Campbell HD, Stallcup MR. Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol. 2004 Mar; 24(5):2103-17. View in: PubMed

Li H, Kim JH, Koh SS, Stallcup MR. Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways. J Biol Chem. 2004 Feb 6; 279(6):4212-20. View in: PubMed

Kim JH, Li H, Stallcup MR. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol Cell. 2003 Dec; 12(6):1537-49. View in: PubMed

Stallcup MR, Kim JH, Teyssier C, Lee YH, Ma H, Chen D. The roles of protein-protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators. J Steroid Biochem Mol Biol. 2003 Jun; 85(2-5):139-45. View in: PubMed

Ma H, Shang Y, Lee DY, Stallcup MR. Study of nuclear receptor-induced transcription complex assembly and histone modification by chromatin immunoprecipitation assays. Methods Enzymol. 2003; 364:284-96. View in: PubMed

Teyssier C, Chen D, Stallcup MR. Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function. J Biol Chem. 2002 Nov 29; 277(48):46066-72. View in: PubMed

Li H, Park S, Kilburn B, Jelinek MA, Henschen-Edman A, Aswad DW, Stallcup MR, Laird-Offringa IA. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem. 2002 Nov 22; 277(47):44623-30. View in: PubMed

Koh SS, Li H, Lee YH, Widelitz RB, Chuong CM, Stallcup MR. Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem. 2002 Jul 19; 277(29):26031-5. View in: PubMed

Lee YH, Koh SS, Zhang X, Cheng X, Stallcup MR. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol. 2002 Jun; 22(11):3621-32. View in: PubMed

Zhou H, Luo MP, Schönthal AH, Pike MC, Stallcup MR, Blumenthal M, Zheng W, Dubeau L. Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity. Cancer Biol Ther. 2002 May-Jun; 1(3):300-6. View in: PubMed

Chen SL, Loffler KA, Chen D, Stallcup MR, Muscat GE. The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. J Biol Chem. 2002 Feb 8; 277(6):4324-33. View in: PubMed

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