Faculty

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Michele T. Pato, MD
Clinical Professor of Psychiatry & The Behavioral Sciences (Part Time)
Psychiatry and The Behavioral Sciences
CSC-2200 2250 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 4000

Overview

Michele Pato, MD is Professor and Associate Chair for Education, Della Martin Chair in Psychiatry and Associate Dean for Academic Scholarship at the Keck School of Medicine, Department of Psychiatry at the University of Southern California (USC). She is the Principal Investigator of the Genomic Psychiatry Cohort, developed clinical trials in pharmacologic and cognitive behavioral treatments of psychiatric illnesses, and teaches students and colleagues how to teach research and clinical skills. Dr. Pato is internationally known for her genetic research, OCD clinical research and teaching. She is the Co-Director of the OCD Treatment and Research Program at Keck School of Medicine, USC.

Publications

Estrada E, Hartz SM, Tran J, Hilty DM, Sklar P, Smoller JW. Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):521-4. View in: PubMed

Perlman G, Kotov R, Fu J, Bromet EJ, Fochtmann LJ, Medeiros H. Symptoms of psychosis in schizophrenia, schizoaffective disorder, and bipolar disorder: A comparison of African Americans and Caucasians in the Genomic Psychiatry Cohort. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):546-55. View in: PubMed

Malaspina D, Walsh-Messinger J, Antonius D, Dracxler R, Rothman K, Puthota J, Gilman C, Feuerstein JL, Keefe D, Goetz D, Goetz RR, Buckley P, Lehrer DS, Pato M, Pato C. Parental age effects on odor sensitivity in healthy subjects and schizophrenia patients. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):513-20. View in: PubMed

Lehrer DS, Pato MT, Nahhas RW, Miller BR, Malaspina D, Buckley PF, Sobell JL, Walsh-Messinger J, Cohort Consortium GP, Pato CN. Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):495-505. View in: PubMed

Guffanti G, Gaudi S, Klengel T, Fallon JH, Mangalam H, Madduri R, Rodriguez A, DeCrescenzo P, Glovienka E, Sobell J, Klengel C, Pato M, Ressler KJ, Pato C, Macciardi F. LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):534-45. View in: PubMed

Montano C, Taub MA, Jaffe A, Briem E, Feinberg JI, Trygvadottir R, Idrizi A, Runarsson A, Berndsen B, Gur RC, Moore TM, Perry RT, Fugman D, Sabunciyan S, Yolken RH, Hyde TM, Kleinman JE, Sobell JL, Pato CN, Pato MT, Go RC, Nimgaonkar V, Weinberger DR, Braff D, Gur RE, Fallin MD, Feinberg AP. Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study. JAMA Psychiatry. 2016 May 1; 73(5):506-14. View in: PubMed

Bigdeli TB, Ripke S, Bacanu SA, Lee SH, Wray NR, Gejman PV, Rietschel M, Cichon S, St Clair D, Corvin A, Kirov G, McQuillin A, Gurling H, Rujescu D, Andreassen OA, Werge T, Blackwood DH, Pato CN, Pato MT, Malhotra AK, O'Donovan MC, Kendler KS, Fanous AH. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. Am J Med Genet B Neuropsychiatr Genet. 2016 Mar; 171(2):276-89. View in: PubMed

Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet. 2015 Oct 1; 97(4):576-92. View in: PubMed

Lee SH, Byrne EM, Hultman CM, Kähler A, Vinkhuyzen AA, Ripke S, Andreassen OA, Frisell T, Gusev A, Hu X, Karlsson R, Mantzioris VX, McGrath JJ, Mehta D, Stahl EA, Zhao Q, Kendler KS, Sullivan PF, Price AL, O'Donovan M, Okada Y, Mowry BJ, Raychaudhuri S, Wray NR. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. Int J Epidemiol. 2015 Oct; 44(5):1706-21. View in: PubMed

Tang VK, Pato MT, Sobell JL, Hammond TC, Valdez MM, Lane CJ. Substance use associated with short sleep duration in patients with schizophrenia or schizoaffective disorder. Am J Med Genet B Neuropsychiatr Genet. 2015 Sep 8. View in: PubMed

Usher CL, Handsaker RE, Esko T, Tuke MA, Weedon MN, Hastie AR, Cao H, Moon JE, Kashin S, Fuchsberger C, Metspalu A, Pato CN, Pato MT, McCarthy MI, Boehnke M, Altshuler DM, Frayling TM, Hirschhorn JN, McCarroll SA. Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. Nat Genet. 2015 Aug; 47(8):921-5. View in: PubMed

Gomes JB, Cordioli A, Van Noppen B, Pato M, Wolitzky-Taylor K, Gonçalves F, Heldt E. Family Accommodation Scale for Obsessive-Compulsive Disorder-Interviewer-Rated (FAS-IR), Brazilian Portuguese version: Internal consistency, reliability, and exploratory factor analysis. Compr Psychiatry. 2015 Feb; 57:155-9. View in: PubMed

Arnedo J, Svrakic DM, Del Val C, Romero-Zaliz R, Hernández-Cuervo H. Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies. Am J Psychiatry. 2015 Feb 1; 172(2):139-53. View in: PubMed

Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL. Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD. Am J Psychiatry. 2015 Jan 1; 172(1):82-93. View in: PubMed

Sassano-Higgins SA, Pato MT. Pindolol augmentation of selective serotonin reuptake inhibitors and clomipramine for the treatment of obsessive-compulsive disorder: A meta-analysis. J Pharmacol Pharmacother. 2015 Jan-Mar; 6(1):36-8. View in: PubMed

Duan J, Shi J, Fiorentino A, Leites C, Chen X, Moy W, Chen J, Alexandrov BS, Usheva A, He D, Freda J, O'Brien NL. A Rare Functional Noncoding Variant at the GWAS-Implicated MIR137/MIR2682 Locus Might Confer Risk to Schizophrenia and Bipolar Disorder. Am J Hum Genet. 2014 Dec 4; 95(6):744-53. View in: PubMed

McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM. Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 53(8):910-9. View in: PubMed

Hartz SM, Bierut LJ, Pato MT. Very small p values-reply. JAMA Psychiatry. 2014 Aug 1; 71(8):969. View in: PubMed

Gomes JB, Van Noppen B, Pato M, Braga DT, Meyer E, Bortoncello CF, Cordioli AV. Patient and family factors associated with family accommodation in obsessive-compulsive disorder. Psychiatry Clin Neurosci. 2014 Aug; 68(8):621-30. View in: PubMed

Rees E, Walters JT, Chambert KD, O'Dushlaine C, Szatkiewicz J, Richards AL, Georgieva L, Mahoney-Davies G, Legge SE, Moran JL, Genovese G, Levinson D, Morris DW, Cormican P, Kendler KS, O'Neill FA, Riley B, Gill M, Corvin A. CNV analysis in a large schizophrenia sample implicates deletions at 16p12. 1 and SLC1A1 and duplications at 1p36. 33 and CGNL1. Hum Mol Genet. 2014 Mar 15; 23(6):1669-76. View in: PubMed

Hartz SM, Pato CN, Medeiros H, Cavazos-Rehg P, Sobell JL, Knowles JA, Bierut LJ, Pato MT. Comorbidity of severe psychotic disorders with measures of substance use. JAMA Psychiatry. 2014 Mar 1; 71(3):248-54. View in: PubMed

Bigdeli TB, Maher BS, Zhao Z, Sun J, Medeiros H, Akula N, McMahon FJ, Carvalho C, Ferreira SR, Azevedo MH, Knowles JA, Pato MT, Pato CN, Fanous AH. Association study of 83 candidate genes for bipolar disorder in chromosome 6q selected using an evidence-based prioritization algorithm. Am J Med Genet B Neuropsychiatr Genet. 2013 Dec; 162(8):898-906. View in: PubMed

Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, Van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM. Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct; 9(10):e1003864. View in: PubMed

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013 Sep; 45(9):984-94. View in: PubMed

Pato MT, Cobb RT, Lusskin SI, Schardt C. Journal club for faculty or residents: a model for lifelong learning and maintenance of certification. Int Rev Psychiatry. 2013 Jun; 25(3):276-83. View in: PubMed

Aberg KA, Liu Y, Bukszár J, McClay JL, Khachane AN, Andreassen OA, Blackwood D, Corvin A, Djurovic S, Gurling H, Ophoff R, Pato CN, Pato MT, Riley B, Webb T, Kendler K, O'Donovan M, Craddock N, Kirov G, Owen M, Rujescu D, St Clair D, Werge T, Hultman CM, Delisi LE, Sullivan P, van den Oord EJ. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry. 2013 Jun; 70(6):573-81. View in: PubMed

Pato MT, Sobell JL, Medeiros H, Abbott C, Sklar BM, Buckley PF, Bromet EJ, Escamilla MA, Fanous AH, Lehrer DS, Macciardi F, Malaspina D, McCarroll SA, Marder SR, Moran J, Morley CP, Nicolini H, Perkins DO, Purcell SM, Rapaport MH, Sklar P, Smoller JW, Knowles JA. The genomic psychiatry cohort: partners in discovery. Am J Med Genet B Neuropsychiatr Genet. 2013 Jun; 162B(4):306-12. View in: PubMed

Zisook S, Anzia J, Atri A, Baroni A, Clayton P, Haller E, Lomax JW, Mann JJ, Oquendo MA, Pato M, Perez-Rodriguez MM, Prabhakar D, Sen S, Thrall G, Yaseen ZS. Teaching evidence-based approaches to suicide risk assessment and prevention that enhance psychiatric training. Compr Psychiatry. 2013 Apr; 54(3):201-8. View in: PubMed

Zisook S, Boland R, Cowley D, Cyr RL, Pato MT, Thrall G. Teaching scholarly activity in psychiatric training: years 6 and 7. Acad Psychiatry. 2013 Mar 1; 37(2):82-6. View in: PubMed

Pato MT, Cyr RL, Manley LN, Morley CP. What to learn and how to teach it: five years of pre-meetings for training directors in psychiatry. Acad Psychiatry. 2013 Mar 1; 37(2):76-81. View in: PubMed

Pataki C, Pato MT, Sugar J, Rizzo AS, Parsons TD, St George C, Kenny P. Virtual patients as novel teaching tools in psychiatry. Acad Psychiatry. 2012 Sep 1; 36(5):398-400. View in: PubMed

Bourgeois JA, Yager J, Chisolm MS, Zisook S, Riba M, Levy BR, Newmark T, Aggarwal NK, Caplan JP, Balon R, Munro S, Pato MT. Why I like being an academic psychiatrist. Acad Psychiatry. 2012 Sep 1; 36(5):422-7. View in: PubMed

Fanous AH, Middleton FA, Gentile K, Amdur RL, Maher BS, Zhao Z, Sun J, Medeiros H, Carvalho C, Ferreira SR, Macedo A, Knowles JA, Azevedo MH, Pato MT, Pato CN. Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population. Am J Med Genet B Neuropsychiatr Genet. 2012 Jun; 159B(4):383-91. View in: PubMed

Baron DA, Pato MT, Cyr RL. Treatment of adults with attention-deficit/hyperactivity disorder. J Am Osteopath Assoc. 2011 Nov; 111(11):610-4. View in: PubMed

Maclean L, Pato MT. Changing recruitment outcomes: the 'why' and the 'how'. Acad Psychiatry. 2011 Jul-Aug; 35(4):241-4. View in: PubMed

Shoemaker E, Pataki C, Pato M, Pato C. Transforming residency training: a case study. Acad Psychiatry. 2011 Mar-Apr; 35(2):149-53. View in: PubMed

Moskvina V, Smith M, Ivanov D, Blackwood D, StClair D, Hultman C, Toncheva D, Gill M, Corvin A, O'Dushlaine C, Morris DW, Wray NR, Sullivan P, Pato C, Pato MT, Sklar P, Purcell S, Holmans P, O'Donovan MC, Owen MJ, Kirov G. Genetic Differences between Five European Populations. Hum Hered. 2010; 70(2):141-9. View in: PubMed

Maia BR, Soares MJ, Gomes A, Marques M, Pereira AT, Cabral A, Valente J, Bos SC, Pato M, Pocinho F, Azevedo MH, Macedo A. Perfectionism in obsessive-compulsive and eating disorders. Rev Bras Psiquiatr. 2009 Dec; 31(4):322-7. View in: PubMed

Soares MJ, Macedo A, Carvalho Bos S, Marques M, Maia B, Pereira AT, Gomes A, Valente J, Pato M, Azevedo MH. Perfectionism and eating attitudes in Portuguese students: a longitudinal study. Eur Eat Disord Rev. 2009 Sep-Oct; 17(5):390-8. View in: PubMed

Parsons TD, Kenny P, Ntuen CA, Pataki CS, Pato MT, Rizzo AA, St-George C, Sugar J. Objective structured clinical interview training using a virtual human patient. Stud Health Technol Inform. 2008; 132:357-62. View in: PubMed

Macedo A, Soares MJ, Azevedo MH, Gomes A, Pereira AT, Maia B, Pato M. Perfectionism and eating attitudes in Portuguese university students. Eur Eat Disord Rev. 2007 Jul; 15(4):296-304. View in: PubMed

Wojtecki CA, Wade MJ, Pato MT. Teaching interested clinicians how to develop research projects. Acad Psychiatry. 2007 Mar-Apr; 31(2):168-70. View in: PubMed

Eisener A, Pato MT, Medeiros H, Carvalho C, Pato CN. Genetics of schizophrenia: recent advances. Psychopharmacol Bull. 2007; 40(4):168-77. View in: PubMed

Shavitt RG, Belotto C, Curi M, Hounie AG, Rosário-Campos MC, Diniz JB, Ferrão YA, Pato MT, Miguel EC. Clinical features associated with treatment response in obsessive-compulsive disorder. Compr Psychiatry. 2006 Jul-Aug; 47(4):276-81. View in: PubMed

Pato MT. What Do You Need to Know About Leadership? Acad Psychiatry. 2006 Jul; 30(4):281-2. View in: PubMed

Middleton FA, Trauzzi MG, Shrimpton AE, Gentile KL, Morley CP, Medeiros H, Pato MT, Pato CN. Complete maternal uniparental isodisomy of chromosome 4 in a subject with major depressive disorder detected by high density SNP genotyping arrays. Am J Med Genet B Neuropsychiatr Genet. 2006 Jan 5; 141B(1):28-32. View in: PubMed

Wong AH, Likhodi O, Trakalo J, Yusuf M, Sinha A, Pato CN, Pato MT, Van Tol HH, Kennedy JL. Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder. Schizophr Res. 2005 Oct 15; 78(2-3):137-46. View in: PubMed

McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP, Laird NM. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95. View in: PubMed

Pato MT. A day in the life of an academic psychiatrist. Michele T. Pato, M. D. Acad Psychiatry. 2005 Sep-Oct; 29(4):378-9. View in: PubMed

Middleton FA, Pato CN, Gentile KL, McGann L, Brown AM, Trauzzi M, Diab H, Morley CP, Medeiros H, Macedo A, Azevedo MH, Pato MT. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5; 136B(1):12-25. View in: PubMed

Pato CN, Middleton FA, Gentile KL, Morley CP, Medeiros H, Macedo A, Azevedo MH, Pato MT. Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5; 134B(1):119-21. View in: PubMed

Wong AH, Trakalo J, Likhodi O, Yusuf M, Macedo A, Azevedo MH, Klempan T, Pato MT, Honer WG, Pato CN, Van Tol HH, Kennedy JL. Association between schizophrenia and the syntaxin 1A gene. Biol Psychiatry. 2004 Jul 1; 56(1):24-9. View in: PubMed

Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D. Assessing the impact of population stratification on genetic association studies. Nat Genet. 2004 Apr; 36(4):388-93. View in: PubMed

Ambrósio AM, Kennedy JL, Macciardi F, Coelho I, Soares MJ, Oliveira CR, Pato MT, Pato CN. Nonparametric linkage analysis between schizophrenia and candidate genes of dopaminergic and serotonergic systems. CNS Spectr. 2004 Apr; 9(4):302-8. View in: PubMed

Pato MT. Taking some unnatural steps: "improvements to complex systems do not occur naturally". Acad Psychiatry. 2004; 28(4):351-3. View in: PubMed

Eisener AF, Pato CN, Dewan M, Pato MT. From genomics to proteomics: new directions in molecular neuropsychiatry. Acta Neuropsychiatr. 2003 Dec; 15(6):388-97. View in: PubMed

Narendran R, Young CM, Pristach CA, Pato MT, Valenti AM, Fass AR. Efficacy of clozapine in the treatment of atypical antipsychotic refractory schizophrenia: a pilot study. J Clin Psychopharmacol. 2003 Feb; 23(1):103-4. View in: PubMed

Pallanti S, Hollander E, Bienstock C, Koran L, Leckman J, Marazziti D, Pato M, Stein D, Zohar J. Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychopharmacol. 2002 Jun; 5(2):181-91. View in: PubMed

Pato MT, Pato CN, Pauls DL. Recent findings in the genetics of OCD. J Clin Psychiatry. 2002; 63 Suppl 6:30-3. View in: PubMed

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